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1

KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation

Pearce, Laura R., Atanassova, Neli, Banton, Matthew C., Bottomley, Bill, van der Klaauw, Agatha A., Revelli, Jean-Pierre, Hendricks, Audrey, Keogh, Julia M., Henning, Elana, Doree, Deon, Jeter-Jones,

Journal:

Year:

2013

Language:

english

File:

PDF, 2.19 MB

english, 2013

2

News you can use! Evaluating the effectiveness of newsjacking based content on social media

Angell, Rob, Gorton, Matthew, Bottomley, Paul, Marder, Ben, Bhaskar, Shikhar, White, John

Journal:

Information Technology & People

Year:

2020

File:

PDF, 199 KB

2020

3

Effect of two different house screening interventions on exposure to malaria vectors and on anaemia in children in The Gambia: a randomised controlled trial

Matthew J Kirby, David Ameh, Christian Bottomley, Clare Green, Musa Jawara, Paul J Milligan, Paul C Snell, David J Conway, Steve W Lindsay

Journal:

Year:

2009

Language:

english

File:

PDF, 625 KB

english, 2009

4

Epidemiology of Group B Streptococcus in developing countries

Johri, Atul Kumar, Lata, Hem, Yadav, Puja, Dua, Meenakshi, Yang, Yonghong, Xu, Xiaoning, Homma, Akira, Barocchi, Michèle Anne, Bottomley, Matthew J., Saul, Allan, Klugman, Keith P., Black, Steven

Journal:

Year:

2013

Language:

english

File:

PDF, 643 KB

english, 2013

5

2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors

Philip Jones, Matthew J. Bottomley, Andrea Carfí, Ottavia Cecchetti, Federica Ferrigno, Paola Lo Surdo, Jesus M. Ontoria, Michael Rowley, Rita Scarpelli, Carsten Schultz-Fademrecht, Christian Steinküh

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 339 KB

english, 2008

6

Palladium-catalyzed hydrogen reduction and decolorization of reactive phthalocyanine dyes

Rosalyn D. Matthews, Lawrence A. Bottomley, Spyros G. Pavlostathis

Journal:

Year:

2009

Language:

english

File:

PDF, 1.87 MB

english, 2009

7

1H,13C and15N backbone assignments for the ligand binding domain of thePseudomonas aeruginosavirulence regulator LasR

Matthew James Bottomley, Ester Muraglia, Renzo Bazzo

Journal:

Biomolecular NMR Assignments

Year:

2007

Language:

english

File:

PDF, 186 KB

english, 2007

8

4812760 Multi-dimensional selective NMR excitation with a single RF pulse

Paul A Bottomley, Christopher J Hardy, Matthew O'Donnell, Peter B Roemer

Journal:

Magnetic Resonance Imaging

Year:

1991

Language:

english

File:

PDF, 89 KB

english, 1991

9

10.1038/89675

Bottomley, Matthew J., Collard, Michael W., Huggenvik, Jodi I., Liu, Zhihong, Gibson, Toby J., Sattler, Michael

Journal:

Natural Structural Biology

Year:

2001

Language:

english

File:

PDF, 5.71 MB

english, 2001

10

The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression

Org, Tõnis, Chignola, Francesca, Hetényi, Csaba, Gaetani, Massimiliano, Rebane, Ana, Liiv, Ingrid, Maran, Uko, Mollica, Luca, Bottomley, Matthew J, Musco, Giovanna

Journal:

Year:

2008

Language:

english

File:

PDF, 302 KB

english, 2008

11

Structures of protein domains that create or recognize histone modifications

Bottomley, Matthew J.

