Volume 41; Issue 4

Drug Metabolism and Disposition

Volume 41; Issue 4

1

Methadone N-Demethylation by the Common CYP2B6 Allelic Variant CYP2B6.6

Gadel, S., Crafford, A., Regina, K., Kharasch, E. D.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 885 KB

english, 2013

2

Reversible Inhibition of Human Carboxylesterases by Acyl Glucuronides

Inoue, N. R., Hall, A., Lai, W. G., Williams, E. T.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.17 MB

english, 2013

3

Characterization of Efflux Transporters Involved in Distribution and Disposition of Apixaban

Zhang, D., He, K., Herbst, J. J., Kolb, J., Shou, W., Wang, L., Balimane, P. V., Han, Y.-H., Gan, J., Frost, C. E., Humphreys, W. G.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 911 KB

english, 2013

4

Tariquidar and Elacridar Are Dose-Dependently Transported by P-Glycoprotein and Bcrp at the Blood-Brain Barrier: A Small-Animal Positron Emission Tomography and In Vitro Study

Bankstahl, J. P., Bankstahl, M., Romermann, K., Wanek, T., Stanek, J., Windhorst, A. D., Fedrowitz, M., Erker, T., Muller, M., Loscher, W., Langer, O., Kuntner, C.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.04 MB

english, 2013

5

Investigating the Enteroenteric Recirculation of Apixaban, a Factor Xa Inhibitor: Administration of Activated Charcoal to Bile Duct-Cannulated Rats and Dogs Receiving an Intravenous Dose and Use of Drug Transporter Knockout Rats

Zhang, D., Frost, C. E., He, K., Rodrigues, A. D., Wang, X., Wang, L., Goosen, T. C., Humphreys, W. G.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.36 MB

english, 2013

6

Organic Anion Transporter 3 Interacts Selectively with Lipophilic -Lactam Antibiotics

Wolman, A. T., Gionfriddo, M. R., Heindel, G. A., Mukhija, P., Witkowski, S., Bommareddy, A., VanWert, A. L.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 919 KB

english, 2013

7

Pharmacokinetics, Metabolism, and Excretion of the Glycogen Synthase Kinase-3 Inhibitor LY2090314 in Rats, Dogs, and Humans: A Case Study in Rapid Clearance by Extensive Metabolism with Low Circulating Metabolite Exposure

Zamek-Gliszczynski, M. J., Abraham, T. L., Alberts, J. J., Kulanthaivel, P., Jackson, K. A., Chow, K. H., McCann, D. J., Hu, H., Anderson, S., Furr, N. A., Barbuch, R. J., Cassidy, K. C.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.39 MB

english, 2013

8

Retrospective Analysis of P-Glycoprotein-Mediated Drug-Drug Interactions at the Blood-Brain Barrier in Humans

Sugimoto, H., Hirabayashi, H., Amano, N., Moriwaki, T.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 175 KB

english, 2013

9

Potential Role of UGT1A4 Promoter SNPs in Anastrozole Pharmacogenomics

Edavana, V. K., Dhakal, I. B., Williams, S., Penney, R., Boysen, G., Yao-Borengasser, A., Kadlubar, S.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 903 KB

english, 2013

10

Pharmacokinetic and Pharmacodynamic Modeling of Hedgehog Inhibitor TAK-441 for the Inhibition of Gli1 messenger RNA Expression and Antitumor Efficacy in Xenografted Tumor Model Mice

Kogame, A., Tagawa, Y., Shibata, S., Tojo, H., Miyamoto, M., Tohyama, K., Kondo, T., Prakash, S., Shyu, W. C., Asahi, S.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 314 KB

english, 2013

11

A Physiologically Based Pharmacokinetic Model to Predict Disposition of CYP2D6 and CYP1A2 Metabolized Drugs in Pregnant Women

Ke, A. B., Nallani, S. C., Zhao, P., Rostami-Hodjegan, A., Isoherranen, N., Unadkat, J. D.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.17 MB

english, 2013

12

Identification and Characterization of Novel Alternative Splice Variants of Human Constitutive Androstane Receptor in Liver Samples of Koreans and Caucasians

Choi, E.-J., Jang, Y.-J., Cha, E.-Y., Shin, J.-G., Lee, S. S.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.75 MB

english, 2013

13

Absorption, Elimination, and Metabolism of CS-1036, a Novel -Amylase Inhibitor in Rats and Monkeys, and the Relationship between Gastrointestinal Distribution and Suppression of Glucose Absorption

Honda, T., Kaneno-Urasaki, Y., Murai, T., Kakuta, M., Nasu, H., Namba, E., Koga, T., Okuno, A., Izumi, T.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1008 KB

english, 2013

14

Evaluation of Hepatic Disposition of Paroxetine Using Sandwich-Cultured Rat and Human Hepatocytes

