Volume 21; Issue 12

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Clinical Cancer Research
Volume 21; Issue 12

Clinical Cancer Research

Volume 21; Issue 12

1

Preclinical Evidence for the Therapeutic Potential of CD38-Targeted Immuno-Chemotherapy in Multiple Myeloma Patients Refractory to Lenalidomide and Bortezomib

Nijhof, I. S., Groen, R. W. J., Noort, W. A., van Kessel, B., de Jong-Korlaar, R., Bakker, J., van Bueren, J. J. L., Parren, P. W. H. I., Lokhorst, H. M., van de Donk, N. W. C. J., Martens, A. C. M.,

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 1.34 MB

english, 2015

2

A Phase I/II Study of the mTOR Inhibitor Everolimus in Combination with HyperCVAD Chemotherapy in Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia

Daver, N., Boumber, Y., Kantarjian, H., Ravandi, F., Cortes, J., Rytting, M. E., Kawedia, J. D., Basnett, J., Culotta, K. S., Zeng, Z., Lu, H., Richie, M. A., Garris, R., Xiao, L., Liu, W., Baggerly,

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 876 KB

english, 2015

3

Progression-Free and Overall Survival in ALK-Positive NSCLC Patients Treated with Sequential Crizotinib and Ceritinib

Gainor, J. F., Tan, D. S. W., De Pas, T., Solomon, B. J., Ahmad, A., Lazzari, C., de Marinis, F., Spitaleri, G., Schultz, K., Friboulet, L., Yeap, B. Y., Engelman, J. A., Shaw, A. T.

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 1.52 MB

english, 2015

4

A Phase I First-in-Human Study of Enoticumab (REGN421), a Fully Human Delta-like Ligand 4 (Dll4) Monoclonal Antibody in Patients with Advanced Solid Tumors

Chiorean, E. G., LoRusso, P., Strother, R. M., Diamond, J. R., Younger, A., Messersmith, W. A., Adriaens, L., Liu, L., Kao, R. J., DiCioccio, A. T., Kostic, A., Leek, R., Harris, A., Jimeno, A.

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 433 KB

english, 2015

5

The Use of Transcriptional Profiling to Improve Personalized Diagnosis and Management of Cutaneous T-cell Lymphoma (CTCL)

Litvinov, I. V., Netchiporouk, E., Cordeiro, B., Dore, M.-A., Moreau, L., Pehr, K., Gilbert, M., Zhou, Y., Sasseville, D., Kupper, T. S.

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 15.37 MB

english, 2015

6

SIRT1/PGC1 -Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer

Vellinga, T. T., Borovski, T., de Boer, V. C. J., Fatrai, S., van Schelven, S., Trumpi, K., Verheem, A., Snoeren, N., Emmink, B. L., Koster, J., Rinkes, I. H. M. B., Kranenburg, O.

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 938 KB

english, 2015

7

Molecular Pathways: Leveraging the BCL-2 Interactome to Kill Cancer Cells--Mitochondrial Outer Membrane Permeabilization and Beyond

Brahmbhatt, H., Oppermann, S., Osterlund, E. J., Leber, B., Andrews, D. W.

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 11.45 MB

english, 2015

8

TBCRC 019: A Phase II Trial of Nanoparticle Albumin-Bound Paclitaxel with or without the Anti-Death Receptor 5 Monoclonal Antibody Tigatuzumab in Patients with Triple-Negative Breast Cancer

Forero-Torres, A., Varley, K. E., Abramson, V. G., Li, Y., Vaklavas, C., Lin, N. U., Liu, M. C., Rugo, H. S., Nanda, R., Storniolo, A. M., Traina, T. A., Patil, S., Van Poznak, C. H., Nangia, J. R., I

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 422 KB

english, 2015

9

The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient-Derived Xenograft Models

Schuller, A. G., Barry, E. R., Jones, R. D. O., Henry, R. E., Frigault, M. M., Beran, G., Linsenmayer, D., Hattersley, M., Smith, A., Wilson, J., Cairo, S., Deas, O., Nicolle, D., Adam, A., Zinda, M.,

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 5.83 MB

english, 2015

10

FDA Approval: Belinostat for the Treatment of Patients with Relapsed or Refractory Peripheral T-cell Lymphoma

Lee, H.-Z., Kwitkowski, V. E., Del Valle, P. L., Ricci, M. S., Saber, H., Habtemariam, B. A., Bullock, J., Bloomquist, E., Li Shen, Y., Chen, X.-H., Brown, J., Mehrotra, N., Dorff, S., Charlab, R., Ka

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 209 KB

english, 2015

11

Phase I Study of Vorinostat as a Radiation Sensitizer with 131I-Metaiodobenzylguanidine (131I-MIBG) for Patients with Relapsed or Refractory Neuroblastoma

DuBois, S. G., Groshen, S., Park, J. R., Haas-Kogan, D. A., Yang, X., Geier, E., Chen, E., Giacomini, K., Weiss, B., Cohn, S. L., Granger, M. M., Yanik, G. A., Hawkins, R., Courtier, J., Jackson, H.,

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 235 KB

english, 2015

12

The Ovarian Cancer Chemokine Landscape Is Conducive to Homing of Vaccine-Primed and CD3/CD28-Costimulated T Cells Prepared for Adoptive Therapy

Zsiros, E., Duttagupta, P., Dangaj, D., Li, H., Frank, R., Garrabrant, T., Hagemann, I. S., Levine, B. L., June, C. H., Zhang, L., Wang, E., Marincola, F. M., Bedognetti, D., Powell, D. J., Tanyi, J.,

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 1.39 MB

english, 2015

13

Immunohistochemical Loss of LKB1 Is a Biomarker for More Aggressive Biology in KRAS-Mutant Lung Adenocarcinoma

Calles, A., Sholl, L. M., Rodig, S. J., Pelton, A. K., Hornick, J. L., Butaney, M., Lydon, C., Dahlberg, S. E., Oxnard, G. R., Jackman, D. M., Janne, P. A.

