Volume 40; Issue 3

Drug Metabolism and Disposition

Volume 40; Issue 3

1

The Effects of Rosuvastatin and the CYP51A1 Inhibitor LEK-935 on the Proteome of Primary Human Hepatocytes

Worner, M., Melchior, K., Monostory, K., Pascussi, J.-M., Huber, C. G., Bernhardt, R.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 194 KB

english, 2012

2

Metabolism and Pharmacokinetics of Morinidazole in Humans: Identification of Diastereoisomeric Morpholine N+-Glucuronides Catalyzed by UDP Glucuronosyltransferase 1A9

Gao, R., Li, L., Xie, C., Diao, X., Zhong, D., Chen, X.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 2.46 MB

english, 2012

3

Human Cytochrome P450scc (CYP11A1) Catalyzes Epoxide Formation with Ergosterol

Tuckey, R. C., Nguyen, M. N., Chen, J., Slominski, A. T., Baldisseri, D. M., Tieu, E. W., Zjawiony, J. K., Li, W.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 1.73 MB

english, 2012

4

Stereospecific Metabolism of Itraconazole by CYP3A4: Dioxolane Ring Scission of Azole Antifungals

Peng, C.-C., Shi, W., Lutz, J. D., Kunze, K. L., Liu, J. O., Nelson, W. L., Isoherranen, N.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 730 KB

english, 2012

5

Use of a Multistaged Time-Dependent Inhibition Assay to Assess the Impact of Intestinal Metabolism on Drug-Drug Interaction Potential

Zientek, M., Dalvie, D.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 529 KB

english, 2012

6

Excretion, Metabolism, and Pharmacokinetics of 1-(8-(2-Chlorophenyl)-9-(4-Chlorophenyl)-9H-Purin-6-yl)-4-(Ethylamino)Piperidine-4-Carboxamide, a Selective Cannabinoid Receptor Antagonist, in Healthy Male Volunteers

Miao, Z., Sun, H., Liras, J., Prakash, C.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 2.26 MB

english, 2012

7

Investigation of Drug-Drug Interactions Caused by Human Pregnane X Receptor-Mediated Induction of CYP3A4 and CYP2C Subfamilies in Chimeric Mice with a Humanized Liver

Hasegawa, M., Tahara, H., Inoue, R., Kakuni, M., Tateno, C., Ushiki, J.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 217 KB

english, 2012

8

Editorial

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 54 KB

english, 2012

9

Influence of MK-467, a Peripherally Acting 2-Adrenoceptor Antagonist on the Disposition of Intravenous Dexmedetomidine in Dogs

Honkavaara, J., Restitutti, F., Raekallio, M., Salla, K., Kuusela, E., Ranta-Panula, V., Rinne, V., Vainio, O., Scheinin, M.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 221 KB

english, 2012

10

Molecular Mechanism of Altered Ezetimibe Disposition in Nonalcoholic Steatohepatitis

Hardwick, R. N., Fisher, C. D., Street, S. M., Canet, M. J., Cherrington, N. J.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 2.15 MB

english, 2012

11

Investigation of Figopitant and Its Metabolites in Rat Tissue by Combining Whole-Body Autoradiography with Liquid Extraction Surface Analysis Mass Spectrometry

Schadt, S., Kallbach, S., Almeida, R., Sandel, J.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 731 KB

english, 2012

12

Clarithromycin Is Absorbed by an Intestinal Uptake Mechanism That Is Sensitive to Major Inhibition by Rifampicin: Results of a Short-Term Drug Interaction Study in Foals

Peters, J., Eggers, K., Oswald, S., Block, W., Lutjohann, D., Lammer, M., Venner, M., Siegmund, W.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 873 KB

english, 2012

13

Evaluation of Hepatic Glutathione Transferase Mu 1 and Theta 1 Activities in Humans and Mice Using Genotype Information

Arakawa, S., Fujimoto, K., Kato, A., Endo, S., Fukahori, A., Shinagawa, A., Fischer, T., Mueller, J., Takasaki, W.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 206 KB

english, 2012

14

Pharmacokinetics, Distribution, and Metabolism of [14C]Sunitinib in Rats, Monkeys, and Humans

