Volume 89; Issue 4

Clinical Pharmacology & Therapeutics

Volume 89; Issue 4

1

Clinical Trials of Antidepressants: “Enrichment Strategies”

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 69 KB

english, 2011

2

Validation and Predictive Performance Assessment of Clinical Trial Simulation Models

Boessen, R, Knol, M J, Groenwold, R H H, Roes, K C B

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 80 KB

english, 2011

3

The Placebo Response Is Part of Good Medicine

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 69 KB

english, 2011

4

Challenges in Obtaining Adequate Genetic Sample Sets in Clinical Trials: The Perspective of the Industry Pharmacogenomics Working Group

Warner, A W, Bhathena, A, Gilardi, S, Mohr, D, Leong, D, Bienfait, K L, Sarang, J, Duprey, S, Franc, M A, Nelsen, A

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 255 KB

english, 2011

5

Coding of DNA Samples and Data in the Pharmaceutical Industry: Current Practices and Future Directions—Perspective of the I-PWG

Franc, M A, Cohen, N, Warner, A W, Shaw, P M, Groenen, P, Snapir, A

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 211 KB

english, 2011

6

Concurrent Assessment of Hepatic and Intestinal Cytochrome P450 3A Activities Using Deuterated Alfentanil

Kharasch, E D, Vangveravong, S, Buck, N, London, A, Kim, T, Blood, J, Mach, R H

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 292 KB

english, 2011

7

Global Requirements for DNA Sample Collections: Results of a Survey of 204 Ethics Committees in 40 Countries

Ricci, D S, Broderick, E D, Tchelet, A, Hong, F, Mayevsky, S, Mohr, D M, Schaffer, M E, Warner, A W, Hakkulinen, P, Snapir, A

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 185 KB

english, 2011

8

Response to “Validation and Assessment of Predictive Performance in Simulation Models of Clinical Trials”

Holford, N, Ma, S C, Ploeger, B A

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 70 KB

english, 2011

9

Current Practices for DNA Sample Collection and Storage in the Pharmaceutical Industry, and Potential Areas for Harmonization: Perspective of the I-PWG

Franc, M A, Warner, A W, Cohen, N, Shaw, P M, Groenen, P, Snapir, A

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 186 KB

english, 2011

10

Response to “Clinical Trials of Antidepressants: ‘Enrichment Strategies'” and “The Placebo Response Is Part of Good Medicine”

Merlo-Pich, E, Alexander, R C, Fava, M, Gomeni, R

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 80 KB

english, 2011

11

Prevalence and Clinical Utility

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 80 KB

english, 2011

12

Functional Characterization of Liver Enhancers That Regulate Drug-Associated Transporters

Kim, M J, Skewes-Cox, P, Fukushima, H, Hesselson, S, Yee, S W, Ramsey, L B, Nguyen, L, Eshragh, J L, Castro, R A, Wen, C C

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 245 KB

english, 2011

13

Mechanism-Based Inactivation of CYP2C8 by Gemfibrozil Occurs Rapidly in Humans

Honkalammi, J, Niemi, M, Neuvonen, P J, Backman, J T

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 246 KB

english, 2011

14

Transporter-Mediated Drug–Drug Interactions

Zhang, L, Huang, S-M, Lesko, L J

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 114 KB

english, 2011

15

Preserved Response to Diuretics in Rosiglitazone-Treated Subjects With Insulin Resistance: A Randomized Double-Blind Placebo-Controlled Crossover Study

Rennings, A J, Russel, F G, Li, Y, Deen, P M, Masereeuw, R, Tack, C J, Smits, P

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 200 KB

english, 2011

16

The Value and Benefits of the International Conference on Harmonisation to Drug Regulatory Authorities: Advancing Harmonization for Better Public Health

Molzon, J A, Giaquinto, A, Lindstrom, L, Tominaga, T, Ward, M, Doerr, P, Hunt, L, Rago, L

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 228 KB

english, 2011

17

From Trial and Error to Trial Simulation III: A Framework for Interim Analysis in Efficacy Trials With Antidepressant Drugs

Santen, G, van Zwet, E, Bettica, P, Gomeni, R A, Danhof, M, Della Pasqua, O

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 262 KB

english, 2011

18

OCT-1 as a Determinant of Response to Antileukemic Treatment

Engler, J R, Hughes, T P, White, D L

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 254 KB

english, 2011

19

A New Trend in Personalized Medicine: Rapid Detection of SNPs in Drug Transporter Genes by the SmartAmp Method

Aw, W, Lezhava, A, Hyashizaki, Y, Ishikawa, T

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 195 KB

english, 2011

20

Multidrug Efflux Pumps and Cancer Stem Cells: Insights Into Multidrug Resistance and Therapeutic Development

Moitra, K, Lou, H, Dean, M

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 744 KB

english, 2011

21

Pharmaceutical Relevance of Drug Transporter Malfunctions

Lancaster, C S, Sparreboom, A

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 73 KB

english, 2011

22

Inhibition of SGLT2: A Novel Strategy for Treatment of Type 2 Diabetes Mellitus

List, J F, Pfister, M, Whaley, J M, Zhang, L

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 282 KB

english, 2011

23

Use of Transgenic and Knockout Mouse Models to Assess Solute Carrier Transporter Function

DeGorter, M K, Kim, R B

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 153 KB

english, 2011

24

ASCPT News

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 173 KB

english, 2011

25

Benzodiazepine-Like Hypnotics and the Associated Risk of Road Traffic Accidents

Orriols, L, Philip, P, Moore, N, Castot, A, Gadegbeku, B, Delorme, B, Mallaret, M, Lagarde, E

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 128 KB

english, 2011

26

Highlights

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 363 KB

english, 2011

27

Drug Interactions Between the Immunosuppressant Tacrolimus and the Cholesterol Absorption Inhibitor Ezetimibe in Healthy Volunteers

Oswald, S, Nassif, A, Modess, C, Keiser, M, Ulrich, A, Runge, D, Hanke, U, Lütjohann, D, Engel, A, Weitschies, W

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 161 KB

english, 2011

28

In This Issue

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 133 KB

english, 2011

29

Response to “Prevalence and Clinical Utility”

Lesko, L J, Huang, S-M

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 71 KB

english, 2011

30

Immunoconjugates Against Solid Tumors: Mind the Gap

Journal:

Clinical Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 370 KB

english, 2011

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