Volume 82

European Journal of Medicinal Chemistry

Volume 82

1

Synthesis and anticancer activity of γ-(triazolyl ethylidene)butenolides and polyfunctional pyrrolinones

Devender, N., Ramakrishna, K.K.G., Hamidullah,, Shukla, Sanjeev K., Konwar, Rituraj, Tripathi, Rama P.

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 3.08 MB

english, 2014

2

4-Benzofuranyloxynicotinamide derivatives are novel potent and orally available TGR5 agonists

Zou, Qingan, Duan, Hongliang, Ning, Mengmeng, Liu, Jia, Feng, Ying, Zhang, Liming, Zhu, Junjie, Leng, Ying, Shen, Jianhua

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.11 MB

english, 2014

3

Thiosemicarbazide, a fragment with promising indolamine-2,3-dioxygenase (IDO) inhibition properties

Serra, Silvia, Moineaux, Laurence, Vancraeynest, Christelle, Masereel, Bernard, Wouters, Johan, Pochet, Lionel, Frédérick, Raphaël

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.57 MB

english, 2014

4

2-Substituted 3-methylnaphtho[1,2-b]furan-4,5-diones as novel L-shaped ortho-quinone substrates for NAD(P)H:quinone oxidoreductase (NQO1)

Bian, Jinlei, Deng, Bang, Xu, Lili, Xu, Xiaoli, Wang, Nan, Hu, Tianhan, Yao, Zeyu, Du, Jianyao, Yang, Li, Lei, Yonghua, Li, Xiang, Sun, Haopeng, Zhang, Xiaojin, You, Qidong

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.95 MB

english, 2014

5

Design of α7 nicotinic acetylcholine receptor ligands in quinuclidine, tropane and quinazoline series. Chemistry, molecular modeling, radiochemistry, in vitro and in rats evaluations of a [18F] quinuclidine derivative

Pin, Frédéric, Vercouillie, Johnny, Ouach, Aziz, Mavel, Sylvie, Gulhan, Zuhal, Chicheri, Gabrielle, Jarry, Christian, Massip, Stephane, Deloye, Jean-Bernard, Guilloteau, Denis, Suzenet, Franck, Chalon

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.73 MB

english, 2014

6

Carbonic anhydrase inhibitors. Synthesis of a novel series of 5-substituted 2,4-dichlorobenzenesulfonamides and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII

Sławiński, Jarosław, Pogorzelska, Aneta, Żołnowska, Beata, Brożewicz, Kamil, Vullo, Daniela, Supuran, Claudiu T.

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.20 MB

english, 2014

7

Synthesis and in vitro antitumor activity of novel 2-alkyl-5-methoxycarbonyl-11-methyl-6H-pyrido[4,3-b]carbazol-2-ium and 2-alkylellipticin-2-ium chloride derivatives

Mori, Ryota, Kato, Asako, Komenoi, Kousuke, Kurasaki, Haruaki, Iijima, Touru, Kawagoshi, Masashi, Kiran, Y.B., Takeda, Sho, Sakai, Norio, Konakahara, Takeo

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 6.81 MB

english, 2014

8

Synthesis and structure–activity relationship studies in serotonin 5-HT4 receptor ligands based on a benzo[de][2,6]naphthridine scaffold

Castriconi, Federica, Paolino, Marco, Giuliani, Germano, Anzini, Maurizio, Campiani, Giuseppe, Mennuni, Laura, Sabatini, Chiara, Lanza, Marco, Caselli, Gianfranco, De Rienzo, Francesca, Menziani, Mari

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.14 MB

english, 2014

9

Group A streptococcus inhibitors by high-throughput virtual screening

Hu, Haipeng, Mao, Shuli, Bugrysheva, Julia V., Pruett, Sarah, Liotta, Dennis C., Scott, June R., Snyder, James P.

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 5.48 MB

english, 2014

10

Syntheses, characterization and evaluation of novel 2,6-diarylpiperidin-4-ones as potential analgesic-antipyretic agents

Tripathi, Purnima, Tripathi, Avinash C., Chawla, Viney, Saraf, Shailendra K.

