Volume 8; Issue 12

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ChemMedChem
Volume 8; Issue 12

ChemMedChem

Volume 8; Issue 12

1

Synthesis and Biological Evaluation of Imidazopyridine-Oxindole Conjugates as Microtubule-Targeting Agents

Kamal, Ahmed, Reddy, Vangala Santhosh, Karnewar, Santosh, Chourasiya, Sumit S., Shaik, Anver Basha, Kumar, G. Bharath, Kishor, Chandan, Reddy, M. Kashi, Narasimha Rao, M. P., Nagabhushana, Ananthamurt

Journal:

Year:

2013

Language:

english

File:

PDF, 1.41 MB

english, 2013

2

Sigma-2 Receptor Agonists as Possible Antitumor Agents in Resistant Tumors: Hints for Collateral Sensitivity

Niso, Mauro, Abate, Carmen, Contino, Marialessandra, Ferorelli, Savina, Azzariti, Amalia, Perrone, Roberto, Colabufo, Nicola Antonio, Berardi, Francesco

Journal:

Year:

2013

Language:

english

File:

PDF, 637 KB

english, 2013

3

Effect of Linker Length and Composition on Heterobivalent Ligand-Mediated Receptor Cross-Talk between the A 1 Adenosine and β 2 Adrenergic Receptors

Barlow, Nicholas, Baker, Stephen P., Scammells, Peter J.

Journal:

Year:

2013

Language:

english

File:

PDF, 551 KB

english, 2013

4

Back Cover: Synthesis and Biological Evaluation of Imidazopyridine-Oxindole Conjugates as Microtubule-Targeting Agents (ChemMedChem 12/2013)

Kamal, Ahmed, Reddy, Vangala Santhosh, Karnewar, Santosh, Chourasiya, Sumit S., Shaik, Anver Basha, Kumar, G. Bharath, Kishor, Chandan, Reddy, M. Kashi, Narasimha Rao, M. P., Nagabhushana, Ananthamurt

Journal:

Year:

2013

File:

PDF, 1.19 MB

2013

5

Computer-Aided Design, Synthesis and Validation of 2-Phenylquinazolinone Fragments as CDK9 Inhibitors with Anti-HIV-1 Tat-Mediated Transcription Activity

Sancineto, Luca, Iraci, Nunzio, Massari, Serena, Attanasio, Vanessa, Corazza, Gianmarco, Barreca, Maria Letizia, Sabatini, Stefano, Manfroni, Giuseppe, Avanzi, Nilla Roberta, Cecchetti, Violetta, Pann

Journal:

Year:

2013

Language:

english

File:

PDF, 1.10 MB

english, 2013

6

De Novo Design, Synthesis and Evaluation of Benzylpiperazine Derivatives as Highly Selective Binders of Mcl-1

Ding, Xiao, Li, Yan, Lv, Li, Zhou, Mi, Han, Li, Zhang, Zhengxi, Ba, Qian, Li, Jingquan, Wang, Hui, Liu, Hong, Wang, Renxiao

Journal:

Year:

2013

Language:

english

File:

PDF, 2.71 MB

english, 2013

7

Synthesis and Structure-Activity Relationship Studies of Quinoxaline Derivatives as Aldose Reductase Inhibitors

Wu, Bobin, Yang, Yanchun, Qin, Xiangyu, Zhang, Shuzhen, Jing, Chaojun, Zhu, Changjin, Ma, Bing

Journal:

Year:

2013

Language:

english

File:

PDF, 584 KB

english, 2013

8

Chromophore-Linked Substrate (CLS405): Probing Metallo-β-Lactamase Activity and Inhibition

Makena, Anne, van Berkel, Sander S., Lejeune, Clarisse, Owens, Raymond J., Verma, Anil, Salimraj, Ramya, Spencer, James, Brem, Jürgen, Schofield, Christopher J.

