Volume 38; Issue 1

Drug Metabolism and Disposition

Volume 38; Issue 1

1

Exploration of Catalytic Properties of CYP2D6 and CYP3A4 Through Metabolic Studies of Levorphanol and Levallorphan

Bonn, B., Masimirembwa, C. M., Castagnoli, N.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 2.08 MB

english, 2009

2

Impact of Molecular Processing in the Hinge Region of Therapeutic IgG4 Antibodies on Disposition Profiles in Cynomolgus Monkeys

Stubenrauch, K., Wessels, U., Regula, J. T., Kettenberger, H., Schleypen, J., Kohnert, U.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 2.39 MB

english, 2009

3

Identification of the Human Cytochrome P450 Enzymes Involved in the Two Oxidative Steps in the Bioactivation of Clopidogrel to Its Pharmacologically Active Metabolite

Kazui, M., Nishiya, Y., Ishizuka, T., Hagihara, K., Farid, N. A., Okazaki, O., Ikeda, T., Kurihara, A.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 1.17 MB

english, 2010

4

In Vitro Metabolism of Haloperidol and Sila-Haloperidol: New Metabolic Pathways Resulting from Carbon/Silicon Exchange

Johansson, T., Weidolf, L., Popp, F., Tacke, R., Jurva, U.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 2.08 MB

english, 2010

5

Comparison of the Drug-Drug Interactions Potential of Erlotinib and Gefitinib via Inhibition of UDP-Glucuronosyltransferases

Liu, Y., Ramirez, J., House, L., Ratain, M. J.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 1.94 MB

english, 2010

6

Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries

Srivastava, A., Lian, L.-Y., Maggs, J. L., Chaponda, M., Pirmohamed, M., Williams, D. P., Park, B. K.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 2.90 MB

english, 2010

7

Comparative Biotransformation of Pyrazinone-Containing Corticotropin-Releasing Factor Receptor-1 Antagonists: Minimizing the Reactive Metabolite Formation

Zhuo, X., Hartz, R. A., Bronson, J. J., Wong, H., Ahuja, V. T., Vrudhula, V. M., Leet, J. E., Huang, S., Macor, J. E., Shu, Y.-Z.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 360 KB

english, 2010

8

Tamoxifen-Induced Adduct Formation and Cell Stress in Human Endometrial Glands

Andersson, H., Helmestam, M., Zebrowska, A., Olovsson, M., Brittebo, E.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 3.08 MB

english, 2010

9

In Vitro Hepatic Metabolism Explains Higher Clearance of Voriconazole in Children versus Adults: Role of CYP2C19 and Flavin-Containing Monooxygenase 3

Yanni, S. B., Annaert, P. P., Augustijns, P., Ibrahim, J. G., Benjamin, D. K., Thakker, D. R.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 957 KB

english, 2010

10

Inhibition of CYP3A by Erythromycin: In Vitro-In Vivo Correlation in Rats

Zhang, X., Galinsky, R. E., Kimura, R. E., Quinney, S. K., Jones, D. R., Hall, S. D.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 1.52 MB

english, 2010

11

Stereoselective Flunoxaprofen-S-acyl-glutathione Thioester Formation Mediated by Acyl-CoA Formation in Rat Hepatocytes

Grillo, M. P., Wait, J. C. M., Tadano Lohr, M., Khera, S., Benet, L. Z.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 383 KB

english, 2010

12

Intestinal Detoxification Limits the Activation of Hepatic Pregnane X Receptor by Lithocholic Acid

Owen, B. M., Milona, A., van Mil, S., Clements, P., Holder, J., Boudjelal, M., Cairns, W., Parker, M., White, R., Williamson, C.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 1.03 MB

english, 2010

13

Contribution of the Different UDP-Glucuronosyltransferase (UGT) Isoforms to Buprenorphine and Norbuprenorphine Metabolism and Relationship with the Main UGT Polymorphisms in a Bank of Human Liver Microsomes

Rouguieg, K., Picard, N., Sauvage, F.-L., Gaulier, J.-M., Marquet, P.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 169 KB

english, 2010

14

Prediction of Vss from In Vitro Tissue-Binding Studies

Berry, L. M., Roberts, J., Be, X., Zhao, Z., Lin, M.-H. J.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 613 KB

english, 2010

15

Induction of UGT1A1 and CYP2B6 by an Antimitogenic Factor in HepG2 Cells Is Mediated through Suppression of Cyclin-Dependent Kinase 2 Activity: Cell Cycle-Dependent Expression

Sugatani, J., Osabe, M., Kurosawa, M., Kitamura, N., Ikari, A., Miwa, M.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 3.24 MB

english, 2010

16

A Possible Mechanism for the Decrease in Serum Thyroxine Level by a 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Like Polychlorinated Biphenyl Congener, 3,3',4,4',5-Pentachlorobiphenyl in Mice

Kato, Y., Haraguchi, K., Kubota, M., Seto, Y., Okura, T., Ikushiro, S.-i., Koga, N., Yamada, S., Degawa, M.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 598 KB

english, 2010

17

Identification of Multiple Glutathione Conjugates of 8-Amino- 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline maleate (Nomifensine) in Liver Microsomes and Hepatocyte Preparations: Evidence of the Bioactivation of Nomifensine

Yu, J., Mathisen, D. E., Burdette, D., Brown, D. G., Becker, C., Aharony, D.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 1.11 MB

english, 2010

18

Functional Characterization of Mouse Organic Anion Transporting Peptide 1a4 in the Uptake and Efflux of Drugs Across the Blood-Brain Barrier

Ose, A., Kusuhara, H., Endo, C., Tohyama, K., Miyajima, M., Kitamura, S., Sugiyama, Y.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 773 KB

english, 2010

19

Gene Regulation of CYP4F11 in Human Keratinocyte HaCaT Cells

Wang, Y., Bell, J. C., Keeney, D. S., Strobel, H. W.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 1.71 MB

english, 2010

20

Glutathione S-Transferase Catalyzed Desulfonylation of a Sulfonylfuropyridine

Bateman, T. J., Debenham, J. S., Madsen-Duggan, C., Toupence, R. B., Walsh, T. F., Truong, Q., Bradley, S. A., Doss, G. A., Kumar, S., Reddy, V. B. G.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 562 KB

english, 2010

21

Evaluation of Cynomolgus Monkey Pregnane X Receptor, Primary Hepatocyte, and in Vivo Pharmacokinetic Changes in Predicting Human CYP3A4 Induction

Kim, S., Dinchuk, J. E., Anthony, M. N., Orcutt, T., Zoeckler, M. E., Sauer, M. B., Mosure, K. W., Vuppugalla, R., Grace, J. E., Simmermacher, J., Dulac, H. A., Pizzano, J., Sinz, M.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 1.08 MB

english, 2010

22

Regulation of Gene Expression in Brain Tissues of Rats Repeatedly Treated by the Highly Abused Opioid Agonist, Oxycodone: Microarray Profiling and Gene Mapping Analysis

Hassan, H. E., Myers, A. L., Lee, I. J., Chen, H., Coop, A., Eddington, N. D.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 1.16 MB

english, 2010

23

Characterization of Human Organic Cation Transporter 1 (OCT1/SLC22A1)- and OCT2 (SLC22A2)-Mediated Transport of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)- 4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small Molecule Survivin Suppressant

Minematsu, T., Iwai, M., Umehara, K.-i., Usui, T., Kamimura, H.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 149 KB

english, 2010

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