Volume 80

European Journal of Medicinal Chemistry

Volume 80

1

Design and synthesis of the novel DNA topoisomerase II inhibitors: Esterification and amination substituted 4′-demethylepipodophyllotoxin derivates exhibiting anti-tumor activity by activating ATM/ATR signaling pathways

Xiao, Li, Zhao, Wei, Li, Hong-Mei, Wan, Duan-Ji, Li, Dong-Sheng, Chen, Tao, Tang, Ya-Jie

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 4.60 MB

english, 2014

2

Anticonvulsant evaluation of clubbed indole-1,2,4-triazine derivatives: A synthetic approach

Ahuja, Priya, Siddiqui, Nadeem

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 4.88 MB

english, 2014

3

Multifunctional nanoliposomes with curcumin–lipid derivative and brain targeting functionality with potential applications for Alzheimer disease

Mourtas, Spyridon, Lazar, Adina N., Markoutsa, Eleni, Duyckaerts, Charles, Antimisiaris, Sophia G.

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.28 MB

english, 2014

4

Synthesis, biological evaluation, molecular docking and theoretical evaluation of ADMET properties of nepodin and chrysophanol derivatives as potential cyclooxygenase (COX-1, COX-2) inhibitors

Grover, Jagdeep, Kumar, Vivek, Singh, Vikram, Bairwa, Khemraj, Sobhia, M. Elizabeth, Jachak, Sanjay M.

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.37 MB

english, 2014

5

Oxazolidinone derivatives: Cytoxazone–Linezolid hybrids induces apoptosis and senescence in DU145 prostate cancer cells

Naresh, Annavareddi, Venkateswara Rao, Maddimsetti, Kotapalli, Sudha Sravanti, Ummanni, Ramesh, Venkateswara Rao, Batchu

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 13.31 MB

english, 2014

6

DNA fastening and ripping actions of novel Knoevenagel condensed dicarboxylic acid complexes in antitumor journey

Raman, Natarajan, Pravin, Narayanaperumal

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.22 MB

english, 2014

7

DNA condensation by copper(II) complexes and their anti-proliferative effect on cancerous and normal fibroblast cells

Rajalakshmi, Subramaniyam, Kiran, Manikantan Syamala, Nair, Balachandran Unni

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 9.10 MB

english, 2014

8

Synthesis, cytotoxicity for mimics of catalase: Inhibitors of lactate dehydrogenase and hypoxia inducible factor

Xue, Juan-Juan, Chen, Qiu-Yun, Kong, Meng-Yun, Zhu, Chun-Yin, Gen, Zhi-Rong, Wang, Zhi-Lin

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 937 KB

english, 2014

9

Synthesis and structure–activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors

Reichelt, Andreas, Bailis, Julie M., Bartberger, Michael D., Yao, Guomin, Shu, Hong, Kaller, Matthew R., Allen, John G., Weidner, Margaret F., Keegan, Kathleen S., Dao, Jennifer H.

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 6.26 MB

english, 2014

10

Towards the development of 5-HT7 ligands combining serotonin-like and arylpiperazine moieties

Spadoni, Gilberto, Bedini, Annalida, Bartolucci, Silvia, Pala, Daniele, Mor, Marco, Riccioni, Teresa, Borsini, Franco, Cabri, Walter, Celona, Diana, Marzi, Mauro, Tarzia, Giorgio, Rivara, Silvia, Mine

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.58 MB

english, 2014

11

Synthesis, cytotoxic study and docking based multidrug resistance modulator potential analysis of 2-(9-oxoacridin-10(9H)-yl)-N-phenyl acetamides

Kumar, Rajesh, Kaur, Maninder, Bahia, Malkeet Singh, Silakari, Om

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.32 MB

english, 2014

12

Synthesis of 5-substituted-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one analogs and their biological evaluation as anticancer agents: mTOR inhibitors

Reddy, G. Lakshma, Guru, Santosh Kumar, Srinivas, M., Pathania, Anup Singh, Mahajan, Priya, Nargotra, Amit, Bhushan, Shashi, Vishwakarma, Ram A., Sawant, Sanghapal D.

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 6.10 MB

english, 2014

13

Synthesis of stable aromatic and heteroaromatic sulfonyl-amidoximes and evaluation of their antioxidant and lipid peroxidation activity

Doulou, Ismini, Kontogiorgis, Christos, Koumbis, Alexandros E., Evgenidou, Eleni, Hadjipavlou-Litina, Dimitra, Fylaktakidou, Konstantina C.

