Volume 187

European Journal of Medicinal Chemistry

Volume 187

1

Apigenin-rivastigmine hybrids as multi-target-directed liagnds for the treatment of Alzheimer’s disease

Sang, Zhipei, Wang, Keren, Shi, Jian, Cheng, Xinfeng, Zhu, Gaofeng, Wei, Rongrui, Ma, Qinge, Yu, Lintao, Zhao, Yiyang, Tan, Zhenghuai, Liu, Wenmin

Journal:

European Journal of Medicinal Chemistry

Year:

2020

Language:

english

File:

PDF, 5.09 MB

english, 2020

2

Synthesis and discovery of triazolo-pyridazine-6-yl-substituted piperazines as effective anti-diabetic drugs; evaluated over dipeptidyl peptidase-4 inhibition mechanism and insulinotropic activities

Bindu, B., Vijayalakshmi, S., Manikandan, A.

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 814 KB

2020

3

Therapeutic significance of β-glucuronidase activity and its inhibitors: A review

Awolade, Paul, Cele, Nosipho, Kerru, Nagaraju, Gummidi, Lalitha, Oluwakemi, Ebenezer, Singh, Parvesh

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 3.72 MB

2020

4

Repurposing a polymer precursor: Synthesis and in vitro medicinal potential of ferrocenyl 1,3-benzoxazine derivatives

Mbaba, Mziyanda, Dingle, Laura M.K., Cash, Devon, Mare, Jo-Anne de la, Laming, Dustin, Taylor, Dale, Hoppe, Heinrich C., Edkins, Adrienne L., Khanye, Setshaba D.

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 2.04 MB

2020

5

Synthesis of certain benzothieno[3,2-d]pyrimidine derivatives as a selective SIRT2 inhibitors

Khalil, Nadia A., Ahmed, Eman M., Zaher, Ashraf F., El-Zoghbi, Mona S., Sobh, Eman A.

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 997 KB

2020

6

Synthesis and structure-activity relationship studies of α-naphthoflavone derivatives as CYP1B1 inhibitors

Dong, Jinyun, Wang, Zengtao, Cui, Jiahua, Meng, Qingqing, Li, Shaoshun

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.29 MB

2020

7

Microtubule inhibitors containing immunostimulatory agents promote cancer immunochemotherapy by inhibiting tubulin polymerization and tryptophan-2,3-dioxygenase

Hua, Shixian, Chen, Feihong, Gou, Shaohua

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 23.31 MB

2020

8

Novel 2, 5-diketopiperazine derivatives as potent selective histone deacetylase 6 inhibitors: Rational design, synthesis and antiproliferative activity

Chen, Xin, Chen, Xinyang, Steimbach, Raphael R., Wu, Tong, Li, Hongmei, Dan, Wenjia, Shi, Peidong, Cao, Chenyu, Li, Ding, Miller, Aubry K., Qiu, Zhixia, Gao, Jinming, Zhu, Yong

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 904 KB

2020

9

Discovery of 4,6-pyrimidinediamine derivatives as novel dual EGFR/FGFR inhibitors aimed EGFR/FGFR1-positive NSCLC

Xie, Zixin, Wu, Kaiqi, Wang, Yuexuan, Pan, Yaqian, Chen, Bo, Cheng, Donghua, Pan, Suwei, Guo, Taoning, Du, Xuze, Fang, Longcheng, Wang, Xuebao, Ye, Faqing

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 4.46 MB

2020

10

Discovery of coumarin-based selective aldehyde dehydrogenase 1A1 inhibitors with glucose metabolism improving activity

Liang, Dailin, Fan, Yazhou, Yang, Zhou, Zhang, Zhenguo, Liu, Meiyang, Liu, Li, Jiang, Cheng

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 659 KB

2020

11

Identification of new potent A1 adenosine receptor antagonists using a multistage virtual screening approach

Wei, Yu, Wang, Mukuo, Li, Yang, Hong, Zhangyong, Li, Dongmei, Lin, Jianping

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.42 MB

2020

12

Discovery of novel 1,2,3-triazole oseltamivir derivatives as potent influenza neuraminidase inhibitors targeting the 430-cavity

Ju, Han, Xiu, Siyu, Ding, Xiao, Shang, Min, Jia, RuiFang, Huang, Bing, Zhan, Peng, Liu, Xinyong

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 922 KB

2020

13

Discovery of novel tRNA-amino acid dual-site inhibitors against threonyl-tRNA synthetase by fragment-based target hopping

Guo, Junsong, Chen, Bingyi, Yu, Ying, Cheng, Bao, Cheng, Yanfang, Ju, Yingchen, Gu, Qiong, Xu, Jun, Zhou, Huihao

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 3.71 MB

2020

14

Development of selective mono or dual PROTAC degrader probe of CDK isoforms

Zhou, Fei, Chen, Luyu, Cao, Chaoguo, Yu, Jiang, Luo, Xiaojiao, Zhou, Peiting, Zhao, Lifeng, Du, Wu, Cheng, Jijun, Xie, Yongmei, Chen, Yuanwei

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 6.55 MB

2020

15

Design, synthesis, and validation of novel nitrogen-based chalcone analogs against triple negative breast cancer

Elkhalifa, Dana, Siddique, Abu Bakar, Qusa, Mohammed, Cyprian, Farhan S., El Sayed, Khalid, Alali, Feras, Al Moustafa, Ala-Eddin, Khalil, Ashraf

