Volume 18; Issue 6

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Clinical Cancer Research
Volume 18; Issue 6

Clinical Cancer Research

Volume 18; Issue 6

1

Bridging the Gap: Moving Predictive and Prognostic Assays from Research to Clinical Use

Williams, P. M., Lively, T. G., Jessup, J. M., Conley, B. A.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 437 KB

english, 2012

2

Local Delivery of lnterleukin-12 Using T Cells Targeting VEGF Receptor-2 Eradicates Multiple Vascularized Tumors in Mice

Kerkar, S. P., Zhang, L., Morgan, R. A., Restifo, N. P., Rosenberg, S. A., Chinnasamy, D., Yu, Z.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 1.15 MB

english, 2012

3

Leveling the Playing Field: Bringing Development of Biomarkers and Molecular Diagnostics up to the Standards for Drug Development

Poste, G., Carbone, D. P., Parkinson, D. R., Verweij, J., Hewitt, S. M., Jessup, J. M.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 570 KB

english, 2012

4

The Fundamental Role of the p53 Pathway in Tumor Metabolism and Its Implication in Tumor Therapy

Shen, L., Sun, X., Fu, Z., Yang, G., Li, J., Yao, L.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 701 KB

english, 2012

5

Molecular Pathways: Microsatellite Instability in Colorectal Cancer: Prognostic, Predictive, and Therapeutic Implications

Sinicrope, F. A., Sargent, D. J.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 726 KB

english, 2012

6

Two Sides of the Same Coin: EGFR Exon 19 Deletions and Insertions in Lung Cancer

Politi, K., Lynch, T. J.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 453 KB

english, 2012

7

EGFR Exon 19 Insertions: A New Family of Sensitizing EGFR Mutations in Lung Adenocarcinoma

He, M., Capelletti, M., Nafa, K., Yun, C.-H., Arcila, M. E., Miller, V. A., Ginsberg, M. S., Zhao, B., Kris, M. G., Eck, M. J.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 839 KB

english, 2012

8

Interleukin-27 Inhibits the Growth of Pediatric Acute Myeloid Leukemia in NOD/SCID/Il2rg-/- Mice

Zorzoli, A., Di Carlo, E., Cocco, C., Ognio, E., Ribatti, D., Ferretti, E., Dufour, C., Locatelli, F., Montagna, D., Airoldi, I.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 1.28 MB

english, 2012

9

Randomized Study of Autologous Cytokine-Induced Killer Cell Immunotherapy in Metastatic Renal Carcinoma

Liu, L., Zhang, W., Qi, X., Li, H., Yu, J., Wei, S., Hao, X., Ren, X.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 339 KB

english, 2012

10

Genome-Wide miRNA Expression Profiling Identifies miR-9-3 and miR-193a as Targets for DNA Methylation in Non-Small Cell Lung Cancers

Heller, G., Weinzierl, M., Noll, C., Babinsky, V., Ziegler, B., Altenberger, C., Minichsdorfer, C., Lang, G., Dome, B., End-Pfutzenreuter, A., Arns, B.-M., Grin, Y., Klepetko, W., Zielinski, C. C., Zo

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 1.47 MB

english, 2012

11

High EGFR Gene Copy Number and Skin Rash as Predictive Markers for EGFR Tyrosine Kinase Inhibitors in Patients with Advanced Squamous Cell Lung Carcinoma

Lee, Y., Shim, H. S., Park, M. S., Kim, J.-H., Ha, S.-J., Kim, S. H., Cho, B. C.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 632 KB

english, 2012

12

Constitutive AP-1 Activity and EBV Infection Induce PD-L1 in Hodgkin Lymphomas and Posttransplant Lymphoproliferative Disorders: Implications for Targeted Therapy

Green, M. R., Rodig, S., Juszczynski, P., Ouyang, J., Sinha, P., O'Donnell, E., Neuberg, D., Shipp, M. A.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 1.25 MB

english, 2012

13

Mechanisms of CHD5 Inactivation in Neuroblastomas

Koyama, H., Zhuang, T., Light, J. E., Kolla, V., Higashi, M., McGrady, P. W., London, W. B., Brodeur, G. M.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 480 KB

english, 2012

14

Integrated Analysis Reveals Critical Genomic Regions in Prostate Tumor Microenvironment Associated with Clinicopathologic Phenotypes

