Volume 38; Issue 9

Drug Metabolism and Disposition

Volume 38; Issue 9

1

Cytochrome P450 3A4 mRNA Is a More Reliable Marker than CYP3A4 Activity for Detecting Pregnane X Receptor-Activated Induction of Drug-Metabolizing Enzymes

Fahmi, O. A., Kish, M., Boldt, S., Obach, R. S.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 569 KB

english, 2010

2

Metabolite Formation Kinetics and Intrinsic Clearance of Phenacetin, Tolbutamide, Alprazolam, and Midazolam in Adenoviral Cytochrome P450-Transfected HepG2 Cells and Comparison with Hepatocytes and In Vivo

Donato, M. T., Hallifax, D., Picazo, L., Castell, J. V., Houston, J. B., Gomez-Lechon, M. J., Lahoz, A.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 563 KB

english, 2010

3

Absorption, Distribution, Metabolism, and Excretion of Ticagrelor in Healthy Subjects

Teng, R., Oliver, S., Hayes, M. A., Butler, K.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 518 KB

english, 2010

4

Identification of Valproic Acid Glucuronide Hydrolase As a Key Enzyme for the Interaction of Valproic Acid with Carbapenem Antibiotics

Suzuki, E., Yamamura, N., Ogura, Y., Nakai, D., Kubota, K., Kobayashi, N., Miura, S.-i., Okazaki, O.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 493 KB

english, 2010

5

Role of P-Glycoprotein in Region-Specific Gastrointestinal Absorption of Talinolol in Rats

Kagan, L., Dreifinger, T., Mager, D. E., Hoffman, A.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 851 KB

english, 2010

6

Profiling Induction of Cytochrome P450 Enzyme Activity by Statins Using a New Liquid Chromatography-Tandem Mass Spectrometry Cocktail Assay in Human Hepatocytes

Feidt, D. M., Klein, K., Hofmann, U., Riedmaier, S., Knobeloch, D., Thasler, W. E., Weiss, T. S., Schwab, M., Zanger, U. M.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 681 KB

english, 2010

7

Role of P-Glycoprotein and Breast Cancer Resistance Protein-1 in the Brain Penetration and Brain Pharmacodynamic Activity of the Novel Phosphatidylinositol 3-Kinase Inhibitor GDC-0941

Salphati, L., Lee, L. B., Pang, J., Plise, E. G., Zhang, X.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 344 KB

english, 2010

8

In Vitro Metabolism, Permeability, and Efflux of Bazedoxifene in Humans

Shen, L., Ahmad, S., Park, S., DeMaio, W., Oganesian, A., Hultin, T., Scatina, J., Bungay, P., Chandrasekaran, A.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 884 KB

english, 2010

9

Methemoglobinemia Induced by 1,2-Dichloro-4-nitrobenzene in Mice with a Disrupted Glutathione S-Transferase Mu 1 Gene

Arakawa, S., Maejima, T., Kiyosawa, N., Yamaguchi, T., Shibaya, Y., Aida, Y., Kawai, R., Fujimoto, K., Manabe, S., Takasaki, W.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 241 KB

english, 2010

10

Pharmacokinetic-Pharmacodynamic Modeling of Tumor Growth Inhibition and Biomarker Modulation by the Novel Phosphatidylinositol 3-Kinase Inhibitor GDC-0941

Salphati, L., Wong, H., Belvin, M., Bradford, D., Edgar, K. A., Prior, W. W., Sampath, D., Wallin, J. J.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 255 KB

english, 2010

11

Effect of the CYP2D6*10 Genotype on Tolterodine Pharmacokinetics

Oishi, M., Chiba, K., Malhotra, B., Suwa, T.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 499 KB

english, 2010

12

CYP2D6 Mediates 4-Hydroxylation of Clonidine In Vitro: Implication for Pregnancy-Induced Changes in Clonidine Clearance

Claessens, A. J., Risler, L. J., Eyal, S., Shen, D. D., Easterling, T. R., Hebert, M. F.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 285 KB

english, 2010

13

Novel Metabolic Bioactivation Mechanism for a Series of Anti-Inflammatory Agents (2,5-Diaminothiophene Derivatives) Mediated by Cytochrome P450 Enzymes

Hu, Y., Yang, S., Shilliday, F. B., Heyde, B. R., Mandrell, K. M., Robins, R. H., Xie, J., Reding, M. T., Lai, Y., Thompson, D. C.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 2.37 MB

english, 2010

14

Inhibition of Hepatic Organic Anion-Transporting Polypeptide by RNA Interference in Sandwich-Cultured Human Hepatocytes: An In Vitro Model to Assess Transporter-Mediated Drug-Drug Interactions

Liao, M., Raczynski, A. R., Chen, M., Chuang, B.-C., Zhu, Q., Shipman, R., Morrison, J., Lee, D., Lee, F. W., Balani, S. K., Xia, C. Q.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 859 KB

english, 2010

15

Histone Deacetylase Inhibitors Induce Cytochrome P450 2B by Activating Nuclear Receptor Constitutive Androstane Receptor

Takizawa, D., Kakizaki, S., Horiguchi, N., Tojima, H., Yamazaki, Y., Ichikawa, T., Sato, K., Mori, M.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 818 KB

english, 2010

16

In Situ Intestinal Perfusion in Knockout Mice Demonstrates Inhibition of Intestinal P-Glycoprotein by Ritonavir Causing Increased Darunavir Absorption

