Volume 7; Issue 8

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ChemMedChem
Volume 7; Issue 8

ChemMedChem

Volume 7; Issue 8

1

Discovery of BAY 94-8862: A Nonsteroidal Antagonist of the Mineralocorticoid Receptor for the Treatment of Cardiorenal Diseases

Dr. Lars Bärfacker, Dr. Alexander Kuhl, Prof. Dr. Alexander Hillisch, Dr. Rolf Grosser, Dr. Santiago Figueroa-Pérez, Dr. Heike Heckroth, Adam Nitsche, Dr. Jens-Kerim Ergüden, Dr. Heike Gielen-Haertwig

Journal:

Year:

2012

Language:

english

File:

PDF, 1.11 MB

english, 2012

2

Three-Dimensional Pharmacophore Design and Biochemical Screening Identifies Substituted 1,2,4-Triazoles as Inhibitors of the Annexin A2–S100A10 Protein Interaction

Dr. Tummala R. K. Reddy, Dr. Chan Li, Prof. Peter M. Fischer, Dr. Lodewijk V. Dekker

Journal:

Year:

2012

Language:

english

File:

PDF, 4.30 MB

english, 2012

3

FimH Antagonists: Structure–Activity and Structure–Property Relationships for Biphenyl α-D-Mannopyranosides

Lijuan Pang, Simon Kleeb, Dr. Katrin Lemme, Dr. Said Rabbani, Dr. Meike Scharenberg, Adam Zalewski, Florentina Schädler, Dr. Oliver Schwardt, Prof. Dr. Beat Ernst

Journal:

Year:

2012

Language:

english

File:

PDF, 1.28 MB

english, 2012

4

The Prospect of FKBP51 as a Drug Target

Dr. Mathias V. Schmidt, Dr. Marcelo Paez-Pereda, Prof. Dr. Florian Holsboer, Dr. Felix Hausch

Journal:

Year:

2012

Language:

english

File:

PDF, 981 KB

english, 2012

5

Cyclosquaramides as Kinase Inhibitors with Anticancer Activity

Dr. Priam Villalonga, Dr. Silvia Fernández de Mattos, Guillem Ramis, Dr. Antònia Obrador-Hevia, Angel Sampedro, Dr. Carmen Rotger, Dr. Antoni Costa

Journal:

Year:

2012

Language:

english

File:

PDF, 826 KB

english, 2012

6

Hepatic Differentiation of Rat Mesenchymal Stem Cells by a Small Molecule

Dr. Jingfeng Ouyang, Jiaan Shao, Dr. Hongbin Zou, Prof. Dr. Yijia Lou, Prof. Dr. Yongping Yu

Journal:

Year:

2012

Language:

english

File:

PDF, 1.86 MB

english, 2012

7

Anticancer Agents That Counteract Tumor Glycolysis

Dr. Carlotta Granchi, Prof. Filippo Minutolo

Journal:

Year:

2012

Language:

english

File:

PDF, 2.65 MB

english, 2012

8

Tritium-Labeled Brivaracetam with High Specific Activity: Preparation, Characterization and Application in Human Brain Samples

Simone Hildenbrand, Prof. Dr. Susanne Schoch, Dr. Marec von Lehe, Dr. Rainer Surges, Prof. Dr. Christa E. Müller

Journal:

Year:

2012

Language:

english

File:

PDF, 391 KB

english, 2012

9

Synthesis and Application of the First Radioligand Targeting the Allosteric Binding Pocket of Chemokine Receptor CXCR3

Viachaslau Bernat, Prof. Dr. Markus R. Heinrich, Paul Baumeister, Prof. Dr. Armin Buschauer, Dr. Nuska Tschammer

Journal:

Year:

2012

Language:

english

File:

PDF, 600 KB

english, 2012

10

Anthranilamide–Pyrazolo[1,5-a]pyrimidine Conjugates as p53 Activators in Cervical Cancer Cells

Dr. Ahmed Kamal, Jaki R. Tamboli, Dr. M. Janaki Ramaiah, Dr. S. F. Adil, G. Koteswara Rao, A. Viswanath, Adla Mallareddy, Dr. S. N. C. V. L. Pushpavalli, Dr. Manika Pal-Bhadra

Journal:

Year:

2012

Language:

english

File:

PDF, 1.31 MB

english, 2012

11

Water Makes the Difference: Rearrangement of Water Solvation Layer Triggers Non-additivity of Functional Group Contributions in Protein–Ligand Binding

Dr. Adam Biela, Michael Betz, Dr. Andreas Heine, Prof. Dr. Gerhard Klebe

Journal:

Year:

2012

Language:

english

File:

PDF, 3.67 MB

english, 2012

12

Synthesis and Antifungal Activities of Glycosylated Derivatives of the Cyclic Peptide Fungicide Caspofungin

Junxiang Guo, Dr. Honggang Hu, Dr. Qingjie Zhao, Dr. Ting Wang, Dr. Yan Zou, Dr. Shichong Yu, Prof. Qiuye Wu, Prof. Zhongwu Guo

