Volume 37; Issue 1

Drug Metabolism and Disposition

Volume 37; Issue 1

1

Key Amino Acid Residues Responsible for the Differences in Substrate Specificity of Human UDP-Glucuronosyltransferase (UGT)1A9 and UGT1A8

Fujiwara, R., Nakajima, M., Yamanaka, H., Yokoi, T.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 526 KB

english, 2008

2

Structural Modulation of Oxidative Metabolism in Design of Improved Benzothiophene Selective Estrogen Receptor Modulators

Qin, Z., Kastrati, I., Ashgodom, R. T., Lantvit, D. D., Overk, C. R., Choi, Y., van Breemen, R. B., Bolton, J. L., Thatcher, G. R. J.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 387 KB

english, 2008

3

Microdialysis Evaluation of Atomoxetine Brain Penetration and Central Nervous System Pharmacokinetics in Rats

Kielbasa, W., Kalvass, J. C., Stratford, R.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 260 KB

english, 2009

4

Circadian Expression Profiles of Drug-Processing Genes and Transcription Factors in Mouse Liver

Zhang, Y.-K. J., Yeager, R. L., Klaassen, C. D.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 812 KB

english, 2009

5

Apixaban Metabolism and Pharmacokinetics after Oral Administration to Humans

Raghavan, N., Frost, C. E., Yu, Z., He, K., Zhang, H., Humphreys, W. G., Pinto, D., Chen, S., Bonacorsi, S., Wong, P. C., Zhang, D.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 233 KB

english, 2009

6

In Vitro Metabolism of Pyrethroid Pesticides by Rat and Human Hepatic Microsomes and Cytochrome P450 Isoforms

Scollon, E. J., Starr, J. M., Godin, S. J., DeVito, M. J., Hughes, M. F.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 250 KB

english, 2009

7

Quantitation of Human Cytochrome P450 2D6 Protein with Immunoblot and Mass Spectrometry Analysis

Yu, A.-M., Qu, J., Felmlee, M. A., Cao, J., Jiang, X.-L.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 377 KB

english, 2009

8

Cytoskeleton Interruption in Human Hepatoma HepG2 Cells Induced by Ketamine Occurs Possibly through Suppression of Calcium Mobilization and Mitochondrial Function

Chang, H.-C., Chen, T.-L., Chen, R.-M.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 570 KB

english, 2009

9

Effect of Oral Ketoconazole on Oral and Intravenous Pharmacokinetics of Simvastatin and Its Acid in Cynomolgus Monkeys

Ogasawara, A., Utoh, M., Nii, K., Ueda, A., Yoshikawa, T., Kume, T., Fukuzaki, K.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 258 KB

english, 2009

10

Mechanism-Based Inactivation of Cytochrome P450 2C9 by Tienilic Acid and ( )-Suprofen: A Comparison of Kinetics and Probe Substrate Selection

Hutzler, J. M., Balogh, L. M., Zientek, M., Kumar, V., Tracy, T. S.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 382 KB

english, 2009

11

Role of NADPH-Cytochrome P450 Reductase and Cytochrome-b5/NADH-b5 Reductase in Variability of CYP3A Activity in Human Liver Microsomes

Gan, L., von Moltke, L. L., Trepanier, L. A., Harmatz, J. S., Greenblatt, D. J., Court, M. H.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 337 KB

english, 2009

12

Prediction of Drug Clearance by Glucuronidation from in Vitro Data: Use of Combined Cytochrome P450 and UDP-Glucuronosyltransferase Cofactors in Alamethicin-Activated Human Liver Microsomes

Kilford, P. J., Stringer, R., Sohal, B., Houston, J. B., Galetin, A.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 208 KB

english, 2009

13

Is 1-Aminobenzotriazole an Appropriate in Vitro Tool as a Nonspecific Cytochrome P450 Inactivator?

Linder, C. D., Renaud, N. A., Hutzler, J. M.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 128 KB

english, 2009

14

Disparity in Intestine Disposition between Formed and Preformed Metabolites and Implications: A Theoretical Study

Sun, H., Pang, K. S.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 1.20 MB

english, 2009

15

Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction

Ohno, S., Nakajin, S.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 315 KB

english, 2009

16

Discovering Plausible Mechanistic Details of Hepatic Drug Interactions

Lam, T. N., Hunt, C. A.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 321 KB

english, 2009

17

A Null Allele Impairs Function of CYP2C76 Gene in Cynomolgus Monkeys: A Possible Genetic Tool for Generation of a Better Animal Model in Drug Metabolism

