Volume 92; Issue 2

Clinical Pharmacology & Therapeutics

Volume 92; Issue 2

1

Gene, Stem Cell, and Future Therapies for Orphan Diseases

Phillips, M Ian

Journal:

Clinical Pharmacology & Therapeutics

Year:

2012

Language:

english

File:

PDF, 690 KB

english, 2012

2

The Effects of Heparins on the Liver: Application of Mechanistic Serum Biomarkers in a Randomized Study in Healthy Volunteers

Harrill, A H, Roach, J, Fier, I, Eaddy, J S, Kurtz, C L, Antoine, D J, Spencer, D M, Kishimoto, T K, Pisetsky, D S, Park, B K, Watkins, P B

Journal:

Clinical Pharmacology & Therapeutics

Year:

2012

Language:

english

File:

PDF, 574 KB

english, 2012

3

Optimizing Drug Outcomes Through Pharmacogenetics: A Case for Preemptive Genotyping

Schildcrout, J S, Denny, J C, Bowton, E, Gregg, W, Pulley, J M, Basford, M A, Cowan, J D, Xu, H, Ramirez, A H, Crawford, D C, Ritchie, M D, Peterson, J F, Masys, D R, Wilke, R A, Roden, D M

Journal:

Clinical Pharmacology & Therapeutics

Year:

2012

Language:

english

File:

PDF, 257 KB

english, 2012

4

Drug Absorption Interactions Between Oral Targeted Anticancer Agents and PPIs: Is pH-Dependent Solubility the Achilles Heel of Targeted Therapy?

Budha, N R, Frymoyer, A, Smelick, G S, Jin, J Y, Yago, M R, Dresser, M J, Holden, S N, Benet, L Z, Ware, J A

Journal:

Clinical Pharmacology & Therapeutics

Year:

2012

Language:

english

File:

PDF, 323 KB

english, 2012

5

Modeling Helps in Understanding Antidepressants

Journal:

Clinical Pharmacology & Therapeutics

Year:

2012

Language:

english

File:

PDF, 177 KB

english, 2012

6

Quantitative Analysis to Guide Orphan Drug Development

Journal:

Clinical Pharmacology & Therapeutics

Year:

2012

Language:

english

File:

PDF, 141 KB

english, 2012

7

The Role of Academic Institutions in the Development of Drugs for Rare and Neglected Diseases

Coles, L D, Cloyd, J C

Journal:

Clinical Pharmacology & Therapeutics

Year:

2012

Language:

english

File:

PDF, 417 KB

english, 2012

8

Ethical Considerations in Orphan Drug Approval and Use

Kesselheim, A S

Journal:

Clinical Pharmacology & Therapeutics

Year:

2012

Language:

english

File:

PDF, 151 KB

english, 2012

9

Rare Diseases: The Bane of Modern Society and the Quest for Cures

Azie, N, Vincent, J

Journal:

Clinical Pharmacology & Therapeutics

Year:

2012

Language:

english

File:

PDF, 449 KB

english, 2012

10

Neglected Infections of Poverty in Texas and the Rest of the United States: Management and Treatment Options

Barry, M A, Bezek, S, Serpa, J A, Hotez, P J, Woc-Colburn, L

Journal:

Clinical Pharmacology & Therapeutics

Year:

2012

Language:

english

File:

PDF, 394 KB

english, 2012

11

Detection of Pharmacovigilance-Related Adverse Events Using Electronic Health Records and Automated Methods

Haerian, K, Varn, D, Vaidya, S, Ena, L, Chase, H S, Friedman, C

Journal:

Clinical Pharmacology & Therapeutics

Year:

2012

Language:

english

File:

PDF, 243 KB

english, 2012

12

Raising Orphans: How Clinical Development Programs of Drugs for Rare and Common Diseases Are Different

Orfali, M, Feldman, L, Bhattacharjee, V, Harkins, P, Kadam, S, Lo, C, Ravi, M, Shringarpure, D T, Mardekian, J, Cassino, C, Coté, T

Journal:

Clinical Pharmacology & Therapeutics

Year:

2012

Language:

english

File:

PDF, 153 KB

english, 2012

13

LX4211, a Dual SGLT1/SGLT2 Inhibitor, Improved Glycemic Control in Patients With Type 2 Diabetes in a Randomized, Placebo-Controlled Trial

Zambrowicz, B, Freiman, J, Brown, P M, Frazier, K S, Turnage, A, Bronner, J, Ruff, D, Shadoan, M, Banks, P, Mseeh, F, Rawlins, D B, Goodwin, N C, Mabon, R, Harrison, B A, Wilson, A, Sands, A, Powell,

Journal:

Clinical Pharmacology & Therapeutics

Year:

2012

Language:

english

File:

PDF, 564 KB

english, 2012

14

Time-Varying Belatacept Exposure and Its Relationship to Efficacy/Safety Responses in Kidney-Transplant Recipients

Zhou, Z, Shen, J, Hong, Y, Kaul, S, Pfister, M, Roy, A

Journal:

Clinical Pharmacology & Therapeutics

Year:

2012

Language:

english

File:

PDF, 346 KB

english, 2012

15

UGT1A4*3 Encodes Significantly Increased Glucuronidation of Olanzapine in Patients on Maintenance Treatment and in Recombinant Systems

Haslemo, T, Loryan, I, Ueda, N, Mannheimer, B, Bertilsson, L, Ingelman-Sundberg, M, Molden, E, Eliasson, E

Journal:

Clinical Pharmacology & Therapeutics

Year:

2012

Language:

english

File:

PDF, 233 KB

english, 2012

16

Equivalent Dynamic Human Brain NK1-Receptor Occupancy Following Single-Dose i.v. Fosaprepitant vs. Oral Aprepitant as Assessed by PET Imaging

Van Laere, K, De Hoon, J, Bormans, G, Koole, M, Derdelinckx, I, De Lepeleire, I, Declercq, R, Sanabria Bohorquez, S M, Hamill, T, Mozley, P D, Tatosian, D, Xie, W, Liu, Y, Liu, F, Zappacosta, P, Mahon

Journal:

Clinical Pharmacology & Therapeutics

Year:

2012

Language:

english

File:

PDF, 547 KB

english, 2012

17

The Current State of Therapeutic Drug Trials in Pregnancy

Endicott, S, Haas, D M

Journal:

Clinical Pharmacology & Therapeutics

Year:

2012

Language:

english

File:

PDF, 134 KB

english, 2012

18

ASCPT News

Journal:

Clinical Pharmacology & Therapeutics

Year:

2012

Language:

english

File:

PDF, 252 KB

english, 2012

19

In This Issue

Journal:

Clinical Pharmacology & Therapeutics

Year:

2012

Language:

english

File:

PDF, 296 KB

english, 2012

20

Off-Label Use of Medicines: Time for Action

Gnjidic, D, Le Couteur, D G, Hilmer, S N

Journal:

Clinical Pharmacology & Therapeutics

Year:

2012

Language:

english

File:

PDF, 67 KB

english, 2012

21

The Future of Orphan Drug Development

Journal:

Clinical Pharmacology & Therapeutics

Year:

2012

Language:

english

File:

PDF, 225 KB

english, 2012

22

Highlights

Journal:

Clinical Pharmacology & Therapeutics

Year:

2012

Language:

english

File:

PDF, 1.41 MB

english, 2012

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