Volume 85; Issue 3

Clinical Pharmacology & Therapeutics

Volume 85; Issue 3

1

Are Migraineurs at Increased Risk of Adverse Drug Responses?: A Meta-Analytic Comparison of Topiramate-Related Adverse Drug Reactions in Epilepsy and Migraine

Luykx, J, Mason, M, Ferrari, MD, Carpay, J

Journal:

Clinical Pharmacology & Therapeutics

Year:

2008

Language:

english

File:

PDF, 646 KB

english, 2008

2

Assessment of the Impact of Renal Impairment on Systemic Exposure of New Molecular Entities: Evaluation of Recent New Drug Applications

Zhang, Y, Zhang, L, Abraham, S, Apparaju, S, Wu, T-C, Strong, JM, Xiao, S, Atkinson Jr, AJ, Thummel, KE, Leeder, JS

Journal:

Clinical Pharmacology & Therapeutics

Year:

2008

Language:

english

File:

PDF, 898 KB

english, 2008

3

Interindividual Variation in the Pharmacokinetics of Δ9-Tetrahydrocannabinol as Related to Genetic Polymorphisms in CYP2C9

Sachse-Seeboth, C, Pfeil, J, Sehrt, D, Meineke, I, Tzvetkov, M, Bruns, E, Poser, W, Vormfelde, SV, Brockmöller, J

Journal:

Clinical Pharmacology & Therapeutics

Year:

2008

Language:

english

File:

PDF, 1.17 MB

english, 2008

4

The CYP3A4*18 Genotype in the Cytochrome P450 3A4 Gene, a Rapid Metabolizer of Sex Steroids, Is Associated With Low Bone Mineral Density

Kang, YS, Park, SY, Yim, CH, Kwak, HS, Gajendrarao, P, Krishnamoorthy, N, Yun, S-C, Lee, KW, Han, KO

Journal:

Clinical Pharmacology & Therapeutics

Year:

2008

Language:

english

File:

PDF, 1.43 MB

english, 2008

5

Irreversible CYP3A Inhibition Accompanied by Plasma Protein–Binding Displacement: A Comparative Analysis in Subjects With Normal and Impaired Liver Function

Orlando, R, De Martin, S, Pegoraro, P, Quintieri, L, Palatini, P

Journal:

Clinical Pharmacology & Therapeutics

Year:

2008

Language:

english

File:

PDF, 795 KB

english, 2008

6

Impact of the CYP2D6 Genotype on the Clinical Effects of Metoprolol: A Prospective Longitudinal Study

Rau, T, Wuttke, H, Michels, LM, Werner, U, Bergmann, K, Kreft, M, Fromm, MF, Eschenhagen, T

Journal:

Clinical Pharmacology & Therapeutics

Year:

2008

Language:

english

File:

PDF, 513 KB

english, 2008

7

High Levels of P-Glycoprotein Activity in Human Lymphocytes in the First 6 Months of Life

Giraud, C, Declèves, X, Perrot, JY, Manceau, S, Pannier, E, Firtion, G, Morini, JP, Chappuy, H, Batteux, F, Chouzenoux, S

Journal:

Clinical Pharmacology & Therapeutics

Year:

2008

Language:

english

File:

PDF, 561 KB

english, 2008

8

Pharmacogenetics of Modafinil After Sleep Loss: Catechol-O-Methyltransferase Genotype Modulates Waking Functions But Not Recovery Sleep

Bodenmann, S, Xu, S, Luhmann, UFO, Arand, M, Berger, W, Jung, HH, Landolt, HP

Journal:

Clinical Pharmacology & Therapeutics

Year:

2008

Language:

english

File:

PDF, 1.05 MB

english, 2008

9

The Use of a Clinical Utility Index to Compare Insomnia Compounds: A Quantitative Basis for Benefit–Risk Assessment

Ouellet, D, Werth, J, Parekh, N, Feltner, D, McCarthy, B, Lalonde, RL

Journal:

Clinical Pharmacology & Therapeutics

Year:

2008

Language:

english

File:

PDF, 930 KB

english, 2008

10

Model-Based Benefit–Risk Assessment: Can Archimedes Help?

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 109 KB

english, 2009

11

Starting With Serotonin: How a High-Rolling Father of Drug Discovery Repeatedly Beat the Odds

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 970 KB

english, 2009

12

Adding a Medicine to the WHO Model List of Essential Medicines

Kishore, SP, Herbstman, BJ

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 231 KB

english, 2009

13

Monitoring for Hepatotoxicity: What Is the Predictive Value of Liver “Function” Tests?

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 743 KB

english, 2009

14

CORRIGENDUM: Government Support for Abstinence-Only-Until-Marriage Education

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

File:

PDF, 99 KB

2009

15

Translational Toxicology and the Work of the Predictive Safety Testing Consortium

Mattes, WB, Walker, EG

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 272 KB

english, 2009

16

Perspectives on Early Communication of Drug Risks to the Public

Seligman, PJ, Osborne, SF

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 1.20 MB

english, 2009

17

Safety Assessment and Dose Selection for First-in-Human Clinical Trials With Immunomodulatory Monoclonal Antibodies

Muller, PY, Brennan, FR

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 2.47 MB

english, 2009

18

Data-Driven Methods to Discover Molecular Determinants of Serious Adverse Drug Events

Chiang, AP, Butte, AJ

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 887 KB

english, 2009

19

Drug Safety and the Role of Clinical Pharmacology in the Safe Use of Therapeutics

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 140 KB

english, 2009

20

—CMR International Institute for Regulatory Science Workshop on Measuring Benefit and Balancing Risk 19–20 June 2008 Washington, DC

Walker, S, McAuslane, N, Liberti, L, Salek, S

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 248 KB

english, 2009

21

Highlights

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 598 KB

english, 2009

22

In This Issue

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 249 KB

english, 2009

23

ASCPT News

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 343 KB

english, 2009

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