Uno, Y., Sakuraba, H., Uehara, S., Kumano, T., Matsuno, K., Nakamura, C., Kito, G., Kamataki, T., Nagata, R.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 130 KB

english, 2009

18

Natural Allelic Variants of Bovine ATP-Binding Cassette Transporter ABCG2: Increased Activity of the Ser581 Variant and Development of Tools for the Discovery of New ABCG2 Inhibitors

Merino, G., Real, R., Baro, M. F., Gonzalez-Lobato, L., Prieto, J. G., Alvarez, A. I., Marques, M. M.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 185 KB

english, 2009

19

Effect of Aging on Glucuronidation of Valproic Acid in Human Liver Microsomes and the Role of UDP-Glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10

Argikar, U. A., Remmel, R. P.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 342 KB

english, 2009

20

High-Affinity Interaction of Sartans with H+/Peptide Transporters

Knutter, I., Kottra, G., Fischer, W., Daniel, H., Brandsch, M.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 467 KB

english, 2009

21

Transepithelial Transport of the Group II Metabotropic Glutamate 2/3 Receptor Agonist (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740) and Its Prodrug (1S,2S,5R,6S)-2-[(2'S)-(2'-Amino)propionyl]aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY544344)

Varma, M. V. S., Eriksson, A. H., Sawada, G., Pak, Y. A., Perkins, E. J., Zimmerman, C. L.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 451 KB

english, 2009

22

Absolute Difference of Hepatobiliary Transporter Multidrug Resistance-Associated Protein (MRP2/Mrp2) in Liver Tissues and Isolated Hepatocytes from Rat, Dog, Monkey, and Human

Li, N., Zhang, Y., Hua, F., Lai, Y.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 343 KB

english, 2009

23

Expression and Functional Analysis of CYP2D6.24, CYP2D6.26, CYP2D6.27, and CYP2D7 Isozymes

Zhang, W.-Y., Tu, Y.-B., Haining, R. L., Yu, A.-M.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 166 KB

english, 2009

24

Human Flavin-Containing Monooxygenase 2.1 Catalyzes Oxygenation of the Antitubercular Drugs Thiacetazone and Ethionamide

Francois, A. A., Nishida, C. R., de Montellano, P. R. O., Phillips, I. R., Shephard, E. A.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 354 KB

english, 2009

25

Three Patterns of Cytochrome P450 Gene Expression during Liver Maturation in Mice

Hart, S. N., Cui, Y., Klaassen, C. D., Zhong, X.-b.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 365 KB

english, 2009

26

Transport of Diclofenac by Breast Cancer Resistance Protein (ABCG2) and Stimulation of Multidrug Resistance Protein 2 (ABCC2)-Mediated Drug Transport by Diclofenac and Benzbromarone

Lagas, J. S., van der Kruijssen, C. M. M., van de Wetering, K., Beijnen, J. H., Schinkel, A. H.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 543 KB

english, 2009

27

The Multiple Depletion Curves Method Provides Accurate Estimates of Intrinsic Clearance (CLint), Maximum Velocity of the Metabolic Reaction (Vmax), and Michaelis Constant (Km): Accuracy and Robustness Evaluated through Experimental Data and Monte Carlo Simulations

Sjogren, E., Lennernas, H., Andersson, T. B., Grasjo, J., Bredberg, U.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 679 KB

english, 2009

28

Tissue Distribution, Gender-Divergent Expression, Ontogeny, and Chemical Induction of Multidrug Resistance Transporter Genes (Mdr1a, Mdr1b, Mdr2) in Mice

Cui, Y. J., Cheng, X., Weaver, Y. M., Klaassen, C. D.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 268 KB

english, 2009

29

Drug Interactions of Thalidomide with Midazolam and Cyclosporine A: Heterotropic Cooperativity of Human Cytochrome P450 3A5

Okada, Y., Murayama, N., Yanagida, C., Shimizu, M., Guengerich, F. P., Yamazaki, H.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 376 KB

english, 2009

30

Prediction of the Effect of Erythromycin, Diltiazem, and Their Metabolites, Alone and in Combination, on CYP3A4 Inhibition

Zhang, X., Jones, D. R., Hall, S. D.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 546 KB

english, 2009

31

Role of Enzymatic N-Hydroxylation and Reduction in Flutamide Metabolite-Induced Liver Toxicity

Ohbuchi, M., Miyata, M., Nagai, D., Shimada, M., Yoshinari, K., Yamazoe, Y.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 491 KB

english, 2009