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 676 KB

english, 2015

14

Radiation Enhancement of Head and Neck Squamous Cell Carcinoma by the Dual PI3K/mTOR Inhibitor PF-05212384

Leiker, A. J., DeGraff, W., Choudhuri, R., Sowers, A. L., Thetford, A., Cook, J. A., Van Waes, C., Mitchell, J. B.

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 1.09 MB

english, 2015

15

Phase I Study to Assess the Combination of Afatinib with Trastuzumab in Patients with Advanced or Metastatic HER2-Positive Breast Cancer

Ring, A., Wheatley, D., Hatcher, H., Laing, R., Plummer, R., Uttenreuther-Fischer, M., Temple, G., Pelling, K., Schnell, D.

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 1.81 MB

english, 2015

16

Methionine Deprivation Induces a Targetable Vulnerability in Triple-Negative Breast Cancer Cells by Enhancing TRAIL Receptor-2 Expression

Strekalova, E., Malin, D., Good, D. M., Cryns, V. L.

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 1.68 MB

english, 2015

17

CD38-Targeted Immunochemotherapy in Refractory Multiple Myeloma: A New Horizon

Laubach, J. P., Richardson, P. G.

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 4.71 MB

english, 2015

18

Prognostic Significance of Tryptophan Catabolism in Adult T-cell Leukemia/Lymphoma

Masaki, A., Ishida, T., Maeda, Y., Suzuki, S., Ito, A., Takino, H., Ogura, H., Totani, H., Yoshida, T., Kinoshita, S., Narita, T., Ri, M., Kusumoto, S., Inagaki, A., Komatsu, H., Niimi, A., Ueda, R.,

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 5.42 MB

english, 2015

19

Significance of Circulating Tumor Cells in Metastatic Triple-Negative Breast Cancer Patients within a Randomized, Phase II Trial: TBCRC 019

Paoletti, C., Li, Y., Muniz, M. C., Kidwell, K. M., Aung, K., Thomas, D. G., Brown, M. E., Abramson, V. G., Irvin, W. J., Lin, N. U., Liu, M. C., Nanda, R., Nangia, J. R., Storniolo, A. M., Traina, T.

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 6.54 MB

english, 2015

20

Management of Cutaneous and Extracutaneous Side Effects of Smoothened Inhibitor Therapy for Advanced Basal Cell Carcinoma

Mohan, S. V., Chang, A. L. S.

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 301 KB

english, 2015

21

Targeting FGFR Signaling in Cancer

Touat, M., Ileana, E., Postel-Vinay, S., Andre, F., Soria, J.-C.

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 1.05 MB

english, 2015

22

HPV Serum Antibodies as Predictors of Survival and Disease Progression in Patients with HPV-Positive Squamous Cell Carcinoma of the Oropharynx

Dahlstrom, K. R., Anderson, K. S., Cheng, J. N., Chowell, D., Li, G., Posner, M., Sturgis, E. M.

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 689 KB

english, 2015

23

CD44 Isoform Status Predicts Response to Treatment with Anti-CD44 Antibody in Cancer Patients

Birzele, F., Voss, E., Nopora, A., Honold, K., Heil, F., Lohmann, S., Verheul, H., Le Tourneau, C., Delord, J.-P., van Herpen, C., Mahalingam, D., Coveler, A. L., Meresse, V., Weigand, S., Runza, V.,

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 1.04 MB

english, 2015

24

"Vertical" Inhibition of HER2 Yields Horizontal Gains in the Clinic

Sledge, G. W., Pegram, M. D.

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 339 KB

english, 2015

25

CCR 20th Anniversary Commentary: From Regulatory T Cells to Checkpoint Monoclonal Antibodies--Immuno-oncology Advances Clinical Cancer Research

Wolf, D., Wolf, A. M.

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 285 KB

english, 2015

26

Estrogen Receptor Expression in 21-Gene Recurrence Score Predicts Increased Late Recurrence for Estrogen-Positive/HER2-Negative Breast Cancer

Dowsett, M., Sestak, I., Buus, R., Lopez-Knowles, E., Mallon, E., Howell, A., Forbes, J. F., Buzdar, A., Cuzick, J.

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 428 KB

english, 2015

27

A Phase I Dose-Escalation Study of Antibody BI-505 in Relapsed/Refractory Multiple Myeloma

Hansson, M., Gimsing, P., Badros, A., Niskanen, T. M., Nahi, H., Offner, F., Salomo, M., Sonesson, E., Mau-Sorensen, M., Stenberg, Y., Sundberg, A., Teige, I., Van Droogenbroeck, J., Wichert, S., Zang

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 273 KB

english, 2015