Volume 3; Issue 10

Current Topics in Medicinal Chemistry

Volume 3; Issue 10

1

G-Protein Coupled Receptor Antagonists-1: Protease Activated Receptor-1 (PAR-1) Antagonists as Novel Cardiovascular Therapeutic Agents (Hot Topic: Structure and property Approaches in Recent Drug Discovery Guest Editor: Guo Zhu Zheng)

Chackalamannil, Samuel

Journal:

Current Topics in Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 72 KB

english, 2003

2

Farnesyl Protein Transferase Inhibitor ZARNESTRA™ R115777 - History of a Discovery

Venet, Marc, End, David, Angibaud, Patrick

Journal:

Current Topics in Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 86 KB

english, 2003

3

Inhibitors of Farnesyltransferase and Geranylgeranyltransferase-I for Antitumor Therapy: Substrate-Based Design, Conformational Constraint and Biological Activity

Dinsmore, Christopher, Bell, Ian

Journal:

Current Topics in Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 256 KB

english, 2003

4

Structure-Activity Relationship Studies: M2 and CCR5 Receptor Antagonists

Boyle, Craig, Palani, Anandan

Journal:

Current Topics in Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 85 KB

english, 2003

5

Preface by Christopher J. Dinsmore (Hot Topic: Farnesyl-Protein Transfrase Inhibitors Guest Editor: Christopher J. Dinsmore

J. Dinsmore, Christopher

Journal:

Current Topics in Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 10 KB

english, 2003

6

Use of Synthetic Isoprenoid Analogues for Understanding Protein Prenyltransferase Mechanism and Structure

Kale, Tamara, Hsieh, Shih-an, Rose, Matt, Distefano, Mark

Journal:

Current Topics in Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 204 KB

english, 2003

7

Theoretical Property Predictions

Livingstone, David

Journal:

Current Topics in Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 407 KB

english, 2003

8

The Role of Absorption, Distribution, Metabolism, Excretion and Toxicity in Drug Discovery

Lin, Jing, Sahakian, Diana, de Morais, Sonia, Xu, Jinghai, Polzer, Robert, Winter, Steven

Journal:

Current Topics in Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 310 KB

english, 2003

9

Sch-66336 (Sarasar®) and Other Benzocycloheptapyridyl Farnesyl Protein Transferase Inhibitors: Discovery, Biology and Clinical Observations

Taveras, Arthur, Kirschmeier, Paul, Baum, Charles

Journal:

Current Topics in Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 140 KB

english, 2003

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