Volume 5; Issue 9

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ChemMedChem
Volume 5; Issue 9

ChemMedChem

Volume 5; Issue 9

1

Novel Peptidyl Aryl Vinyl Sulfones as Highly Potent and Selective Inhibitors of Cathepsins L and B

Laura Mendieta, Anna Picó, Teresa Tarragó, Meritxell Teixidó, Marcos Castillo, Llorenç Rafecas, Albert Moyano, Ernest Giralt

Journal:

Year:

2010

Language:

english

File:

PDF, 995 KB

english, 2010

2

Heme Oxygenase Inhibition by 1-Aryl-2-(1H-imidazol-1-yl/1H-1,2,4-triazol-1-yl)ethanones and Their Derivatives

Gheorghe Roman, Jason Z. Vlahakis, Dragic Vukomanovic, Kanji Nakatsu, Walter A. Szarek

Journal:

Year:

2010

Language:

english

File:

PDF, 380 KB

english, 2010

3

New Anacardic Acid-Inspired Benzamides: Histone Lysine Acetyltransferase Activators

José A. Souto, Rosaria Benedetti, Katharina Otto, Marco Miceli, Rosana Álvarez, Lucia Altucci, Angel R. de Lera

Journal:

Year:

2010

Language:

english

File:

PDF, 487 KB

english, 2010

4

Prediction of the Three-Dimensional Structure for the Rat Urotensin II Receptor, and Comparison of the Antagonist Binding Sites and Binding Selectivity between Human and Rat Receptors from Atomistic Simulations

Soo-Kyung Kim, Youyong Li, Changmoon Park, Ravinder Abrol, William A. Goddard III

Journal:

Year:

2010

Language:

english

File:

PDF, 1.69 MB

english, 2010

5

Novel 3-Carboxy- and 3-Phosphonopyrazoline Amino Acids as Potent and Selective NMDA Receptor Antagonists: Design, Synthesis, and Pharmacological Characterization

Paola Conti, Andrea Pinto, Lucia Tamborini, Ulf Madsen, Birgitte Nielsen, Hans Bräuner-Osborne, Kasper B. Hansen, Elisa Landucci, Domenico E. Pellegrini-Giampietro, Giovambattista De Sarro, Eugenio Do

Journal:

Year:

2010

Language:

english

File:

PDF, 468 KB

english, 2010

6

Discovery Process and Characterization of Novel Carbohydrazide Derivatives as Potent and Selective GHSR1a Antagonists

Fabio Maria Sabbatini, Romano Di Fabio, Mauro Corsi, Paolo Cavanni, Steve M. Bromidge, Yves St-Denis, Lucilla D'Adamo, Stefania Contini, Marilisa Rinaldi, Sebastien Guery, Chiara Savoia, Claudia Mundi

Journal:

Year:

2010

Language:

english

File:

PDF, 319 KB

english, 2010

7

Synthesis, Cytotoxicity, and Insight into the Mode of Action of Re(CO)3 Thymidine Complexes

Mark D. Bartholomä, Anthony R. Vortherms, Shawn Hillier, Birgit Ploier, John Joyal, John Babich, Robert P. Doyle, Jon Zubieta

Journal:

Year:

2010

Language:

english

File:

PDF, 384 KB

english, 2010

8

Multitarget Drugs: Synthesis and Preliminary Pharmacological Characterization of Zileuton Analogues Endowed with Dual 5-LO Inhibitor and NO-Dependent Activities

Donatella Boschi, Marta Giorgis, Clara Cena, Naveen Chandra Talniya, Antonella Di Stilo, Giuseppina Morini, Gabriella Coruzzi, Elena Guaita, Roberta Fruttero, Alberto Gasco

Journal:

Year:

2010

Language:

english

File:

PDF, 300 KB

english, 2010

9

Bidentate Zinc Chelators for α-Carbonic Anhydrases that Produce a Trigonal Bipyramidal Coordination Geometry

Johannes Schulze Wischeler, Alessio Innocenti, Daniela Vullo, Arpita Agrawal, Seth M. Cohen, Andreas Heine, Claudiu T. Supuran, Gerhard Klebe

Journal:

Year:

2010

Language:

english

File:

PDF, 653 KB

english, 2010

10

Praziquantel and Schistosomiasis

Alexander Dömling, Kareem Khoury

Journal:

Year:

2010

Language:

english

File:

PDF, 1.39 MB

english, 2010

11

Bicyclic Derivatives of the Potent Dual Aromatase–Steroid Sulfatase Inhibitor 2-Bromo-4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenylsulfamate: Synthesis, SAR, Crystal Structure, and in vitro and in vivo Activities

Paul M. Wood, L. W. Lawrence Woo, Jean-Robert Labrosse, Mark P. Thomas, Mary F. Mahon, Surinder K. Chander, Atul Purohit, Michael J. Reed, Barry V. L. Potter

Journal:

Year:

2010

Language:

english

File:

PDF, 697 KB

english, 2010

12

Erythroid Induction of Chronic Myelogenous Leukemia K562 Cells Following Treatment with a Photoproduct Derived from the UV-A Irradiation of 5-Methoxypsoralen

Alessia Salvador, Stefano Dall'Acqua, Manlio Sutera Sardo, Sergio Caffieri, Daniela Vedaldi, Francesco Dall'Acqua, Monica Borgatti, Cristina Zuccato, Nicoletta Bianchi, Roberto Gambari

Journal:

Year:

2010

Language:

english

File:

