Volume 42; Issue 1

Drug Metabolism and Disposition

Volume 42; Issue 1

1

Correlating Structure and Function of Drug-Metabolizing Enzymes: Progress and Ongoing Challenges

Johnson, E. F., Connick, J. P., Reed, J. R., Backes, W. L., Desai, M. C., Xu, L., Estrada, D. F., Laurence, J. S., Scott, E. E.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.97 MB

english, 2013

2

In Vitro Drug Metabolism by Human Carboxylesterase 1: Focus on Angiotensin-Converting Enzyme Inhibitors

Thomsen, R., Rasmussen, H. B., Linnet, K.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 576 KB

english, 2013

3

In Vitro Hydrolysis and Transesterification of CDP323, an 4 1/ 4 7 Integrin Antagonist Ester Prodrug

Chanteux, H., Rosa, M., Delatour, C., Prakash, C., Smith, S., Nicolas, J.-M.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.12 MB

english, 2013

4

Selective Inhibition of Cytochrome P450 2D6 by Sarpogrelate and Its Active Metabolite, M-1, in Human Liver Microsomes

Cho, D.-Y., Bae, S. H., Lee, J. K., Kim, Y. W., Kim, B.-T., Bae, S. K.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 927 KB

english, 2013

5

Hepatic Cytochrome P450s, Phase II Enzymes and Nuclear Receptors Are Downregulated in a Th2 Environment during Schistosoma mansoni Infection

Mimche, S. M., Nyagode, B. A., Merrell, M. D., Lee, C.-M., Prasanphanich, N. S., Cummings, R. D., Morgan, E. T.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 705 KB

english, 2013

6

Tissue-Specific Metabolism of Benzo[a]pyrene in Rainbow Trout (Oncorhynchus mykiss): A Comparison between the Liver and Immune Organs

Moller, A.-M., Hermsen, C., Floehr, T., Lamoree, M. H., Segner, H.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 413 KB

english, 2013

7

Essential Role of the Cytochrome P450 Enzyme CYP2A5 in Olfactory Mucosal Toxicity of Naphthalene

Hu, J., Sheng, L., Li, L., Zhou, X., Xie, F., D'Agostino, J., Li, Y., Ding, X.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1020 KB

english, 2013

8

Candidate Gene Polymorphisms in Patients with Acetaminophen-Induced Acute Liver Failure

Court, M. H., Peter, I., Hazarika, S., Vasiadi, M., Greenblatt, D. J., Lee, W. M.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 657 KB

english, 2013

9

Effects of Single-Nucleotide Polymorphisms of FMO3 and FMO6 Genes on Pharmacokinetic Characteristics of Sulindac Sulfide in Premature Labor

Park, S., Lee, N. R., Lee, K. E., Park, J. Y., Kim, Y. J., Gwak, H. S.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 111 KB

english, 2013

10

Evaluation and Mechanistic Analysis of the Cytotoxicity of the Acyl Glucuronide of Nonsteroidal Anti-Inflammatory Drugs

Miyashita, T., Kimura, K., Fukami, T., Nakajima, M., Yokoi, T.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 748 KB

english, 2013

11

MicroRNA-561 Promotes Acetaminophen-Induced Hepatotoxicity in HepG2 Cells and Primary Human Hepatocytes through Downregulation of the Nuclear Receptor Corepressor Dosage-Sensitive Sex-Reversal Adrenal Hypoplasia Congenital Critical Region on the X Chromosome, Gene 1 (DAX-1)

Li, M., Yang, Y., He, Z.-X., Zhou, Z.-W., Yang, T., Guo, P., Zhang, X., Zhou, S.-F.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.73 MB

english, 2013

12

Oatp1a1 Requires PDZK1 to Traffic to the Plasma Membrane by Selective Recruitment of Microtubule-Based Motor Proteins

Wang, W.-J., Murray, J. W., Wolkoff, A. W.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 712 KB

english, 2013

13

Interindividual Variability in Hepatic Organic Anion-Transporting Polypeptides and P-Glycoprotein (ABCB1) Protein Expression: Quantification by Liquid Chromatography Tandem Mass Spectroscopy and Influence of Genotype, Age, and Sex

