Volume 38; Issue 10

Drug Metabolism and Disposition

Volume 38; Issue 10

1

Characterization of Inhibitory Effect of Carbapenem Antibiotics on the Deconjugation of Valproic Acid Glucuronide

Masuo, Y., Ito, K., Yamamoto, T., Hisaka, A., Honma, M., Suzuki, H.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 1.32 MB

english, 2010

2

Significance and Regional Dependency of Peptide Transporter (PEPT) 1 in the Intestinal Permeability of Glycylsarcosine: In Situ Single-Pass Perfusion Studies in Wild-Type and Pept1 Knockout Mice

Jappar, D., Wu, S.-P., Hu, Y., Smith, D. E.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 832 KB

english, 2010

3

Development of a Systematic Approach to Identify Metabolites for Herbal Homologs Based on Liquid Chromatography Hybrid Ion Trap Time-of-Flight Mass Spectrometry: Gender-Related Difference in Metabolism of Schisandra Lignans in Rats

Liang, Y., Hao, H., Xie, L., Kang, A., Xie, T., Zheng, X., Dai, C., Hao, K., Sheng, L., Wang, G.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 5.85 MB

english, 2010

4

Extensive Intestinal First-Pass Elimination and Predominant Hepatic Distribution of Berberine Explain Its Low Plasma Levels in Rats

Liu, Y.-T., Hao, H.-P., Xie, H.-G., Lai, L., Wang, Q., Liu, C.-X., Wang, G.-J.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 380 KB

english, 2010

5

Characterization of Erythrocytic Uptake and Release and Disposition Pathways of Nitrite, Nitrate, Methemoglobin, and Iron-Nitrosyl Hemoglobin in the Human Circulation

Hon, Y. Y., Sun, H., Dejam, A., Gladwin, M. T.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 549 KB

english, 2010

6

Hepatobiliary Toxicity of Furan: Identification of Furan Metabolites in Bile of Male F344/N Rats

Hamberger, C., Kellert, M., Schauer, U. M., Dekant, W., Mally, A.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 458 KB

english, 2010

7

Impact of Polyinosinic/Polycytidylic Acid on Placental and Hepatobiliary Drug Transporters in Pregnant Rats

Petrovic, V., Piquette-Miller, M.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 1.10 MB

english, 2010

8

Alternatively Spliced Products of the UGT1A Gene Interact with the Enzymatically Active Proteins to Inhibit Glucuronosyltransferase Activity In Vitro

Bellemare, J., Rouleau, M., Girard, H., Harvey, M., Guillemette, C.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 538 KB

english, 2010

9

In Vitro Investigation of the Hepatobiliary Disposition Mechanisms of the Antifungal Agent Micafungin in Humans and Rats

Yanni, S. B., Augustijns, P. F., Benjamin, D. K., Brouwer, K. L. R., Thakker, D. R., Annaert, P. P.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 923 KB

english, 2010

10

Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid-Containing Drugs Based on the Chemical Stability of Acyl Glucuronide

Sawamura, R., Okudaira, N., Watanabe, K., Murai, T., Kobayashi, Y., Tachibana, M., Ohnuki, T., Masuda, K., Honma, H., Kurihara, A., Okazaki, O.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 592 KB

english, 2010

11

Effects of Typical Inducers on Olfactory Xenobiotic-Metabolizing Enzyme, Transporter, and Transcription Factor Expression in Rats

Thiebaud, N., Sigoillot, M., Chevalier, J., Artur, Y., Heydel, J.-M., Le Bon, A.-M.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 3.85 MB

english, 2010

12

Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver

Sugiura, T., Kato, S., Shimizu, T., Wakayama, T., Nakamichi, N., Kubo, Y., Iwata, D., Suzuki, K., Soga, T., Asano, M., Iseki, S., Tamai, I., Tsuji, A., Kato, Y.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 1.27 MB

english, 2010

13

Assessment of a Micropatterned Hepatocyte Coculture System to Generate Major Human Excretory and Circulating Drug Metabolites

Wang, W. W., Khetani, S. R., Krzyzewski, S., Duignan, D. B., Obach, R. S.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 256 KB

english, 2010

14

Metabolism and Pharmacokinetics of EAPB0203 and EAPB0503, Two Imidazoquinoxaline Compounds Previously Shown to Have Antitumoral Activity on Melanoma and T-Lymphomas

Khier, S., Gattacceca, F., El Messaoudi, S., Lafaille, F., Deleuze-Masquefa, C., Bompart, J., Cooper, J.-F., Solassol, I., Pinguet, F., Bonnet, P.-A., Bressolle, F. M. M.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 792 KB

english, 2010

15

Metabolic Disposition of Casopitant, a Potent Neurokinin-1 Receptor Antagonist, in Mice, Rats, and Dogs

Miraglia, L., Pagliarusco, S., Bordini, E., Martinucci, S., Pellegatti, M.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 1.77 MB

english, 2010

16

Effects of Dose, Administration Route, and/or Vehicle on Decabromodiphenyl Ether Concentrations in Plasma of Maternal, Fetal, and Neonatal Rats and in Milk of Maternal Rats

