Volume 8; Issue 1-4

Main
Drug Development Research
Volume 8; Issue 1-4

Drug Development Research

Volume 8; Issue 1-4

1

Masthead

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 77 KB

english, 1986

2

33 Years of drug development research: A tribute to Paul Janssen

Dr. Paul Janssen

Journal:

Drug Development Research

Year:

1986

File:

PDF, 51 KB

1986

3

Thirty-three years of drug discovery and research with Dr. Paul Janssen

S. van Gestel, V. Schuermans

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 671 KB

english, 1986

4

Impact of Janssen drugs for the identification of brain receptors

Pierre M. Laduron, Josée E. Leysen, Walter Gommeren, Paul F. M. Janssen, Alain Schotte, Jacky van Dun, Paul van Gompel, Mady Verwimp, Walter Wouters

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 753 KB

english, 1986

5

Chemical development of astemizole-like compounds

Dr. Frans Janssens, Marcel A. C. Janssen, Frans Awouters, Carlos J. E. Niemegeers, Gabriel Vanden Bussche

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 485 KB

english, 1986

6

Excretion and biotransformation of astemizole in rats, guinea-pigs, dogs, and man

Dr. Willem Meuldermans, Jan Hendrickx, William Lauwers, Robert Hurkmans, Eric Swysen, Jozef Heykants

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 841 KB

english, 1986

7

Pharmacokinetics and tissue distribution of astemizole in the dog

Marcel Michiels, Achiel van Peer, Robert Woestenborghs, Jozef Heykants

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 519 KB

english, 1986

8

Radioimmunoassay procedures for astemizole and metabolites in plasma

Dr. Robert Woestenborghs, Ivo Geuens, Marcel Michiels, Rik Hendriks, Jozef Heykants

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 396 KB

english, 1986

9

Dose-proportionality, bioavailability, and steady-state kinetics of astemizole in man

Jozef Heykants, Achiel van Peer, Robert Woestenborghs, Anton Jageneau, Gabriel Vanden Bussche

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 484 KB

english, 1986

10

Therapeutic effect of astemizole and terfenadine in students suffering from seasonal allergic rhinitis: A double-blind comparison

Niekol E. I. Rombaut, Jean P. van Roy, Emmanuel Bracke, Gabriel Vanden Bussche

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 359 KB

english, 1986

11

Levocabastine (R 50547): The prototype of a chemical series of compounds with specific H1-antihistaminic activity

Raymond A. Stokbroekx, Marcel G. M. Luyckx, Johan J. M. Willems, Marcel Janssen, Johan O. M. M. Bracke, Robert L. P. Joosen, Jean P. van Wauwe

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 354 KB

english, 1986

12

Oral antiallergic activity in ascaris hypersensitive dogs: A study of known antihistamines and of the new compounds ramastine (R 57 959) and levocabastine (R 50 547)

Dr. Frans Awouters, Jozef Vermeire, Frans Smeyers, Patrick Vermote, René van Beek, Carlos J. E. Niemegeers

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 425 KB

english, 1986

13

Monte Carlo method for the estimation of statistical significance in pharmacological testing

Paul J. Lewi, Roger C. A. Keersmaekers, Frans Awouters

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 285 KB

english, 1986

14

Haemodynamic effects in man during exercise of a single oral dose of narbivolol (R 67555), a new beta-1-adrenoceptor blocking agent: A comparative study with atenolol, pindolol, and propranolol

Jean De Crée, Hedwig Geukens, Jos Leempoels, Herman Verhaegen

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 473 KB

english, 1986

15

Drug-receptor dissociation time, new tool for drug research: Receptor binding affinity and drug-receptor dissociation profiles of serotonin-S2, Dopamine-D2, histamine-H1 antagonists, and opiates

Dr. Josée E. Leysen, Walter Gommeren

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 796 KB

english, 1986

16

The chemical development of selective and specific serotonin S2-antagonists

Ludo E. J. Kennis, Jan Vandenberk, Jozef M. Boey, Jos C. Mertens, Albert H. M. van Heertum, Marcel Janssen, Frans Awouters

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 450 KB

english, 1986

17

Conformational analysis of ketanserin

Dr. Jan P. Tollenaere, Henri Moereels, Marleen van Loon

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 433 KB

english, 1986

18

Correction by ketanserin of the platelet-mediated inhibition of peripheral collateral circulation in the cat: Measurement of blood flow with radioactive microspheres

