Volume 188

European Journal of Medicinal Chemistry

Volume 188

1

N-thiadiazole-4-hydroxy-2-quinolone-3-carboxamides bearing heteroaromatic rings as novel antibacterial agents: Design, synthesis, biological evaluation and target identification

Xue, Wenjie, Li, Xueyao, Ma, Guixing, Zhang, Hongmin, Chen, Ya, Kirchmair, Johannes, Xia, Jie, Wu, Song

Journal:

European Journal of Medicinal Chemistry

Year:

2020

Language:

english

File:

PDF, 991 KB

english, 2020

2

N-thiadiazole-4-hydroxy-2-quinolone-3-carboxamides bearing heteroaromatic rings as novel antibacterial agents: Design, synthesis, biological evaluation and target identification

Xue, Wenjie, Li, Xueyao, Ma, Guixing, Zhang, Hongmin, Chen, Ya, Kirchmair, Johannes, Xia, Jie, Wu, Song

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 991 KB

2020

3

Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice

Zaręba, Paula, Gryzło, Beata, Malawska, Katarzyna, Sałat, Kinga, Höfner, Georg C., Nowaczyk, Alicja, Fijałkowski, Łukasz, Rapacz, Anna, Podkowa, Adrian, Furgała, Anna, Żmudzki, Paweł, Wanner, Klaus T.

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 3.94 MB

2020

4

Quinolizidine alkaloids derivatives from Sophora alopecuroides Linn: Bioactivities, structure-activity relationships and preliminary molecular mechanisms

Li, Yang, Wang, Guan, Liu, Jie, Ouyang, Liang

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 2.98 MB

2020

5

Design, synthesis and biological evaluation of vincamine derivatives as potential pancreatic β-cells protective agents for the treatment of type 2 diabetes mellitus

Wang, Junwei, Lv, Xue, Xu, Jiawen, Liu, Xinpeng, Du, Te, Sun, Guanglong, Chen, Jing, Shen, Xu, Wang, Jiaying, Hu, Lihong

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 3.34 MB

2020

6

Design, synthesis and biological evaluation of indole-2-carboxylic acid derivatives as IDO1/TDO dual inhibitors

Cui, Guonan, Lai, Fangfang, Wang, Xiaoyu, Chen, Xiaoguang, Xu, Bailing

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.47 MB

2020

7

Design, synthesis and biological evaluation of quinoxaline compounds as anti-HIV agents targeting reverse transcriptase enzyme

Fabian, Lucas, Taverna Porro, Marisa, Gómez, Natalia, Salvatori, Melina, Turk, Gabriela, Estrin, Darío, Moglioni, Albertina

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.01 MB

2020

8

Minor chemical modifications of the aminosteroid derivative RM-581 lead to major impact on its anticancer activity, metabolic stability and aqueous solubility

Maltais, René, Perreault, Martin, Roy, Jenny, Poirier, Donald

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 783 KB

2020

9

A 18β-glycyrrhetinic acid conjugate with Vorinostat degrades HDAC3 and HDAC6 with improved antitumor effects

Huang, Min, Xie, Xiaorui, Gong, Ping, Wei, Yunfei, Du, Heliang, Xu, Yuanbo, Xu, Qihao, Jing, Yongkui, Zhao, Linxiang

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 4.19 MB

2020

10

Semisynthesis and biological evaluation of amidochelocardin derivatives as broad-spectrum antibiotics

Grandclaudon, Charlotte, Birudukota, N.V. Suryanarayana, Elgaher, Walid A.M., Jumde, Ravindra P., Yahiaoui, Samir, Arisetti, Nanaji, Hennessen, Fabienne, Hüttel, Stephan, Stadler, Marc, Herrmann, Jenn

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 815 KB

2020

11

Novel pleconaril derivatives: Influence of substituents in the isoxazole and phenyl rings on the antiviral activity against enteroviruses

Egorova, Anna, Kazakova, Elena, Jahn, Birgit, Ekins, Sean, Makarov, Vadim, Schmidtke, Michaela

