Volume 1

Cell Death Discovery

Volume 1

1

Resveratrol chemosensitizes HER-2-overexpressing breast cancer cells to docetaxel chemoresistance by inhibiting docetaxel-mediated activation of HER-2–Akt axis

Vinod, B S, Nair, H H, Vijayakurup, V, Shabna, A, Shah, S, Krishna, A, Pillai, K S, Thankachan, S, Anto, R J

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 2.28 MB

english, 2015

2

WWOX dysfunction induces sequential aggregation of TRAPPC6AΔ, TIAF1, tau and amyloid β, and causes apoptosis

Chang, J-Y, Chang, N-S

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 4.34 MB

english, 2015

3

CYP epoxygenase metabolites of docosahexaenoic acid protect HL-1 cardiac cells against LPS-induced cytotoxicity through SIRT1

Samokhvalov, V, Jamieson, K L, Vriend, J, Quan, S, Seubert, J M

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 2.87 MB

english, 2015

4

AMPK maintains energy homeostasis and survival in cancer cells via regulating p38/PGC-1α-mediated mitochondrial biogenesis

Chaube, B, Malvi, P, Singh, S V, Mohammad, N, Viollet, B, Bhat, M K

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 1.90 MB

english, 2015

5

Current questions and possible controversies in autophagy

Lindqvist, L M, Simon, A K, Baehrecke, E H

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 1.15 MB

english, 2015

6

Characterization of GSK′963: a structurally distinct, potent and selective inhibitor of RIP1 kinase

Berger, SB, Harris, P, Nagilla, R, Kasparcova, V, Hoffman, S, Swift, B, Dare, L, Schaeffer, M, Capriotti, C, Ouellette, M, King, BW, Wisnoski, D, Cox, J, Reilly, M, Marquis, RW, Bertin, J, Gough, PJ

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 1.80 MB

english, 2015

7

Silencing of RUNX2 enhances gemcitabine sensitivity of p53-deficient human pancreatic cancer AsPC-1 cells through the stimulation of TAp63-mediated cell death

Sugimoto, H, Nakamura, M, Yoda, H, Hiraoka, K, Shinohara, K, Sang, M, Fujiwara, K, Shimozato, O, Nagase, H, Ozaki, T

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 2.32 MB

english, 2015

8

Modulation of dendritic cell function by the radiation-mediated secretory protein γ-synuclein

Kang, S-M, Kim, M-H, Song, K-H, Jung, S-Y, Ahn, J, Hwang, S-G, Lee, J-H, Lim, D-S, Song, J-Y

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 2.05 MB

english, 2015

9

Histone deacetylase inhibition protects hearing against acute ototoxicity by activating the Nf-κB pathway

Layman, W S, Williams, D M, Dearman, J A, Sauceda, M A, Zuo, J

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 2.34 MB

english, 2015

10

Stereospecific induction of apoptosis in tumor cells via endogenous C16-ceramide and distinct transcripts

Blaess, M, Le, HP, Claus, RA, Kohl, M, Deigner, H-P

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 751 KB

english, 2015

11

Muscle LIM protein/CSRP3: a mechanosensor with a role in autophagy

Rashid, M M, Runci, A, Polletta, L, Carnevale, I, Morgante, E, Foglio, E, Arcangeli, T, Sansone, L, Russo, M A, Tafani, M

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 3.39 MB

english, 2015

12

Involvement of inhibitory PAS domain protein in neuronal cell death in Parkinson’s disease

Torii, S, Kasai, S, Suzuki, A, Todoroki, Y, Yokozawa, K, Yasumoto, K-I, Seike, N, Kiyonari, H, Mukumoto, Y, Kakita, A, Sogawa, K

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 1.96 MB

english, 2015

13

Pro-survival function of MEF2 in cardiomyocytes is enhanced by β-blockers

Hashemi, S, Salma, J, Wales, S, McDermott, JC

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 2.77 MB

english, 2015

14

CDDiscovery

Silke, J, Melino, G

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 874 KB

english, 2015

15

Caspase-independent apoptosis in infected macrophages triggered by sulforaphane via Nrf2/p38 signaling pathways

Bonay, M, Roux, A-L, Floquet, J, Retory, Y, Herrmann, J-L, Lofaso, F, Deramaudt, TB