Fred De Clerck, Wim Loots, Anton Jageneau, André Nevelsteen

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 583 KB

english, 1986

19

Ketanserin: A novel cardiovascular drug

Jan Symoens, Monique Janssens

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 829 KB

english, 1986

20

The serotonin-S2 Receptor: A receptor-transducer coupling model to explain insurmountable antagonist effects

Didier de Chaffoy De Courcelles, Josée E. Leysen, Peter Roevens, Herman van Belle

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 373 KB

english, 1986

21

Protective activity of ketanserin against serotonin-induced embryotoxicity and teratogenicity in rats

Dr. Herman van Cauteren, John Vandenberghe, Robert Marsboom

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 367 KB

english, 1986

22

Comparative pharmacological profile of ritanserin and ketanserin

Jan M. van Nueten, Jan A. J. Schuurkes, Walter J. E. De Ridder, Jan J. M. D. Kuyps, Walter J. Janssens

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 511 KB

english, 1986

23

A comparative study of the effects of ritanserin (R 55 667) and chlordiazepoxide on rat open field behavior

Dr. Theo F. Meert

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 473 KB

english, 1986

24

Thymosthenic effects of ritanserin (R 55667), a centrally acting serotonin-S2 receptor blocker

André Reyntjens, Yves G. Gelders, Marie-Lise J. A. Hoppenbrouwers, GabriëL Vanden Bussche

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 361 KB

english, 1986

25

Dextran-induced edema formation in mouse ear: A pharmacological evaluation

Jean P. van Wauwe, Jan G. Goossens

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 377 KB

english, 1986

26

Treatment of chronic myopathies in horses with the serotonin S2-antagonist R 50970: A preclinical study

Leo A. A. Ooms, Anne-Dominique A. Y. Degryse, Jan L. A. Fransen, Kris A. C. van Mol

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 367 KB

english, 1986

27

Synthesis of cisapride, a gastrointestinal stimulant derived from cis-4-amino-3-methoxypiperidine

Georges H. P. van Daele, Marcel F. L. De Bruyn, François M. Sommen, Marcel Janssen, Jan M. van Nueten, Jan A. J. Schuurkes, Carlos J. E. Niemegeers, Josée E. Leysen

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 448 KB

english, 1986

28

Stimulation of gastroduodenal motor activity: Dopaminergic and cholinergic modulation

Jan A. J. Schuurkes, Ludo F. M. Helsen, Etienne C. R. Ghoos, Jan G. M. G. Eelen, Jan M. van Nueten

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 527 KB

english, 1986

29

Non-antidopaminergic, non-cholinergic stimulation of gastric emptying with cisapride (R 51 619) in rats

Anton A. H. P. Megens, Luc L. J. Canters, Kamiel S. K. Artois, Frans Smeyers, Roger C. A. Keersmaekers, Frans Awouters

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 459 KB

english, 1986

30

Development and clinical use of the new gastrointestinal prokinetic drug cisapride (R 51 619)

André Reyntjens, Marleen Verlinden, Tonny Aerts

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 730 KB

english, 1986

31

A comparative study on the in vitro metabolism of cisapride using subcellular liver fractions of dog, rabbit, and male and female rats

Karel L. M. Lavrijsen, Willem Meuldermans, Fons A. G. Knaeps, William Lauwers, Jozef Heykants

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 657 KB

english, 1986

32

Antidiarrheal specificity and safety of the n-oxide of loperamide (R 58 425) in rats

Carlos J. E. Niemegeers, Frans Awouters, Fred M. Lenaerts, Kamiel S. K. Artois, Jozef Vermeire

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 480 KB

english, 1986

33

Cytochrome p-450: Target for itraconazole

Hugo Vanden Bossche, Dany Bellens, Willy Cools, Jos Gorrens, Patrick Marichal, Hugo Verhoeven, Gustaaf Willemsens, Roland De Coster, Dominiek Beerens, Christian Haelterman, Marie-Claire Coene, William

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 736 KB

english, 1986

34

Ketoconazole: From an antimycotic to a drug for prostate cancer

Dr. Willem K. Amery, Roland De Coster, Ivo Caers

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 635 KB

english, 1986

35

The in vivo antifungal activity of broad-spectrum azoles

Jan van Cutsem, Frans van Gerven

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 433 KB

english, 1986

36

Itraconazole (R 51 211): A clinical review of its antimycotic activity in dermatology, gynecology, and internal medicine

