Volume 6; Issue 9

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ChemMedChem
Volume 6; Issue 9

ChemMedChem

Volume 6; Issue 9

1

Unexpected Opioid Activity Profiles of Analogues of the Novel Peptide Kappa Opioid Receptor Ligand CJ-15,208

Prof. Jane V. Aldrich, Dr. Santosh S. Kulkarni, Dr. Sanjeewa N. Senadheera, Dr. Nicolette C. Ross, Kate J. Reilley, Shainnel O. Eans, Michelle L. Ganno, Prof. Thomas F. Murray, Dr. Jay P. McLaughlin

Journal:

Year:

2011

Language:

english

File:

PDF, 724 KB

english, 2011

2

An Amphiphilic Conjugate Approach toward the Design and Synthesis of Betulinic Acid–Polyphenol Conjugates as Inhibitors of the HIV-1 gp41 Fusion Core Formation

Dr. Yan Liu, Dr. Zhuofeng Ke, Kwok Yiu Wu, Prof. Shuwen Liu, Prof. Wen-Hua Chen, Prof. Shibo Jiang, Prof. Zhi-Hong Jiang

Journal:

Year:

2011

Language:

english

File:

PDF, 2.27 MB

english, 2011

3

Synthesis and Structure–Activity Relationships of Constrained Heterocyclic Analogues of Combretastatin A4

Dr. Martin Arthuis, Dr. Renée Pontikis, Dr. Guy G. Chabot, Johanne Seguin, Lionel Quentin, Dr. Stéphane Bourg, Dr. Luc Morin-Allory, Dr. Jean-Claude Florent

Journal:

Year:

2011

Language:

english

File:

PDF, 853 KB

english, 2011

4

Design, Synthesis, and Biological Evaluation of Ring-Opened Bengamide Analogues

Wan-Yi Tai, Run-Tao Zhang, Yi-Ming Ma, Min Gu, Gang Liu, Dr. Jia Li, Prof. Dr. Fa-Jun Nan

Journal:

Year:

2011

Language:

english

File:

PDF, 223 KB

english, 2011

5

Design, Synthesis, and Biological Activity of Urea Derivatives as Anaplastic Lymphoma Kinase Inhibitors

Gustav Boije af Gennäs, Dr. Luca Mologni, Dr. Shaheen Ahmed, Dr. Mohanathas Rajaratnam, Prof. Oriano Marin, Niko Lindholm, Michela Viltadi, Prof. Carlo Gambacorti-Passerini, Prof. Leonardo Scapozza, P

Journal:

Year:

2011

Language:

english

File:

PDF, 1.42 MB

english, 2011

6

The Inverse Type II β-Turn on D-Trp-Phe, a Pharmacophoric Motif for MOR Agonists

Prof. Dr. Luca Gentilucci, Dr. Alessandra Tolomelli, Dr. Rossella De Marco, Prof. Santi Spampinato, Dr. Andrea Bedini, Dr. Roberto Artali

Journal:

Year:

2011

Language:

english

File:

PDF, 3.85 MB

english, 2011

7

From Activity Cliffs to Target-Specific Scoring Models and Pharmacophore Hypotheses

Birte Seebeck, Dr. Markus Wagener, Prof. Dr. Matthias Rarey

Journal:

Year:

2011

Language:

english

File:

PDF, 2.32 MB

english, 2011

8

Adamantyl Ethanone Pyridyl Derivatives: Potent and Selective Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1

Dr. Xiangdong Su, Dr. Fabienne Pradaux-Caggiano, Dr. Nigel Vicker, Dr. Mark P. Thomas, Dr. Heather Halem, Dr. Michael D. Culler, Prof. Barry V. L. Potter

Journal:

Year:

2011

Language:

english

File:

PDF, 800 KB

english, 2011

9

A Partial Convergence in Action of Methylene Blue and Artemisinins: Antagonism with Chloroquine, a Reversal with Verapamil, and an Insight into the Antimalarial Activity of Chloroquine