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 5.89 MB

2020

16

Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer

Tokay, Esra, Güngör, Tuğba, Hacıoğlu, Nelin, Önder, Ferah Cömert, Gülhan, Ünzile Güven, Tok, Tuğba Taşkın, Çelik, Ayhan, Ay, Mehmet, Köçkar, Feray

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.84 MB

2020

17

Identification of 6′-β-fluoro-homoaristeromycin as a potent inhibitor of chikungunya virus replication

Shin, Young Sup, Jarhad, Dnyandev B., Jang, Min Hwan, Kovacikova, Kristina, Kim, Gyudong, Yoon, Ji-seong, Kim, Hong-Rae, Hyun, Young Eum, Tipnis, Amol S., Chang, Tong-Shin, van Hemert, Martijn J., Jeo

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 632 KB

2020

18

Synthesis and anti-Mycobacterium tuberculosis activity of imide-β-carboline and carbomethoxy-β-carboline derivatives

Lopes-Ortiz, Mariana Aparecida, Panice, Manuela Ribeiro, Borges de Melo, Eduardo, Ataide Martins, João Paulo, Baldin, Vanessa Pietrowski, Agostinho Pires, Cláudia Terêncio, Caleffi-Ferracioli, Katiany

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.86 MB

2020

19

Usnic acid derivatives as tau-aggregation and neuroinflammation inhibitors

Shi, Cun-Jian, Peng, Wan, Zhao, Jin-Hua, Yang, Hua-Li, Qu, Lai-Liang, Wang, Cheng, Kong, Ling-Yi, Wang, Xiao-Bing

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.16 MB

2020

20

Fluorine-substituted tetracationic ABAB-phthalocyanines for efficient photodynamic inactivation of Gram-positive and Gram-negative bacteria

Revuelta-Maza, Miguel Á., González-Jiménez, Patricia, Hally, Cormac, Agut, Montserrat, Nonell, Santi, de la Torre, Gema, Torres, Tomás

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.21 MB

2020

21

Design and synthesis of novel ferrocene-quinoline conjugates and evaluation of their electrochemical and antiplasmodium properties

Minić, Aleksandra, Van de Walle, Tim, Van Hecke, Kristof, Combrinck, Jill, Smith, Peter J., Chibale, Kelly, D’hooghe, Matthias

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.04 MB

2020

22

Novel linked butanolide dimer compounds increase adiponectin production during adipogenesis in human mesenchymal stem cells through peroxisome proliferator-activated receptor γ modulation

Ahn, Sungjin, Basavana Gowda, M.K., Lee, Moonyoung, Masagalli, Jagadeesh Nagarajappa, Mailar, Karabasappa, Choi, Won Jun, Noh, Minsoo

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 9.01 MB

2020

23

The discovery of novel indazole derivatives as tubulin colchicine site binding agents that displayed potent antitumor activity both in vitro and in vivo

Cui, Ying-Jie, Ma, Chen-Chen, Zhang, Cheng-Mei, Tang, Long-Qian, Liu, Zhao-Peng

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 2.49 MB

2020

24

Development of cell-permeable peptide-based PROTACs targeting estrogen receptor α

Dai, Yuxuan, Yue, Na, Gong, Junni, Liu, Chunxia, Li, Qifei, Zhou, Jiaqi, Huang, Wenlong, Qian, Hai

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 2.39 MB

2020

25

Synthesis and anti-cancer activity studies of dammarane-type triterpenoid derivatives

Ma, Lu, Wang, Xude, Li, Wei, Miao, Dongyu, Li, Yan, Lu, Jincai, Zhao, Yuqing

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 2.25 MB

2020

26

Antitumor agents 7. Synthesis, antiproliferative activity and molecular modeling of new l-lysine-conjugated pyridophenoxazinones as potent DNA-binding ligands and topoisomerase IIα inhibitors

Pedatella, Silvana, Cerchia, Carmen, Manfra, Michele, Cioce, Anna, Bolognese, Adele, Lavecchia, Antonio

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 2.77 MB

2020

27

Apigenin-rivastigmine hybrids as multi-target-directed liagnds for the treatment of Alzheimer’s disease

Sang, Zhipei, Wang, Keren, Shi, Jian, Cheng, Xinfeng, Zhu, Gaofeng, Wei, Rongrui, Ma, Qinge, Yu, Lintao, Zhao, Yiyang, Tan, Zhenghuai, Liu, Wenmin

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 5.09 MB

2020

28

Hydrogen sulfide releasing oridonin derivatives induce apoptosis through extrinsic and intrinsic pathways

Li, Haonan, Mu, Jiahui, Sun, Jianan, Xu, Shengtao, Liu, Weiwei, Xu, Fanxing, Li, Zhanlin, Xu, Jinyi, Hua, Huiming, Li, Dahong

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 4.22 MB

2020

29

Discovery of novel N-sulfonamide-tetrahydroquinolines as potent retinoic acid receptor-related orphan receptor γt inverse agonists for the treatment of autoimmune diseases

Sun, Nannan, Ma, Xiaojun, Zhou, Kaifeng, Zhu, Chen, Cao, Zhonglian, Wang, Yonghui, Xu, Jun, Fu, Wei

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 3.63 MB

2020

30

Editorial Board

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 45 KB

2020

31

Graphical abstract TOC

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 277 KB

2020

32

Graphical abstract TOC

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 279 KB

2020

33

Graphical abstract TOC continued

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 2.62 MB

2020