Volume 36; Issue 7

Drug Metabolism and Disposition

Volume 36; Issue 7

1

Effect of Plasma Protein Binding on in Vitro-in Vivo Correlation of Biliary Excretion of Drugs Evaluated by Sandwich-Cultured Rat Hepatocytes

Fukuda, H., Ohashi, R., Tsuda-Tsukimoto, M., Tamai, I.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 423 KB

english, 2008

2

Inhibitory Effects of Seven Components of Danshen Extract on Catalytic Activity of Cytochrome P450 Enzyme in Human Liver Microsomes

Qiu, F., Zhang, R., Sun, J., A, J., Hao, H., Peng, Y., Ai, H., Wang, G.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 239 KB

english, 2008

3

Drug Transporter and Cytochrome P450 mRNA Expression in Human Ocular Barriers: Implications for Ocular Drug Disposition

Zhang, T., Xiang, C. D., Gale, D., Carreiro, S., Wu, E. Y., Zhang, E. Y.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 422 KB

english, 2008

4

Metabolism and Disposition of Dasatinib after Oral Administration to Humans

Christopher, L. J., Cui, D., Wu, C., Luo, R., Manning, J. A., Bonacorsi, S. J., Lago, M., Allentoff, A., Lee, F. Y. F., McCann, B., Galbraith, S., Reitberg, D. P., He, K., Barros, A., Blackwood-Chirch

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 317 KB

english, 2008

5

Prediction of Pharmacokinetic Drug-Drug Interactions Using Human Hepatocyte Suspension in Plasma and Cytochrome P450 Phenotypic Data. III. In Vitro-in Vivo Correlation with Fluconazole

Lu, C., Berg, C., Prakash, S. R., Lee, F. W., Balani, S. K.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 152 KB

english, 2008

6

Aldehyde Oxidase-Catalyzed Metabolism of N1-Methylnicotinamide in Vivo and in Vitro in Chimeric Mice with Humanized Liver

Kitamura, S., Nitta, K., Tayama, Y., Tanoue, C., Sugihara, K., Inoue, T., Horie, T., Ohta, S.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 197 KB

english, 2008

7

Inhibitory Effects of Terpenoids on Multidrug Resistance-Associated Protein 2- and Breast Cancer Resistance Protein-Mediated Transport

Yoshida, N., Takada, T., Yamamura, Y., Adachi, I., Suzuki, H., Kawakami, J.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 187 KB

english, 2008

8

Down-Regulation of a Hepatic Transporter Multidrug Resistance-Associated Protein 2 Is Involved in Alteration of Pharmacokinetics of Glycyrrhizin and Its Metabolites in a Rat Model of Chronic Liver Injury

Makino, T., Ohtake, N., Watanabe, A., Tsuchiya, N., Imamura, S., Iizuka, S., Inoue, M., Mizukami, H.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 333 KB

english, 2008

9

Osmotic Regulation of a Novel Flavin-Containing Monooxygenase in Primary Cultured Cells from Rainbow Trout (Oncorhynchus mykiss)

Rodriguez-Fuentes, G., Aparicio-Fabre, R., Li, Q., Schlenk, D.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 325 KB

english, 2008

10

The Biotransformation of Prasugrel, a New Thienopyridine Prodrug, by the Human Carboxylesterases 1 and 2

Williams, E. T., Jones, K. O., Ponsler, G. D., Lowery, S. M., Perkins, E. J., Wrighton, S. A., Ruterbories, K. J., Kazui, M., Farid, N. A.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 197 KB

english, 2008

11

An in Vitro Mechanistic Study to Elucidate the Desipramine/Bupropion Clinical Drug-Drug Interaction

Reese, M. J., Wurm, R. M., Muir, K. T., Generaux, G. T., St. John-Williams, L., Mcconn, D. J.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 167 KB

english, 2008

12

Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 670 Drug Compounds

Obach, R. S., Lombardo, F., Waters, N. J.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 857 KB

english, 2008

13

Functional Expression and Comparative Characterization of Nine Murine Cytochromes P450 by Fluorescent Inhibition Screening

McLaughlin, L. A., Dickmann, L. J., Wolf, C. R., Henderson, C. J.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 565 KB

english, 2008

14

The Antiapoptotic Factor Growth Arrest and DNA-Damage-Inducible 45 Regulates the Nuclear Receptor Constitutive Active/Androstane Receptor-Mediated Transcription

Yamamoto, Y., Negishi, M.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 256 KB

english, 2008

15

The Mibefradil Derivative NNC55-0396, a Specific T-Type Calcium Channel Antagonist, Exhibits Less CYP3A4 Inhibition than Mibefradil

Bui, P. H., Quesada, A., Handforth, A., Hankinson, O.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 474 KB

english, 2008

16

Effects of Spice Constituents on P-Glycoprotein-Mediated Transport and CYP3A4-Mediated Metabolism in Vitro

