Volume 36; Issue 8

Drug Metabolism and Disposition

Volume 36; Issue 8

1

Expression of UGT1A and UGT2B mRNA in Human Normal Tissues and Various Cell Lines

Nakamura, A., Nakajima, M., Yamanaka, H., Fujiwara, R., Yokoi, T.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 320 KB

english, 2008

2

Mechanisms Underlying Saturable Intestinal Absorption of Metformin

Proctor, W. R., Bourdet, D. L., Thakker, D. R.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 438 KB

english, 2008

3

Investigation of the Role of Breast Cancer Resistance Protein (Bcrp/Abcg2) on Pharmacokinetics and Central Nervous System Penetration of Abacavir and Zidovudine in the Mouse

Giri, N., Shaik, N., Pan, G., Terasaki, T., Mukai, C., Kitagaki, S., Miyakoshi, N., Elmquist, W. F.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 469 KB

english, 2008

4

Plasma and Urinary Tanshinol from Salvia miltiorrhiza (Danshen) Can Be Used as Pharmacokinetic Markers for Cardiotonic Pills, a Cardiovascular Herbal Medicine

Lu, T., Yang, J., Gao, X., Chen, P., Du, F., Sun, Y., Wang, F., Xu, F., Shang, H., Huang, Y., Wang, Y., Wan, R., Liu, C., Zhang, B., Li, C.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 363 KB

english, 2008

5

Comparative Disposition and Metabolism of Paraherquamide in Sheep, Gerbils, and Dogs

Aloysius, H. A., Elipe, M. V. S., Arison, B. H., Faidley, T. D., Michael, B. F., Blizzard, T. A., Thompson, D. R., Shoop, W. L., Tschirret-Guth, R. A.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 547 KB

english, 2008

6

Peroxidase-Mediated Bioactivation of Hydroxylated Metabolites of Carbamazepine and Phenytoin

Lu, W., Uetrecht, J. P.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 684 KB

english, 2008

7

Developmental Changes in Human Liver CYP2D6 Expression

Stevens, J. C., Marsh, S. A., Zaya, M. J., Regina, K. J., Divakaran, K., Le, M., Hines, R. N.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 175 KB

english, 2008

8

Curcuminoids Inhibit Multiple Human Cytochromes P450, UDP-Glucuronosyltransferase, and Sulfotransferase Enzymes, whereas Piperine Is a Relatively Selective CYP3A4 Inhibitor

Volak, L. P., Ghirmai, S., Cashman, J. R., Court, M. H.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 317 KB

english, 2008

9

Rapid Distribution of Liposomal Short-Chain Ceramide in Vitro and in Vivo

Zolnik, B. S., Stern, S. T., Kaiser, J. M., Heakal, Y., Clogston, J. D., Kester, M., McNeil, S. E.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 210 KB

english, 2008

10

Squalenoylation Favorably Modifies the in Vivo Pharmacokinetics and Biodistribution of Gemcitabine in Mice

Reddy, L. H., Khoury, H., Paci, A., Deroussent, A., Ferreira, H., Dubernet, C., Decleves, X., Besnard, M., Chacun, H., Lepetre-Mouelhi, S., Desmaele, D., Rousseau, B., Laugier, C., Cintrat, J.-C., Vas

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 257 KB

english, 2008

11

A Comprehensive in Vitro and in Silico Analysis of Antibiotics That Activate Pregnane X Receptor and Induce CYP3A4 in Liver and Intestine

Yasuda, K., Ranade, A., Venkataramanan, R., Strom, S., Chupka, J., Ekins, S., Schuetz, E., Bachmann, K.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 341 KB

english, 2008

12

Relevance of the Organic Cation Transporters 1 and 2 for Antiretroviral Drug Therapy in Human Immunodeficiency Virus Infection