Ashida, S., Orloff, M. S., Bebek, G., Zhang, L., Zheng, P., Peehl, D. M., Eng, C.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 826 KB

english, 2012

15

Met Kinase Inhibitor E7050 Reverses Three Different Mechanisms of Hepatocyte Growth Factor-Induced Tyrosine Kinase Inhibitor Resistance in EGFR Mutant Lung Cancer

Wang, W., Li, Q., Takeuchi, S., Yamada, T., Koizumi, H., Nakamura, T., Matsumoto, K., Mukaida, N., Nishioka, Y., Sone, S., Nakagawa, T., Uenaka, T., Yano, S.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 752 KB

english, 2012

16

Combined MEK and VEGFR Inhibition in Orthotopic Human Lung Cancer Models Results in Enhanced Inhibition of Tumor Angiogenesis, Growth, and Metastasis

Takahashi, O., Komaki, R., Smith, P. D., Jurgensmeier, J. M., Ryan, A., Bekele, B. N., Wistuba, I. I., Jacoby, J. J., Korshunova, M. V., Biernacka, A., Erez, B., Hosho, K., Herbst, R. S., O'Reilly, M.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 2.65 MB

english, 2012

17

Single-Cell Pharmacodynamic Monitoring of S6 Ribosomal Protein Phosphorylation in AML Blasts during a Clinical Trial Combining the mTOR Inhibitor Sirolimus and Intensive Chemotherapy

Perl, A. E., Kasner, M. T., Shank, D., Luger, S. M., Carroll, M.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 604 KB

english, 2012

18

IGFBP Ratio Confers Resistance to IGF Targeting and Correlates with Increased Invasion and Poor Outcome in Breast Tumors

Becker, M. A., Hou, X., Harrington, S. C., Weroha, S. J., Gonzalez, S. E., Jacob, K. A., Carboni, J. M., Gottardis, M. M., Haluska, P.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 886 KB

english, 2012

19

A Phase I Trial of Erlotinib and Concurrent Chemoradiotherapy for Stage III and IV (M0) Squamous Cell Carcinoma of the Head and Neck

Gilbert, J., Rudek, M. A., Higgins, M. J., Zhao, M., Bienvenu, S., Tsottles, N., Wahl, R., Forastiere, A., Gillison, M.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 160 KB

english, 2012

20

Imaging Tumor Sensitivity to a Bioreductive Prodrug: Two for the Price of One!

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 217 KB

english, 2012

21

Impact of Preanalytic Factors on the Design and Application of Integral Biomarkers for Directing Patient Therapy

Hewitt, S. M., Badve, S. S., True, L. D.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 283 KB

english, 2012

22

The 2-Nitroimidazole EF5 Is a Biomarker for Oxidoreductases That Activate the Bioreductive Prodrug CEN-209 under Hypoxia

Wang, J., Foehrenbacher, A., Su, J., Patel, R., Hay, M. P., Hicks, K. O., Wilson, W. R.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 505 KB

english, 2012

23

Characterization of Gene Amplification-Driven SKP2 Overexpression in Myxofibrosarcoma: Potential Implications in Tumor Progression and Therapeutics

Li, C.-F., Wang, J.-M., Kang, H.-Y., Huang, C.-K., Wang, J.-W., Fang, F.-M., Wang, Y.-H., Wu, W.-R., Li, S.-H., Yu, S.-C., Lee, J.-C., Lan, J., Shiue, Y.-L., Wu, L.-C., Huang, H.-Y.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 2.93 MB

english, 2012

24

Retraction: Characterizing the Clinical Relevance of an Embryonic Stem Cell Phenotype in Lung Adenocarcinoma

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 144 KB

english, 2012

25

PIK3CA/PTEN Mutations and Akt Activation As Markers of Sensitivity to Allosteric mTOR Inhibitors

Meric-Bernstam, F., Akcakanat, A., Chen, H., Do, K.-A., Sangai, T., Adkins, F., Gonzalez-Angulo, A. M., Rashid, A., Crosby, K., Dong, M., Phan, A. T., Wolff, R. A., Gupta, S., Mills, G. B., Yao, J.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 1.14 MB

english, 2012

26

Biomarker Discovery, Development, and Implementation in France: A Report from the French National Cancer Institute and Cooperative Groups

