Volume 9; Issue 12

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ChemMedChem
Volume 9; Issue 12

ChemMedChem

Volume 9; Issue 12

1

Benzofuran-Chalcone Hybrids as Potential Multifunctional Agents against Alzheimer’s Disease: Synthesis and in vivo Studies with Transgenic Caenorhabditis elegans

Sashidhara, Koneni V., Modukuri, Ram K., Jadiya, Pooja, Dodda, Ranga Prasad, Kumar, Manoj, Sridhar, Balasubramaniam, Kumar, Vikash, Haque, Rizwanul, Siddiqi, Mohammad Imran, Nazir, Aamir

Journal:

Year:

2014

Language:

english

File:

PDF, 2.23 MB

english, 2014

2

Design, Synthesis, and Biological Evaluation of Shikonin and Alkannin Derivatives as Potential Anticancer Agents via a Prodrug Approach

Wang, Ru-Bing, Zhou, Wen, Meng, Qing-Qing, Zhang, Xu, Ding, Jing, Xu, Yan, Song, Hua-Long, Yang, Kai, Cui, Jia-Hua, Li, Shao-Shun

Journal:

Year:

2014

Language:

english

File:

PDF, 630 KB

english, 2014

3

The Importance of Hydration Thermodynamics in Fragment-to-Lead Optimization

Ichihara, Osamu, Shimada, Yuzo, Yoshidome, Daisuke

Journal:

Year:

2014

Language:

english

File:

PDF, 1.33 MB

english, 2014

4

Structure-Activity Relationship of Tumor-Selective 5-Substituted 2-Amino-3-carboxymethylthiophene Derivatives

Thomas, Joice, Jejcic, Alenka, Vervaeke, Peter, Romagnoli, Romeo, Liekens, Sandra, Balzarini, Jan, Dehaen, Wim

Journal:

Year:

2014

Language:

english

File:

PDF, 1.58 MB

english, 2014

5

Synthetic 1-Deoxynojirimycin N-Substituted Peptides Offer Prolonged Disruption to N-Linked Glycan Processing

Aguilar, Aimé López, Escribano, Jaime, Wentworth, Paul, Butters, Terry D.

Journal:

Year:

2014

Language:

english

File:

PDF, 562 KB

english, 2014

6

Design and Synthesis of N-Acylated Aza-Goniothalamin Derivatives and Evaluation of Their in vitro and in vivo Antitumor Activity

Barcelos, Rosimeire Coura, Pastre, Julio Cezar, Vendramini-Costa, Débora Barbosa, Caixeta, Vanessa, Longato, Giovanna Barbarini, Monteiro, Paula Araújo, de Carvalho, João Ernesto, Pilli, Ronaldo Alois

Journal:

Year:

2014

Language:

english

File:

PDF, 1.64 MB

english, 2014

7

Pramipexole Derivatives as Potent and Selective Dopamine D 3 Receptor Agonists with Improved Human Microsomal Stability

Chen, Jianyong, Jiang, Cheng, Levant, Beth, Li, Xiaoqin, Zhao, Ting, Wen, Bo, Luo, Ruijuan, Sun, Duxin, Wang, Shaomeng

Journal:

Year:

2014

Language:

english

File:

PDF, 403 KB

english, 2014

8

Anticancer Profile of a Series of Gold(III) (2-phenyl)pyridine Complexes

Rubbiani, Riccardo, Zehnder, Thomas N., Mari, Cristina, Blacque, Olivier, Venkatesan, Koushik, Gasser, Gilles

Journal:

Year:

2014

Language:

english

File:

PDF, 602 KB

english, 2014

9

Targeting Promoter G-Quadruplex DNAs by Indenopyrimidine-Based Ligands

Diveshkumar, K. V., Sakrikar, Saaz, Harikrishna, S., Dhamodharan, V., Pradeepkumar, P. I.

Journal:

Year:

2014

Language:

english

File:

PDF, 2.28 MB

english, 2014

10

Discovery of a Highly Selective PLD2 Inhibitor (ML395): A New Probe with Improved Physiochemical Properties and Broad-Spectrum Antiviral Activity against Influenza Strains

O'Reilly, Matthew C., Oguin, Thomas H., Scott, Sarah A., Thomas, Paul G., Locuson, Charles W., Morrison, Ryan D., Daniels, J. Scott, Brown, H. Alex, Lindsley, Craig W.

Journal:

Year:

2014

Language:

english

File:

PDF, 677 KB

english, 2014

11

Structure-Activity Relationship Study of Spider Polyamine Toxins as Inhibitors of Ionotropic Glutamate Receptors

Xiong, Xiao-Feng, Poulsen, Mette H., Hussein, Rama A., Nørager, Niels G., Strømgaard, Kristian

Journal:

Year:

2014

Language:

english

File:

PDF, 756 KB

english, 2014

12

Iminosugar-Based Galactoside Mimics as Inhibitors of Galactocerebrosidase: SAR Studies and Comparison with Other Lysosomal Galactosidases

Biela-Banaś, Anna, Oulaïdi, Farah, Front, Sophie, Gallienne, Estelle, Ikeda-Obatake, Kyoko, Asano, Naoki, Wenger, David A., Martin, Olivier R.

Journal:

Year:

2014

Language:

english

File:

PDF, 290 KB

english, 2014

13

Modeling the Interaction between Dendrimers and Nucleic Acids: a Molecular Perspective through Hierarchical Scales

Pavan, Giovanni M.

