Volume 7; Issue 2

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ChemMedChem
Volume 7; Issue 2

ChemMedChem

Volume 7; Issue 2

1

Application of Barluenga Boronic Coupling (BBC) to the Parallel Synthesis of Drug-like and Drug Fragment-like Molecules

Shoko Nakagawa, Katie A. Bainbridge, Ken Butcher, Dr. Dave Ellis, Dr. Wolfgang Klute, Dr. Thomas Ryckmans

Journal:

Year:

2012

Language:

english

File:

PDF, 447 KB

english, 2012

2

Synthesis and Functional Characterization of Tridegin and Its Analogues: Inhibitors and Substrates of Factor XIIIa

Miriam Böhm, Toni Kühl, Kornelia Hardes, Richard Coch, Dr. Christoph Arkona, Dr. Bernhard Schlott, Prof. Dr. Torsten Steinmetzer, Prof. Dr. Diana Imhof

Journal:

Year:

2012

Language:

english

File:

PDF, 454 KB

english, 2012

3

Immunosuppressive Effects of Subglutinol Derivatives

Won-Gil Lee, Woo-Seok Kim, Prof. Dr. Sung-Gyoo Park, Prof. Dr. Hyoungsu Kim, Prof. Dr. Jiyong Hong, Dr. Hyojin Ko, Prof. Dr. Yong-Chul Kim

Journal:

Year:

2012

Language:

english

File:

PDF, 522 KB

english, 2012

4

Study of the Anticancer Properties of Tin(IV) Carboxylate Complexes on a Panel of Human Tumor Cell Lines

Lourdes Rocamora-Reverte, Dr. Estefanía Carrasco-García, Jesús Ceballos-Torres, Dr. Sanjiv Prashar, Dr. Goran N. Kaluđerović, Prof. José A. Ferragut, Dr. Santiago Gómez-Ruiz

Journal:

Year:

2012

Language:

english

File:

PDF, 558 KB

english, 2012

5

Discovery and Characterization of Atropisomer PH-797804, a p38 MAP Kinase Inhibitor, as a Clinical Drug Candidate

Dr. Li Xing, Dr. Balekudru Devadas, Dr. Rajesh V. Devraj, Dr. Shaun R. Selness, Dr. Huey Shieh, Dr. John K. Walker, Dr. Michael Mao, Dean Messing, Brian Samas, Dr. Jerry Z. Yang, Gary D. Anderson, Eli

Journal:

Year:

2012

Language:

english

File:

PDF, 694 KB

english, 2012

6

RAFT-Derived Polymer–Drug Conjugates: Poly(hydroxypropyl methacrylamide) (HPMA)–7-Ethyl-10-hydroxycamptothecin (SN-38) Conjugates

Dr. Charlotte C. Williams, Dr. San H. Thang, Tina Hantke, Uwe Vogel, Prof. Dr. Peter H. Seeberger, Dr. John Tsanaktsidis, Dr. Bernd Lepenies

Journal:

Year:

2012

Language:

english

File:

PDF, 3.17 MB

english, 2012

7

Galloflavin (CAS 568-80-9): A Novel Inhibitor of Lactate Dehydrogenase

Dr. Marcella Manerba, Dr. Marina Vettraino, Prof. Luigi Fiume, Prof. Giuseppina Di Stefano, Dr. Andrea Sartini, Dr. Elisa Giacomini, Dr. Rosa Buonfiglio, Prof. Marinella Roberti, Prof. Maurizio Recana

Journal:

Year:

2012

Language:

english

File:

PDF, 522 KB

english, 2012

8

Remarkable Stability and Cytostatic Effect of a Quercetin Conjugate, 3,7-Bis-O-Pivaloxymethyl (POM) Quercetin

Mi Kyoung Kim, Kwang-Su Park, Prof. Youhoon Chong

Journal:

Year:

2012

Language:

english

File:

PDF, 706 KB

english, 2012

9

Intermolecular and Intramolecular Hydrogen Bonds Involving Fluorine Atoms: Implications for Recognition, Selectivity, and Chemical Properties

Dr. Claudio Dalvit, Dr. Anna Vulpetti

Journal:

Year:

2012

Language:

english

File:

PDF, 2.55 MB

english, 2012

10

Design, Synthesis and Biological Evaluation of Noncovalent Inhibitors of Human CD38 NADase

Dr. Yi Zhou, Kai Yiu Ting, Connie Mo Ching Lam, Anna Ka Yee Kwong, Jie Xia, Dr. Hongwei Jin, Dr. Zhenming Liu, Prof. Liangren Zhang, Prof. Hon Cheung Lee, Prof. Lihe Zhang

Journal:

Year:

2012

Language:

english

File:

PDF, 708 KB

english, 2012

11

Experimental and Computational Active Site Mapping as a Starting Point to Fragment-Based Lead Discovery

Dr. Jürgen Behnen, Helene Köster, Gerd Neudert, Dr. Tobias Craan, Dr. Andreas Heine, Prof. Gerhard Klebe

Journal:

Year:

2012

Language:

english

File:

PDF, 2.11 MB

english, 2012

12

Elucidation of the Structure–Activity Relationships of Apelin: Influence of Unnatural Amino Acids on Binding, Signaling, and Plasma Stability