Journal:

Year:

2013

Language:

english

File:

PDF, 467 KB

english, 2013

9

para -Substituted 2-Phenyl-3,4-dihydroquinazolin-4-ones As Potent and Selective Tankyrase Inhibitors

Haikarainen, Teemu, Koivunen, Jarkko, Narwal, Mohit, Venkannagari, Harikanth, Obaji, Ezeogo, Joensuu, Päivi, Pihlajaniemi, Taina, Lehtiö, Lari

Journal:

Year:

2013

Language:

english

File:

PDF, 1.45 MB

english, 2013

10

Discovery of MK-8742: An HCV NS5A Inhibitor with Broad Genotype Activity

Coburn, Craig A., Meinke, Peter T., Chang, Wei, Fandozzi, Christine M., Graham, Donald J., Hu, Bin, Huang, Qian, Kargman, Stacia, Kozlowski, Joseph, Liu, Rong, McCauley, John A., Nomeir, Amin A., Soll

Journal:

Year:

2013

Language:

english

File:

PDF, 463 KB

english, 2013

11

Amythiamicin D and Related Thiopeptides as Inhibitors of the Bacterial Elongation Factor EF-Tu: Modification of the Amino Acid at Carbon Atom C2 of Ring C Dramatically Influences Activity

Gross, Stefan, Nguyen, Fabian, Bierschenk, Matthias, Sohmen, Daniel, Menzel, Thomas, Antes, Iris, Wilson, Daniel N., Bach, Thorsten

Journal:

Year:

2013

Language:

english

File:

PDF, 1.31 MB

english, 2013

12

Probing Binding and Cellular Activity of Pyrrolidinone and Piperidinone Small Molecules Targeting the Urokinase Receptor

Mani, Timmy, Liu, Degang, Zhou, Donghui, Li, Liwei, Knabe, William Eric, Wang, Fang, Oh, Kyungsoo, Meroueh, Samy O.

Journal:

Year:

2013

Language:

english

File:

PDF, 2.85 MB

english, 2013

13

Synthesis, Characterization, and Metabolism Studies of Fluspidine Enantiomers

Holl, Katharina, Falck, Evamaria, Köhler, Jens, Schepmann, Dirk, Humpf, Hans-Ulrich, Brust, Peter, Wünsch, Bernhard

Journal:

Year:

2013

Language:

english

File:

PDF, 449 KB

english, 2013

14

Spotlights on our sister journals: ChemMedChem 12/2013

Journal:

Year:

2013

Language:

english

File:

PDF, 1.67 MB

english, 2013

15

A Template-Based Approach to Inhibitors of Calpain 2, 20S Proteasome, and HIV-1 Protease

Jones, Seth A., Neilsen, Paul M., Siew, Limei, Callen, David F., Goldfarb, Nathan E., Dunn, Ben M., Abell, Andrew D.

Journal:

Year:

2013

Language:

english

File:

PDF, 263 KB

english, 2013

16

Cover Picture: Chromophore-Linked Substrate (CLS405): Probing Metallo-β-Lactamase Activity and Inhibition (ChemMedChem 12/2013)

Makena, Anne, van Berkel, Sander S., Lejeune, Clarisse, Owens, Raymond J., Verma, Anil, Salimraj, Ramya, Spencer, James, Brem, Jürgen, Schofield, Christopher J.

Journal:

Year:

2013

Language:

english

File:

PDF, 712 KB

english, 2013

17

Inside Cover: Sigma-2 Receptor Agonists as Possible Antitumor Agents in Resistant Tumors: Hints for Collateral Sensitivity (ChemMedChem 12/2013)

Niso, Mauro, Abate, Carmen, Contino, Marialessandra, Ferorelli, Savina, Azzariti, Amalia, Perrone, Roberto, Colabufo, Nicola Antonio, Berardi, Francesco

Journal:

Year:

2013

File:

PDF, 854 KB

2013

18

Design and Generation of Highly Diverse Fluorinated Fragment Libraries and their Efficient Screening with Improved 19 F NMR Methodology

Vulpetti, Anna, Dalvit, Claudio

Journal:

Year:

2013

Language:

english

File:

PDF, 665 KB

english, 2013

19

Corrigendum: Small-Molecule Modulators for Epigenetics Targets

Knapp, Stefan, Weinmann, Hilmar

Journal:

Year:

2013

File:

PDF, 74 KB

2013

20

Development of Rhodesain Inhibitors with a 3-Bromoisoxazoline Warhead

Ettari, Roberta, Tamborini, Lucia, Angelo, Ilenia C., Grasso, Silvana, Schirmeister, Tanja, Lo Presti, Leonardo, De Micheli, Carlo, Pinto, Andrea, Conti, Paola

Journal:

Year:

2013

Language:

english

File:

PDF, 375 KB

english, 2013

21

Graphical Abstract: ChemMedChem 12/2013

Journal:

Year:

2013

Language:

english

File:

PDF, 2.94 MB

english, 2013