Volume 39; Issue 6

Drug Metabolism and Disposition

Volume 39; Issue 6

1

A Refined Cytochrome P450 IC50 Shift Assay for Reliably Identifying CYP3A Time-Dependent Inhibitors

Li, P., Lu, C., Balani, S. K., Gan, L.-S.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 335 KB

english, 2011

2

Metabolic Intermediate Complex Formation of Human Cytochrome P450 3A4 by Lapatinib

Takakusa, H., Wahlin, M. D., Zhao, C., Hanson, K. L., New, L. S., Chan, E. C. Y., Nelson, S. D.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 442 KB

english, 2011

3

Pharmacokinetics and Metabolism in Rats, Dogs, and Monkeys of the Cathepsin K Inhibitor Odanacatib: Demethylation of a Methylsulfonyl Moiety as a Major Metabolic Pathway

Kassahun, K., Black, W. C., Nicoll-Griffith, D., McIntosh, I., Chauret, N., Day, S., Rosenberg, E., Koeplinger, K.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 560 KB

english, 2011

4

Complex Drug Interactions of HIV Protease Inhibitors 1: Inactivation, Induction, and Inhibition of Cytochrome P450 3A by Ritonavir or Nelfinavir

Kirby, B. J., Collier, A. C., Kharasch, E. D., Whittington, D., Thummel, K. E., Unadkat, J. D.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 1.76 MB

english, 2011

5

ATP-Binding Cassette Transporter Expression in Human Placenta as a Function of Pregnancy Condition

Mason, C. W., Buhimschi, I. A., Buhimschi, C. S., Dong, Y., Weiner, C. P., Swaan, P. W.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 1.36 MB

english, 2011

6

Prediction of Human Renal Clearance from Preclinical Species for a Diverse Set of Drugs That Exhibit Both Active Secretion and Net Reabsorption

Paine, S. W., Menochet, K., Denton, R., McGinnity, D. F., Riley, R. J.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 366 KB

english, 2011

7

Cytochrome P450 2S1 is Reduced by NADPH-Cytochrome P450 Reductase

Xiao, Y., Shinkyo, R., Guengerich, F. P.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 111 KB

english, 2011

8

Identification of Amiodarone Metabolites in Human Bile by Ultraperformance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry

Deng, P., You, T., Chen, X., Yuan, T., Huang, H., Zhong, D.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 2.03 MB

english, 2011

9

CYP3A Time-Dependent Inhibition Risk Assessment Validated with 400 Reference Drugs

Zimmerlin, A., Trunzer, M., Faller, B.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 1.08 MB

english, 2011

10

Suppression of Cytochrome P450 Reductase (POR) Expression in Hepatoma Cells Replicates the Hepatic Lipidosis Observed in Hepatic POR-Null Mice

Porter, T. D., Banerjee, S., Stolarczyk, E. I., Zou, L.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 1.37 MB

english, 2011

11

Correction to "Disposition and Metabolism of [14C]SB-649868, an Orexin 1 and 2 Receptor Antagonist, in Humans"

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 52 KB

english, 2011

12

The Tissue-Specific Toxicity of Methimazole in the Mouse Olfactory Mucosa Is Partly Mediated through Target-Tissue Metabolic Activation by CYP2A5

Xie, F., Zhou, X., Genter, M. B., Behr, M., Gu, J., Ding, X.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 798 KB

english, 2011

13

Role of Intestinal Cytochrome P450 (P450) in Modulating the Bioavailability of Oral Lovastatin: Insights from Studies on the Intestinal Epithelium-Specific P450 Reductase Knockout Mouse

Zhu, Y., D'Agostino, J., Zhang, Q.-Y.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 167 KB

english, 2011

14

Pharmacokinetics of the Monohydroxy Derivative of Oxcarbazepine and Its Enantiomers after a Single Intravenous Dose Given as Racemate Compared with a Single Oral Dose of Oxcarbazepine

Flesch, G., Czendlik, C., Renard, D., Lloyd, P.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 360 KB

english, 2011

15

Absorption, Distribution, Metabolism, and Excretion of [14C]GDC-0449 (Vismodegib), an Orally Active Hedgehog Pathway Inhibitor, in Rats and Dogs: A Unique Metabolic Pathway via Pyridine Ring Opening

Yue, Q., Chen, Y.-H., Mulder, T., Deese, A., Takahashi, R., Rudewicz, P. J., Reynolds, M., Solon, E., Hop, C. E. C. A., Wong, H., Khojasteh, S. C.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 1.88 MB

english, 2011

16

Substituted Imidazole of 5-Fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine Inactivates Cytochrome P450 2D6 by Protein Adduction

Nagy, L. D., Mocny, C. S., Diffenderfer, L. E., Hsi, D. J., Butler, B. F., Arthur, E. J., Fletke, K. J., Palamanda, J. R., Nomeir, A. A., Furge, L. L.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 1.39 MB

english, 2011

17

Role of Organic Anion-Transporting Polypeptides for Cellular Mesalazine (5-Aminosalicylic Acid) Uptake

Konig, J., Glaeser, H., Keiser, M., Mandery, K., Klotz, U., Fromm, M. F.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 212 KB

english, 2011

18

Prediction of the Overall Renal Tubular Secretion and Hepatic Clearance of Anionic Drugs and a Renal Drug-Drug Interaction Involving Organic Anion Transporter 3 in Humans by In Vitro Uptake Experiments

Watanabe, T., Kusuhara, H., Watanabe, T., Debori, Y., Maeda, K., Kondo, T., Nakayama, H., Horita, S., Ogilvie, B. W., Parkinson, A., Hu, Z., Sugiyama, Y.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 274 KB

english, 2011

19

Studies on the Metabolism and Biological Activity of the Epimers of Sulindac

Brunell, D., Sagher, D., Kesaraju, S., Brot, N., Weissbach, H.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 1.21 MB

english, 2011

20

Influence of Non-Steroidal Anti-Inflammatory Drugs on Organic Anion Transporting Polypeptide (OATP) 1B1- and OATP1B3-Mediated Drug Transport

Kindla, J., Muller, F., Mieth, M., Fromm, M. F., Konig, J.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 1.59 MB

english, 2011

21

Alteration of Hepatic but Not Renal Transporter Expression in Diet-Induced Obese Mice

More, V. R., Slitt, A. L.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 1.70 MB

english, 2011

22

Pharmacokinetics and Hepatic Uptake of Eltrombopag, a Novel Platelet-Increasing Agent

Takeuchi, K., Sugiura, T., Umeda, S., Matsubara, K., Horikawa, M., Nakamichi, N., Silver, D. L., Ishiwata, N., Kato, Y.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 1.47 MB

english, 2011

23

Quantitative Time-Lapse Imaging-Based Analysis of Drug-Drug Interaction Mediated by Hepatobiliary Transporter, Multidrug Resistance-Associated Protein 2, in Sandwich-Cultured Rat Hepatocytes

Nakanishi, T., Shibue, Y., Fukuyama, Y., Yoshida, K., Fukuda, H., Shirasaka, Y., Tamai, I.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 1.33 MB

english, 2011