PDF, 449 KB

english, 2010

13

Design, Synthesis, and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors

Leonardo Pisani, Marco Catto, Ilenia Giangreco, Francesco Leonetti, Orazio Nicolotti, Angela Stefanachi, Saverio Cellamare, Angelo Carotti

Journal:

Year:

2010

Language:

english

File:

PDF, 575 KB

english, 2010

14

Probing the Peptidylglycine α-Hydroxylating Monooxygenase Active Site with Novel 4-Phenyl-3-butenoic Acid Based Inhibitors

Emma Langella, Sébastien Pierre, Wadih Ghattas, Michel Giorgi, Marius Réglier, Michele Saviano, Luciana Esposito, Renaud Hardré

Journal:

Year:

2010

Language:

english

File:

PDF, 838 KB

english, 2010

15

Specific Inhibitors of the Breast Cancer Resistance Protein (BCRP)

Anne Pick, Werner Klinkhammer, Michael Wiese

Journal:

Year:

2010

Language:

english

File:

PDF, 423 KB

english, 2010

16

Improved 2,4-Diarylthiazole-Based Antiprion Agents: Switching the Sense of the Amide Group at C5 Leads to an Increase in Potency

Mark J. Thompson, Jennifer C. Louth, Gemma K. Greenwood, Fiona J. Sorrell, Sandra G. Knight, Nathan B. P. Adams, Beining Chen

Journal:

Year:

2010

Language:

english

File:

PDF, 591 KB

english, 2010

17

Synthesis of Anti-Microtubule N-(2-Arylindol-7-yl)benzenesulfonamide Derivatives and Their Antitumor Mechanisms

Chun-Tang Chiou, Grace Shiahuy Chen, Meng-Ling Chen, Huoming Li, Lei Shi, Xiang-Hong Huang, Wei-Ming Dai, Ji-Wang Chern

Journal:

Year:

2010

Language:

english

File:

PDF, 590 KB

english, 2010

18

Synthesis of Bioactive 2-Aza-Analogues of Ipecac and Alangium Alkaloids

Michael Kölzer, Kerstin Weitzel, H. Ulrich Göringer, Eckhard Thines, Till Opatz

Journal:

Year:

2010

Language:

english

File:

PDF, 440 KB

english, 2010

19

Discovery of 1-(2,4-Dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophen-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a Potential Peripheral Cannabinoid-1 Receptor Inverse Agonist

Ming-Shiu Hung, Chun-Ping Chang, Ting-Chieh Li, Teng-Kuang Yeh, Jen-Shin Song, Yinchiu Lin, Chien-Huang Wu, Po-Chu Kuo, Prashanth K. Amancha, Ying-Chieh Wong, Wen-Chi Hsiao, Yu-Sheng Chao, Kak-Shan Sh

Journal:

Year:

2010

Language:

english

File:

PDF, 313 KB

english, 2010

20

Ease of Synthesis, Controllable Sizes, and In Vivo Large-Animal-Lymph Migration of Polymeric Nanoparticles

Kimberly Ann V. Zubris, Onkar V. Khullar, Aaron P. Griset, Summer Gibbs-Strauss, John V. Frangioni, Yolonda L. Colson, Mark W. Grinstaff

Journal:

Year:

2010

Language:

english

File:

PDF, 496 KB

english, 2010

21

Cover Picture: Ease of Synthesis, Controllable Sizes, and In Vivo Large-Animal-Lymph Migration of Polymeric Nanoparticles (ChemMedChem 9/2010)

Kimberly Ann V. Zubris, Onkar V. Khullar, Aaron P. Griset, Summer Gibbs-Strauss, John V. Frangioni, Yolonda L. Colson, Mark W. Grinstaff

Journal:

Year:

2010

Language:

english

File:

PDF, 1.69 MB

english, 2010

22

Inside Cover: Improved 2,4-Diarylthiazole-Based Antiprion Agents: Switching the Sense of the Amide Group at C5 Leads to an Increase in Potency (ChemMedChem 9/2010)

Mark J. Thompson, Jennifer C. Louth, Gemma K. Greenwood, Fiona J. Sorrell, Sandra G. Knight, Nathan B. P. Adams, Beining Chen

Journal:

Year:

2010

Language:

english

File:

PDF, 444 KB

english, 2010

23

Graphical Abstract: ChemMedChem 9/2010

Journal:

Year:

2010

Language:

english

File:

PDF, 1.01 MB

english, 2010

24

Corrigendum: Cover Picture: Discovery of a Class of Diketopiperazines as Antiprion Compounds (ChemMedChem 8/2010)

Maria Laura Bolognesi, Hoang Ngoc Ai Tran, Matteo Staderini, Alessandra Monaco, Alberto López-Cobeñas, Salvatore Bongarzone, Xevi Biarnés, Pilar López-Alvarado, Nieves Cabezas, Maria Caramelli, Paolo

Journal:

Year:

2010

File:

PDF, 58 KB

2010

25

Spotlights on our sister journals: ChemMedChem 9/2010

Journal:

Year:

2010

Language:

english

File:

PDF, 793 KB

english, 2010

26

Preview: ChemMedChem 10/2010

Journal:

Year:

2010

Language:

english

File:

PDF, 91 KB

english, 2010

27

Corrigendum: Pentalysine β-Carbonylphthalocyanine Zinc: An Effective Tumor-Targeting Photosensitizer for Photodynamic Therapy

Zhuo Chen, Shanyong Zhou, Jincan Chen, Yicai Deng, Zhipu Luo, Hongwei Chen, Michael R. Hamblin, Mingdong Huang

Journal:

Year:

2010

File:

PDF, 65 KB

2010

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