Volume 35; Issue 6

Drug Metabolism and Disposition

Volume 35; Issue 6

1

Use of Hepatocytes to Assess the Contribution of Hepatic Uptake to Clearance in Vivo

Soars, M. G., Grime, K., Sproston, J. L., Webborn, P. J. H., Riley, R. J.

Journal:

Drug Metabolism and Disposition

Year:

2007

Language:

english

File:

PDF, 197 KB

english, 2007

2

Induction of Phase I and II Drug Metabolism in Rat Small Intestine and Colon in Vitro

van de Kerkhof, E. G., de Graaf, I. A. M., de Jager, M. H., Groothuis, G. M. M.

Journal:

Drug Metabolism and Disposition

Year:

2007

Language:

english

File:

PDF, 512 KB

english, 2007

3

Metabolism of Prazosin in Rat, Dog, and Human Liver Microsomes and Cryopreserved Rat and Human Hepatocytes and Characterization of Metabolites by Liquid Chromatography/Tandem Mass Spectrometry

Erve, J. C. L., Vashishtha, S. C., DeMaio, W., Talaat, R. E.

Journal:

Drug Metabolism and Disposition

Year:

2007

Language:

english

File:

PDF, 488 KB

english, 2007

4

Stereoselective Metabolism of Prasugrel in Humans Using a Novel Chiral Liquid Chromatography-Tandem Mass Spectrometry Method

Wickremsinhe, E. R., Tian, Y., Ruterbories, K. J., Verburg, E. M., Weerakkody, G. J., Kurihara, A., Farid, N. A.

Journal:

Drug Metabolism and Disposition

Year:

2007

Language:

english

File:

PDF, 215 KB

english, 2007

5

Valproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell Line

Valentini, A., Biancolella, M., Amati, F., Gravina, P., Miano, R., Chillemi, G., Farcomeni, A., Bueno, S., Vespasiani, G., Desideri, A., Federici, G., Novelli, G., Bernardini, S.

Journal:

Drug Metabolism and Disposition

Year:

2007

Language:

english

File:

PDF, 184 KB

english, 2007

6

Induction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2

Fisher, C. D., Augustine, L. M., Maher, J. M., Nelson, D. M., Slitt, A. L., Klaassen, C. D., Lehman-McKeeman, L. D., Cherrington, N. J.

Journal:

Drug Metabolism and Disposition

Year:

2007

Language:

english

File:

PDF, 439 KB

english, 2007

7

Effect of DPC 333 [(2R)-2- -N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor -Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case Study

Luo, G., Garner, C. E., Xiong, H., Hu, H., Richards, L. E., Brouwer, K. L. R., Duan, J., Decicco, C. P., Maduskuie, T., Shen, H., Lee, F. W., Gan, L.-S.

Journal:

Drug Metabolism and Disposition

Year:

2007

Language:

english

File:

PDF, 286 KB

english, 2007

8

Regional Expression and Activity of Breast Cancer Resistance Protein (Bcrp/Abcg2) in Mouse Intestine: Overlapping Distribution with Sulfotransferases

Enokizono, J., Kusuhara, H., Sugiyama, Y.

Journal:

Drug Metabolism and Disposition

Year:

2007

Language:

english

File:

PDF, 372 KB

english, 2007

9

Morin (3,5,7,2',4'-Pentahydroxyflavone) Exhibits Potent Inhibitory Actions on Urate Transport by the Human Urate Anion Transporter (hURAT1) Expressed in Human Embryonic Kidney Cells

Yu, Z., Fong, W. P., Cheng, C. H. K.

Journal:

Drug Metabolism and Disposition

Year:

2007

Language:

english

File:

PDF, 234 KB

english, 2007

10

Computational and Experimental Analyses of Mammalian Arylamine N-Acetyltransferase Structure and Function

Walraven, J. M., Trent, J. O., Hein, D. W.

Journal:

Drug Metabolism and Disposition

Year:

2007

Language:

english

File:

PDF, 516 KB

english, 2007

11

A Functional Genetic Polymorphism on Human Carbonyl Reductase 1 (CBR1 V88I) Impacts on Catalytic Activity and NADPH Binding Affinity

Gonzalez-Covarrubias, V., Ghosh, D., Lakhman, S. S., Pendyala, L., Blanco, J. G.