Prasad, B., Evers, R., Gupta, A., Hop, C. E. C. A., Salphati, L., Shukla, S., Ambudkar, S. V., Unadkat, J. D.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.31 MB

english, 2013

14

A Role for Cytochrome b5 in the In Vivo Disposition of Anticancer and Cytochrome P450 Probe Drugs in Mice

Henderson, C. J., McLaughlin, L. A., Finn, R. D., Ronseaux, S., Kapelyukh, Y., Wolf, C. R.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 948 KB

english, 2013

15

Localization of Multidrug Resistance-Associated Proteins along the Blood-Testis Barrier in Rat, Macaque, and Human Testis

Klein, D. M., Wright, S. H., Cherrington, N. J.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.38 MB

english, 2013

16

Association of Plasma Concentration of 4 -Hydroxycholesterol with CYP3A5 Polymorphism and Plasma Concentration of Indoxyl Sulfate in Stable Kidney Transplant Recipients

Suzuki, Y., Itoh, H., Fujioka, T., Sato, F., Kawasaki, K., Sato, Y., Sato, Y., Ohno, K., Mimata, H., Kishino, S.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 749 KB

english, 2013

17

Deoxyschizandrin, a Naturally Occurring Lignan, Is a Specific Probe Substrate of Human Cytochrome P450 3A

Wu, J., Cao, Y., Zhang, Y., Liu, Y., Hong, J. Y., Zhu, L., Ge, G., Yang, L.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 415 KB

english, 2013

18

Nonlinear Pharmacokinetics of ( )3,4-Methylenedioxymethamphetamine (MDMA) and Its Pharmacodynamic Consequences in the Rat

Concheiro, M., Baumann, M. H., Scheidweiler, K. B., Rothman, R. B., Marrone, G. F., Huestis, M. A.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 504 KB

english, 2013

19

Multiple Cytochrome P450 Isoforms Are Involved in the Generation of a Pharmacologically Active Thiol Metabolite, whereas Paraoxonase 1 and Carboxylesterase 1 Catalyze the Formation of a Thiol Metabolite Isomer from Ticlopidine

Kim, M.-J., Jeong, E. S., Park, J.-S., Lee, S.-J., Ghim, J. L., Choi, C.-S., Shin, J.-G., Kim, D.-H.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 887 KB

english, 2013

20

Role of Constitutive Androstane Receptor in Toll-Like Receptor-Mediated Regulation of Gene Expression of Hepatic Drug-Metabolizing Enzymes and Transporters

Shah, P., Guo, T., Moore, D. D., Ghose, R.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.08 MB

english, 2013

21

Utility of Oatp1a/1b-Knockout and OATP1B1/3-Humanized Mice in the Study of OATP-Mediated Pharmacokinetics and Tissue Distribution: Case Studies with Pravastatin, Atorvastatin, Simvastatin, and Carboxydichlorofluorescein

Higgins, J. W., Bao, J. Q., Ke, A. B., Manro, J. R., Fallon, J. K., Smith, P. C., Zamek-Gliszczynski, M. J.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 1.02 MB

english, 2013

22

In Vivo to In Vitro Effects of Six Bioactive Lignans of Wuzhi Tablet (Schisandra Sphenanthera Extract) on the CYP3A/P-glycoprotein-Mediated Absorption and Metabolism of Tacrolimus

Qin, X. L., Chen, X., Wang, Y., Xue, X. P., Wang, Y., Li, J. L., Wang, X. D., Zhong, G. P., Wang, C. X., Yang, H., Huang, M., Bi, H. C.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 442 KB

english, 2013

23

Correction to "Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac"

Journal:

Drug Metabolism and Disposition

Year:

2013

File:

PDF, 52 KB

2013

24

Studies on the Role of Metabolic Activation in Tyrosine Kinase Inhibitor-Dependent Hepatotoxicity: Induction of CYP3A4 Enhances the Cytotoxicity of Lapatinib in HepaRG Cells

Hardy, K. D., Wahlin, M. D., Papageorgiou, I., Unadkat, J. D., Rettie, A. E., Nelson, S. D.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 380 KB

english, 2013