Volume 41; Issue 2

Drug Metabolism and Disposition

Volume 41; Issue 2

1

Metabolic Pathways of Inhaled Glucocorticoids by the CYP3A Enzymes

Moore, C. D., Roberts, J. K., Orton, C. R., Murai, T., Fidler, T. P., Reilly, C. A., Ward, R. M., Yost, G. S.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.83 MB

english, 2013

2

RBCK1, an E3 Ubiquitin Ligase, Interacts with and Ubiquinates the Human Pregnane X Receptor

Rana, R., Coulter, S., Kinyamu, H., Goldstein, J. A.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 783 KB

english, 2013

3

Metabolic Transformation of Antitumor Acridinone C-1305 but Not C-1311 via Selective Cellular Expression of UGT1A10 Increases Cytotoxic Response: Implications for Clinical Use

Pawlowska, M., Chu, R., Fedejko-Kap, B., Augustin, E., Mazerska, Z., Radominska-Pandya, A., Chambers, T. C.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.31 MB

english, 2013

4

Pharmacokinetics, Metabolism, and Excretion of the Antidiabetic Agent Ertugliflozin (PF-04971729) in Healthy Male Subjects

Miao, Z., Nucci, G., Amin, N., Sharma, R., Mascitti, V., Tugnait, M., Vaz, A. D., Callegari, E., Kalgutkar, A. S.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.84 MB

english, 2013

5

The Potential of Sutherlandia frutescens for Herb-Drug Interaction

Fasinu, P. S., Gutmann, H., Schiller, H., James, A.-D., Bouic, P. J., Rosenkranz, B.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.89 MB

english, 2013

6

In Vitro Investigations into the Roles of Drug Transporters and Metabolizing Enzymes in the Disposition and Drug Interactions of Dolutegravir, a HIV Integrase Inhibitor

Reese, M. J., Savina, P. M., Generaux, G. T., Tracey, H., Humphreys, J. E., Kanaoka, E., Webster, L. O., Harmon, K. A., Clarke, J. D., Polli, J. W.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 893 KB

english, 2013

7

Species Differences in Biliary Clearance and Possible Relevance of Hepatic Uptake and Efflux Transporters Involvement

Grime, K., Paine, S. W.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 623 KB

english, 2013

8

Isoform-Specific Regulation of Cytochromes P450 Expression by Estradiol and Progesterone

Choi, S.-Y., Koh, K. H., Jeong, H.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 828 KB

english, 2013

9

Cytochrome P450 Regulation by -Tocopherol in Pxr-Null and PXR-Humanized Mice

Johnson, C. H., Bonzo, J. A., Cheng, J., Krausz, K. W., Kang, D. W., Luecke, H., Idle, J. R., Gonzalez, F. J.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 304 KB

english, 2013

10

Hepatobiliary Disposition of 17-OHPC and Taurocholate in Fetal Human Hepatocytes: A Comparison with Adult Human Hepatocytes

Sharma, S., Ellis, E. C. S., Gramignoli, R., Dorko, K., Tahan, V., Hansel, M., Mattison, D. R., Caritis, S. N., Hines, R. N., Venkataramanan, R., Strom, S. C.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 371 KB

english, 2013

11

Alteration of the Expression of Pesticide-Metabolizing Enzymes in Pregnant Mice: Potential Role in the Increased Vulnerability of the Developing Brain

Fortin, M. C., Aleksunes, L. M., Richardson, J. R.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 859 KB

english, 2013

12

Compartmental and Enzyme Kinetic Modeling To Elucidate the Biotransformation Pathway of a Centrally Acting Antitrypanosomal Prodrug

Generaux, C. N., Ainslie, G. R., Bridges, A. S., Ismail, M. A., Boykin, D. W., Tidwell, R. R., Thakker, D. R., Paine, M. F.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 887 KB

english, 2013

13

Hepatic Cyp2d and Cyp26a1 mRNAs and Activities Are Increased During Mouse Pregnancy

Topletz, A. R., Le, H. N., Lee, N., Chapman, J. D., Kelly, E. J., Wang, J., Isoherranen, N.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 716 KB

english, 2013

14

Gestational Age-Dependent Changes in Gene Expression of Metabolic Enzymes and Transporters in Pregnant Mice

Shuster, D. L., Bammler, T. K., Beyer, R. P., MacDonald, J. W., Tsai, J. M., Farin, F. M., Hebert, M. F., Thummel, K. E., Mao, Q.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.18 MB

english, 2013

15

Compartmentalization and Antiviral Effect of Efavirenz Metabolites in Blood Plasma, Seminal Plasma, and Cerebrospinal Fluid

Avery, L. B., VanAusdall, J. L., Hendrix, C. W., Bumpus, N. N.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 758 KB

english, 2013

16

Analysis of the Repaglinide Concentration Increase Produced by Gemfibrozil and Itraconazole Based on the Inhibition of the Hepatic Uptake Transporter and Metabolic Enzymes

Kudo, T., Hisaka, A., Sugiyama, Y., Ito, K.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.15 MB

english, 2013

17

Induction of Hepatic CYP3A Enzymes by Pregnancy-Related Hormones: Studies in Human Hepatocytes and Hepatic Cell Lines