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 1.86 MB

english, 2015

16

The MDM2 small-molecule inhibitor RG7388 leads to potent tumor inhibition in p53 wild-type neuroblastoma

Lakoma, A, Barbieri, E, Agarwal, S, Jackson, J, Chen, Z, Kim, Y, McVay, M, Shohet, J M, Kim, E S

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 1.52 MB

english, 2015

17

Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2

Gurgis, FMS, Åkerfeldt, MC, Heng, B, Wong, C, Adams, S, Guillemin, GJ, Johns, TG, Chircop, M, Munoz, L

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 1.50 MB

english, 2015

18

miRNAs in mtDNA-less cell mitochondria

Dasgupta, N, Peng, Y, Tan, Z, Ciraolo, G, Wang, D, Li, R

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 848 KB

english, 2015

19

Defining the minimal peptide sequence of the ING1b tumour suppressor capable of efficiently inducing apoptosis

Boyko, A, Riabowol, K

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 2.87 MB

english, 2015

20

Blood vessels and cancer much more than just angiogenesis

Pezzella, F, Harris, A L, Tavassoli, M, Gatter, K C

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 395 KB

english, 2015

21

Rap1-mediated nuclear factor-kappaB (NF-κB) activity regulates the paracrine capacity of mesenchymal stem cells in heart repair following infarction

Zhang, Y, Chiu, S, Liang, X, Gao, F, Zhang, Z, Liao, S, Liang, Y, Chai, Y-H, Low, D J H, Tse, H-F, Tergaonkar, V, Lian, Q

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 5.25 MB

english, 2015

22

Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia

Watson, AS, Riffelmacher, T, Stranks, A, Williams, O, De Boer, J, Cain, K, MacFarlane, M, McGouran, J, Kessler, B, Khandwala, S, Chowdhury, O, Puleston, D, Phadwal, K, Mortensen, M, Ferguson, D, Soill

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 1.73 MB

english, 2015

23

Post-translational allosteric activation of the P2X7 receptor through glycosaminoglycan chains of CD44 proteoglycans

Moura, GEDD, Lucena, SV, Lima, MA, Nascimento, FD, Gesteira, TF, Nader, HB, Paredes-Gamero, EJ, Tersariol, ILS

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 12.99 MB

english, 2015

24

c-MYC responds to glucose deprivation in a cell-type-dependent manner

Wu, S, Yin, X, Fang, X, Zheng, J, Li, L, Liu, X, Chu, L

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 2.10 MB

english, 2015

25

Cytosolic phospholipase A2 regulates alcohol-mediated astrocyte inflammatory responses in HIV-associated neurocognitive disorders

Pandey, R, Ghorpade, A

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 4.20 MB

english, 2015

26

Tumor suppressor Nf2/merlin drives Schwann cell changes following electromagnetic field exposure through Hippo-dependent mechanisms

Colciago, A, Melfi, S, Giannotti, G, Bonalume, V, Ballabio, M, Caffino, L, Fumagalli, F, Magnaghi, V

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 2.87 MB

english, 2015

27

Curcumin induces crosstalk between autophagy and apoptosis mediated by calcium release from the endoplasmic reticulum, lysosomal destabilization and mitochondrial events

Moustapha, A, Pérétout, PA, Rainey, NE, Sureau, F, Geze, M, Petit, J-M, Dewailly, E, Slomianny, C, Petit, PX

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 2.67 MB

english, 2015

28

mTORC2 controls cancer cell survival by modulating gluconeogenesis

Khan, MW, Biswas, D, Ghosh, M, Mandloi, S, Chakrabarti, S, Chakrabarti, P

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 2.96 MB

english, 2015

29

Gingival fibroblasts resist apoptosis in response to oxidative stress in a model of periodontal diseases

Cheng, R, Choudhury, D, Liu, C, Billet, S, Hu, T, Bhowmick, NA

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 2.17 MB

english, 2015

30

FGFR1 inhibition in lung squamous cell carcinoma: questions and controversies

Weeden, CE, Solomon, B, Asselin-Labat, M-L

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 357 KB

english, 2015

31

ALS-associated mutant FUS inhibits macroautophagy which is restored by overexpression of Rab1

Soo, K Y, Sultana, J, King, AE, Atkinson, RAK, Warraich, S T, Sundaramoorthy, V, Blair, I, Farg, M A, Atkin, J D

