Volume 34; Issue 11

Drug Metabolism and Disposition

Volume 34; Issue 11

1

Innovative Methods to Study Human Intestinal Drug Metabolism in Vitro: Precision-Cut Slices Compared with Ussing Chamber Preparations

van de Kerkhof, E. G., Ungell, A.-L. B., Sjoberg, A. K., de Jager, M. H., Hilgendorf, C., de Graaf, I. A. M., Groothuis, G. M. M.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 611 KB

english, 2006

2

Synthesis of Substituted Phenyl Diaziridines and Characterization as Mechanism-Based Inactivators of Human Cytochrome P450 2B6

Sridar, C., Kobayashi, Y., Brevig, H., Kent, U. M., Puppali, S. G., Rimoldi, J. M., Hollenberg, P. F.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 231 KB

english, 2006

3

Regulation of mRNA Expression of Xenobiotic Transporters by the Pregnane X Receptor in Mouse Liver, Kidney, and Intestine

Cheng, X., Klaassen, C. D.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 174 KB

english, 2006

4

PDZ Adaptor Protein PDZK2 Stimulates Transport Activity of Organic Cation/Carnitine Transporter OCTN2 by Modulating Cell Surface Expression

Watanabe, C., Kato, Y., Sugiura, T., Kubo, Y., Wakayama, T., Iseki, S., Tsuji, A.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 503 KB

english, 2006

5

Rifampin Induces the in Vitro Oxidative Metabolism, but Not the in Vivo Clearance of Diclofenac in Rhesus Monkeys

Prueksaritanont, T., Li, C., Tang, C., Kuo, Y., Strong-Basalyga, K., Carr, B.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 199 KB

english, 2006

6

Disposition of [14C]Ruboxistaurin in Humans

Burkey, J. L., Campanale, K. M., Barbuch, R., O'Bannon, D., Rash, J., Benson, C., Small, D.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 324 KB

english, 2006

7

Porcine Brain Microvessel Endothelial Cells as an in Vitro Model to Predict in Vivo Blood-Brain Barrier Permeability

Zhang, Y., Li, C. S. W., Ye, Y., Johnson, K., Poe, J., Johnson, S., Bobrowski, W., Garrido, R., Madhu, C.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 466 KB

english, 2006

8

Clofibrate Increases Hepatic Triiodothyronine (T3)- and Thyroxine (T4)-Glucuronosyltransferase Activities and Lowers Plasma T3 and T4 Concentrations in Pigs

Luci, S., Kluge, H., Hirche, F., Eder, K.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 150 KB

english, 2006

9

Uptake and Intracellular Binding of Lipophilic Amine Drugs by Isolated Rat Hepatocytes and Implications for Prediction of in Vivo Metabolic Clearance

Hallifax, D., Houston, J. B.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 343 KB

english, 2006

10

Metabolic Profile of FYX-051 (4-(5-Pyridin-4-yl-1H-[1,2,4]triazol-3-yl)pyridine-2-carbonitrile) in the Rat, Dog, Monkey, and Human: Identification of N-Glucuronides and N-Glucosides

Nakazawa, T., Miyata, K., Omura, K., Iwanaga, T., Nagata, O.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 346 KB

english, 2006

11

Molecular Identification and Functional Characterization of Rat Multidrug and Toxin Extrusion Type Transporter 1 as an Organic Cation/H+ Antiporter in the Kidney

Ohta, K.-y., Inoue, K., Hayashi, Y., Yuasa, H.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 248 KB

english, 2006

12

Rat Cytochrome P450 2C11 in Liver Microsomes Involved in Oxidation of Anesthetic Agent Propofol and Deactivated by Prior Treatment with Propofol

Yamazaki, H., Shimizu, M., Nagashima, T., Minoshima, M., Murayama, N.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 143 KB

english, 2006

13

Elucidation of the Effects of the CYP1A2 Deficiency Polymorphism in the Metabolism of 4-Cyclohexyl-1-ethyl-7-methylpyrido[2,3-d]pyrimidine-2-(1H)-one (YM-64227), a Phosphodiesterase Type 4 Inhibitor, and Its Metabolites in Dogs

Tenmizu, D., Noguchi, K., Kamimura, H.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 291 KB

english, 2006

14

Enzyme Source Effects on CYP2C9 Kinetics and Inhibition

Kumar, V., Rock, D. A., Warren, C. J., Tracy, T. S., Wahlstrom, J. L.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 247 KB

english, 2006

15

Disposition of Flavonoids via Enteric Recycling: Structural Effects and Lack of Correlations between in Vitro and in Situ Metabolic Properties

Wang, S. W. J., Chen, J., Jia, X., Tam, V. H., Hu, M.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 570 KB

english, 2006

16

Lack of Dose-Dependent Effects of Itraconazole on the Pharmacokinetic Interaction with Fexofenadine

Uno, T., Shimizu, M., Sugawara, K., Tateishi, T.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 135 KB

english, 2006

17

Characterization of Ebastine, Hydroxyebastine, and Carebastine Metabolism by Human Liver Microsomes and Expressed Cytochrome P450 Enzymes: Major Roles for CYP2J2 and CYP3A

Liu, K.-H., Kim, M.-G., Lee, D.-J., Yoon, Y.-J., Kim, M.-J., Shon, J.-H., Choi, C. S., Choi, Y. K., Desta, Z., Shin, J.-G.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 275 KB

english, 2006

18

Pharmacokinetics, Metabolism, and Routes of Excretion of Intravenous Irofulven in Patients with Advanced Solid Tumors

Paci, A., Rezai, K., Deroussent, A., De Valeriola, D., Re, M., Weill, S., Cvitkovic, E., Kahatt, C., Shah, A., Waters, S., Weems, G., Vassal, G., Lokiec, F.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 538 KB

english, 2006

19

Identification of Enzymes Responsible for Primary and Sequential Oxygenation Reactions of Capravirine in Human Liver Microsomes

Bu, H.-Z., Zhao, P., Kang, P., Pool, W. F., Wu, E. Y.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 243 KB

english, 2006

20

Metabolism and Disposition of Vatalanib (PTK787/ZK-222584) in Cancer Patients

Jost, L. M., Gschwind, H.-P., Jalava, T., Wang, Y., Guenther, C., Souppart, C., Rottmann, A., Denner, K., Waldmeier, F., Gross, G., Masson, E., Laurent, D.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 520 KB

english, 2006

21

Human Metabolism of Nebicapone (BIA 3-202), a Novel Catechol-O-Methyltransferase Inhibitor: Characterization of in Vitro Glucuronidation

Loureiro, A. I., Bonifacio, M. J., Fernandes-Lopes, C., Almeida, L., Wright, L. C., Soares-Da-Silva, P.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 314 KB

english, 2006