Volume 45; Issue 2

Drug Metabolism and Disposition

Volume 45; Issue 2

1

Extrapolation of Elementary Rate Constants of P-glycoprotein–Mediated Transport from MDCKII-hMDR1-NKI to Caco-2 Cells

Meng, Zhou, Ellens, Harma, Bentz, Joe

Journal:

Drug Metabolism and Disposition

Year:

2017

Language:

english

File:

PDF, 266 KB

english, 2017

2

In Vivo Hepatic Enhancer Elements in the Human ABCG2 Locus

Eclov, Rachel J., Kim, Mee J., Smith, Robin P., Liang, Xiaomin, Ahituv, Nadav, Kroetz, Deanna L.

Journal:

Drug Metabolism and Disposition

Year:

2017

Language:

english

File:

PDF, 4.42 MB

english, 2017

3

Impact of Probe Substrate Selection on Cytochrome P450 Reaction Phenotyping Using the Relative Activity Factor

Siu, Y. Amy, Lai, W. George

Journal:

Drug Metabolism and Disposition

Year:

2017

Language:

english

File:

PDF, 2.11 MB

english, 2017

4

Comparative Evaluation of Dehydroepiandrosterone Sulfate Potential to Predict Hepatic Organic Anion Transporting Polypeptide Transporter-Based Drug-Drug Interactions

Nishizawa, Kei, Nakanishi, Takeo, Tamai, Ikumi

Journal:

Drug Metabolism and Disposition

Year:

2017

Language:

english

File:

PDF, 802 KB

english, 2017

5

Management of Rodent Populations by Anticoagulant Rodenticides: Toward Third-Generation Anticoagulant Rodenticides

Damin-Pernik, Marlène, Espana, Bernadette, Lefebvre, Sebastien, Fourel, Isabelle, Caruel, Hervé, Benoit, Etienne, Lattard, Virginie

Journal:

Drug Metabolism and Disposition

Year:

2017

Language:

english

File:

PDF, 367 KB

english, 2017

6

Target-Site Investigation for the Plasma Prolactin Response: Mechanism-Based Pharmacokinetic-Pharmacodynamic Analysis of Risperidone and Paliperidone in the Rat

Shimizu, Shinji, den Hoedt, Sandra M., Mangas-Sanjuan, Victor, Cristea, Sinziana, Geuer, Jana K., van den Berg, Dirk-Jan, Hartman, Robin, Bellanti, Francisco, de Lange, Elizabeth C. M.

Journal:

Drug Metabolism and Disposition

Year:

2017

Language:

english

File:

PDF, 541 KB

english, 2017

7

Impact of Organic Cation Transporters (OCT-SLC22A) on Differential Diagnosis of Intrahepatic Lesions

Visentin, Michele, van Rosmalen, Belle V., Hiller, Christian, Bieze, Matthanja, Hofstetter, Lia, Verheij, Joanne, Kullak-Ublick, Gerd A., Koepsell, Hermann, Phoa, Saffire S.K.S., Tamai, Ikumi, Bennink

Journal:

Drug Metabolism and Disposition

Year:

2017

Language:

english

File:

PDF, 6.15 MB

english, 2017

8

Metabolism of the MEK1/2 Inhibitor Pimasertib Involves a Novel Conjugation with Phosphoethanolamine in Patients with Solid Tumors

Scheible, Holger, Kraetzer, Friedrich, Marx, Andreas, Johne, Andreas, Wimmer, Elmar

Journal:

Drug Metabolism and Disposition

Year:

2017

Language:

english

File:

PDF, 1.81 MB

english, 2017

9

Hepatic Dipeptidyl Peptidase-4 Controls Pharmacokinetics of Vildagliptin In Vivo

Asakura, Mitsutoshi, Fukami, Tatsuki, Nakajima, Miki, Fujii, Hideaki, Atsuda, Koichiro, Itoh, Tomoo, Fujiwara, Ryoichi

Journal:

Drug Metabolism and Disposition

Year:

2017

Language:

english

File:

PDF, 4.05 MB

english, 2017

10

Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants

Boberg, Mikael, Vrana, Marc, Mehrotra, Aanchal, Pearce, Robin E., Gaedigk, Andrea, Bhatt, Deepak Kumar, Leeder, J. Steven, Prasad, Bhagwat

Journal:

Drug Metabolism and Disposition

Year:

2017

Language:

english

File:

PDF, 714 KB

english, 2017

11

Evaluation of a Novel Renewable Hepatic Cell Model for Prediction of Clinical CYP3A4 Induction Using a Correlation-Based Relative Induction Score Approach

Zuo, Rongjun, Li, Feng, Parikh, Sweta, Cao, Li, Cooper, Kirsten L., Hong, Yulong, Liu, Jin, Faris, Ronald A., Li, Daochuan, Wang, Hongbing

Journal:

Drug Metabolism and Disposition

Year:

2017

Language:

english

File:

PDF, 1.17 MB

english, 2017

12

Species Differences in Human and Rodent PEPT2-Mediated Transport of Glycylsarcosine and Cefadroxil in Pichia Pastoris Transformants

Song, Feifeng, Hu, Yongjun, Jiang, Huidi, Smith, David E.

Journal:

Drug Metabolism and Disposition

Year:

2017

Language:

english

File:

PDF, 615 KB

english, 2017

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