Volume 37; Issue 7

Drug Metabolism and Disposition

Volume 37; Issue 7

1

Metabolic Activation of Nevirapine in Human Liver Microsomes: Dehydrogenation and Inactivation of Cytochrome P450 3A4

Wen, B., Chen, Y., Fitch, W. L.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 358 KB

english, 2009

2

Discovery of Novel Functional Variants and Extensive Evaluation of CYP2D6 Genetic Polymorphisms in Koreans

Lee, S.-J., Lee, S. S., Jung, H.-J., Kim, H.-S., Park, S.-J., Yeo, C.-W., Shin, J.-G.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 278 KB

english, 2009

3

In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective

Chu, V., Einolf, H. J., Evers, R., Kumar, G., Moore, D., Ripp, S., Silva, J., Sinha, V., Sinz, M., Skerjanec, A.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 276 KB

english, 2009

4

The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America

Grimm, S. W., Einolf, H. J., Hall, S. D., He, K., Lim, H.-K., Ling, K.-H. J., Lu, C., Nomeir, A. A., Seibert, E., Skordos, K. W., Tonn, G. R., Van Horn, R., Wang, R. W., Wong, Y. N., Yang, T. J., Obac

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 334 KB

english, 2009

5

Unbound Brain Concentration Determines Receptor Occupancy: A Correlation of Drug Concentration and Brain Serotonin and Dopamine Reuptake Transporter Occupancy for Eighteen Compounds in Rats

Liu, X., Vilenski, O., Kwan, J., Apparsundaram, S., Weikert, R.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 434 KB

english, 2009

6

Regulation of Tissue-Specific Carboxylesterase Expression by Pregnane X Receptor and Constitutive Androstane Receptor

Xu, C., Wang, X., Staudinger, J. L.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 494 KB

english, 2009

7

Evaluation of in Vitro Models for Screening Alkaline Phosphatase-Mediated Bioconversion of Phosphate Ester Prodrugs

Yuan, H., Li, N., Lai, Y.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 208 KB

english, 2009

8

Budesonide and Ciclesonide: Effect of Tissue Binding on Pulmonary Receptor Binding

Wu, K., Blomgren, A. L., Ekholm, K., Weber, B., Edsbaecker, S., Hochhaus, G.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 195 KB

english, 2009

9

Relationship between Exposure of (-)-N- -4-fluorobenzamide (YM758), a "Funny" If Current Channel Inhibitor, and Heart Rate Reduction in Tachycardia-Induced Beagle Dogs

Umehara, K.-i., Wada, K., Noguchi, K., Iwatsubo, T., Usui, T., Kamimura, H.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 226 KB

english, 2009

10

CORRECTION TO "CYTOCHROME P450 EXPRESSION AND REGULATION IN CYP3A4/CYP2D6 DOUBLE TRANSGENIC HUMANIZED MICE"

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 57 KB

english, 2009

11

Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier

Taguchi, K., Urata, Y., Anraku, M., Maruyama, T., Watanabe, H., Sakai, H., Horinouchi, H., Kobayashi, K., Tsuchida, E., Kai, T., Otagiri, M.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 245 KB

english, 2009

12

The Drug of Abuse -Hydroxybutyrate Is a Substrate for Sodium-Coupled Monocarboxylate Transporter (SMCT) 1 (SLC5A8): Characterization of SMCT-Mediated Uptake and Inhibition

Cui, D., Morris, M. E.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 318 KB

english, 2009

13

Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion

Perfetti, X., O'Mathuna, B., Pizarro, N., Cuyas, E., Khymenets, O., Almeida, B., Pellegrini, M., Pichini, S., Lau, S. S., Monks, T. J., Farre, M., Pascual, J. A., Joglar, J., de la Torre, R.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 343 KB

english, 2009

14

Characterization of the Binding of Drugs to Human Intestinal Fatty Acid Binding Protein (IFABP): Potential Role of IFABP as an Alternative to Albumin for in Vitro-in Vivo Extrapolation of Drug Kinetic Parameters