Papageorgiou, I., Grepper, S., Unadkat, J. D.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 352 KB

english, 2013

18

Metabolism and Pharmacokinetics of 3-n-Butylphthalide (NBP) in Humans: The Role of Cytochrome P450s and Alcohol Dehydrogenase in Biotransformation

Diao, X., Deng, P., Xie, C., Li, X., Zhong, D., Zhang, Y., Chen, X.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 962 KB

english, 2013

19

Increased Hospital Stay and Allograft Disfunction in Renal Transplant Recipients with Cyp2c19 AA Variant in SNP rs4244285

Boso, V., Herrero, M. J., Bea, S., Galiana, M., Marrero, P., Marques, M. R., Hernandez, J., Sanchez-Plumed, J., Poveda, J. L., Alino, S. F.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 530 KB

english, 2013

20

Evaluation of Metabolism and Disposition of GDC-0152 in Rats Using 14C Labeling Strategy at Two Different Positions: A Novel Formation of Hippuric Acid from 4-Phenyl-5-Amino-1,2,3-Thiadiazole

Yue, Q., Mulder, T., Rudewicz, P. J., Solon, E., Budha, N., Ware, J. A., Lyssikatos, J., Hop, C. E. C. A., Wong, H., Khojasteh, S. C.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.45 MB

english, 2013

21

In Vitro Cytochrome P450 Activity Decreases in Children with High Pediatric End-Stage Liver Disease Scores

De Bock, L., Boussery, K., Van Winckel, M., De Paepe, P., Rogiers, X., Stephenne, X., Sokal, E., Van Bocxlaer, J.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 985 KB

english, 2013

22

Drug Metabolism and Transport During Pregnancy: How Does Drug Disposition Change during Pregnancy and What Are the Mechanisms that Cause Such Changes?

Isoherranen, N., Thummel, K. E.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 743 KB

english, 2013

23

Down-Regulation of Brush Border Efflux Transporter Expression in the Kidneys of Pregnant Mice

Yacovino, L. L., Gibson, C. J., Aleksunes, L. M.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 612 KB

english, 2013

24

Prediction of Crizotinib-Midazolam Interaction Using the Simcyp Population-Based Simulator: Comparison of CYP3A Time-Dependent Inhibition between Human Liver Microsomes versus Hepatocytes

Mao, J., Johnson, T. R., Shen, Z., Yamazaki, S.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 895 KB

english, 2013

25

Dietary Regulation of Mouse Intestinal P450 Expression and Drug Metabolism

Zhang, P., Jia, K., Fang, C., Zhou, X., Ding, X., Zhang, Q.-Y.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.02 MB

english, 2013

26

Intraindividual and Interindividual Variabilities in Endogenous Cortisol 6 -Hydroxylation Clearance as an Index for In Vivo CYP3A Phenotyping in Humans

Shibasaki, H., Hosoda, K., Goto, M., Suzuki, A., Yokokawa, A., Ishii, K., Furuta, T.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 383 KB

english, 2013

27

Application of Hybrid Approach Based on Empirical and Physiological Concept for Predicting Pharmacokinetics in Humans--Usefulness of Exponent on Prospective Evaluation of Predictability

Sayama, H., Komura, H., Kogayu, M.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 958 KB

english, 2013

28

Tissue Distribution and Relative Gene Expression of UDP-Glucuronosyltransferases (2B7, 2B15, 2B17) in the Human Fetus

Ekstrom, L., Johansson, M., Rane, A.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 811 KB

english, 2013

29

Cotinine in Human Placenta Predicts Induction of Gene Expression in Fetal Tissues

Vyhlidal, C. A., Riffel, A. K., Haley, K. J., Sharma, S., Dai, H., Tantisira, K. G., Weiss, S. T., Leeder, J. S.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 731 KB

english, 2013

30

Quantitative Prediction of CYP2B6 Induction by Estradiol During Pregnancy: Potential Explanation for Increased Methadone Clearance During Pregnancy

Dickmann, L. J., Isoherranen, N.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 691 KB

english, 2013

31

Immunohistochemical and Functional Characterization of Peptide, Organic Cation, Neutral and Basic Amino Acid, and Monocarboxylate Drug Transporters in Human Ocular Tissues

Kadam, R. S., Vooturi, S. K., Kompella, U. B.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.31 MB

english, 2013

32

Induction of Hepatic Multidrug Resistance-Associated Protein 3 by Ethynylestradiol Is Independent of Cholestasis and Mediated by Estrogen Receptor

Ruiz, M. L., Rigalli, J. P., Arias, A., Villanueva, S., Banchio, C., Vore, M., Mottino, A. D., Catania, V. A.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 498 KB

english, 2013

33

The Role of Cytochrome P450-Dependent Metabolism in the Regulation of Mouse Hepatic Growth Hormone Signaling Components and Target Genes by 3-Methylcholanthrene

Lee, C., Ding, X., Riddick, D. S.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 962 KB

english, 2013

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