Matsunaga, N., Nunoya, K.-i., Okada, M., Ogawa, M., Tamai, I.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.82 MB

english, 2013

15

Transport of A1 Adenosine Receptor Agonist Tecadenoson by Human and Mouse Nucleoside Transporters: Evidence for Blood-Brain Barrier Transport by Murine Equilibrative Nucleoside Transporter 1 mENT1

Lepist, E.-I., Damaraju, V. L., Zhang, J., Gati, W. P., Yao, S. Y. M., Smith, K. M., Karpinski, E., Young, J. D., Leung, K. H., Cass, C. E.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 199 KB

english, 2013

16

Application of a Physiologically Based Pharmacokinetic Model to Assess Propofol Hepatic and Renal Glucuronidation in Isolation: Utility of In Vitro and In Vivo Data

Gill, K. L., Gertz, M., Houston, J. B., Galetin, A.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 627 KB

english, 2013

17

Characterization of Four New Mouse Cytochrome P450 Enzymes of the CYP2J Subfamily

Graves, J. P., Edin, M. L., Bradbury, J. A., Gruzdev, A., Cheng, J., Lih, F. B., Masinde, T. A., Qu, W., Clayton, N. P., Morrison, J. P., Tomer, K. B., Zeldin, D. C.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.60 MB

english, 2013

18

The Relative Protein Abundance of UGT1A Alternative Splice Variants as a Key Determinant of Glucuronidation Activity In Vitro

Rouleau, M., Roberge, J., Falardeau, S.-A., Villeneuve, L., Guillemette, C.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 384 KB

english, 2013

19

Predicting Metabolic Clearance for Drugs That Are Actively Transported into Hepatocytes: Incubational Binding as a Consequence of in Vitro Hepatocyte Concentration Is a Key Factor

Nordell, P., Svanberg, P., Bird, J., Grime, K.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 253 KB

english, 2013

20

Lysosomal Sequestration (Trapping) of Lipophilic Amine (Cationic Amphiphilic) Drugs in Immortalized Human Hepatocytes (Fa2N-4 Cells)

Kazmi, F., Hensley, T., Pope, C., Funk, R. S., Loewen, G. J., Buckley, D. B., Parkinson, A.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.60 MB

english, 2013

21

The Inactivation of Human CYP2E1 by Phenethyl Isothiocyanate, a Naturally Occurring Chemopreventive Agent, and Its Oxidative Bioactivation

Yoshigae, Y., Sridar, C., Kent, U. M., Hollenberg, P. F.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.68 MB

english, 2013

22

Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity

Arico-Muendel, C. C., Belanger, B., Benjamin, D., Blanchette, H. S., Caiazzo, T. M., Centrella, P. A., DeLorey, J., Doyle, E. G., Gradhand, U., Griffin, S. T., Hill, S., Labenski, M. T., Morgan, B. A.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.19 MB

english, 2013

23

Serum Levels of 25-Hydroxyvitamin D and the CYP3A Biomarker 4 -Hydroxycholesterol in a High-Dose Vitamin D Supplementation Study

Bjorkhem-Bergman, L., Nylen, H., Norlin, A.-C., Lindh, J. D., Ekstrom, L., Eliasson, E., Bergman, P., Diczfalusy, U.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 698 KB

english, 2013

24

Drug Transporters on Arachnoid Barrier Cells Contribute to the Blood-Cerebrospinal Fluid Barrier

Yasuda, K., Cline, C., Vogel, P., Onciu, M., Fatima, S., Sorrentino, B. P., Thirumaran, R. K., Ekins, S., Urade, Y., Fujimori, K., Schuetz, E. G.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.52 MB

english, 2013

25

RNA-Sequencing Quantification of Hepatic Ontogeny and Tissue Distribution of mRNAs of Phase II Enzymes in Mice

Lu, H., Gunewardena, S., Cui, J. Y., Yoo, B., Zhong, X.-b., Klaassen, C. D.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.75 MB

english, 2013

26

Identification of the Active Components in Shenmai Injection that Differentially Affect Cyp3a4-Mediated 1'-Hydroxylation and 4-Hydroxylation of Midazolam

Zeng, C., He, F., Xia, C., Zhang, H., Xiong, Y.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 462 KB

english, 2013

27

Interleukins-12 and -23 Do Not Alter Expression or Activity of Multiple Cytochrome P450 Enzymes in Cryopreserved Human Hepatocytes

Dallas, S., Chattopadhyay, S., Sensenhauser, C., Batheja, A., Singer, M., Silva, J.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 766 KB

english, 2013

28

Correction to "Characterization of Human Cytochrome P450s Involved in the Bioactivation of Clozapine"

Journal:

Drug Metabolism and Disposition

Year:

2013

File:

PDF, 50 KB

2013

29

Peginesatide Clearance, Distribution, Metabolism, and Excretion in Monkeys following Intravenous Administration

Woodburn, K. W., Fong, K.-L., Wilson, S. D., Sloneker, S., Strzemienski, P., Solon, E., Moriya, Y., Tagawa, Y.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.96 MB

english, 2013

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