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 489 KB

english, 2014

14

Discovery of dihydroxylated 2,4-diphenyl-6-thiophen-2-yl-pyridine as a non-intercalative DNA-binding topoisomerase II-specific catalytic inhibitor

Jun, Kyu-Yeon, Kwon, Hanbyeol, Park, So-Eun, Lee, Eunyoung, Karki, Radha, Thapa, Pritam, Lee, Jun-Ho, Lee, Eung-Seok, Kwon, Youngjoo

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.25 MB

english, 2014

15

Synthesis of novel 1,2,3-triazole substituted-N-alkyl/aryl nitrone derivatives, their anti-inflammatory and anticancer activity

Sambasiva Rao, P., Kurumurthy, C., Veeraswamy, B., Santhosh Kumar, G., Poornachandra, Y., Ganesh Kumar, C., Vasamsetti, Sathish Babu, Kotamraju, Srigiridhar, Narsaiah, B.

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 425 KB

english, 2014

16

Synthesis of amino acid appended indoles: Appreciable anti-fungal activity and inhibition of ergosterol biosynthesis as their probable mode of action

Pooja,, Prasher, Parteek, Singh, Palwinder, Pawar, Kalpana, Vikramdeo, Kunwar Somesh, Mondal, Neelima, Komath, Sneha Sudha

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.05 MB

english, 2014

17

Enantiopure bifunctional chelators for copper radiopharmaceuticals – Does chirality matter in radiotracer design?

Singh, Ajay N., Dakanali, Marianna, Hao, Guiyang, Ramezani, Saleh, Kumar, Amit, Sun, Xiankai

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 927 KB

english, 2014

18

In vitro and in vivo evaluation of the antidiabetic activity of ursolic acid derivatives

Wu, Pan-Pan, Zhang, Kun, Lu, Yu-Jing, He, Ping, Zhao, Su-Qing

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.59 MB

english, 2014

19

Synthesis of new N-acryl-1-amino-2-phenylethanol and N-acyl-1-amino-3-aryloxypropanols and evaluation of their antihyperlipidemic, LDL-oxidation and antioxidant activity

Sarkar, Satinath, Sonkar, Ravi, Bhatia, Gitika, Tadigoppula, Narender

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.04 MB

english, 2014

20

Synthesis, molecular structure, DNA-binding, cytotoxicity, apoptosis and antioxidant activity of compounds containing aryloxazole

Wang, Xiu-Zhen, Jiang, Guang-Bin, Lin, Gan-Jian, Huang, Hong-Liang, Xie, Yang-Yin, Liu, Yun-Jun

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.79 MB

english, 2014

21

Synthesis of N-benzenesulfonamide-1H-pyrazoles bearing arylsulfonyl moiety: Novel celecoxib analogs as potent anti-inflammatory agents

Abdel-Aziz, Hatem A., Al-Rashood, Khalid A., ElTahir, Kamal Eldin H., Suddek, Ghada M.

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 712 KB

english, 2014

22

Polycyclic propargylamine and acetylene derivatives as multifunctional neuroprotective agents

Zindo, Frank T., Barber, Quinton R., Joubert, Jacques, Bergh, Jacobus J., Petzer, Jacobus P., Malan, Sarel F.

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.08 MB

english, 2014

23

Quinazolines: New horizons in anticonvulsant therapy

Ugale, Vinod G., Bari, Sanjay B.

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 8.97 MB

english, 2014

24

Synthesis and biological evaluation of some new pyrazoline substituted benzenesulfonylurea/thiourea derivatives as anti-hyperglycaemic agents and aldose reductase inhibitors

Ovais, Syed, Pushpalatha, H., Reddy, G. Bhanuprakash, Rathore, Pooja, Bashir, Rafia, Yaseen, Shafiya, Dheyaa, Alhamza, Yaseen, Raed, Tanwar, Omprakash, Akthar, Mymoona, Samim, Mohammed, Javed, Kalim

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.11 MB

english, 2014

25

Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity

Carrasco, Marta P., Newton, Ana S., Gonçalves, Lídia, Góis, Ana, Machado, Marta, Gut, Jiri, Nogueira, Fátima, Hänscheid, Thomas, Guedes, Rita C., dos Santos, Daniel J.V.A., Rosenthal, Philip J., Morei

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 712 KB

english, 2014

26

Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease

Wang, Li, Esteban, Gerard, Ojima, Masaki, Bautista-Aguilera, Oscar M., Inokuchi, Tsutomu, Moraleda, Ignacio, Iriepa, Isabel, Samadi, Abdelouahid, Youdim, Moussa B.H., Romero, Alejandro, Soriano, Elena

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.96 MB

english, 2014

27

A one-pot approach to bio-synthesize globotriose and its derivatives from simpler substrates

Zhao, Xueer, Zou, Yang, Xue, Mengyang, Ma, Zhongrui, Wang, Shuaishuai, Wang, Peng George, Chen, Min

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 625 KB

english, 2014

28

Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: Enzyme and cellular studies