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 584 KB

english, 2014

11

Synthesis and biological evaluation of salpichrolide analogs as antiestrogenic agents

Sonego, Juan M., Rivero, Ezequiel M., Gargiulo, Lucía, Lüthy, Isabel, Alvarez, Lautaro D., Veleiro, Adriana S., Burton, Gerardo

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.68 MB

english, 2014

12

Synthesis and biological evaluation of novel naphthalene compounds as potential antidepressant agents

Ang, Wei, Chen, Gong, Xiong, Li, Chang, Ying, Pi, Weiyi, Liu, Yuanyuan, Li, Chunlong, Zheng, Jiajia, Zhou, Liangxue, Yang, Bo, Deng, Yong, Yang, Shengyong, Luo, Youfu, Wei, Yuquan

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.57 MB

english, 2014

13

Discovery and characterization of novel imidazopyridine derivative CHEQ-2 as a potent CDC25 inhibitor and promising anticancer drug candidate

Song, Yu'ning, Lin, Xiaoqian, Kang, Dongwei, Li, Xiao, Zhan, Peng, Liu, Xinyong, Zhang, Qingzhu

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 3.34 MB

english, 2014

14

Conformationally constrained goniofufurone mimics as inhibitors of tumour cells growth: Design, synthesis and SAR study

Benedeković, Goran, Francuz, Jovana, Kovačević, Ivana, Popsavin, Mirjana, Zelenović, Bojana Srećo, Kojić, Vesna, Bogdanović, Gordana, Divjaković, Vladimir, Popsavin, Velimir

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 3.45 MB

english, 2014

15

Design and synthesis of a new series of modified CH-diarylpyrimidines as drug-resistant HIV non-nucleoside reverse transcriptase inhibitors

Meng, Ge, Liu, Yang, Zheng, Aqun, Chen, Fener, Chen, Wenxue, De Clercq, Erik, Pannecouque, Christophe, Balzarini, Jan

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.49 MB

english, 2014

16

Design, synthesis and structure–activity relationship of novel semi-synthetic flavonoids as antiproliferative agents

Ragab, F.A., Yahya, T.A.A., El-Naa, M.M., Arafa, R.K.

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.26 MB

english, 2014

17

Development of second generation EP2 antagonists with high selectivity

Ganesh, Thota, Jiang, Jianxiong, Dingledine, Ray

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.29 MB

english, 2014

18

Synthesis and anti-cholinesterase activity of new 7-hydroxycoumarin derivatives

Alipour, Masoumeh, Khoobi, Mehdi, Moradi, Alireza, Nadri, Hamid, Homayouni Moghadam, Farshad, Emami, Saeed, Hasanpour, Zeinab, Foroumadi, Alireza, Shafiee, Abbas

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 6.22 MB

english, 2014

19

Inhibition of 17β-HSD1: SAR of bicyclic substituted hydroxyphenylmethanones and discovery of new potent inhibitors with thioether linker

Abdelsamie, Ahmed S., Bey, Emmanuel, Hanke, Nina, Empting, Martin, Hartmann, Rolf W., Frotscher, Martin

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.16 MB

english, 2014

20

New mixed ligand zinc(II) complexes based on the antiepileptic drug sodium valproate and bioactive nitrogen-donor ligands. Synthesis, structure and biological properties

Darawsheh, Mohanad, Abu Ali, Hijazi, Abuhijleh, A. Latif, Rappocciolo, Emilia, Akkawi, Mutaz, Jaber, Suhair, Maloul, Salam, Hussein, Yasmeen

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.19 MB

english, 2014

21

Tricyclic pyrazoles. Part 6. Benzofuro[3,2-c]pyrazole: A versatile architecture for CB2 selective ligands

Pinna, Giovanni, Loriga, Giovanni, Lazzari, Paolo, Ruiu, Stefania, Falzoi, Matteo, Frau, Simona, Pau, Amedeo, Murineddu, Gabriele, Asproni, Battistina, Pinna, Gerard A.

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.14 MB

english, 2014

22

Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages

Hansen, Finn K., Sumanadasa, Subathdrage D.M., Stenzel, Katharina, Duffy, Sandra, Meister, Stephan, Marek, Linda, Schmetter, Rebekka, Kuna, Krystina, Hamacher, Alexandra, Mordmüller, Benjamin, Kassack

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 547 KB

english, 2014

23

Design, synthesis and antifungal activity of novel triazole derivatives containing substituted 1,2,3-triazole-piperdine side chains

Jiang, Zhigan, Gu, Julin, Wang, Chen, Wang, Shengzheng, Liu, Na, Jiang, Yan, Dong, Guoqiang, Wang, Yan, Liu, Yang, Yao, Jianzhong, Miao, Zhenyuan, Zhang, Wannian, Sheng, Chunquan

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 3.60 MB

english, 2014

24

Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3)

Chen, Haijun, Yang, Zhengduo, Ding, Chunyong, Xiong, Ailian, Wild, Christopher, Wang, Lili, Ye, Na, Cai, Guoshuai, Flores, Rudolfo M., Ding, Ye, Shen, Qiang, Zhou, Jia

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.64 MB

english, 2014

25

Synthesis, antibacterial and antitubercular activities of benzimidazole bearing substituted 2-pyridone motifs

Desai, N.C., Shihory, N.R., Kotadiya, G.M., Desai, Priyanka

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.04 MB

english, 2014

26

Design and synthesis of novel 1,2,3-triazole derivatives of coronopilin as anti-cancer compounds

Khazir, Jabeena, Hyder, Irfan, Gayatri, J. Laxmi, Prasad Yandrati, Leela, Nalla, Naresh, Chasoo, Gousia, Mahajan, Ajay, Saxena, A.K., Alam, M.S., Qazi, G.N., Sampath Kumar, Halmuthur M.