Rowland, A., Knights, K. M., Mackenzie, P. I., Miners, J. O.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 341 KB

english, 2009

15

Molecular Basis for Reduced Estrone Sulfate Transport and Altered Modulator Sensitivity of Transmembrane Helix (TM) 6 and TM17 Mutants of Multidrug Resistance Protein 1 (ABCC1)

Maeno, K., Nakajima, A., Conseil, G., Rothnie, A., Deeley, R. G., Cole, S. P. C.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 484 KB

english, 2009

16

Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids

Mazur, A., Lichti, C. F., Prather, P. L., Zielinska, A. K., Bratton, S. M., Gallus-Zawada, A., Finel, M., Miller, G. P., Radominska-Pandya, A., Moran, J. H.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 528 KB

english, 2009

17

Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)

Fujita, K., Nakayama, H., Ichikawa, W., Yamamoto, W., Endo, H., Nagashima, F., Tanaka, R., Miya, T., Sunakawa, Y., Yamashita, K., Mizuno, K., Ishida, H., Araki, K., Narabayashi, M., Miwa, K., Ando, Y.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 109 KB

english, 2009

18

Effects of Plantago ovata Husk on Levodopa (with Carbidopa) Bioavailability in Rabbits with Autonomic Gastrointestinal Disorders

Garcia, J. J., Fernandez, N., Calle, A. P., Diez, M. J., Sahagun, A., Sierra, M.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 462 KB

english, 2009

19

Regulation of Human CYP2C18 and CYP2C19 in Transgenic Mice: Influence of Castration, Testosterone, and Growth Hormone

Lofgren, S., Baldwin, R. M., Carleros, M., Terelius, Y., Fransson-Steen, R., Mwinyi, J., Waxman, D. J., Ingelman-Sundberg, M.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 366 KB

english, 2009

20

Correlation between Apical Localization of Abcc2/Mrp2 and Phosphorylation Status of Ezrin in Rat Intestine

Nakano, T., Sekine, S., Ito, K., Horie, T.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 399 KB

english, 2009

21

Influence of the Cyp1B1 L432V Gene Polymorphism and Exposure to Tobacco Smoke on Cyp1B1 mRNA Expression in Human Leukocytes

Helmig, S., Hadzaad, B., Dohrel, J., Schneider, J.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 283 KB

english, 2009

22

Biotransformation of an 4 2 Nicotinic Acetylcholine Receptor Partial Agonist in Sprague-Dawley Rats and the Dispositional Characterization of Its N-Carbamoyl Glucuronide Metabolite

Shaffer, C. L., Ryder, T. F., Venkatakrishnan, K., Henne, I. K., O'Connell, T. N.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 240 KB

english, 2009

23

The Role of P-Glycoprotein in Limiting Brain Penetration of the Peripherally Acting Anticholinergic Overactive Bladder Drug Trospium Chloride

Geyer, J., Gavrilova, O., Petzinger, E.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 131 KB

english, 2009

24

Prediction of the Hepatic and Renal Clearance of Transporter Substrates in Rats Using in Vitro Uptake Experiments

Watanabe, T., Maeda, K., Kondo, T., Nakayama, H., Horita, S., Kusuhara, H., Sugiyama, Y.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 251 KB

english, 2009

25

Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function

Dutheil, F., Dauchy, S., Diry, M., Sazdovitch, V., Cloarec, O., Mellottee, L., Bieche, I., Ingelman-Sundberg, M., Flinois, J.-P., de Waziers, I., Beaune, P., Decleves, X., Duyckaerts, C., Loriot, M.-A

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 587 KB

english, 2009

26

In Vitro Metabolism of the Novel, Highly Selective Oral Angiogenesis Inhibitor Motesanib Diphosphate in Preclinical Species and in Humans

Li, C., Kuchimanchi, M., Hickman, D., Poppe, L., Hayashi, M., Zhou, Y., Subramanian, R., Kumar, G., Surapaneni, S.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 1.57 MB

english, 2009

27

Human Arylacetamide Deacetylase Is a Principal Enzyme in Flutamide Hydrolysis

Watanabe, A., Fukami, T., Nakajima, M., Takamiya, M., Aoki, Y., Yokoi, T.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 355 KB

english, 2009