Volume 29; Issue 2

Drug Metabolism and Pharmacokinetics

Volume 29; Issue 2

1

A Common Variant of Organic Anion Transporter 4 (OAT4/SLC22A11) Gene Is Associated with Renal Underexcretion Type Gout

Sakiyama, Masayuki, Matsuo, Hirotaka, Shimizu, Seiko, Nakashima, Hiroshi, Nakayama, Akiyoshi, Chiba, Toshinori, Naito, Mariko, Takada, Tappei, Suzuki, Hiroshi, Hamajima, Nobuyuki, Ichida, Kimiyoshi, S

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 116 KB

english, 2014

2

Characteristics of Pemetrexed Transport by Renal Basolateral Organic Anion Transporter hOAT3

Kurata, Tomohiko, Iwamoto, Takuya, Kawahara, Yuki, Okuda, Masahiro

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 1.05 MB

english, 2014

3

Effects of Peritoneal Dialysis on Pharmacotherapy: A Deductive Pharmacokinetic-model Approach to Predict Drug Concentration Profiles in Plasma and Peritoneal Fluid

Horiuchi, Mizuki, Moriyama, Soichiro, Takahata, Yukiko, Aiba, Tetsuya, Kurosaki, Yuji

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 1.33 MB

english, 2014

4

Development of a Pharmacokinetic Interaction Model for Co-administration of Simvastatin and Amlodipine

Son, Hankil, Lee, Donghwan, Lim, Lay Ahyoung, Jang, Seong Bok, Roh, Hyerang, Park, Kyungsoo

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 2.13 MB

english, 2014

5

Role of CYP3A in Isoniazid Metabolism In Vivo

Liu, Ke, Li, Feng, Lu, Jie, Gao, Zhiwei, Klaassen, Curtis D., Ma, Xiaochao

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 572 KB

english, 2014

6

Variability of Bioavailability and Intestinal Absorption Mechanisms of Metoprolol

Fukao, Miki, Ishida, Kazuya, Horie, Asuka, Taguchi, Masato, Nozawa, Takashi, Inoue, Hiroshi, Hashimoto, Yukiya

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 737 KB

english, 2014

7

Cocktail-substrate Approach-based High-throughput Assay for Evaluation of Direct and Time-dependent Inhibition of Multiple Cytochrome P450 Isoforms

Kozakai, Kazumasa, Yamada, Yasuhiro, Oshikata, Motoji, Kawase, Taiji, Suzuki, Etsuko, Haramaki, Yukari, Taniguchi, Hideki

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 1.76 MB

english, 2014

8

Identification and Characterization of Human UDP-glucuronosyltransferases Responsible for the Glucuronidation of Fraxetin

Xia, Yang-Liu, Liang, Si-Cheng, Zhu, Liang-Liang, Ge, Guang-Bo, He, Gui-Yuan, Ning, Jing, Lv, Xia, Ma, Xiao-Chi, Yang, Ling, Yang, Sheng-Li

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 1.10 MB

english, 2014

9

Single-dose Pharmacokinetics of the HCV Polymerase Inhibitor Mericitabine in Healthy Caucasian and Japanese Subjects

Washington, Carla, Moreira, Sebastian, Haznedar, Joshua, Goelzer, Petra, Chen, Ya-Chi

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 1.24 MB

english, 2014

10

Involvement of AP-1 and NF-κB in the Up-regulation of P-gp in Vinblastine Resistant Caco-2 Cells

Chen, Qiuxia, Bian, Yicong, Zeng, Su

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 897 KB

english, 2014

11

Functional Analysis of Purine Nucleoside Phosphorylase as a Key Enzyme in Ribavirin Metabolism

Furihata, Tomomi, Kishida, Satoshi, Sugiura, Hanae, Kamiichi, Atsuko, Iikura, Minami, Chiba, Kan

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 736 KB

english, 2014

12

Drug-induced Liver Toxicity Studies: Research into Human Metabolites Clarifies Their Role in Drug Development

Yamazaki, Hiroshi

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 47 KB

english, 2014

13

Differences in the Glucuronidation of Resveratrol and Pterostilbene: Altered Enzyme Specificity and Potential Gender Differences

Dellinger, Ryan W., Gomez Garcia, Angela M., Meyskens, Frank L.

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 1.72 MB

english, 2014

14

Sex Differences in the Constitutive Gene Expression of Sulfotransferases and UDP-glucuronosyltransferases in the Pig Liver: Androgen-mediated Regulation

Kojima, Misaki, Degawa, Masakuni

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 1.39 MB

english, 2014

15

Association of the CYP2B6 c.516G>T Polymorphism with High Blood Propofol Concentrations in Women from Northern Greece

Mastrogianni, Orthodoxia, Gbandi, Emma, Orphanidis, Amvrosios, Raikos, Nikolaos, Goutziomitrou, Evangelia, Kolibianakis, Efstratios M., Tarlatzis, Basil C., Goulas, Antonis

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 301 KB

english, 2014

16

Glucuronidation and Subsequent Biliary Excretion of Mycophenolic Acid in Rat Sandwich-cultured Hepatocytes

Tetsuka, Kazuhiro, Gerst, Nicolas, Tamura, Kouichi, Masters, Jeffrey N.

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 879 KB

english, 2014

17

Deeper Insight into the Reducing Biotransformation of Bupropion in the Human Liver

Skarydova, Lucie, Tomanova, Radana, Havlikova, Lucie, Stambergova, Hana, Solich, Petr, Wsol, Vladimir

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 1.19 MB

english, 2014

18

Assessing the Impact of HER2 Status on the Antitumor Activity of an HSP90 Inhibitor in Human Tumor Xenograft Mice Using Pharmacokinetic–Pharmacodynamic Modeling

Saitoh, Ryoichi, Nagayasu, Miho, Shibahara, Norihito, Ono, Naomi, Suda, Atsushi, Kato, Motohiro, Ishigai, Masaki

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 2.03 MB

english, 2014

19

Utility of Cryopreserved Hepatocytes Suspended in Serum to Predict Hepatic Clearance in Dogs and Monkeys

Shibata, Yoshihiro, Kuze, Jiro, Chiba, Masato

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 1005 KB

english, 2014

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