Alexandre Murza, Alexandre Parent, Elie Besserer-Offroy, Hugo Tremblay, Félix Karadereye, Nicolas Beaudet, Prof. Richard Leduc, Prof. Philippe Sarret, Prof. Éric Marsault

Journal:

Year:

2012

Language:

english

File:

PDF, 286 KB

english, 2012

13

A Synthetic Lipid A Mimetic Modulates Human TLR4 Activity

Dr. Matteo Piazza, Dr. Valentina Calabrese, Gaetana Damore, Roberto Cighetti, Prof. Theresa Gioannini, Prof. Jerrold Weiss, Prof. Francesco Peri

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Year:

2012

Language:

english

File:

PDF, 527 KB

english, 2012

14

M. Alami

Journal:

Year:

2012

Language:

english

File:

PDF, 377 KB

english, 2012

15

Engineering and Functionalization of the Disulfide-Constrained Miniprotein Min-23 as a Scaffold for Diagnostic Application

Frederic Zoller, Thimon Schwaebel, Dr. Annette Markert, Prof. Dr. Uwe Haberkorn, Dr. Walter Mier

Journal:

Year:

2012

Language:

english

File:

PDF, 2.31 MB

english, 2012

16

A Decade of the Human Genome Sequence—How Does the Medicinal Chemist Benefit?

Dr. Andreas Brunschweiger, Prof. Jonathan Hall

Journal:

Year:

2012

Language:

english

File:

PDF, 1.36 MB

english, 2012

17

3-Substituted 2-Phenylimidazo[2,1-b]benzothiazoles: Synthesis, Anticancer Activity, and Inhibition of Tubulin Polymerization

Dr. Ahmed Kamal, Farheen Sultana, Dr. M. Janaki Ramaiah, Dr. Y. V. V. Srikanth, A. Viswanath, Chandan Kishor, Pranjal Sharma, Dr. S. N. C. V. L. Pushpavalli, Dr. Anthony Addlagatta, Dr. Manika Pal-Bha

Journal:

Year:

2012

Language:

english

File:

PDF, 1.46 MB

english, 2012

18

Discovery of Novel Stem Cell Mobilizers That Target the CXCR4 Receptor

Dr. Chien-Huang Wu, Dr. Chun-Ping Chang, Dr. Jen-Shin Song, Jiing-Jyh Jan, Ming-Chen Chou, Szu-Huei Wu, Kai-Chia Yeh, Dr. Ying-Chieh Wong, Chieh-Jui Hsieh, Dr. Chiung-Tong Chen, Tzu-Ting Kao, Dr. Su-Y

Journal:

Year:

2012

Language:

english

File:

PDF, 349 KB

english, 2012

19

A Synthetic C34 Trimer of HIV-1 gp41 Shows Significant Increase in Inhibition Potency

Dr. Wataru Nomura, Chie Hashimoto, Aki Ohya, Dr. Kosuke Miyauchi, Dr. Emiko Urano, Dr. Tomohiro Tanaka, Dr. Tetsuo Narumi, Toru Nakahara, Dr. Jun A. Komano, Prof. Dr. Naoki Yamamoto, Prof. Dr. Hirokaz

Journal:

Year:

2012

Language:

english

File:

PDF, 408 KB

english, 2012

20

Antiviral Drug Strategies. Edited by Erik De Clercq.

Dr. Gilles Gosselin

Journal:

Year:

2012

Language:

english

File:

PDF, 89 KB

english, 2012

21

Cover Picture: Engineering and Functionalization of the Disulfide-Constrained Miniprotein Min-23 as a Scaffold for Diagnostic Application (ChemMedChem 2/2012)

Frederic Zoller, Thimon Schwaebel, Dr. Annette Markert, Prof. Dr. Uwe Haberkorn, Dr. Walter Mier

Journal:

Year:

2012

File:

PDF, 629 KB

2012

22

Inside Cover: RAFT-Derived Polymer–Drug Conjugates: Poly(hydroxypropyl methacrylamide) (HPMA)–7-Ethyl-10-hydroxycamptothecin (SN-38) Conjugates (ChemMedChem 2/2012)

Dr. Charlotte C. Williams, Dr. San H. Thang, Tina Hantke, Uwe Vogel, Prof. Dr. Peter H. Seeberger, Dr. John Tsanaktsidis, Dr. Bernd Lepenies

Journal:

Year:

2012

File:

PDF, 1016 KB

2012

23

Graphical Abstract: ChemMedChem 2/2012

Journal:

Year:

2012

Language:

english

File:

PDF, 3.47 MB

english, 2012

24

Spotlights on our sister journals: ChemMedChem 2/2012

Journal:

Year:

2012

Language:

english

File:

PDF, 1.24 MB

english, 2012

25

Preview: ChemMedChem 3/2012

Journal:

Year:

2012

Language:

english

File:

PDF, 96 KB

english, 2012

26

Back Cover: Discovery of Novel Stem Cell Mobilizers That Target the CXCR4 Receptor (ChemMedChem 2/2012)

Dr. Chien-Huang Wu, Dr. Chun-Ping Chang, Dr. Jen-Shin Song, Jiing-Jyh Jan, Ming-Chen Chou, Szu-Huei Wu, Kai-Chia Yeh, Dr. Ying-Chieh Wong, Chieh-Jui Hsieh, Dr. Chiung-Tong Chen, Tzu-Ting Kao, Dr. Su-Y

Journal:

Year:

2012

File:

PDF, 940 KB

2012

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