Jung, N., Lehmann, C., Rubbert, A., Knispel, M., Hartmann, P., van Lunzen, J., Stellbrink, H.-J., Faetkenheuer, G., Taubert, D.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 517 KB

english, 2008

13

In Vitro Drug-Drug Interaction Screens for Canine Veterinary Medicines: Evaluation of Cytochrome P450 Reversible Inhibition

Aidasani, D., Zaya, M. J., Malpas, P. B., Locuson, C. W.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 148 KB

english, 2008

14

Identification of the Transporters Involved in the Hepatobiliary Transport and Intestinal Efflux of Methyl 1-(3,4-Dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) Glucuronide, a Pharmacologically Active Metabolite of S-8921

Sakamoto, S., Kusuhara, H., Horie, K., Takahashi, K., Baba, T., Ishizaki, J., Sugiyama, Y.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 281 KB

english, 2008

15

Role of Organic Anion Transporters in the Pharmacokinetics of Zonampanel, an -Amino-3-hydroxy-5-methylisoxazole-4-propionate Receptor Antagonist, in Rats

Minematsu, T., Hashimoto, T., Aoki, T., Usui, T., Kamimura, H.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 294 KB

english, 2008

16

The Traditional Chinese Herbal Remedy Tian Xian Activates Pregnane X Receptor and Induces CYP3A Gene Expression in Hepatocytes

Lichti-Kaiser, K., Staudinger, J. L.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 344 KB

english, 2008

17

The Influence of CYP3A5 Genotype on Dexamethasone Induction of CYP3A Activity in African Americans

Roberts, P. J., Rollins, K. D., Kashuba, A. D. M., Paine, M. F., Nelsen, A. C., Williams, E. E., Moran, C., Lamba, J. K., Schuetz, E. G., Hawke, R. L.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 167 KB

english, 2008

18

The Macrolide Everolimus Forms an Unusual Metabolite in Animals and Humans: Identification of a Phosphocholine Ester

Zollinger, M., Sayer, C., Dannecker, R., Schuler, W., Sedrani, R.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 154 KB

english, 2008

19

Pathways of Carbamazepine Bioactivation in Vitro. III. The Role of Human Cytochrome P450 Enzymes in the Formation of 2,3-Dihydroxycarbamazepine

Pearce, R. E., Lu, W., Wang, Y., Uetrecht, J. P., Correia, M. A., Leeder, J. S.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 699 KB

english, 2008

20

A Combined Model for Predicting CYP3A4 Clinical Net Drug-Drug Interaction Based on CYP3A4 Inhibition, Inactivation, and Induction Determined in Vitro

Fahmi, O. A., Maurer, T. S., Kish, M., Cardenas, E., Boldt, S., Nettleton, D.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 228 KB

english, 2008

21

Regio- and Stereospecific N-Glucuronidation of Medetomidine: The Differences between UDP Glucuronosyltransferase (UGT) 1A4 and UGT2B10 Account for the Complex Kinetics of Human Liver Microsomes

Kaivosaari, S., Toivonen, P., Aitio, O., Sipila, J., Koskinen, M., Salonen, J. S., Finel, M.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 284 KB

english, 2008

22

Intestinal and Hepatobiliary Transport of Ximelagatran and Its Metabolites in Pigs

Sjodin, E., Fritsch, H., Eriksson, U. G., Logren, U., Nordgren, A., Forsell, P., Knutson, L., Lennernas, H.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 346 KB

english, 2008

23

Effect of Interleukin-2 Pretreatment on Paclitaxel Absorption and Tissue Disposition after Oral and Intravenous Administration in Mice

Hosten, B., Abbara, C., Petit, B., Dauvin, A., Bourasset, F., Farinotti, R., Gonin, P., Bonhomme-Faivre, L.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 196 KB

english, 2008

24

Plasma Profiling of Intact Isoflavone Metabolites by High-Performance Liquid Chromatography and Mass Spectrometric Identification of Flavone Glycosides Daidzin and Genistin in Human Plasma after Administration of Kinako