Biesemeier, J. A., Beck, M. J., Silberberg, H., Myers, N. R., Ariano, J. M., Bodle, E. S., Sved, D. W., Jacobi, S., Stump, D. G., Hardy, M., Stedeford, T.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 417 KB

english, 2010

17

Influence of Cytidine Deaminase on Antitumor Activity of 2'-Deoxycytidine Analogs In Vitro and In Vivo

Yoshida, T., Endo, Y., Obata, T., Kosugi, Y., Sakamoto, K., Sasaki, T.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 562 KB

english, 2010

18

Hepatobiliary Disposition of 3 ,6 ,7 ,12 -Tetrahydroxy-Cholanoyl Taurine: A Substrate for Multiple Canalicular Transporters

Megaraj, V., Iida, T., Jungsuwadee, P., Hofmann, A. F., Vore, M.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 1.20 MB

english, 2010

19

Role of Breast Cancer Resistance Protein in the Adaptive Response to Cholestasis

Mennone, A., Soroka, C. J., Harry, K. M., Boyer, J. L.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 1.18 MB

english, 2010

20

Alprazolam as an In Vivo Probe for Studying Induction of CYP3A in Cynomolgus Monkeys

Ohtsuka, T., Yoshikawa, T., Kozakai, K., Tsuneto, Y., Uno, Y., Utoh, M., Yamazaki, H., Kume, T.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 665 KB

english, 2010

21

Nutritional Status Affects Fluvastatin-Induced Hepatotoxicity and Myopathy in Rats

Sugatani, J., Sadamitsu, S., Kurosawa, M., Ikushiro, S.-i., Sakaki, T., Ikari, A., Miwa, M.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 1.95 MB

english, 2010

22

Microsomal Cytochrome P450-Mediated Metabolism of Protopanaxatriol Ginsenosides: Metabolite Profile, Reaction Phenotyping, and Structure-Metabolism Relationship

Hao, H., Lai, L., Zheng, C., Wang, Q., Yu, G., Zhou, X., Wu, L., Gong, P., Wang, G.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 1.77 MB

english, 2010

23

Direct and Rapid Genotyping of Glutathione-S-transferase M1 and T1 from Human Blood Specimens Using the SmartAmp2 Method

Okada, R., Ishizu, Y., Endo, R., Lezhava, A., Ieiri, I., Kusuhara, H., Sugiyama, Y., Hayashizaki, Y.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 477 KB

english, 2010

24

Aldehyde Dehydrogenase 1B1: Molecular Cloning and Characterization of a Novel Mitochondrial Acetaldehyde-Metabolizing Enzyme

Stagos, D., Chen, Y., Brocker, C., Donald, E., Jackson, B. C., Orlicky, D. J., Thompson, D. C., Vasiliou, V.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 3.01 MB

english, 2010

25

The Role of the Placenta in Fetal Exposure to Xenobiotics: Importance of Membrane Transporters and Human Models for Transfer Studies

Prouillac, C., Lecoeur, S.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 566 KB

english, 2010

26

In Vitro Metabolism Studies of Nomifensine Monooxygenation Pathways: Metabolite Identification, Reaction Phenotyping, and Bioactivation Mechanism

Yu, J., Brown, D. G., Burdette, D.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 771 KB

english, 2010

27

Regulatory Xenobiotic Responsive Elements in the Distal 5'-Flanking Region of the Mouse Cyp1a2 Gene Required for Transcriptional Activation by 3-Methylcholanthrene and 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Kawasaki, Y., Sakuma, T., Goto, Y., Nemoto, N.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 196 KB

english, 2010

28

O-Methylation of Catechol Estrogens by Human Placental Catechol-O-Methyltransferase: Interindividual Differences in Sensitivity to Heat Inactivation and to Inhibition by Dietary Polyphenols

Zhu, B. T., Wu, K. Y., Wang, P., Cai, M. X., Conney, A. H.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 6.07 MB

english, 2010

29

Metabolism of Dicentrine: Identification of the Phase I and Phase II Metabolites in Miniature Pig Urine

Lai, Y.-C., Kuo, T.-F., Chen, C.-K., Tsai, H.-J., Lee, S.-S.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 1.76 MB

english, 2010

30

Drug Transporter Expression and Localization in Rat Nasal Respiratory and Olfactory Mucosa and Olfactory Bulb

Genter, M. B., Krishan, M., Augustine, L. M., Cherrington, N. J.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 1.11 MB

english, 2010

31

Adenosine Transport by Plasma Membrane Monoamine Transporter: Reinvestigation and Comparison with Organic Cations

Zhou, M., Duan, H., Engel, K., Xia, L., Wang, J.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 475 KB

english, 2010

32

Interaction between Topically and Systemically Coadministered P-Glycoprotein Substrates/Inhibitors: Effect on Vitreal Kinetics

Hippalgaonkar, K., Srirangam, R., Avula, B., Khan, I. A., Majumdar, S.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 574 KB

english, 2010

33

In Vitro Hepatic Metabolism of Cediranib, a Potent Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitor: Interspecies Comparison and Human Enzymology

Schulz-Utermoehl, T., Spear, M., Pollard, C. R. J., Pattison, C., Rollison, H., Sarda, S., Ward, M., Bushby, N., Jordan, A., Harrison, M.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 944 KB

english, 2010

34

Molecular Cloning, Expression, and Initial Characterization of Members of the CYP3A Family in Horses

Knych, H. K. D., McKemie, D. S., Stanley, S. D.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 733 KB

english, 2010