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.34 MB

2020

12

Synthesis and antitumor activities investigation of a C-nucleoside analogue of ribavirin

Sabat, Nazarii, Migianu-Griffoni, Evelyne, Tudela, Tiffany, Lecouvey, Marc, Kellouche, Sabrina, Carreiras, Franck, Gallier, Florian, Uziel, Jacques, Lubin-Germain, Nadège

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.39 MB

2020

13

Novel benzimidazole-acrylonitrile hybrids and their derivatives: Design, synthesis and antimycobacterial activity

Sirim, Mustafa Mert, Krishna, Vagolu Siva, Sriram, Dharmarajan, Unsal Tan, Oya

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 534 KB

2020

14

Discovery of 6′-chloro-N-methyl-5’-(phenylsulfonamido)-[3,3′-bipyridine]-5-carboxamide (CHMFL-PI4K-127) as a novel Plasmodium falciparum PI(4)K inhibitor with potent antimalarial activity against both blood and liver stages of Plasmodium

Liang, Xiaofei, Jiang, Zongru, Huang, Zhenghui, Li, Feng, Chen, Cheng, Hu, Chen, Wang, Wenliang, Hu, Zhenquan, Liu, Qingwang, Wang, Beilei, Wang, Li, Qi, Ziping, Liu, Jing, Jiang, Lubin, Liu, Qingsong

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 2.99 MB

2020

15

Pyrrolo and pyrrolopyrimidine sulfonamides act as cytotoxic agents in hypoxia via inhibition of transmembrane carbonic anhydrases

Khalil, Omneya M., Kamal, Aliaa M., Bua, Silvia, El Sayed Teba, Heba, Nissan, Yassin M., Supuran, Claudiu T.

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.53 MB

2020

16

The optimization of xanthine derivatives leading to HBK001 hydrochloride as a potent dual ligand targeting DPP-IV and GPR119

Li, Gang, Meng, Bingxu, Yuan, Baokun, Huan, Yi, Zhou, Tian, Jiang, Qian, Lei, Lei, Sheng, Li, Wang, Weiping, Gong, Ningbo, Lu, Yang, Ma, Chen, Li, Yan, Shen, Zhufang, Huang, Haihong

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.26 MB

2020

17

Biological evaluation and chemoproteomics reveal potential antibacterial targets of a cajaninstilbene-acid analogue

Lu, Kuo, Hou, Wen, Xu, Xiao-Fang, Chen, Qi, Li, Zhengqiu, Lin, Jing, Chen, Wei-Min

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 961 KB

2020

18

Discovery of novel pyrido-pyrrolidine hybrid compounds as alpha-glucosidase inhibitors and alternative agent for control of type 1 diabetes

Luthra, Tania, Banothu, Venkanna, Adepally, Uma, Kumar, Krishna, M, Swathi, Chakrabarti, Saikat, Maddi, Srinivas R., Sen, Subhabrata

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.43 MB

2020

19

Therapeutic potentials of curcumin in the treatment of glioblstoma

Shabaninejad, Zahra, Pourhanifeh, Mohammad Hossein, Movahedpour, Ahmad, Mottaghi, Reza, Nickdasti, Ali, Mortezapour, Erfan, Shafiee, Alimohammad, Hajighadimi, Sarah, Moradizarmehri, Sanaz, Sadeghian,

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.40 MB

2020

20

Novel modified leucine and phenylalanine dipeptides modulate viability and attachment of cancer cells

Jorda, Radek, Magar, Pratibha, Hendrychová, Denisa, Pauk, Karel, Dibuš, Michal, Pilařová, Eliška, Imramovský, Aleš, Kryštof, Vladimír

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.28 MB

2020

21

Graphical abstract TOC

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 368 KB

2020

22

Editorial Board

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 47 KB

2020

23

Graphical abstract TOC

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 278 KB

2020

24

Graphical abstract TOC continued

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.83 MB

2020

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