Andre, F., Nowak, F., Arnedos, M., Lacroix, L., Viens, P., Calvo, F.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 623 KB

english, 2012

27

Prognostic and Predictive Significance of Plasma HGF and IL-8 in a Phase III Trial of Chemoradiation with or without Tirapazamine in Locoregionally Advanced Head and Neck Cancer

Le, Q.-T., Fisher, R., Oliner, K. S., Young, R. J., Cao, H., Kong, C., Graves, E., Hicks, R. J., McArthur, G. A., Peters, L., O'Sullivan, B., Giaccia, A., Rischin, D.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 357 KB

english, 2012

28

Expression of Interleukin-4 Receptor Alpha in Human Pleural Mesothelioma Is Associated with Poor Survival and Promotion of Tumor Inflammation

Burt, B. M., Bader, A., Winter, D., Rodig, S. J., Bueno, R., Sugarbaker, D. J.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 1023 KB

english, 2012

29

Phospho-specific Flow: Fixating on the Target

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 4.85 MB

english, 2012

30

Development and Use of Integral Assays in Clinical Trials

Schilsky, R. L., Doroshow, J. H., LeBlanc, M., Conley, B. A.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 284 KB

english, 2012

31

Phase I Dose-Escalation Study of Intravenous Aflibercept in Combination with Docetaxel in Patients with Advanced Solid Tumors

Isambert, N., Freyer, G., Zanetta, S., You, B., Fumoleau, P., Falandry, C., Favier, L., Assadourian, S., Soussan-Lazard, K., Ziti-Ljajic, S., Trillet-Lenoir, V.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 302 KB

english, 2012

32

Search for a Gene Expression Signature of Breast Cancer Local Recurrence in Young Women

Servant, N., Bollet, M. A., Halfwerk, H., Bleakley, K., Kreike, B., Jacob, L., Sie, D., Kerkhoven, R. M., Hupe, P., Hadhri, R., Fourquet, A., Bartelink, H., Barillot, E., Sigal-Zafrani, B., van de Vij

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 382 KB

english, 2012

33

Failure of Iniparib to Inhibit Poly(ADP-Ribose) Polymerase In Vitro

Patel, A. G., De Lorenzo, S. B., Flatten, K. S., Poirier, G. G., Kaufmann, S. H.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 1.54 MB

english, 2012

34

Eribulin Mesylate for the Treatment of Patients with Refractory Metastatic Breast Cancer: Use of a "Physician's Choice" Control Arm in a Randomized Approval Trial

Donoghue, M., Lemery, S. J., Yuan, W., He, K., Sridhara, R., Shord, S., Zhao, H., Marathe, A., Kotch, L., Jee, J., Wang, Y., Zhou, L., Adams, W. M., Jarral, V., Pilaro, A., Lostritto, R., Gootenberg,

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 306 KB

english, 2012

35

Lessons Learned from the Investigational Device Exemption Review of Children's Oncology Group Trial AAML1031

Meshinchi, S., Hunger, S. P., Aplenc, R., Adamson, P. C., Jessup, J. M.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 357 KB

english, 2012

36

A Phase I Study of Veliparib in Combination with Metronomic Cyclophosphamide in Adults with Refractory Solid Tumors and Lymphomas

Kummar, S., Ji, J., Morgan, R., Lenz, H.-J., Puhalla, S. L., Belani, C. P., Gandara, D. R., Allen, D., Kiesel, B., Beumer, J. H., Newman, E. M., Rubinstein, L., Chen, A., Zhang, Y., Wang, L., Kinders,

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 715 KB

english, 2012

37

Relationship between 18F-Fluorodeoxyglucose Accumulation and KRAS/BRAF Mutations in Colorectal Cancer

Kawada, K., Nakamoto, Y., Kawada, M., Hida, K., Matsumoto, T., Murakami, T., Hasegawa, S., Togashi, K., Sakai, Y.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 585 KB

english, 2012

38

Molecular Diagnostics: Are We There Yet?

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 173 KB

english, 2012

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