Volume 39; Issue 12

Drug Metabolism and Disposition

Volume 39; Issue 12

1

Intestinal Ciprofloxacin Efflux: The Role of Breast Cancer Resistance Protein (ABCG2)

Haslam, I. S., Wright, J. A., O'Reilly, D. A., Sherlock, D. J., Coleman, T., Simmons, N. L.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 1.08 MB

english, 2011

2

Effect of Hepatic Cytochrome P450 (P450) Oxidoreductase Deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 Reductase Conditional Null Mice

Arlt, V. M., Singh, R., Stiborova, M., Gamboa da Costa, G., Frei, E., Evans, J. D., Farmer, P. B., Wolf, C. R., Henderson, C. J., Phillips, D. H.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 367 KB

english, 2011

3

Development of a Highly Sensitive Method Using Liquid Chromatography-Multiple Reaction Monitoring to Quantify Membrane P-Glycoprotein in Biological Matrices and Relationship to Transport Function

Miliotis, T., Ali, L., Palm, J. E., Lundqvist, A. J., Ahnoff, M., Andersson, T. B., Hilgendorf, C.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 854 KB

english, 2011

4

Monomethylarsenic Diglutathione Transport by the Human Multidrug Resistance Protein 1 (MRP1/ABCC1)

Carew, M. W., Naranmandura, H., Shukalek, C. B., Le, X. C., Leslie, E. M.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 727 KB

english, 2011

5

A Novel Method for the Immunoquantification of UDP-Glucuronosyltransferases in Human Tissue

Milne, A. M., Burchell, B., Coughtrie, M. W. H.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 577 KB

english, 2011

6

Biosynthesis and Identification of an N-Oxide/N-Glucuronide Metabolite and First Synthesis of an N-O-Glucuronide Metabolite of Lu AA21004

Uldam, H. K., Juhl, M., Pedersen, H., Dalgaard, L.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 2.32 MB

english, 2011

7

Inhibition of Human Liver Aldehyde Oxidase: Implications for Potential Drug-Drug Interactions

Barr, J. T., Jones, J. P.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 922 KB

english, 2011

8

Excretion, Metabolism, and Pharmacokinetics of CP-945,598, a Selective Cannabinoid Receptor Antagonist, in Rats, Mice, and Dogs

Miao, Z., Scott, D. O., Griffith, D. A., Day, R., Prakash, C.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 865 KB

english, 2011

9

CYP2C19 Progress Curve Analysis and Mechanism-Based Inactivation by Three Methylenedioxyphenyl Compounds

Salminen, K. A., Meyer, A., Imming, P., Raunio, H.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 1.02 MB

english, 2011

10

Involvement of Different Human Glutathione Transferase Isoforms in the Glutathione Conjugation of Reactive Metabolites of Troglitazone

Okada, R., Maeda, K., Nishiyama, T., Aoyama, S., Tozuka, Z., Hiratsuka, A., Ikeda, T., Kusuhara, H., Sugiyama, Y.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 400 KB

english, 2011

11

Production of Ibuprofen Acyl Glucosides by Human UGT2B7

Buchheit, D., Dragan, C.-A., Schmitt, E. I., Bureik, M.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 1.24 MB

english, 2011

12

Systemic and Direct Nose-to-Brain Transport Pharmacokinetic Model for Remoxipride after Intravenous and Intranasal Administration

Stevens, J., Ploeger, B. A., van der Graaf, P. H., Danhof, M., de Lange, E. C. M.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 980 KB

english, 2011

13

Characterization of the Expression and Activity of Carboxylesterases 1 and 2 from the Beagle Dog, Cynomolgus Monkey, and Human

Williams, E. T., Bacon, J. A., Bender, D. M., Lowinger, J. J., Guo, W.-K., Ehsani, M. E., Wang, X., Wang, H., Qian, Y.-W., Ruterbories, K. J., Wrighton, S. A., Perkins, E. J.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 878 KB

english, 2011

14

Variations in ATP-Binding Cassette Transporter Regulation during the Progression of Human Nonalcoholic Fatty Liver Disease

Hardwick, R. N., Fisher, C. D., Canet, M. J., Scheffer, G. L., Cherrington, N. J.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 3.31 MB

english, 2011

15

Differences in the Disposition of Silymarin between Patients with Nonalcoholic Fatty Liver Disease and Chronic Hepatitis C

Schrieber, S. J., Hawke, R. L., Wen, Z., Smith, P. C., Reddy, K. R., Wahed, A. S., Belle, S. H., Afdhal, N. H., Navarro, V. J., Meyers, C. M., Doo, E., Fried, M. W.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 536 KB

english, 2011

16

Role of Residue 87 in the Activity and Regioselectivity of Clozapine Metabolism by Drug-Metabolizing CYP102A1 M11H: Application for Structural Characterization of Clozapine GSH Conjugates

Rea, V., Dragovic, S., Boerma, J. S., de Kanter, F. J. J., Vermeulen, N. P. E., Commandeur, J. N. M.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 1.34 MB

english, 2011

17

Analysis and Prediction of Drug Transfer into Human Milk Taking into Consideration Secretion and Reuptake Clearances across the Mammary Epithelia

