Volume 35; Issue 1

Drug Metabolism and Disposition

Volume 35; Issue 1

1

PEGylated Proteins: Evaluation of Their Safety in the Absence of Definitive Metabolism Studies

Webster, R., Didier, E., Harris, P., Siegel, N., Stadler, J., Tilbury, L., Smith, D.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 190 KB

english, 2006

2

Humanized IgG1 Variants with Differential Binding Properties to the Neonatal Fc Receptor: Relationship to Pharmacokinetics in Mice and Primates

Datta-Mannan, A., Witcher, D. R., Tang, Y., Watkins, J., Jiang, W., Wroblewski, V. J.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 334 KB

english, 2006

3

Identification of Human Cytochrome P450 Isozymes Involved in Diphenhydramine N-Demethylation

Akutsu, T., Kobayashi, K., Sakurada, K., Ikegaya, H., Furihata, T., Chiba, K.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 292 KB

english, 2006

4

A New CYP3A5 Variant, CYP3A5*11, Is Shown to Be Defective in Nifedipine Metabolism in a Recombinant cDNA Expression System

Lee, S.-J., van der Heiden, I. P., Goldstein, J. A., van Schaik, R. H. N.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 191 KB

english, 2006

5

Cellular Localization Studies on Human Estrogen Sulfotransferase SULT1E1 in Human Embryonic Kidney 293 Cells

Kapoor, R., Nimmagadda, D., Sheng, J. J.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 256 KB

english, 2006

6

An Evaluation of the Cytochrome P450 Inhibition Potential of Lisdexamfetamine in Human Liver Microsomes

Krishnan, S., Moncrief, S.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 106 KB

english, 2006

7

CYP2E1

Gonzalez, F. J.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 285 KB

english, 2006

8

Organic Anion Transporting Polypeptide 2B1 and Breast Cancer Resistance Protein Interact in the Transepithelial Transport of Steroid Sulfates in Human Placenta

Grube, M., Reuther, S., Meyer zu Schwabedissen, H., Kock, K., Draber, K., Ritter, C. A., Fusch, C., Jedlitschky, G., Kroemer, H. K.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 453 KB

english, 2006

9

Impact of Curcumin-Induced Changes in P-Glycoprotein and CYP3A Expression on the Pharmacokinetics of Peroral Celiprolol and Midazolam in Rats

Zhang, W., Tan, T. M. C., Lim, L.-Y.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 208 KB

english, 2006

10

Tissue- and Gender-Specific mRNA Expression of UDP-Glucuronosyltransferases (UGTs) in Mice

Buckley, D. B., Klaassen, C. D.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 306 KB

english, 2006

11

A Novel Model for the Prediction of Drug-Drug Interactions in Humans Based on in Vitro Cytochrome P450 Phenotypic Data

Lu, C., Miwa, G. T., Prakash, S. R., Gan, L.-S., Balani, S. K.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 163 KB

english, 2006

12

Elevated Warfarin Metabolism in Warfarin-Resistant Roof Rats (Rattus rattus) in Tokyo

Ishizuka, M., Okajima, F., Tanikawa, T., Min, H., Tanaka, K. D., Sakamoto, K. Q., Fujita, S.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 198 KB

english, 2006

13

Isolation of the UDP-Glucuronosyltransferase 1A3 and 1A4 Proximal Promoters and Characterization of Their Dependence on the Transcription Factor Hepatocyte Nuclear Factor 1

Gardner-Stephen, D. A., Mackenzie, P. I.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 246 KB

english, 2006

14

Cytochrome P450 and Glutathione S-Transferase mRNA Expression in Human Fetal Liver Hematopoietic Stem Cells

Shao, J., Stapleton, P. L., Lin, Y. S., Gallagher, E. P.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 279 KB

english, 2006

15

Genetic Variation of Human Cytochrome P450 Reductase as a Potential Biomarker for Mitomycin C-Induced Cytotoxicity

Wang, S.-L., Han, J.-F., He, X.-Y., Wang, X.-R., Hong, J.-Y.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 231 KB

english, 2006

16

A Real-Time Fluorescence Assay for Measuring N-Dealkylation

Mayer, R. T., Dolence, E. K., Mayer, G. E.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 236 KB

english, 2006

17

Specificity of Aminoacylase III-Mediated Deacetylation of Mercapturic Acids

Newman, D., Abuladze, N., Scholz, K., Dekant, W., Tsuprun, V., Ryazantsev, S., Bondar, G., Sassani, P., Kurtz, I., Pushkin, A.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 402 KB

english, 2006

18

Gender Dictates the Nuclear Receptor-Mediated Regulation of CYP3A44

Anakk, S., Huang, W., Staudinger, J. L., Tan, K., Cole, T. J., Moore, D. D., Strobel, H. W.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 444 KB

english, 2006

19

Involvement of Multiple Cytochrome P450 and UDP-Glucuronosyltransferase Enzymes in the in Vitro Metabolism of Muraglitazar

Zhang, D., Wang, L., Chandrasena, G., Ma, L., Zhu, M., Zhang, H., Davis, C. D., Humphreys, W. G.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 588 KB

english, 2006

20

Biotransformation of Geldanamycin and 17-Allylamino-17-Demethoxygeldanamycin by Human Liver Microsomes: Reductive versus Oxidative Metabolism and Implications

Lang, W., Caldwell, G. W., Li, J., Leo, G. C., Jones, W. J., Masucci, J. A.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 461 KB

english, 2006

21

Pregnane X Receptor-Dependent Induction of the CYP3A4 Gene by o,p'-1,1,1,-Trichloro-2,2-Bis (p-Chlorophenyl)ethane

Medina-Diaz, I. M., Arteaga-Illan, G., de Leon, M. B., Cisneros, B., Sierra-Santoyo, A., Vega, L., Gonzalez, F. J., Elizondo, G.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 298 KB

english, 2006

22

CYP2B6, CYP2D6, and CYP3A4 Catalyze the Primary Oxidative Metabolism of Perhexiline Enantiomers by Human Liver Microsomes

Davies, B. J., Coller, J. K., Somogyi, A. A., Milne, R. W., Sallustio, B. C.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 523 KB

english, 2006

23

The Disposition and Metabolism of Naveglitazar, a Peroxisome Proliferator-Activated Receptor - Dual, -Dominant Agonist in Mice, Rats, and Monkeys

Yi, P., Hadden, C. E., Annes, W. F., Jackson, D. A., Peterson, B. C., Gillespie, T. A., Johnson, J. T.

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 538 KB

english, 2006

24

Comparative Metabolism of Radiolabeled Muraglitazar in Animals and Humans by Quantitative and Qualitative Metabolite Profiling

Zhang, D., Wang, L., Raghavan, N., Zhang, H., Li, W., Cheng, P. T., Yao, M., Zhang, L., Zhu, M., Bonacorsi, S., Yeola, S., Mitroka, J., Hariharan, N., Hosagrahara, V., Chandrasena, G., Shyu, W. C., Hu

Journal:

Drug Metabolism and Disposition

Year:

2006

Language:

english

File:

PDF, 829 KB

english, 2006

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