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 892 KB

english, 2014

27

Synthesis and identification of cytotoxic diphyllin glycosides as vacuolar H+-ATPase inhibitors

Zhang, Zhitao, Ma, Jinlong, Zhu, Li, Zhao, Yu

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 3.01 MB

english, 2014

28

Design and synthesis of calcium responsive magnetic resonance imaging agent: Its relaxation and luminescence studies

Tanwar, Jyoti, Datta, Anupama, Chauhan, Kanchan, Kumaran, S. Senthil, Tiwari, Anjani K., Kadiyala, K. Ganesh, Pal, Sunil, Thirumal, M., Mishra, Anil K.

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 819 KB

english, 2014

29

Synthesis and cytotoxic effect on cancer cell lines and macrophages of novel progesterone derivatives having an ester or a carbamate function at C-3 and C-17

Chávez-Riveros, Alejandra, Garrido, Mariana, Ramírez Apan, María Teresa, Zambrano, Armando, Díaz, Mario, Bratoeff, Eugene

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.16 MB

english, 2014

30

Synthesis, characterization and cytotoxic activity of novel platinum(II) iodido complexes

Savić, Aleksandar, Filipović, Lana, Aranđelović, Sandra, Dojčinović, Biljana, Radulović, Siniša, Sabo, Tibor J., Grgurić-Šipka, Sanja

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.86 MB

english, 2014

31

New insights into the biological properties of Crocus sativus L.: chemical modifications, human monoamine oxidases inhibition and molecular modeling studies

De Monte, Celeste, Carradori, Simone, Chimenti, Paola, Secci, Daniela, Mannina, Luisa, Alcaro, Francesca, Petzer, Anél, N'Da, Clarina I., Gidaro, Maria Concetta, Costa, Giosuè, Alcaro, Stefano, Petzer

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.06 MB

english, 2014

32

1-Substituted-5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazoles and their isosteric analogs: A new class of selective antitubercular agents active against drug-susceptible and multidrug-resistant mycobacteria

Karabanovich, Galina, Roh, Jaroslav, Smutný, Tomáš, Němeček, Jan, Vicherek, Petr, Stolaříková, Jiřina, Vejsová, Marcela, Dufková, Ida, Vávrová, Kateřina, Pávek, Petr, Klimešová, Věra, Hrabálek, Alexan

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 815 KB

english, 2014

33

Biological evaluation of new nickel(II) metallates: Synthesis, DNA/protein binding and mitochondrial mediated apoptosis in human lung cancer cells (A549) via ROS hypergeneration and depletion of cellular antioxidant pool

Kalaivani, P., Saranya, S., Poornima, P., Prabhakaran, R., Dallemer, F., Vijaya Padma, V., Natarajan, K.

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 13.77 MB

english, 2014

34

Design, synthesis and antiproliferative activity of functionalized flavone-triazole-tetrahydropyran conjugates against human cancer cell lines

Ahmed, Naseem, Konduru, Naveen Kumar, Ahmad, Sarfaraz, Owais, Mohammad

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 3.54 MB

english, 2014

35

Ruthenium(II) polypyridyl complexes: Cellular uptake, cell image and apoptosis of HeLa cancer cells induced by double targets

Yu, Qianqian, Liu, Yanan, Xu, Lei, Zheng, Chuping, Le, Fangling, Qin, Xiuying, Liu, Yanyu, Liu, Jie

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 3.82 MB

english, 2014

36

Antiproliferative and quinone reductase-inducing activities of withanolides derivatives

García, Manuela E., Nicotra, Viviana E., Oberti, Juan C., Ríos-Luci, Carla, León, Leticia G., Marler, Laura, Li, Guannan, Pezzuto, John M., van Breemen, Richard B., Padrón, José M., Hueso-Falcón, Idai

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 809 KB

english, 2014

37

Editorial board

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 57 KB

english, 2014

38

Graphical contents list

Journal:

European Journal of Medicinal Chemistry

Year:

2014

File:

PDF, 4.28 MB

2014

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