Prof. Dr. Richard K. Haynes, Kwan-Wing Cheu, Ka-Yan Li, Maggie Mei-Ki Tang, Dr. Ho-Ning Wong, Min-Jiao Chen, Dr. Zu-Feng Guo, Prof. Dr. Zhi-Hong Guo, Dr. Paolo Coghi, Prof. Dr. Diego Monti

Journal:

Year:

2011

Language:

english

File:

PDF, 1.05 MB

english, 2011

10

Tissue Uptake Study and Photodynamic Therapy of Melanoma-Bearing Mice with a Nontoxic, Effective Chlorin

Dr. Janusz M. Dąbrowski, Martyna Krzykawska, Prof. Luis G. Arnaut, Prof. Mariette M. Pereira, Carlos J. P. Monteiro, Prof. Sérgio Simões, Prof. Krystyna Urbańska, Prof. Grażyna Stochel

Journal:

Year:

2011

Language:

english

File:

PDF, 1.17 MB

english, 2011

11

Identification of a Glycogen Synthase Kinase-3β Inhibitor that Attenuates Hyperactivity in CLOCK Mutant Mice

Prof. Alan P. Kozikowski, Dr. Hendra Gunosewoyo, Dr. Songpo Guo, Dr. Irina N. Gaisina, Dr. Richard L. Walter, Ariel Ketcherside, Prof. Colleen A. McClung, Prof. Andrew D. Mesecar, Dr. Barbara Caldaron

Journal:

Year:

2011

Language:

english

File:

PDF, 1005 KB

english, 2011

12

Development of Antitrypanosomal and Antiplasmodial Nonpeptidic Cysteine Protease Inhibitors based on N-Protected-Guanidino-Furan and -Pyrrole Building Blocks

Sebastian Langolf, Dr. Uwe Machon, Martin Ehlers, Wilhelm Sicking, Prof. Dr. Tanja Schirmeister, Dr. Christian Büchhold, Dr. Christoph Gelhaus, Prof. Philip J. Rosenthal, Prof. Dr. Carsten Schmuck

Journal:

Year:

2011

Language:

english

File:

PDF, 735 KB

english, 2011

13

[3H]UR-MK136: A Highly Potent and Selective Radioligand for Neuropeptide Y Y1 Receptors

Dr. Max Keller, Prof. Dr. Günther Bernhardt, Prof. Dr. Armin Buschauer

Journal:

Year:

2011

Language:

english

File:

PDF, 667 KB

english, 2011

14

Light-Activated Release of Nitric Oxide with Fluorescence Reporting in Living Cells

Dr. Elisa Vittorino, Dr. Maria Teresa Sciortino, Dr. Gabriel Siracusano, Prof. Salvatore Sortino

Journal:

Year:

2011

Language:

english

File:

PDF, 405 KB

english, 2011

15

Camptothecin and Thiocamptothecin: the Role of Sulfur in Shifting the Hydrolysis Equilibrium towards the Closed Lactone Form

Dr. Marco Pistolozzi, Dr. Greta Varchi, Alessandra Degli Esposti, Andrea Guerrini, Dr. Giovanna Sotgiu, Marco Ballestri, Dr. Claudia Ferroni, Dr. Alessandro Venturini, Prof. Carlo Bertucci

Journal:

Year:

2011

Language:

english

File:

PDF, 629 KB

english, 2011

16

Synthesis of Aryl-Substituted Naphthalene-Linked Pyrrolobenzodiazepine Conjugates as Potential Anticancer Agents with Apoptosis-Inducing Ability

Dr. Ahmed Kamal, M. Kashi Reddy, Dr. M. Janaki Ramaiah, Y. V. V. Srikanth, Rajender, V. Santosh Reddy, G. Bharath Kumar, Dr. S. N. C. V. L. Pushpavalli, Indira Bag, Dr. Aarti Juvekar, Dr. Subrata Sen,

Journal:

Year:

2011

Language:

english

File:

PDF, 885 KB

english, 2011

17

Structure-Guided Design of a Highly Selective Glycogen Synthase Kinase-3β Inhibitor: a Superior Neuroprotective Pyrazolone Showing Antimania Effects

Dr. Wenwen Chen, Dr. Irina N. Gaisina, Dr. Hendra Gunosewoyo, Sam A. Malekiani, Dr. Taleen Hanania, Prof. Dr. Alan P. Kozikowski

Journal:

Year:

2011

Language:

english

File:

PDF, 4.44 MB

english, 2011

18

Small Molecule Binding to Proteins: Affinity and Binding/Unbinding Dynamics from Atomistic Simulations

Danzhi Huang, Amedeo Caflisch

Journal:

Year:

2011

Language:

english

File:

PDF, 788 KB

english, 2011

19

Hepatitis C: Antiviral Drug Discovery and Development. Edited by Seng-Lai Tan and Yupeng He.

Dr. Pierre L. Beaulieu

Journal:

Year:

2011

Language:

english

File:

PDF, 121 KB

english, 2011

20

Application of the Guanidine–Acylguanidine Bioisosteric Approach to Argininamide-Type NPY Y2 Receptor Antagonists

Nikola Pluym, Dr. Albert Brennauer, Dr. Max Keller, Dr. Ralf Ziemek, Dr. Nathalie Pop, Prof. Dr. Günther Bernhardt, Prof. Dr. Armin Buschauer

Journal:

Year:

2011

Language:

english

File:

PDF, 444 KB

english, 2011

21

Acetamide Scanning around Bicyclic Thiazoles: SAR at the H3 Receptor

Dr. Frédéric Denonne , Dr. Sylvain Célanire, Dr. Bernard Christophe, Sabine Defays, Christel Delaunoy, Dr. Marie-Laure Delporte, Dr. Eric Detrait, Véronique Durieu, Dr. Michel Gillard, Dr. Yves Lamber

Journal:

Year:

2011

Language:

english

File:

PDF, 392 KB

english, 2011

22

Bromophycolide A Targets Heme Crystallization in the Human Malaria Parasite Plasmodium falciparum

Dr. E. Paige Stout, Serena Cervantes, Jacques Prudhomme, Prof. Dr. Stefan France, Dr. James J. La Clair, Prof. Dr. Karine Le Roch, Prof. Dr. Julia Kubanek

Journal:

Year:

2011

Language:

english

File:

PDF, 896 KB

english, 2011

23

New Frontiers in Chemical Biology: Enabling Drug Discovery. Edited by Mark E. Bunnage.

Dr. Joshua Kritzer

Journal:

Year:

2011

Language:

english

File:

PDF, 160 KB

english, 2011

24

The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs. By Enrique Raviña.

Dr. Henning Steinhagen

Journal:

Year:

2011

Language:

english

File:

PDF, 222 KB

english, 2011

25

Cover Picture: From Activity Cliffs to Target-Specific Scoring Models and Pharmacophore Hypotheses (ChemMedChem 9/2011)

Birte Seebeck, Dr. Markus Wagener, Prof. Dr. Matthias Rarey

Journal:

Year:

2011

File:

PDF, 856 KB

2011

26

Inside Cover: Light-Activated Release of Nitric Oxide with Fluorescence Reporting in Living Cells (ChemMedChem 9/2011)

Dr. Elisa Vittorino, Dr. Maria Teresa Sciortino, Dr. Gabriel Siracusano, Prof. Salvatore Sortino

Journal:

Year:

2011

Language:

english

File:

PDF, 1.11 MB

english, 2011

27

Graphical Abstract: ChemMedChem 9/2011

Journal:

Year:

2011

Language:

english

File:

PDF, 2.48 MB

english, 2011

28

Spotlights on our sister journals: ChemMedChem 9/2011

Journal:

Year:

2011

Language:

english

File:

PDF, 1.40 MB

english, 2011

29

Preview: ChemMedChem 10/2011

Journal:

Year:

2011

Language:

english

File:

PDF, 71 KB

english, 2011