Carradori, Simone, Rotili, Dante, De Monte, Celeste, Lenoci, Alessia, D'Ascenzio, Melissa, Rodriguez, Veronica, Filetici, Patrizia, Miceli, Marco, Nebbioso, Angela, Altucci, Lucia, Secci, Daniela, Mai

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.48 MB

english, 2014

29

Ruthenium(II) complexes as apoptosis inducers by stabilizing c-myc G-quadruplex DNA

Zhang, Zhao, Wu, Qiong, Wu, Xiao-Hui, Sun, Fen-Yong, Chen, Lan-Mei, Chen, Jin-Chan, Yang, Shu-Ling, Mei, Wen-Jie

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.25 MB

english, 2014

30

Structure–activity relationships studies of quinoxalinone derivatives as aldose reductase inhibitors

Hussain, Saghir, Parveen, Shagufta, Hao, Xin, Zhang, Shuzhen, Wang, Wei, Qin, Xiangyu, Yang, Yanchun, Chen, Xin, Zhu, Shaojuan, Zhu, Changjin, Ma, Bing

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.20 MB

english, 2014

31

Localization and interaction of hydroxyflavones with lipid bilayer model membranes: A study using DSC and multinuclear NMR

Sinha, Ragini, Joshi, Akshada, Joshi, Urmila J., Srivastava, Sudha, Govil, Girjesh

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.63 MB

english, 2014

32

Investigation of amino acid conjugates of (S)-1-[1-(4-aminobenzoyl)-2,3-dihydro-1H-indol-6-sulfonyl]-4-phenyl-imidazolidin-2-one (DW2282) as water soluble anticancer prodrugs

Lee, Ki-Cheul, Venkateswararao, Eeda, Sharma, Vinay Kumar, Jung, Sang-Hun

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 718 KB

english, 2014

33

New 2H-chromene-3-carboxamide derivatives: Design, synthesis and use as inhibitors of hMAO

Pan, Zhi-Xiang, He, Xu, Chen, Yan-Yan, Tang, Wen-Jian, Shi, Jing-Bo, Tang, Yu-Lan, Song, Bao-An, Li, Jun, Liu, Xin-Hua

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 904 KB

english, 2014

34

Synthesis and optimization of an original V-shaped collection of 4-7-disubstituted Pyrido[3,2-d]pyrimidines as CDK5 and DYRK1A inhibitors

Dehbi, Oussama, Tikad, Abdellatif, Bourg, Stéphane, Bonnet, Pascal, Lozach, Olivier, Meijer, Laurent, Aadil, Mina, Akssira, Mohammed, Guillaumet, Gérald, Routier, Sylvain

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.79 MB

english, 2014

35

Design, synthesis, and evaluation of novel fluoroquinolone–flavonoid hybrids as potent antibiotics against drug-resistant microorganisms

Xiao, Zhu-Ping, Wang, Xu-Dong, Wang, Peng-Fei, Zhou, Yin, Zhang, Jing-Wen, Zhang, Lei, Zhou, Jiao, Zhou, Sha-Sha, Ouyang, Hui, Lin, Xiao-Yi, Mustapa, Manzira, Reyinbaike, Asaimuguli, Zhu, Hai-Liang

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.63 MB

english, 2014

36

New indolylarylsulfones as highly potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors

Famiglini, Valeria, La Regina, Giuseppe, Coluccia, Antonio, Pelliccia, Sveva, Brancale, Andrea, Maga, Giovanni, Crespan, Emmanuele, Badia, Roger, Clotet, Bonaventura, Esté, José A., Cirilli, Roberto,

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.23 MB

english, 2014

37

Benzofurazan derivatives as antifungal agents against phytopathogenic fungi

Wang, Lili, Zhang, Ying-Ying, Wang, Lei, Liu, Feng-you, Cao, Ling-Ling, Yang, Jing, Qiao, Chunhua, Ye, Yonghao

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.09 MB

english, 2014

38

Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: From potassium channel openers to calcium entry blockers?

Florence, Xavier, Desvaux, Vincent, Goffin, Eric, de Tullio, Pascal, Pirotte, Bernard, Lebrun, Philippe

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 792 KB

english, 2014

39

Exploration of the dihydropyrimidine scaffold for the development of new potential anti-inflammatory agents blocking prostaglandin E2 synthase-1 enzyme (mPGES-1)

Lauro, Gianluigi, Strocchia, Maria, Terracciano, Stefania, Bruno, Ines, Fischer, Katrin, Pergola, Carlo, Werz, Oliver, Riccio, Raffaele, Bifulco, Giuseppe

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.33 MB

english, 2014

40

Synthesis and preliminary biological evaluation of 1,2,3-triazole-Jaspine B hybrids as potential cytotoxic agents

