Volume 41; Issue 5

Drug Metabolism and Disposition

Volume 41; Issue 5

1

Disposition and Metabolism of GSK2251052 in Humans: A Novel Boron-Containing Antibiotic

Bowers, G. D., Tenero, D., Patel, P., Huynh, P., Sigafoos, J., O'Mara, K., Young, G. C., Dumont, E., Cunningham, E., Kurtinecz, M., Stump, P., Conde, J. J., Chism, J. P., Reese, M. J., Yueh, Y. L., To

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 3.05 MB

english, 2013

2

Induction of Xenobiotic Receptors, Transporters, and Drug Metabolizing Enzymes by Oxycodone

Hassan, H. E., Myers, A. L., Lee, I. J., Mason, C. W., Wang, D., Sinz, M. W., Wang, H., Eddington, N. D.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 337 KB

english, 2013

3

Interaction of Silymarin Flavonolignans with Organic Anion-Transporting Polypeptides

Kock, K., Xie, Y., Hawke, R. L., Oberlies, N. H., Brouwer, K. L. R.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 743 KB

english, 2013

4

Which Metabolites Circulate?

Loi, C.-M., Smith, D. A., Dalvie, D.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.58 MB

english, 2013

5

Elucidation of the Metabolic Pathways and the Resulting Multiple Metabolites of Almorexant, a Dual Orexin Receptor Antagonist, in Humans

Dingemanse, J., Hoever, P., Hoch, M., Treiber, A., Wagner-Redeker, W., Miraval, T., Hopfgartner, G., Shakeri-Nejad, K.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.90 MB

english, 2013

6

Metabolism-Dependent Inhibition of CYP3A4 by Lapatinib: Evidence for Formation of a Metabolic Intermediate Complex with a Nitroso/Oxime Metabolite Formed via a Nitrone Intermediate

Barbara, J. E., Kazmi, F., Parkinson, A., Buckley, D. B.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.58 MB

english, 2013

7

Involvement of Organic Anion-Transporting Polypeptides in the Hepatic Uptake of Dioscin in Rats and Humans

Zhang, A., Wang, C., Liu, Q., Meng, Q., Peng, J., Sun, H., Ma, X., Huo, X., Liu, K.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 260 KB

english, 2013

8

Interindividual Variability of Carboxymethylenebutenolidase Homolog, a Novel Olmesartan Medoxomil Hydrolase, in the Human Liver and Intestine

Ishizuka, T., Rozehnal, V., Fischer, T., Kato, A., Endo, S., Yoshigae, Y., Kurihara, A., Izumi, T.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 963 KB

english, 2013

9

Hydroxylation of CYP11A1-Derived Products of Vitamin D3 Metabolism by Human and Mouse CYP27B1

Tang, E. K. Y., Chen, J., Janjetovic, Z., Tieu, E. W., Slominski, A. T., Li, W., Tuckey, R. C.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.47 MB

english, 2013

10

Modification of the Catalytic Function of Human Hydroxysteroid Sulfotransferase hSULT2A1 by Formation of Disulfide Bonds

Qin, X., Teesch, L. M., Duffel, M. W.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.19 MB

english, 2013

11

Effect of Ketoconazole on the Pharmacokinetics of the 11 -Hydroxysteroid Dehydrogenase Type 1 Inhibitor ABT-384 and Its Two Active Metabolites in Healthy Volunteers: Population Analysis of Data from a Drug-Drug Interaction Study

An, G., Liu, W., Katz, D. A., Marek, G., Awni, W., Dutta, S.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 264 KB

english, 2013

12

Species Difference in the Mechanism of Nonlinear Pharmacokinetics of E2074, a Novel Sodium Channel Inhibitor, in Rats, Dogs, and Monkeys

Nagaya, Y., Takenaka, O., Kusano, K., Yoshimura, T.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 255 KB

english, 2013

13

Decreased CYP3A Expression and Activity in Guinea Pig Models of Diet-Induced Metabolic Syndrome: Is Fatty Liver Infiltration Involved?

Patoine, D., Levac, X., Pilote, S., Drolet, B., Simard, C.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.96 MB

english, 2013

14

Quantitative Prediction of Repaglinide-Rifampicin Complex Drug Interactions Using Dynamic and Static Mechanistic Models: Delineating Differential CYP3A4 Induction and OATP1B1 Inhibition Potential of Rifampicin

Varma, M. V. S., Lin, J., Bi, Y.-A., Rotter, C. J., Fahmi, O. A., Lam, J. L., El-Kattan, A. F., Goosen, T. C., Lai, Y.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 939 KB

english, 2013

15

Drug Cocktail Interaction Study on the Effect of the Orally Administered Lavender Oil Preparation Silexan on Cytochrome P450 Enzymes in Healthy Volunteers

Doroshyenko, O., Rokitta, D., Zadoyan, G., Klement, S., Schlafke, S., Dienel, A., Gramatte, T., Luck, H., Fuhr, U.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 691 KB

english, 2013

16

Alcohol Cirrhosis Alters Nuclear Receptor and Drug Transporter Expression in Human Liver

More, V. R., Cheng, Q., Donepudi, A. C., Buckley, D. B., Lu, Z. J., Cherrington, N. J., Slitt, A. L.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.07 MB

english, 2013

17

Contribution of Artifacts to N-Methylated Piperazine Cyanide Adduct Formation In Vitro from N-Alkyl Piperazine Analogs

Zhang, M., Resuello, C. M., Guo, J., Powell, M. E., Elmore, C. S., Hu, J., Vishwanathan, K.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 526 KB

english, 2013

18

Significance of Reductive Metabolism in Human Intestine and Quantitative Prediction of Intestinal First-Pass Metabolism by Cytosolic Reductive Enzymes

Nishimuta, H., Nakagawa, T., Nomura, N., Yabuki, M.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.02 MB

english, 2013

19

Pharmacokinetic Interactions between Monoamine Oxidase A Inhibitor Harmaline and 5-Methoxy-N,N-Dimethyltryptamine, and the Impact of CYP2D6 Status

Jiang, X.-L., Shen, H.-W., Mager, D. E., Yu, A.-M.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.80 MB

english, 2013

20

Pulmonary Metabolism of Resveratrol: In Vitro and In Vivo Evidence

Sharan, S., Nagar, S.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 846 KB

english, 2013

21

Metabolism of Bis(4-fluorobenzyl)trisulfide and Its Formation of Hemoglobin Adduct in Rat Erythrocytes

Pan, H., Gu, L., Sun, S., Chen, Z., Zhou, H., Zeng, S., Jiang, H.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.05 MB

english, 2013

22

Biotransformation of Two -Secretase Inhibitors Including Ring Opening and Contraction of a Pyrimidine Ring

Lindgren, A., Eklund, G., Turek, D., Malmquist, J., Swahn, B.-M., Holenz, J., von Berg, S., Karlstrom, S., Bueters, T.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 2.68 MB

english, 2013

23

Tissue Distribution and Identification of Radioactivity Components at Elimination Phase after Oral Administration of [14C]CS-1036, an -Amylase Inhibitor, to Rats

Honda, T., Takakusa, H., Murai, T., Izumi, T.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.45 MB

english, 2013