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 4.53 MB

english, 2015

32

Inhibition of malignant thyroid carcinoma cell proliferation by Ras and galectin-3 inhibitors

Menachem, A, Bodner, O, Pastor, J, Raz, A, Kloog, Y

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 1.31 MB

english, 2015

33

p53 Configures the G2/M arrest response of nucleostemin-deficient cells

Huang, G, Meng, L, Tsai, RYL

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 2.23 MB

english, 2015

34

The H1047R point mutation in p110 alpha changes the morphology of human colon HCT116 cancer cells

Wan, G, Pehlke, C, Pepermans, R, Cannon, JL, Lidke, D, Rajput, A

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 3.97 MB

english, 2015

35

NRG1 and KITL signal downstream of retinoic acid in the germline to support soma-free syncytial growth of differentiating spermatogonia

Chapman, KM, Medrano, GA, Chaudhary, J, Hamra, FK

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 12.87 MB

english, 2015

36

The interplay of autophagy and β-Catenin signaling regulates differentiation in acute myeloid leukemia

Kühn, K, Cott, C, Bohler, S, Aigal, S, Zheng, S, Villringer, S, Imberty, A, Claudinon, J, Römer, W

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 2.18 MB

english, 2015

37

Necrotic enlargement of cone photoreceptor cells and the release of high-mobility group box-1 in retinitis pigmentosa

Murakami, Y, Ikeda, Y, Nakatake, S, Tachibana, T, Fujiwara, K, Yoshida, N, Notomi, S, Nakao, S, Hisatomi, T, Miller, J W, Vavvas, DG, Sonoda, KH, Ishibashi, T

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 1.49 MB

english, 2015

38

Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models

Lamas, DJMartinel, Nicoud, MB, Sterle, HA, Carabajal, E, Tesan, F, Perazzo, JC, Cremaschi, GA, Rivera, ES, Medina, VA

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 3.78 MB

english, 2015

39

Exposure to Endosulfan can result in male infertility due to testicular atrophy and reduced sperm count

Sebastian, R, Raghavan, SC

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 3.07 MB

english, 2015

40

Novel β-carbolines against colorectal cancer cell growth via inhibition of Wnt/β-catenin signaling

Li, X, Bai, B, Liu, L, Ma, P, Kong, L, Yan, J, Zhang, J, Ye, Z, Zhou, H, Mao, B, Zhu, H, Li, Y

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 2.39 MB

english, 2015

41

Quinazoline-based tricyclic compounds that regulate programmed cell death, induce neuronal differentiation, and are curative in animal models for excitotoxicity and hereditary brain disease

Vainshtein, A, Veenman, L, Shterenberg, A, Singh, S, Masarwa, A, Dutta, B, Island, B, Tsoglin, E, Levin, E, Leschiner, S, Maniv, I, Pe’er, L, Otradnov, I, Zubedat, S, Aga-Mizrachi, S, Weizman, A, Avit

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 4.20 MB

english, 2015

42

Local anesthetics induce autophagy in young permanent tooth pulp cells

Zhuang, H, Hu, D, Singer, D, Walker, J V, Nisr, R B, Tieu, K, Ali, K, Tredwin, C, Luo, S, Ardu, S, Hu, B

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 4.36 MB

english, 2015

43

The NAE inhibitor pevonedistat (MLN4924) synergizes with TNF-α to activate apoptosis

Wolenski, F S, Fisher, C D, Sano, T, Wyllie, S D, Cicia, L A, Gallacher, M J, Baker, R A, Kirby, P J, Senn, J J

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 2.10 MB

english, 2015

44

Factor VII promotes hepatocellular carcinoma progression through ERK-TSC signaling

Tsai, M-C, Chen, K-D, Wang, C-C, Huang, K-T, Wu, C-H, Kuo, I-Y, Chen, L-Y, Hu, T-H, Goto, S, Nakano, T, Dorling, A, McVey, J H, Chen, C-L, Lin, C-C

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 3.75 MB

english, 2015

45

A dual role for Caspase8 and NF-κB interactions in regulating apoptosis and necroptosis of ovarian cancer, with correlation to patient survival

Hernandez, L, Kim, M K, Noonan, A M, Sagher, E, Kohlhammer, H, Wright, G, Lyle, L T, Steeg, P S, Anver, M, Bowtell, D D, Annunziata, C M