Holmstock, N., Mols, R., Annaert, P., Augustijns, P.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 198 KB

english, 2010

17

Protein Phosphatase 2C l Regulates Human Pregnane X Receptor-Mediated CYP3A4 Gene Expression in HepG2 Liver Carcinoma Cells

Pondugula, S. R., Tong, A. A., Wu, J., Cui, J., Chen, T.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 285 KB

english, 2010

18

Constitutive Androgen Receptor-Null Mice Are Sensitive to the Toxic Effects of Parathion: Association with Reduced Cytochrome P450-Mediated Parathion Metabolism

Mota, L. C., Hernandez, J. P., Baldwin, W. S.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 755 KB

english, 2010

19

Cyclosporine A, but Not Tacrolimus, Shows Relevant Inhibition of Organic Anion-Transporting Protein 1B1-Mediated Transport of Atorvastatin

Amundsen, R., Christensen, H., Zabihyan, B., Asberg, A.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 499 KB

english, 2010

20

Antioxidant Activities of Hydroxytyrosol Main Metabolites Do Not Contribute to Beneficial Health Effects after Olive Oil Ingestion

Khymenets, O., Fito, M., Tourino, S., Munoz-Aguayo, D., Pujadas, M., Torres, J. L., Joglar, J., Farre, M., Covas, M.-I., de la Torre, R.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 610 KB

english, 2010

21

Dabigatran Acylglucuronide, the Major Human Metabolite of Dabigatran: In Vitro Formation, Stability, and Pharmacological Activity

Ebner, T., Wagner, K., Wienen, W.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 822 KB

english, 2010

22

Proton-Coupled Erythromycin Antiport at Rat Blood-Placenta Barrier

Sai, Y., Nishimura, T., Ochi, K., Tanaka, N., Takagi, A., Tomi, M., Kose, N., Kobayashi, Y., Miyakoshi, N., Kitagaki, S., Mukai, C., Nakashima, E.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 1.02 MB

english, 2010

23

Liverbeads: A Practical and Relevant In Vitro Model for Gene Induction Investigations

Al Khansa, I., Blanck, O., Guillouzo, A., Bars, R.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 884 KB

english, 2010

24

Increased Glyburide Clearance in the Pregnant Mouse Model

Zhou, L., Zhang, Y., Hebert, M. F., Unadkat, J. D., Mao, Q.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 150 KB

english, 2010

25

Estimation of Transporters Involved in the Hepatobiliary Transport of TA-0201CA Using Sandwich-Cultured Rat Hepatocytes from Normal and Multidrug Resistance-Associated Protein 2-Deficient Rats

Fukuda, H., Ohashi, R., Ohashi, N., Yabuuchi, H., Tamai, I.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 1.02 MB

english, 2010

26

Activation of Cyclosporin A Transport by a Novel Light Chain of Human Ig Surface Antigen-Related Gene in Xenopus laevis Oocytes

Kobayashi, Y., Umemoto, T., Ohbayashi, M., Kohyama, N., Sanada, Y., Yamamoto, T.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 1.06 MB

english, 2010

27

Discontinuous Drug Binding to Proteins: Binding of an Antineoplastic Benzyl Styryl Sulfone to Albumin and Enzymes In Vitro and in Phase I Clinical Trials

Cho, S. Y., Ohnuma, T., Silverman, L. R., Holland, J. F., Roboz, J.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 918 KB

english, 2010

28

Cynomolgus Monkey CYP2D44 Newly Identified in Liver, Metabolizes Bufuralol, and Dextromethorphan

Uno, Y., Uehara, S., Kohara, S., Murayama, N., Yamazaki, H.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 215 KB

english, 2010

29

Purified Mouse CYP27B1 Can Hydroxylate 20,23-Dihydroxyvitamin D3, Producing 1 ,20,23-Trihydroxyvitamin D3, Which Has Altered Biological Activity

Tang, E. K. Y., Li, W., Janjetovic, Z., Nguyen, M. N., Wang, Z., Slominski, A., Tuckey, R. C.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 1.04 MB

english, 2010

30

Preferential Glutathione Conjugation of a Reverse Diol Epoxide Compared with a Bay Region Diol Epoxide of Benzo[a]pyrene in Human Hepatocytes

Upadhyaya, P., Hochalter, J. B., Balbo, S., McIntee, E. J., Hecht, S. S.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 184 KB

english, 2010

31

The Dipeptidyl Peptidase-4 Inhibitor Linagliptin Exhibits Time- and Dose-Dependent Localization in Kidney, Liver, and Intestine after Intravenous Dosing: Results from High Resolution Autoradiography in Rats

Greischel, A., Binder, R., Baierl, J.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 5.61 MB

english, 2010

32

Metabolism of Tanshinol Borneol Ester in Rat and Human Liver Microsomes

Liu, D., Zheng, X., Tang, Y., Zi, J., Nan, Y., Wang, S., Xiao, C., Zhu, J., Chen, C.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 1.08 MB

english, 2010

33

Arylacetamide Deacetylase Is a Determinant Enzyme for the Difference in Hydrolase Activities of Phenacetin and Acetaminophen

Watanabe, A., Fukami, T., Takahashi, S., Kobayashi, Y., Nakagawa, N., Nakajima, M., Yokoi, T.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 658 KB

english, 2010

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