Zhang, W., Lim, L.-Y.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 243 KB

english, 2008

17

Evaluation of HepaRG Cells as an in Vitro Model for Human Drug Metabolism Studies

Kanebratt, K. P., Andersson, T. B.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 341 KB

english, 2008

18

Prediction of Pharmacokinetic Drug-Drug Interactions Using Human Hepatocyte Suspension in Plasma and Cytochrome P450 Phenotypic Data. II. In Vitro-in Vivo Correlation with Ketoconazole

Lu, C., Hatsis, P., Berg, C., Lee, F. W., Balani, S. K.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 95 KB

english, 2008

19

Comparative Analysis of CYP3A Heteroactivation by Steroid Hormones and Flavonoids in Different in Vitro Systems and Potential in Vivo Implications

Henshall, J., Galetin, A., Harrison, A., Houston, J. B.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 242 KB

english, 2008

20

Prediction of the Pharmacokinetics of Atorvastatin, Cerivastatin, and Indomethacin Using Kinetic Models Applied to Isolated Rat Hepatocytes

Paine, S. W., Parker, A. J., Gardiner, P., Webborn, P. J. H., Riley, R. J.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 223 KB

english, 2008

21

Cellular Accumulation of Cholyl-Glycylamido-Fluorescein in Sandwich-Cultured Rat Hepatocytes: Kinetic Characterization, Transport Mechanisms, and Effect of Human Immunodeficiency Virus Protease Inhibitors

Ye, Z.-w., Augustijns, P., Annaert, P.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 244 KB

english, 2008

22

Differential Genotype Dependent Inhibition of CYP2C9 in Humans

Kumar, V., Brundage, R. C., Oetting, W. S., Leppik, I. E., Tracy, T. S.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 228 KB

english, 2008

23

In Silico Methods for Unraveling the Mechanistic Complexities of Intestinal Absorption: Metabolism-Efflux Transport Interactions

Garmire, L. X., Hunt, C. A.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 625 KB

english, 2008

24

Pharmacokinetic Parameters of Chlorzoxazone and Its Main Metabolite, 6-Hydroxychlorzoxazone, after Intravenous and Oral Administration of Chlorzoxazone to Liver Cirrhotic Rats with Diabetes Mellitus

Ahn, C. Y., Bae, S. K., Jung, Y. S., Lee, I., Kim, Y. C., Lee, M. G., Shin, W. G.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 185 KB

english, 2008

25

Biotransformation of [14C]Dasatinib: In Vitro Studies in Rat, Monkey, and Human and Disposition after Administration to Rats and Monkeys

Christopher, L. J., Cui, D., Li, W., Barros, A., Arora, V. K., Zhang, H., Wang, L., Zhang, D., Manning, J. A., He, K., Fletcher, A. M., Ogan, M., Lago, M., Bonacorsi, S. J., Humphreys, W. G., Iyer, R.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 785 KB

english, 2008

26

Closing the Gaps: A Full Scan of the Intestinal Expression of P-Glycoprotein, Breast Cancer Resistance Protein, and Multidrug Resistance-Associated Protein 2 in Male and Female Rats

MacLean, C., Moenning, U., Reichel, A., Fricker, G.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 259 KB

english, 2008

27

Hepatocellular Binding of Drugs: Correction for Unbound Fraction in Hepatocyte Incubations Using Microsomal Binding or Drug Lipophilicity Data

Kilford, P. J., Gertz, M., Houston, J. B., Galetin, A.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 161 KB

english, 2008

28

Rate-Limiting Steps in Hepatic Drug Clearance: Comparison of Hepatocellular Uptake and Metabolism with Microsomal Metabolism of Saquinavir, Nelfinavir, and Ritonavir

Parker, A. J., Houston, J. B.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 223 KB

english, 2008

29

Use of Online Microdialysis Sampling to Determine the in Vivo Rate of Phenol Glucuronidation in Rainbow Trout

Nichols, J. W., Hoffman, A. D., Fitzsimmons, P. N., Lien, G. J., Jenson, C. T.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 233 KB

english, 2008

30

Pharmacokinetic-Pharmacodynamic Modeling of Biomarker Response and Tumor Growth Inhibition to an Orally Available cMet Kinase Inhibitor in Human Tumor Xenograft Mouse Models

Yamazaki, S., Skaptason, J., Romero, D., Lee, J. H., Zou, H. Y., Christensen, J. G., Koup, J. R., Smith, B. J., Koudriakova, T.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 421 KB

english, 2008

31

Bioactivation of Flutamide Metabolites by Human Liver Microsomes

Kang, P., Dalvie, D., Smith, E., Zhou, S., Deese, A., Nieman, J. A.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 524 KB

english, 2008

32

Disposition of Lasofoxifene, a Next-Generation Selective Estrogen Receptor Modulator, in Healthy Male Subjects

Prakash, C., Johnson, K. A., Gardner, M. J.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 391 KB

english, 2008

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