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 2.37 MB

english, 2015

46

SAG-UPS attenuates proapoptotic SARM and Noxa to confer survival advantage to early hepatocellular carcinoma

Chang, S C, Choo, W Q W, Toh, H C, Ding, J L

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 3.33 MB

english, 2015

47

Calcium oxalate toxicity in renal epithelial cells: the mediation of crystal size on cell death mode

Sun, X-Y, Gan, Q-Z, Ouyang, J-M

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 2.68 MB

english, 2015

48

Polyphenols act synergistically with doxorubicin and etoposide in leukaemia cell lines

Mahbub, AA, Le Maitre, CL, Haywood-Small, SL, Cross, NA, Jordan-Mahy, N

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 5.63 MB

english, 2015

49

Heme-based catalytic properties of human serum albumin

Ascenzi, P, di Masi, A, Fanali, G, Fasano, M

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 942 KB

english, 2015

50

BH3-Only protein bmf is required for the maintenance of glucose homeostasis in an in vivo model of HNF1α-MODY diabetes

Pfeiffer, S, Halang, L, Düssmann, H, Byrne, MM, Prehn, JHM

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 2.06 MB

english, 2015

51

Sphingolipids modulate the epithelial–mesenchymal transition in cancer

Levade, T, Andrieu-Abadie, N, Micheau, O, Legembre, P, Ségui, B

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 373 KB

english, 2015

52

Helicobacter pylori VacA induces apoptosis by accumulation of connexin 43 in autophagic vesicles via a Rac1/ERK-dependent pathway

Yahiro, K, Akazawa, Y, Nakano, M, Suzuki, H, Hisatune, J, Isomoto, H, Sap, J, Noda, M, Moss, J, Hirayama, T

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 4.77 MB

english, 2015

53

PPARγ regulated CIDEA affects pro-apoptotic responses in glioblastoma

Chatterjee, A, Mondal, P, Ghosh, S, Mehta, VS, Sen, E

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 2.29 MB

english, 2015

54

Questions & Controversies

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 118 KB

english, 2015

55

Current questions and controversies in chromosome fragile site research: does WWOX, the gene product of common fragile site FRA16D, have a passive or active role in cancer?

Hazan, I, Aqeilan, RI

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 289 KB

english, 2015

56

Recombinant Bcl-xL attenuates vascular hyperpermeability in a rat model of hemorrhagic shock

Tharakan, B, McNeal, SI, Hunter, FA, Sawant, DA, Smythe, WR, Childs, EW

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 1.34 MB

english, 2015

57

Cigarette smoke-induced cell death of a spermatocyte cell line can be prevented by inactivating the Aryl hydrocarbon receptor

Esakky, P, Hansen, D A, Drury, A M, Cusumano, A, Moley, K H

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 4.86 MB

english, 2015

58

Cisplatin-induced apoptosis in auditory, renal, and neuronal cells is associated with nitration and downregulation of LMO4

Rathinam, R, Ghosh, S, Neumann, WL, Jamesdaniel, S

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 2.66 MB

english, 2015

59

Secondary necrotic neutrophils release interleukin-16C and macrophage migration inhibitory factor from stores in the cytosol

Roth, S, Agthe, M, Eickhoff, S, Möller, S, Karsten, C M, Borregaard, N, Solbach, W, Laskay, T

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 1.74 MB

english, 2015

60

The p53 co-activator Zac1 neither induces cell cycle arrest nor apoptosis in chicken Lim1 horizontal progenitor cells

Fard, S Shirazi, Blixt, MKE, Hallböök, F

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 3.35 MB

english, 2015

61

DIDS (4,4'-Diisothiocyanatostilbene-2,2'-disulfonate) directly inhibits caspase activity in HeLa cell lysates

Benítez-Rangel, E, López-Méndez, MC, García, L, Guerrero-Hernández, A

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 1.89 MB

english, 2015

62

Igf1 and Pacap rescue cerebellar granule neurons from apoptosis via a common transcriptional program

Maino, B, D’Agata, V, Severini, C, Ciotti, MT, Calissano, P, Copani, A, Chang, Y-C, DeLisi, C, Cavallaro, S

Journal:

Cell Death Discovery

Year:

2015

Language:

english

File:

PDF, 2.74 MB

english, 2015

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