Volume 36; Issue 10

Drug Metabolism and Disposition

Volume 36; Issue 10

1

In Silico Modeling of Nonspecific Binding to Human Liver Microsomes

Gao, H., Yao, L., Mathieu, H. W., Zhang, Y., Maurer, T. S., Troutman, M. D., Scott, D. O., Ruggeri, R. B., Lin, J.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 359 KB

english, 2008

2

Enzymatic Reduction and Glutathione Conjugation of Benzoquinone Ansamycin Heat Shock Protein 90 Inhibitors: Relevance for Toxicity and Mechanism of Action

Guo, W., Reigan, P., Siegel, D., Ross, D.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 381 KB

english, 2008

3

Biotransformation of the Chemopreventive Agent 2',4',4-Trihydroxychalcone (Isoliquiritigenin) by UDP-Glucuronosyltransferases

Guo, J., Liu, A., Cao, H., Luo, Y., Pezzuto, J. M., van Breemen, R. B.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 380 KB

english, 2008

4

Stereoselective First-Pass Metabolism of Verapamil in the Small Intestine and Liver in Rats

Hanada, K., Ikemi, Y., Kukita, K., Mihara, K., Ogata, H.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 200 KB

english, 2008

5

Involvement of Multiple Transporters in the Hepatobiliary Transport of Rosuvastatin

Kitamura, S., Maeda, K., Wang, Y., Sugiyama, Y.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 271 KB

english, 2008

6

Involvement of the Pyrilamine Transporter, a Putative Organic Cation Transporter, in Blood-Brain Barrier Transport of Oxycodone

Okura, T., Hattori, A., Takano, Y., Sato, T., Hammarlund-Udenaes, M., Terasaki, T., Deguchi, Y.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 525 KB

english, 2008

7

Role of Vitamin D Receptor in the Lithocholic Acid-Mediated CYP3A Induction in Vitro and in Vivo

Matsubara, T., Yoshinari, K., Aoyama, K., Sugawara, M., Sekiya, Y., Nagata, K., Yamazoe, Y.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 223 KB

english, 2008

8

Effect of Albumin on the Biliary Clearance of Compounds in Sandwich-Cultured Rat Hepatocytes

Wolf, K. K., Brouwer, K. R., Pollack, G. M., Brouwer, K. L. R.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 279 KB

english, 2008

9

Pharmacokinetics of the Novel Nicotinic Receptor Antagonist N,N'-Dodecane-1,12-diyl-bis-3-picolinium Dibromide in the Rat

Albayati, Z. A. F., Dwoskin, L. P., Crooks, P. A.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 243 KB

english, 2008

10

Metabolism, Pharmacokinetics, and Excretion of a Cholesteryl Ester Transfer Protein Inhibitor, Torcetrapib, in Rats, Monkeys, and Mice: Characterization of Unusual and Novel Metabolites by High-Resolution Liquid Chromatography-Tandem Mass Spectrometry and 1H Nuclear Magnetic Resonance

Prakash, C., Chen, W., Rossulek, M., Johnson, K., Zhang, C., O'Connell, T., Potchoiba, M., Dalvie, D.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 748 KB

english, 2008

11

Metabolic Activity of Cytochrome P450 Isoforms in Hepatocytes Cryopreserved with Wheat Protein Extract

Grondin, M., Hamel, F., Sarhan, F., Averill-Bates, D. A.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 604 KB

english, 2008

12

Carbonyl Reductase 1 Is a Predominant Doxorubicin Reductase in the Human Liver

Kassner, N., Huse, K., Martin, H.-J., Godtel-Armbrust, U., Metzger, A., Meineke, I., Brockmoller, J., Klein, K., Zanger, U. M., Maser, E., Wojnowski, L.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 314 KB

english, 2008

13

CYP2C8- and CYP3A-Mediated C-Demethylation of (3- -phenoxy)-acetic Acid (CP-533,536), an EP2 Receptor-Selective Prostaglandin E2 Agonist: Characterization of Metabolites by High-Resolution Liquid Chromatography-Tandem Mass Spectrometry and Liquid Chromatography/Mass Spectrometry-Nuclear Magnetic Resonance

Prakash, C., Wang, W., O'Connell, T., Johnson, K. A.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 649 KB

english, 2008

14

Enhancement of Zidovudine Uptake by Dehydroepiandrosterone Sulfate in Rat Syncytiotrophoblast Cell Line TR-TBT 18d-1

Nishimura, T., Seki, Y., Sato, K., Chishu, T., Kose, N., Terasaki, T., Kang, Y.-S., Sai, Y., Nakashima, E.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 211 KB

english, 2008

15

Re-engineering of CYP2C9 to Probe Acid-Base Substrate Selectivity

Tai, G., Dickmann, L. J., Matovic, N., DeVoss, J. J., Gillam, E. M. J., Rettie, A. E.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 179 KB

english, 2008

16

Biodistribution and Plasma Protein Binding of Zoledronic Acid

Weiss, H. M., Pfaar, U., Schweitzer, A., Wiegand, H., Skerjanec, A., Schran, H.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 419 KB

english, 2008

17

Multiple Substrate Binding by Cytochrome P450 3A4: Estimation of the Number of Bound Substrate Molecules

Kapelyukh, Y., Paine, M. J. I., Marechal, J.-D., Sutcliffe, M. J., Wolf, C. R., Roberts, G. C. K.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 361 KB

english, 2008

18

Extractive Biotransformation for Production of Metabolites of Poorly Soluble Compounds: Synthesis of 32-Hydroxy-rifalazil

Mozhaev, V. V., Mozhaeva, L. V., Michels, P. C., Khmelnitsky, Y. L.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 507 KB

english, 2008

19

Suppression of CYP2B Induction by Alendronate-Mediated Farnesyl Diphosphate Synthase Inhibition in Primary Cultured Rat Hepatocytes

Jackson, N. M., Kocarek, T. A.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 225 KB

english, 2008

20

Lipopolysaccharide Increases Cell Surface P-glycoprotein That Exhibits Diminished Activity in Intestinal Epithelial Cells

Mishra, J., Zhang, Q., Rosson, J. L., Moran, J., Dopp, J. M., Neudeck, B. L.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 234 KB

english, 2008

21

Identification of Human Hepatic Cytochrome P450 Enzymes Involved in the Biotransformation of Cholic and Chenodeoxycholic Acid

Deo, A. K., Bandiera, S. M.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 541 KB

english, 2008

22

The Development of Drug Metabolism Research as Expressed in the Publications of ASPET: Part 3, 1984-2008

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 80 KB

english, 2008