Speed, B., Bu, H.-Z., Pool, W. F., Peng, G. W., Wu, E. Y., Patyna, S., Bello, C., Kang, P.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 1.95 MB

english, 2012

15

Trapping of cis-2-Butene-1,4-dial to Measure Furan Metabolism in Human Liver Microsomes by Cytochrome P450 Enzymes

Gates, L. A., Lu, D., Peterson, L. A.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 1.20 MB

english, 2012

16

Expression of Organic Anion Transporter 2 in the Human Kidney and Its Potential Role in the Tubular Secretion of Guanine-Containing Antiviral Drugs

Cheng, Y., Vapurcuyan, A., Shahidullah, M., Aleksunes, L. M., Pelis, R. M.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 1.05 MB

english, 2012

17

Characterization of Hepatic and Intestinal Glucuronidation of Magnolol: Application of the Relative Activity Factor Approach to Decipher the Contributions of Multiple UDP-Glucuronosyltransferase Isoforms

Zhu, L., Ge, G., Zhang, H., Liu, H., He, G., Liang, S., Zhang, Y., Fang, Z., Dong, P., Finel, M., Yang, L.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 1.12 MB

english, 2012

18

In Vivo Biliary Clearance Should Be Predicted by Intrinsic Biliary Clearance in Sandwich-Cultured Hepatocytes

Nakakariya, M., Ono, M., Amano, N., Moriwaki, T., Maeda, K., Sugiyama, Y.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 811 KB

english, 2012

19

Polychlorinated Biphenyl Congeners that Increase the Glucuronidation and Biliary Excretion of Thyroxine Are Distinct from the Congeners that Enhance the Serum Disappearance of Thyroxine

Martin, L. A., Wilson, D. T., Reuhl, K. R., Gallo, M. A., Klaassen, C. D.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 334 KB

english, 2012

20

Which CYP2B6 Variants Have Functional Consequences for Cyclophosphamide Bioactivation?

Helsby, N. A., Tingle, M. D.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 84 KB

english, 2012

21

Inhibition of Heme Oxygenase-1 Partially Reverses the Arsenite-Mediated Decrease of CYP1A1, CYP1A2, CYP3A23, and CYP3A2 Catalytic Activity in Isolated Rat Hepatocytes

Anwar-Mohamed, A., Klotz, L.-O., El-Kadi, A. O. S.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 1.69 MB

english, 2012

22

Species Comparison of In Vivo P-Glycoprotein-Mediated Brain Efflux Using mdr1a-Deficient Rats and Mice

Bundgaard, C., Jensen, C. J. N., Garmer, M.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 375 KB

english, 2012

23

Inhibition of Genistein Glucuronidation by Bisphenol A in Human and Rat Liver Microsomes

Coughlin, J. L., Thomas, P. E., Buckley, B.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 505 KB

english, 2012

24

Unimolecular and Bimolecular Binding System for the Prediction of CYP2D6-Mediated Metabolism

Sato, K., Yamazoe, Y.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 2.73 MB

english, 2012

25

Oral Availability of Cefadroxil Depends on ABCC3 and ABCC4

de Waart, D. R., van de Wetering, K., Kunne, C., Duijst, S., Paulusma, C. C., Oude Elferink, R. P. J.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 982 KB

english, 2012

26

Deuterium Isotope Effects on Drug Pharmacokinetics. I. System-Dependent Effects of Specific Deuteration with Aldehyde Oxidase Cleared Drugs

Sharma, R., Strelevitz, T. J., Gao, H., Clark, A. J., Schildknegt, K., Obach, R. S., Ripp, S. L., Spracklin, D. K., Tremaine, L. M., Vaz, A. D. N.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 603 KB

english, 2012

27

Complex Drug Interactions of the HIV Protease Inhibitors 3: Effect of Simultaneous or Staggered Dosing of Digoxin and Ritonavir, Nelfinavir, Rifampin, or Bupropion

Kirby, B. J., Collier, A. C., Kharasch, E. D., Whittington, D., Thummel, K. E., Unadkat, J. D.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 1.01 MB

english, 2012

28

Changes in Expression of Drug-Metabolizing Enzymes by Single-Walled Carbon Nanotubes in Human Respiratory Tract Cells

Hitoshi, K., Katoh, M., Suzuki, T., Ando, Y., Nadai, M.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 1.25 MB

english, 2012