Volume 86; Issue 1

Clinical Pharmacology & Therapeutics

Volume 86; Issue 1

1

The Influence of Underlying Assumptions on Evaluating the Relative Merits of Concentration-Controlled and Dose-Controlled Trials

Lledó-García, R, Hennig, S, Karlsson, MO

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 192 KB

english, 2009

2

Addressing the Challenges of the Clinical Application of Pharmacogenetic Testing

Ikediobi, ON, Shin, J, Nussbaum, RL, Phillips, KA

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 113 KB

english, 2009

3

Chutes and Ladders on the Critical Path:Comparative Effectiveness, Product Value, and the Use of Biomarkers in Drug Development

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 67 KB

english, 2009

4

Efficacy of 3,4-Diaminopyridine and Pyridostigmine in the Treatment of Lambert–Eaton Myasthenic Syndrome: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

Wirtz, PW, Verschuuren, JJ, van Dijk, JG, de Kam, ML, Schoemaker, RC, van Hasselt, JGC, Titulaer, MJ, Tjaden, UR, den Hartigh, J, van Gerven, JMA

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 133 KB

english, 2009

5

Clinically Available Pharmacogenomics Tests

Flockhart, DA, Skaar, T, Berlin, DS, Klein, TE, Nguyen, AT

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 99 KB

english, 2009

6

Relative Impact of Genotype and Enzyme Induction on the Metabolic Capacity of CYP2C9 in Healthy Volunteers

Vormfelde, SV, Brockmöller, J, Bauer, S, Herchenhein, P, Kuon, J, Meineke, I, Roots, I, Kirchheiner, J

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 157 KB

english, 2009

7

Bronchodilatory Effect of the PPAR-γ Agonist Rosiglitazone in Smokers With Asthma

Spears, M, Donnelly, I, Jolly, L, Brannigan, M, Ito, K, McSharry, C, Lafferty, J, Chaudhuri, R, Braganza, G, Bareille, P

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 115 KB

english, 2009

8

Mechanistic Modeling of a Magnetic Marker Monitoring Study Linking Gastrointestinal Tablet Transit, In Vivo Drug Release, and Pharmacokinetics

Bergstrand, M, Söderlind, E, Weitschies, W, Karlsson, MO

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 154 KB

english, 2009

9

Modeling and Simulation of the Time Course of Asenapine Exposure Response and Dropout Patterns in Acute Schizophrenia

Friberg, LE, de Greef, R, Kerbusch, T, Karlsson, MO

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 551 KB

english, 2009

10

CORRIGENDUM: Abstract PII-56: Integrated Modeling of PANSS and Dropout Analysis in Patients With Acute Schizophrenia

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

File:

PDF, 32 KB

2009

11

Biomarker Discovery: Identification of a Growth Factor Gene Signature

Loboda, A, Nebozhyn, M, Cheng, C, Vessey, R, Huang, P, Dai, H, Watters, JW

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 294 KB

english, 2009

12

Direct-to-Consumer Genetic Testing: The Need to Get Retail Genomics Right

Schickedanz, AD, Herdman, RC

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 91 KB

english, 2009

13

Biomarkers in Clinical Drug Development

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 82 KB

english, 2009

14

Direct-to-Consumer Genetic Testing: Failure Is Not an Option

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 80 KB

english, 2009

15

I-SPY 2: An Adaptive Breast Cancer Trial Design in the Setting of Neoadjuvant Chemotherapy

Barker, AD, Sigman, CC, Kelloff, GJ, Hylton, NM, Berry, DA, Esserman, LJ

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 139 KB

english, 2009

16

The Value, Qualification, and Regulatory Use of Surrogate End Points in Drug Development

Lathia, CD, Amakye, D, Dai, W, Girman, C, Madani, S, Mayne, J, MacCarthy, P, Pertel, P, Seman, L, Stoch, A

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 225 KB

english, 2009

17

QT as a Safety Biomarker in Drug Development

Whellan, DJ, Green, CL, Piccini, JP, Krucoff, MW

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 121 KB

english, 2009

18

The Clinical Utility Index as a Practical Multiattribute Approach to Drug Development Decisions

Poland, B, Hodge, FL, Khan, A, Clemen, RT, Wagner, JA, Dykstra, K, Krishna, R

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 180 KB

english, 2009

19

Personalized Medicine: A Perk of Privilege?

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 82 KB

english, 2009

20

Educating for Personalized Medicine: A Perspective From Oncology

Parkinson, DR, Ziegler, J

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 86 KB

english, 2009

21

Biomarkers: Principles, Policies, and Practice

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 134 KB

english, 2009

22

ASCPT News

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 300 KB

english, 2009

23

Highlights

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 257 KB

english, 2009

24

In This Issue

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 63 KB

english, 2009

25

Comparison of Dose-Finding Designs for Narrow-Therapeutic-Index Drugs: Concentration-Controlled vs. Dose-Controlled Trials

Lledó-García, R, Hennig, S, Karlsson, MO

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 248 KB

english, 2009

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