Volume 36; Issue 5

Drug Metabolism and Disposition

Volume 36; Issue 5

1

Subcellular Distribution of Inorganic and Methylated Arsenic Compounds in Human Urothelial Cells and Human Hepatocytes

Dopp, E., von Recklinghausen, U., Hartmann, L. M., Stueckradt, I., Pollok, I., Rabieh, S., Hao, L., Nussler, A., Katier, C., Hirner, A. V., Rettenmeier, A. W.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 326 KB

english, 2008

2

Detection of Novel Reactive Metabolites of Trazodone: Evidence for CYP2D6-Mediated Bioactivation of m-Chlorophenylpiperazine

Wen, B., Ma, L., Rodrigues, A. D., Zhu, M.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 403 KB

english, 2008

3

CYP1B1 Is Not a Major Determinant of the Disposition of Aromatase Inhibitors in Epithelial Cells of Invasive Ductal Carcinoma

Rahman, M., Lax, S. F., Sutter, C. H., Tran, Q. T., Stevens, G. L., Emmert, G. L., Russo, J., Santen, R. J., Sutter, T. R.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 442 KB

english, 2008

4

In Vitro Metabolism of 2-[6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl] Acetic Acid (Licofelone, ML3000), an Inhibitor of Cyclooxygenase-1 and -2 and 5-Lipoxygenase

Albrecht, W., Unger, A., Nussler, A. K., Laufer, S.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 433 KB

english, 2008

5

The "Albumin Effect" and in Vitro-in Vivo Extrapolation: Sequestration of Long-Chain Unsaturated Fatty Acids Enhances Phenytoin Hydroxylation by Human Liver Microsomal and Recombinant Cytochrome P450 2C9

Rowland, A., Elliot, D. J., Knights, K. M., Mackenzie, P. I., Miners, J. O.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 206 KB

english, 2008

6

Two Allelic Variants of Aldo-Keto Reductase 1A1 Exhibit Reduced in Vitro Metabolism of Daunorubicin

Bains, O. S., Takahashi, R. H., Pfeifer, T. A., Grigliatti, T. A., Reid, R. E., Riggs, K. W.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 301 KB

english, 2008

7

Effect of Breed upon Cytochromes P450 and Phase II Enzyme Expression in Cattle Liver

Giantin, M., Carletti, M., Capolongo, F., Pegolo, S., Lopparelli, R. M., Gusson, F., Nebbia, C., Cantiello, M., Martin, P., Pineau, T., Dacasto, M.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 280 KB

english, 2008

8

Unique Transcription Start Sites and Distinct Promoter Regions Differentiate the Pregnane X Receptor (PXR) Isoforms PXR 1 and PXR 2

Tompkins, L. M., Sit, T. L., Wallace, A. D.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 291 KB

english, 2008

9

Slipping Past UGT1A1 and Multidrug Resistance-Associated Protein 2 in the Liver: Effects of Steric Compression and Hydrogen Bonding on the Hepatobiliary Elimination of Synthetic Bilirubins

McDonagh, A. F., Boiadjiev, S. E., Lightner, D. A.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 439 KB

english, 2008

10

Markers of Electrophilic Stress Caused by Chemically Reactive Metabolites in Human Hepatocytes

Takakusa, H., Masumoto, H., Mitsuru, A., Okazaki, O., Sudo, K.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 314 KB

english, 2008

11

Generation of Mice Transgenic for Human CYP2C18 and CYP2C19: Characterization of the Sexually Dimorphic Gene and Enzyme Expression

Lofgren, S., Baldwin, R. M., Hiratsuka, M., Lindqvist, A., Carlberg, A., Sim, S. C., Schulke, M., Snait, M., Edenro, A., Fransson-Steen, R., Terelius, Y., Ingelman-Sundberg, M.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 296 KB

english, 2008

12

Role of Human Pregnane X Receptor in Tamoxifen- and 4-Hydroxytamoxifen-Mediated CYP3A4 Induction in Primary Human Hepatocytes and LS174T Cells

Sane, R. S., Buckley, D. J., Buckley, A. R., Nallani, S. C., Desai, P. B.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 274 KB

english, 2008

13

Synergism of Glucocorticoid Hormone with Growth Hormone for Female-Specific Mouse Cyp3a44 Gene Expression

Sakuma, T., Bhadhprasit, W., Hashita, T., Nemoto, N.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 357 KB

english, 2008

14

Differential Roles of P-Glycoprotein, Multidrug Resistance-Associated Protein 2, and CYP3A on Saquinavir Oral Absorption in Sprague-Dawley Rats

Usansky, H. H., Hu, P., Sinko, P. J.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 174 KB

english, 2008

15

Impact of Basolateral Multidrug Resistance-Associated Protein (Mrp) 3 and Mrp4 on the Hepatobiliary Disposition of Fexofenadine in Perfused Mouse Livers

Tian, X., Swift, B., Zamek-Gliszczynski, M. J., Belinsky, M. G., Kruh, G. D., Brouwer, K. L. R.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 149 KB

english, 2008

16

Biotransformation of 3-Amino-5,6,7,8-tetrahydro-2- quinazolin-4(3H)-one (TZB-30878), a Novel 5-Hydroxytryptamine (5-HT)1A Agonist/5-HT3 Antagonist, in Human Hepatic Cytochrome P450 Enzymes

Minato, K., Suzuki, R., Asagarasu, A., Matsui, T., Sato, M.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 382 KB

english, 2008

17

Time-Dependent Effects of Klebsiella Pneumoniae Endotoxin (KPLPS) on the Pharmacokinetics of Theophylline in Rats: Return of the Parameters in 96-Hour KPLPS Rats to the Control Levels

Yang, K. H., Jung, Y. S., Lee, D. Y., Lee, J. H., Kim, Y. C., Lee, M. G.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 209 KB

english, 2008

18

Glucuronidation of Tobacco-Specific Nitrosamines by UGT2B10

Chen, G., Dellinger, R. W., Sun, D., Spratt, T. E., Lazarus, P.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 215 KB

english, 2008

19

Scaling of in Vitro Membrane Permeability to Predict P-glycoprotein-Mediated Drug Absorption in Vivo

Shirasaka, Y., Masaoka, Y., Kataoka, M., Sakuma, S., Yamashita, S.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 284 KB

english, 2008

20

Role of Haptoglobin on the Uptake of Native and -Chain [Trimesoyl-(Lys82) -(Lys82) ] Cross-Linked Human Hemoglobins in Isolated Perfused Rat Livers

Chow, E. C. Y., Liu, L., Ship, N., Kluger, R. H., Pang, K. S.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 290 KB

english, 2008

21

Modest Effect of Impaired P-glycoprotein on the Plasma Concentrations of Fexofenadine, Quinidine, and Loperamide following Oral Administration in Collies

Kitamura, Y., Koto, H., Matsuura, S., Kawabata, T., Tsuchiya, H., Kusuhara, H., Tsujimoto, H., Sugiyama, Y.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 137 KB

english, 2008

22

Contribution of the N-Glucuronidation Pathway to the Overall in Vitro Metabolic Clearance of Midazolam in Humans

Klieber, S., Hugla, S., Ngo, R., Arabeyre-Fabre, C., Meunier, V., Sadoun, F., Fedeli, O., Rival, M., Bourrie, M., Guillou, F., Maurel, P., Fabre, G.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 642 KB

english, 2008