Journal:

Year:

2014

Language:

english

File:

PDF, 2.42 MB

english, 2014

14

From Antidiabetic to Antifungal: Discovery of Highly Potent Triazole-Thiazolidinedione Hybrids as Novel Antifungal Agents

Wu, Shanchao, Zhang, Yongqiang, He, Xiaomeng, Che, Xiaoying, Wang, Shengzheng, Liu, Yang, Jiang, Yan, Liu, Na, Dong, Guoqiang, Yao, Jianzhong, Miao, Zhenyuan, Wang, Yan, Zhang, Wannian, Sheng, Chunqua

Journal:

Year:

2014

Language:

english

File:

PDF, 472 KB

english, 2014

15

Exploring the Active Conformation of Cyclohexane Carboxylate Positive Allosteric Modulators of the Type 4 Metabotropic Glutamate Receptor

Rovira, Xavier, Harrak, Youssef, Trapero, Ana, González-Bulnes, Patricia, Malhaire, Fanny, Pin, Jean-Philippe, Goudet, Cyril, Giraldo, Jesús, Llebaria, Amadeu

Journal:

Year:

2014

Language:

english

File:

PDF, 1.06 MB

english, 2014

16

Design and Synthesis of Imidazo[2,1- b ]thiazole-Chalcone Conjugates: Microtubule-Destabilizing Agents

Kamal, Ahmed, Balakrishna, Moku, Nayak, V. Lakshma, Shaik, Thokhir Basha, Faazil, Shaikh, Nimbarte, Vijaykumar D.

Journal:

Year:

2014

Language:

english

File:

PDF, 2.06 MB

english, 2014

17

Comparative Cytotoxicity of Artemisinin and Cisplatin and Their Interactions with Chlorogenic Acids in MCF7 Breast Cancer Cells

Suberu, John O., Romero-Canelón, Isolda, Sullivan, Neil, Lapkin, Alexei A., Barker, Guy C.

Journal:

Year:

2014

Language:

english

File:

PDF, 381 KB

english, 2014

18

Inside Cover: From Antidiabetic to Antifungal: Discovery of Highly Potent Triazole-Thiazolidinedione Hybrids as Novel Antifungal Agents (ChemMedChem 12/2014)

Wu, Shanchao, Zhang, Yongqiang, He, Xiaomeng, Che, Xiaoying, Wang, Shengzheng, Liu, Yang, Jiang, Yan, Liu, Na, Dong, Guoqiang, Yao, Jianzhong, Miao, Zhenyuan, Wang, Yan, Zhang, Wannian, Sheng, Chunqua

Journal:

Year:

2014

File:

PDF, 1.11 MB

2014

19

Bioreducible Guanidinylated Polyethylenimine for Efficient Gene Delivery

Lee, Duhwan, Lee, Yeong Mi, Jeong, Cherlhyun, Lee, Jun, Kim, Won Jong

Journal:

Year:

2014

Language:

english

File:

PDF, 1.48 MB

english, 2014

20

Quantitative Insight into the Design of Compounds Recognized by the L -Type Amino Acid Transporter 1 (LAT1)

Ylikangas, Henna, Malmioja, Kalle, Peura, Lauri, Gynther, Mikko, Nwachukwu, Emmanuel O., Leppänen, Jukka, Laine, Krista, Rautio, Jarkko, Lahtela-Kakkonen, Maija, Huttunen, Kristiina M., Poso, Antti

Journal:

Year:

2014

Language:

english

File:

PDF, 423 KB

english, 2014

21

Cover Picture: Structure-Activity Relationship Study of Spider Polyamine Toxins as Inhibitors of Ionotropic Glutamate Receptors (ChemMedChem 12/2014)

Xiong, Xiao-Feng, Poulsen, Mette H., Hussein, Rama A., Nørager, Niels G., Strømgaard, Kristian

Journal:

Year:

2014

Language:

english

File:

PDF, 900 KB

english, 2014

22

Biological Drug Products: Development and Strategies . Edited by Wei Wang and Manmohan Singh

Kennedy, Eileen J.

Journal:

Year:

2014

Language:

english

File:

PDF, 175 KB

english, 2014

23

Biotherapeutics: Recent Developments using Chemical and Molecular Biology . Edited by Lyn H. Jones, Andrew J. McKnight

Walsh, Garry M.

Journal:

Year:

2014

Language:

english

File:

PDF, 171 KB

english, 2014

24

Spotlights on our sister journals: ChemMedChem 12/2014

Journal:

Year:

2014

Language:

english

File:

PDF, 1.79 MB

english, 2014

25

Corrigendum: Phosphinic Acid Functionalized Polyazacycloalkane Chelators for Radiodiagnostics and Radiotherapeutics: Unique Characteristics and Applications

Notni, Johannes, Šimeček, Jakub, Wester, Hans-Jürgen

Journal:

Year:

2014

Language:

english

File:

PDF, 74 KB

english, 2014

26

Back Cover: Discovery of a Highly Selective PLD2 Inhibitor (ML395): A New Probe with Improved Physiochemical Properties and Broad-Spectrum Antiviral Activity against Influenza Strains (ChemMedChem 12/2014)

O'Reilly, Matthew C., Oguin, Thomas H., Scott, Sarah A., Thomas, Paul G., Locuson, Charles W., Morrison, Ryan D., Daniels, J. Scott, Brown, H. Alex, Lindsley, Craig W.

Journal:

Year:

2014

File:

PDF, 1.72 MB

2014

27

Graphical Abstract: ChemMedChem 12/2014

Journal:

Year:

2014

Language:

english

File:

PDF, 3.17 MB

english, 2014