Xu, Jin-Mei, Zhang, En, Shi, Xiao-Jing, Wang, Yan-Chao, Yu, Bin, Jiao, Wei-Wei, Guo, Ya-Zhuo, Liu, Hong-Min

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.05 MB

english, 2014

41

Discovery of novel type II c-Met inhibitors based on BMS-777607

Zhang, Wei, Ai, Jing, Shi, Dakuo, Peng, Xia, Ji, Yinchun, Liu, Jian, Geng, Meiyu, Li, Yingxia

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.94 MB

english, 2014

42

Discovery of novel diarylpyrimidines as potent HIV NNRTIs via a structure-guided core-refining approach

Li, Xiao, Chen, Wenmin, Tian, Ye, Liu, Huiqing, Zhan, Peng, De Clercq, Erik, Pannecouque, Christophe, Balzarini, Jan, Liu, Xinyong

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.02 MB

english, 2014

43

Design, synthesis, and biological evaluation of novel FAK scaffold inhibitors targeting the FAK–VEGFR3 protein–protein interaction

Gogate, Priyanka N., Ethirajan, Manivannan, Kurenova, Elena V., Magis, Andrew T., Pandey, Ravindra K., Cance, William G.

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 6.37 MB

english, 2014

44

Editorial board

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 49 KB

english, 2014

45

PET radiotracer [18F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: Preliminary investigation

Perrone, Maria Grazia, Malerba, Paola, Uddin, Md. Jashim, Vitale, Paola, Panella, Andrea, Crews, Brenda C., Daniel, Cristina K., Ghebreselasie, Kebreab, Nickels, Mike, Tantawy, Mohammed N., Manning, H

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 861 KB

english, 2014

46

Unraveling the structure–activity relationship of tomatidine, a steroid alkaloid with unique antibiotic properties against persistent forms of Staphylococcus aureus

Chagnon, Félix, Guay, Isabelle, Bonin, Marc-André, Mitchell, Gabriel, Bouarab, Kamal, Malouin, François, Marsault, Éric

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.05 MB

english, 2014

47

B-ring modified aurones as promising allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase

Meguellati, Amel, Ahmed-Belkacem, Abdelhakim, Yi, Wei, Haudecoeur, Romain, Crouillère, Marie, Brillet, Rozenn, Pawlotsky, Jean-Michel, Boumendjel, Ahcène, Peuchmaur, Marine

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.59 MB

english, 2014

48

Graphical contents list

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 4.11 MB

english, 2014

49

Synthesis, antiproliferative activity and DNA binding properties of novel 5-Aminobenzimidazo[1,2-a]quinoline-6-carbonitriles

Perin, Nataša, Nhili, Raja, Ester, Katja, Laine, William, Karminski-Zamola, Grace, Kralj, Marijeta, David-Cordonnier, Marie-Hélène, Hranjec, Marijana

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.15 MB

english, 2014

50

Dual inhibition of the α-glucosidase and butyrylcholinesterase studied by Molecular Field Topology Analysis

Jabeen, Farukh, Oliferenko, Polina V., Oliferenko, Alexander A., Pillai, Girinath G., Ansari, Farzana Latif, Hall, C. Dennis, Katritzky, Alan R.

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.06 MB

english, 2014

51

Lead optimization of dual tubulin and Hsp27 inhibitors

Zhong, Bo, Lama, Rati, Kulman, Daniel G., Li, Bibo, Su, Bin

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.21 MB

english, 2014

52

Semisynthesis and in vitro cytotoxic evaluation of new analogues of 1-O-acetylbritannilactone, a sesquiterpene from Inula britannica

Dong, Shuai, Tang, Jiang-Jiang, Zhang, Cheng-Chen, Tian, Jun-Mian, Guo, Jun-Tao, Zhang, Qiang, Li, He, Gao, Jin-Ming

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.58 MB

english, 2014

53

Optimization of 2-(3-(arylalkyl amino carbonyl) phenyl)-3-(2-methoxyphenyl)-4-thiazolidinone derivatives as potent antitumor growth and metastasis agents

Wu, Jing, Yu, Linxi, Yang, Feifei, Li, Jingjie, Wang, Peng, Zhou, Wenbo, Qin, Liwen, Li, Yunqi, Luo, Jian, Yi, Zhengfang, Liu, Mingyao, Chen, Yihua

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.77 MB

english, 2014

54

Design and synthesis of novel 2-phenyl-5-(1,3-diphenyl-1H-pyrazol-4-yl)-1,3,4-oxadiazoles as selective COX-2 inhibitors with potent anti-inflammatory activity

Bansal, Sumit, Bala, Manju, Suthar, Sharad Kumar, Choudhary, Shivani, Bhattacharya, Shoumyo, Bhardwaj, Varun, Singla, Sumit, Joseph, Alex

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 993 KB

english, 2014

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