Volume 45; Issue 4

Drug Metabolism and Disposition

Volume 45; Issue 4

1

A Physiologically-Based Pharmacokinetic Modeling Approach To Predict Drug–Drug Interactions of Sonidegib (LDE225) with Perpetrators of CYP3A in Cancer Patients

Einolf, Heidi J., Zhou, Jocelyn, Won, Christina, Wang, Lai, Rebello, Sam

Journal:

Drug Metabolism and Disposition

Year:

2017

Language:

english

File:

PDF, 586 KB

english, 2017

2

Intrinsic Clearance Assay Incubational Binding: A Method Comparison

Chen, Sofia, Prieto Garcia, Luna, Bergström, Fredrik, Nordell, Pär, Grime, Ken

Journal:

Drug Metabolism and Disposition

Year:

2017

Language:

english

File:

PDF, 473 KB

english, 2017

3

Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell–Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury

Bell, Catherine C., Lauschke, Volker M., Vorrink, Sabine U., Palmgren, Henrik, Duffin, Rodger, Andersson, Tommy B., Ingelman-Sundberg, Magnus

Journal:

Drug Metabolism and Disposition

Year:

2017

Language:

english

File:

PDF, 7.77 MB

english, 2017

4

Application of Physiologically Based Pharmacokinetic Modeling to the Understanding of Bosutinib Pharmacokinetics: Prediction of Drug–Drug and Drug–Disease Interactions

Ono, Chiho, Hsyu, Poe-Hirr, Abbas, Richat, Loi, Cho-Ming, Yamazaki, Shinji

Journal:

Drug Metabolism and Disposition

Year:

2017

Language:

english

File:

PDF, 2.88 MB

english, 2017

5

Regional Expression Levels of Drug Transporters and Metabolizing Enzymes along the Pig and Human Intestinal Tract and Comparison with Caco-2 Cells

Vaessen, Stefan F.C., van Lipzig, Marola M.H., Pieters, Raymond H.H., Krul, Cyrille A.M., Wortelboer, Heleen M., van de Steeg, Evita

Journal:

Drug Metabolism and Disposition

Year:

2017

Language:

english

File:

PDF, 837 KB

english, 2017

6

Alternative Splicing in the Cytochrome P450 Superfamily Expands Protein Diversity to Augment Gene Function and Redirect Human Drug Metabolism

Annalora, Andrew J., Marcus, Craig B., Iversen, Patrick L.

Journal:

Drug Metabolism and Disposition

Year:

2017

Language:

english

File:

PDF, 1.58 MB

english, 2017

7

Cholic Acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice

Pan, Xian, Kent, Rebecca, Won, Kyoung-Jae, Jeong, Hyunyoung

Journal:

Drug Metabolism and Disposition

Year:

2017

Language:

english

File:

PDF, 2.35 MB

english, 2017

8

Quantitative Prediction of Human Renal Clearance and Drug-Drug Interactions of Organic Anion Transporter Substrates Using In Vitro Transport Data: A Relative Activity Factor Approach

Mathialagan, Sumathy, Piotrowski, Mary A., Tess, David A., Feng, Bo, Litchfield, John, Varma, Manthena V.

Journal:

Drug Metabolism and Disposition

Year:

2017

Language:

english

File:

PDF, 1.03 MB

english, 2017

9

Comparison between Radioanalysis and 19 F Nuclear Magnetic Resonance Spectroscopy in the Determination of Mass Balance, Metabolism, and Distribution of Pefloxacin

Hu, Haitao, Katyayan, Kishore Kumar, Czeskis, Boris A., Perkins, Everett J., Kulanthaivel, Palaniappan

Journal:

Drug Metabolism and Disposition

Year:

2017

Language:

english

File:

PDF, 944 KB

english, 2017

10

Correction to “p38 MAP Kinase Links CAR Activation and Inactivation in the Nucleus via Phosphorylation at Threonine 38 s”

Journal:

Drug Metabolism and Disposition

Year:

2017

File:

PDF, 51 KB

2017

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