Journal:

Year:

2012

Language:

english

File:

PDF, 520 KB

english, 2012

13

In vitro Percutaneous Absorption of 14C-Labeled β-Lactone Promises Topical Delivery of New Bacterial Virulence Inhibitors

Dr. Katrin Lorenz-Baath, Dr. Vadim S. Korotkov, Dr. Christoph Lierse von Gostomski, Prof. Dr. Stephan A. Sieber

Journal:

Year:

2012

Language:

english

File:

PDF, 959 KB

english, 2012

14

The Effects of Ultrasound and Light on Indocyanine-Green-Treated Tumour Cells and Tissues

Dr. Nikolitsa Nomikou, Christine Sterrett, Ciara Arthur, Dr. Bridgeen McCaughan, Dr. John F. Callan, Prof. Anthony P. McHale

Journal:

Year:

2012

Language:

english

File:

PDF, 577 KB

english, 2012

15

Cardiovascular Properties of a Nitric Oxide Releasing Rofecoxib Analogue: Beneficial Anti-hypertensive Activity and Enhanced Recovery in an Ischemic Reperfusion Injury Model

Dr. Atul Bhardwaj, Dr. Sri N. Batchu, Dr. Jatinder Kaur, Dr. Zhangjian Huang, Prof. John M. Seubert, Prof. Edward E. Knaus

Journal:

Year:

2012

Language:

english

File:

PDF, 909 KB

english, 2012

16

Ribonucleoside 3′-Phosphates as Pro-Moieties for an Orally Administered Drug

Michael J. Palte, Amy K. F. Davis, Dr. Nicholas A. McGrath, Prof. Carol A. Spiegel, Prof. Ronald T. Raines

Journal:

Year:

2012

Language:

english

File:

PDF, 374 KB

english, 2012

17

Selectivity Enhancement Arising from Interactions at the PI3K Unique Pocket

Yujeong Jeong, Junghyun Lee, Yoonji Lee, Kyungrok Ham, Prof. Sun Choi, Prof. Sungwoo Hong

Journal:

Year:

2012

Language:

english

File:

PDF, 1.57 MB

english, 2012

18

Development of Therapeutic Agents Handbook. Edited by Shayne Cox Gad.

Dr. Katrin Rackelmann-Silber

Journal:

Year:

2012

Language:

english

File:

PDF, 208 KB

english, 2012

19

A Monoreactive Bifunctional Triazacyclononane Phosphinate Chelator with High Selectivity for Gallium-68

Jakub Šimeček, Ondřej Zemek, Prof. Dr. Petr Hermann, Prof. Dr. Hans-Jürgen Wester, Dr. Johannes Notni

Journal:

Year:

2012

Language:

english

File:

PDF, 448 KB

english, 2012

20

Polypharmacology in Drug Discovery. Edited by Jens-Uwe Peters.

Dr. David Ritchie

Journal:

Year:

2012

Language:

english

File:

PDF, 148 KB

english, 2012

21

Cover Picture: Discovery of BAY 94-8862: A Nonsteroidal Antagonist of the Mineralocorticoid Receptor for the Treatment of Cardiorenal Diseases (ChemMedChem 8/2012)

Dr. Lars Bärfacker, Dr. Alexander Kuhl, Prof. Dr. Alexander Hillisch, Dr. Rolf Grosser, Dr. Santiago Figueroa-Pérez, Dr. Heike Heckroth, Adam Nitsche, Dr. Jens-Kerim Ergüden, Dr. Heike Gielen-Haertwig

Journal:

Year:

2012

Language:

english

File:

PDF, 768 KB

english, 2012

22

Inside Cover: Ribonucleoside 3′-Phosphates as Pro-Moieties for an Orally Administered Drug (ChemMedChem 8/2012)

Michael J. Palte, Amy K. F. Davis, Dr. Nicholas A. McGrath, Prof. Carol A. Spiegel, Prof. Ronald T. Raines

Journal:

Year:

2012

File:

PDF, 942 KB

2012

23

Graphical Abstract: ChemMedChem 8/2012

Journal:

Year:

2012

Language:

english

File:

PDF, 3.24 MB

english, 2012

24

Spotlights on our sister journals: ChemMedChem 8/2012

Journal:

Year:

2012

Language:

english

File:

PDF, 1.29 MB

english, 2012

25

Preview: ChemMedChem 9/2012

Journal:

Year:

2012

Language:

english

File:

PDF, 78 KB

english, 2012

26

Back Cover: FimH Antagonists: Structure–Activity and Structure–Property Relationships for Biphenyl α-D-Mannopyranosides (ChemMedChem 8/2012)

Lijuan Pang, Simon Kleeb, Dr. Katrin Lemme, Dr. Said Rabbani, Dr. Meike Scharenberg, Adam Zalewski, Florentina Schädler, Dr. Oliver Schwardt, Prof. Dr. Beat Ernst

Journal:

Year:

2012

File:

PDF, 914 KB

2012

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