Journal:

Drug Metabolism and Disposition

Year:

2007

Language:

english

File:

PDF, 416 KB

english, 2007

12

Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation

Kalgutkar, A. S., Dalvie, D. K., Aubrecht, J., Smith, E. B., Coffing, S. L., Cheung, J. R., Vage, C., Lame, M. E., Chiang, P., McClure, K. F., Maurer, T. S., Coelho, R. V., Soliman, V. F., Schildknegt

Journal:

Drug Metabolism and Disposition

Year:

2007

Language:

english

File:

PDF, 978 KB

english, 2007

13

Characterization of the Novel Defective CYP2C9*24 Allele

Herman, D., Dolzan, V., Ingelman-Sundberg, M.

Journal:

Drug Metabolism and Disposition

Year:

2007

Language:

english

File:

PDF, 126 KB

english, 2007

14

Cyp1b1 Protein in the Mouse Eye during Development: An Immunohistochemical Study

Choudhary, D., Jansson, I., Rezaul, K., Han, D. K. M., Sarfarazi, M., Schenkman, J. B.

Journal:

Drug Metabolism and Disposition

Year:

2007

Language:

english

File:

PDF, 513 KB

english, 2007

15

Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]- -amine)

Hu, S. X., Soll, R., Yee, S., Lohse, D. L., Kousba, A., Zeng, B., Yu, X., McPherson, A., Renick, J., Cao, J., Tabak, A., Hood, J., Doukas, J., Noronha, G., Martin, M.

Journal:

Drug Metabolism and Disposition

Year:

2007

Language:

english

File:

PDF, 364 KB

english, 2007

16

Structure-Activity Relationships for Interaction with Multidrug Resistance Protein 2 (ABCC2/MRP2): The Role of Torsion Angle for a Series of Biphenyl-Substituted Heterocycles

Lai, Y., Xing, L., Poda, G. I., Hu, Y.

Journal:

Drug Metabolism and Disposition

Year:

2007

Language:

english

File:

PDF, 342 KB

english, 2007

17

Pharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)

Midgley, I., Fitzpatrick, K., Taylor, L. M., Houchen, T. L., Henderson, S. J., Wright, S. J., Cybulski, Z. R., John, B. A., McBurney, A., Boykin, D. W., Trendler, K. L.

Journal:

Drug Metabolism and Disposition

Year:

2007

Language:

english

File:

PDF, 320 KB

english, 2007

18

Metabolism, Pharmacokinetics, and Excretion of the Substance P Receptor Antagonist CP-122,721 in Humans: Structural Characterization of the Novel Major Circulating Metabolite 5-Trifluoromethoxy Salicylic Acid by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and NMR Spectroscopy

Colizza, K., Awad, M., Kamel, A.

Journal:

Drug Metabolism and Disposition

Year:

2007

Language:

english

File:

PDF, 945 KB

english, 2007

19

Evaluation of 3-O-Methylfluorescein as a Selective Fluorometric Substrate for CYP2C19 in Human Liver Microsomes

Sudsakorn, S., Skell, J., Williams, D. A., O'Shea, T. J., Liu, H.

Journal:

Drug Metabolism and Disposition

Year:

2007

Language:

english

File:

PDF, 351 KB

english, 2007

20

Investigation of the Metabolism and Reductive Activation of Carcinogenic Aristolochic Acids in Rats

Chan, W., Luo, H.-B., Zheng, Y., Cheng, Y.-K., Cai, Z.

Journal:

Drug Metabolism and Disposition

Year:

2007

Language:

english

File:

PDF, 453 KB

english, 2007

21

Pharmacokinetics of ML3403 ( -(1-phenylethyl)-amine), a 4-Pyridinylimidazole-Type p38 Mitogen-Activated Protein Kinase Inhibitor

Kammerer, B., Scheible, H., Albrecht, W., Gleiter, C. H., Laufer, S.

Journal:

Drug Metabolism and Disposition

Year:

2007

Language:

english

File:

PDF, 533 KB

english, 2007

22

Molecular Mechanism of Basal CYP3A4 Regulation by Hepatocyte Nuclear Factor 4 : Evidence for Direct Regulation in the Intestine

Tegude, H., Schnabel, A., Zanger, U. M., Klein, K., Eichelbaum, M., Burk, O.

Journal:

Drug Metabolism and Disposition

Year:

2007

Language:

english

File:

PDF, 430 KB

english, 2007