Koshimichi, H., Ito, K., Hisaka, A., Honma, M., Suzuki, H.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 4.13 MB

english, 2011

18

Complex Drug Interactions of HIV Protease Inhibitors 2: In Vivo Induction and In Vitro to In Vivo Correlation of Induction of Cytochrome P450 1A2, 2B6, and 2C9 by Ritonavir or Nelfinavir

Kirby, B. J., Collier, A. C., Kharasch, E. D., Dixit, V., Desai, P., Whittington, D., Thummel, K. E., Unadkat, J. D.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 842 KB

english, 2011

19

Absorption and Metabolism of Chlorogenic Acids in Cultured Gastric Epithelial Monolayers

Farrell, T. L., Dew, T. P., Poquet, L., Hanson, P., Williamson, G.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 879 KB

english, 2011

20

Utility of P-Glycoprotein and Organic Cation Transporter 1 Double-Transfected LLC-PK1 Cells for Studying the Interaction of YM155 Monobromide, Novel Small-Molecule Survivin Suppressant, with P-Glycoprotein

Iwai, M., Minematsu, T., Li, Q., Iwatsubo, T., Usui, T.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 1.24 MB

english, 2011

21

Raloxifene Glucuronidation in Human Intestine, Kidney, and Liver Microsomes and in Human Liver Microsomes Genotyped for the UGT1A1*28 Polymorphism

Trdan Lusin, T., Trontelj, J., Mrhar, A.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 732 KB

english, 2011

22

Thr302 Is the Site for the Covalent Modification of Human Cytochrome P450 2B6 Leading to Mechanism-Based Inactivation by tert-Butylphenylacetylene

Lin, H.-l., Zhang, H., Pratt-Hyatt, M. J., Hollenberg, P. F.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 564 KB

english, 2011

23

Complex N-Acetylation of Triethylenetetramine

Cerrada-Gimenez, M., Weisell, J., Hyvonen, M. T., Hee Park, M., Alhonen, L., Vepsalainen, J., Keinanen, T. A.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 1.05 MB

english, 2011

24

Studies to Further Investigate the Inhibition of Human Liver Microsomal CYP2C8 by the Acyl- -Glucuronide of Gemfibrozil

Jenkins, S. M., Zvyaga, T., Johnson, S. R., Hurley, J., Wagner, A., Burrell, R., Turley, W., Leet, J. E., Philip, T., Rodrigues, A. D.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 1.60 MB

english, 2011

25

Proluciferin Acetals as Bioluminogenic Substrates for Cytochrome P450 Activity and Probes for CYP3A Inhibition

Meisenheimer, P. L., Uyeda, H. T., Ma, D., Sobol, M., McDougall, M. G., Corona, C., Simpson, D., Klaubert, D. H., Cali, J. J.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 2.11 MB

english, 2011

26

Correction for Nonspecific Binding to Various Components of Ultrafiltration Apparatus and Impact on Estimating In Vivo Rat Clearance for a Congeneric Series of 5-Ethyl, 5-n-Alkyl Barbituric Acids

Ballard, P., Rowland, M.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 99 KB

english, 2011

27

Cardiac Arrest and Therapeutic Hypothermia Decrease Isoform-Specific Cytochrome P450 Drug Metabolism

Zhou, J., Empey, P. E., Bies, R. R., Kochanek, P. M., Poloyac, S. M.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 1.82 MB

english, 2011

28

Preclinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human Pharmacokinetics

Jayaraman, R., Pilla Reddy, V., Khalid Pasha, M., Wang, H., Sangthongpitag, K., Yeo, P., Yong Hu, C., Wu, X., Xin, L., Goh, E., Sun New, L., Ethirajulu, K.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 2.36 MB

english, 2011

29

Small Molecule Quantification by Liquid Chromatography-Mass Spectrometry for Metabolites of Drugs and Drug Candidates

Dahal, U. P., Jones, J. P., Davis, J. A., Rock, D. A.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 830 KB

english, 2011

30

Effect of Culture Time on the Basal Expression Levels of Drug Transporters in Sandwich-Cultured Primary Rat Hepatocytes

Tchaparian, E. H., Houghton, J. S., Uyeda, C., Grillo, M. P., Jin, L.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 1.69 MB

english, 2011

31

Effect of Dose Escalation on the In Vivo Oral Absorption and Disposition of Glycylsarcosine in Wild-Type and Pept1 Knockout Mice

Jappar, D., Hu, Y., Smith, D. E.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 2.24 MB

english, 2011

32

Independent and Combined Effects of Ethanol Self-Administration and Nicotine Treatment on Hepatic CYP2E1 in African Green Monkeys

Ferguson, C. S., Miksys, S., Palmour, R., Tyndale, R. F.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 2.73 MB

english, 2011

33

Hepatic Uptake in the Dog: Comparison of Uptake in Hepatocytes and Human Embryonic Kidney Cells Expressing Dog Organic Anion-Transporting Polypeptide 1B4

Wilby, A. J., Maeda, K., Courtney, P. F., Debori, Y., Webborn, P. J. H., Kitamura, Y., Kusuhara, H., Riley, R. J., Sugiyama, Y.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 697 KB

english, 2011

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