Hosoda, K., Furuta, T., Yokokawa, A., Ogura, K., Hiratsuka, A., Ishii, K.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 987 KB

english, 2008

25

Functional Consequences of Active Hepatic Uptake on Cytochrome P450 Inhibition in Rat and Human Hepatocytes

Grime, K., Webborn, P. J. H., Riley, R. J.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 226 KB

english, 2008

26

Assessment of the Medicines Lidocaine, Prilocaine, and Their Metabolites, 2,6-Dimethylaniline and 2-Methylaniline, for DNA Adduct Formation in Rat Tissues

Duan, J.-D., Jeffrey, A. M., Williams, G. M.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 242 KB

english, 2008

27

Hepatic Nuclear Factor 1 Inhibitor Ursodeoxycholic Acid Influences Pharmacokinetics of the Organic Anion Transporting Polypeptide 1B1 Substrate Rosuvastatin and Bilirubin

He, Y.-J., Zhang, W., Tu, J.-H., Kirchheiner, J., Chen, Y., Guo, D., Li, Q., Li, Z.-Y., Chen, H., Hu, D.-L., Wang, D., Zhou, H.-H.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 110 KB

english, 2008

28

UDP-Glucuronosyltransferase 1A6 Is the Major Isozyme Responsible for Protocatechuic Aldehyde Glucuronidation in Human Liver Microsomes

Liu, H.-X., Liu, Y., Zhang, J.-W., Li, W., Liu, H.-T., Yang, L.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 405 KB

english, 2008

29

Cytochrome P450 2B6 Catalyzes the Formation of Pharmacologically Active Sibutramine (N- -N,N-dimethylamine) Metabolites in Human Liver Microsomes

Bae, S. K., Cao, S., Seo, K.-A., Kim, H., Kim, M.-J., Shon, J.-H., Liu, K.-H., Zhou, H.-H., Shin, J.-G.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 514 KB

english, 2008

30

Metabolism of the Cysteine S-Conjugate of Busulfan Involves a -Lyase Reaction

Cooper, A. J. L., Younis, I. R., Niatsetskaya, Z. V., Krasnikov, B. F., Pinto, J. T., Petros, W. P., Callery, P. S.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 178 KB

english, 2008

31

Extensive Metabolism and Hepatic Accumulation of Gemcitabine After Multiple Oral and Intravenous Administration in Mice

Veltkamp, S. A., Pluim, D., van Tellingen, O., Beijnen, J. H., Schellens, J. H. M.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 634 KB

english, 2008

32

CORRECTION TO "IDENTIFICATION AND CHARACTERIZATION OF POTENT CYP2B6 INHIBITORS IN WOOHWANGCHEONGSIMWON SUSPENSION, AN HERBAL PREPARATION USED IN THE TREATMENT AND PREVENTION OF APOPLEXY IN KOREA AND CHINA"

Journal:

Drug Metabolism and Disposition

Year:

2008

File:

PDF, 50 KB

2008

33

Effects of Ketoconazole and Quinidine on Pharmacokinetics of Pactimibe and Its Plasma Metabolite, R-125528, in Humans

Kotsuma, M., Tokui, T., Freudenthaler, S., Nishimura, K.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 244 KB

english, 2008

34

Deletion of the NADPH-Cytochrome P450 Reductase Gene in Cardiomyocytes Does Not Protect Mice against Doxorubicin-Mediated Acute Cardiac Toxicity

Fang, C., Gu, J., Xie, F., Behr, M., Yang, W., Abel, E. D., Ding, X.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 379 KB

english, 2008

35

The Nrf2 Activator Oltipraz Also Activates the Constitutive Androstane Receptor

Merrell, M. D., Jackson, J. P., Augustine, L. M., Fisher, C. D., Slitt, A. L., Maher, J. M., Huang, W., Moore, D. D., Zhang, Y., Klaassen, C. D., Cherrington, N. J.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 252 KB

english, 2008