Geert Cauwenbergh, Piet De Doncker

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 435 KB

english, 1986

37

Quantitative aspects of the antisporulant activity of imazalil, an agricultural fungicide

Jef van Gestel, Leo Van Leemput, Patrick Marichal

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 402 KB

english, 1986

38

Post-harvest treatment of apples with imazalil: Fate of the fungicide during fruit storage and juice production

Leo van Leemput, Willem Meuldermans, Robert Woestenborghs, Jan Hendrickx, Rik Hendriks, Jozef Heykants

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 444 KB

english, 1986

39

Alfentanil and sufentanil: Towards a more specific use of narcotics in anesthesia

Gabriël Vanden Bussche, Henk Noorduin

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 375 KB

english, 1986

40

Alfentanil infusions for peroperative and postoperative analgesia

Henk Noorduin, Heather Waldron, Achiel van Peer, Gabriel Vanden Bussche

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 361 KB

english, 1986

41

R 62 818, a new analgesic: A comparative study with codeine

Karel H. L. Schellekens, Frans Awouters, Kamiel S. K. Artois, Remi E. J. Frederickx, Herman M. R. Hendrickx, Willy van Bruggen, Carlos J. E. Niemegeers

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 525 KB

english, 1986

42

In vivo pharmacological activity of r 47 243 in rat: A comparison with putative α2-adrenoceptor antagonists

Francis C. Colpaert, Leen Raeymaekers

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 666 KB

english, 1986

43

R 58 735: A new antihypoxic drug with anticonvulsant properties and possible effects on cognitive functions

Dr. Albert Wauquier, Gilbert Clincke, David Ashton, Marc De Ryck, Joannes Fransen, Gust van Clemen

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 483 KB

english, 1986

44

R 58 735, a novel antihypoxic drug improves memory in rats

Gilbert Clincke, Arjun Sahgal

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 334 KB

english, 1986

45

Structural damage of the ischemic brain: Involvement of calcium and effects of postischemic treatment with calcium entry blockers

Jos van Reempts, Marc Haseldonckx, Bruno van Deuren, Luc Wouters, Marcel Borgers

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 716 KB

english, 1986

46

Comparative action of flunarizine, phenytoin, carbamazepine and two calcium-entry blockers on spontaneous epileptiforrn bursts in the low calcium-hippocampal slice preparation

David Ashton, Kenneth Reid, Roland Willems, Roger Marrannes, Albert Wauquier

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 593 KB

english, 1986

47

Evaluation of protective effects of lidoflazine and mioflazine in cardiac ischemia

Guo-Shu Liu, Marcel Borgers, Raymond Xhonneux, Patrick van Overloop, Fred Thoné, Luc Wouters, Lambert Leijssen

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 618 KB

english, 1986

48

An efficient method to evaluate protective drugs against regional ischemia of the heart

Godelieve Vandeplassche, Luc Wouters, Carlo Hermans, Raymond Xhonneux, Marcel Borgers, Willem Flameng

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 414 KB

english, 1986

49

Nucleoside transport inhibition and the release of purine metabolites from hypoperfused isolated guinea pig hearts

Dr. Herman van Belle, Jozef Wynants, Frans Goossens

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 407 KB

english, 1986

50

Comparative studies on cardiovascular, respiratory and gastrointestinal effects of the sedatives R 51163 and xylazine in cattle

Anne-Dominique A. Y. Degryse, Leo A. A. Ooms

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 466 KB

english, 1986

To build up a library is to create a life. It’s never just a random collection of books.

— Carlos María Domínguez

Official channel

Z-Library Desktop Launcher

Tor version

Z-Library

Z-Library Since 2009 support@z-lib.do

EnglishРусскийEspañolItalianoελληνικάاللغة العربيةBahasa IndonesiaBahasa Malaysiaहिन्दीDeutschFrançaisPortuguêsУкраїнськаPolski中文繁體中文日本語Tiếng ViệtAzərbaycan DiliՀայոց լեզուภาษาไทยTürk Diliქართველიবাংলাپښتوతెలుగుاردو한국어SrpskiБългарски