Journal:

Year:

2004

Language:

english

File:

PDF, 568 KB

english, 2004

12

Letter to the Editor:1H,13C and15N backbone resonance assignments of the SAND domains from glucocorticoid modulatory element binding proteins-1 and -2

Matthew J. Bottomley, Michael Sattler

Journal:

Journal of Biomolecular NMR

Year:

2003

Language:

english

File:

PDF, 58 KB

english, 2003

13

DNA-PK contributes to the phosphorylation of AIRE: Importance in transcriptional activity

Ingrid Liiv, Ana Rebane, Tõnis Org, Mario Saare, Julia Maslovskaja, Kai Kisand, Erkki Juronen, Leena Valmu, Matthew James Bottomley, Nisse Kalkkinen, Pärt Peterson

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2008

Language:

english

File:

PDF, 558 KB

english, 2008

14

Structural characterization of the Hepatitis C Virus NS3 protease from genotype 3a: The basis of the genotype 1b vs. 3a inhibitor potency shift

Mariana Gallo, Matthew James Bottomley, Matteo Pennestri, Tommaso Eliseo, Maurizio Paci, Uwe Koch, Renzo Bazzo, Vincenzo Summa, Andrea Carfì, Daniel O. Cicero

Journal:

Year:

2010

Language:

english

File:

PDF, 2.41 MB

english, 2010

15

Endocytosis: How dynamin sets vesicles PHree!

Matthew J. Bottomley, Paola Lo Surdo, Paul C. Driscoll

Journal:

Current Biology

Year:

1999

Language:

english

File:

PDF, 103 KB

english, 1999

16

Environmental endocrine disrupters dysregulate estrogen metabolism and Ca2+ homeostasis in fish and mammals via receptor-independent mechanisms

Christopher J. Kirk, Laura Bottomley, Nicholas Minican, Howard Carpenter, Selena Shaw, Navdeep Kohli, Matthew Winter, Edwin W. Taylor, Rosemary H. Waring, Francesco Michelangeli, Robert M. Harris

Journal:

Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology

Year:

2003

Language:

english

File:

PDF, 128 KB

english, 2003

17

The structure of Clostridium difficile toxin A glucosyltransferase domain bound to Mn2+ and UDP provides insights into glucosyltransferase activity and product release

Nunzia D’Urzo, Enrico Malito, Marco Biancucci, Matthew J. Bottomley, Domenico Maione, Maria Scarselli, Manuele Martinelli

Journal:

Year:

2012

Language:

english

File:

PDF, 696 KB

english, 2012

18

Expression and Characterization of a Very-Late Antigen-4 (α4β1) Integrin-Binding Fragment of Vascular Cell-Adhesion Molecule-1

Timothy J. Dudgeon, Matthew J. Bottomley, Paul C. Driscoll, Martin J. Humphries, A. Paul Mould, George I. Wingfield, John M. Clements

Journal:

Year:

1994

Language:

english

File:

PDF, 758 KB

english, 1994

19

RETRACTED: Structure and Functional Analysis of the MYND Domain

Roberta Spadaccini, Hélène Perrin, Matthew J. Bottomley, Stéphane Ansieau, Michael Sattler

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 678 KB

english, 2006

20

Retraction notice to “Structure and functional analysis of the MYND domain” [J. Mol. Biol. (2006) 358, 498–508]

Roberta Spadaccini, Hélène Perrin, Matthew J. Bottomley, Stéphane Ansieau, Michael Sattler

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 75 KB

english, 2008

21

Binding of a Noncovalent Inhibitor Exploiting the S′ region Stabilizes the Hepatitis C virus NS3 Protease Conformation in the Absence of Cofactor

Mariana Gallo, Matteo Pennestri, Matthew James Bottomley, Gaetano Barbato, Tommaso Eliseo, Maurizio Paci, Frank Narjes, Raffaele De Francesco, Vincenzo Summa, Uwe Koch, Renzo Bazzo, Daniel O. Cicero

Journal:

Journal of Molecular Biology

Year:

2009

Language:

english

File:

PDF, 1.68 MB

english, 2009

22

Future challenges in the elimination of bacterial meningitis

Matthew J. Bottomley, Davide Serruto, Marco Aurélio Palazzi Sáfadi, Keith P. Klugman

Journal:

Year:

2012

Language:

english

File:

PDF, 317 KB

english, 2012

23

The new multicomponent vaccine against meningococcal serogroup B, 4CMenB: Immunological, functional and structural characterization of the antigens

Davide Serruto, Matthew J. Bottomley, Sanjay Ram, Marzia M. Giuliani, Rino Rappuoli

Journal:

Year:

2012

Language:

english

File:

PDF, 857 KB

english, 2012

24

The major splice variant of human 5-aminolevulinate synthase-2 contributes significantly to erythroid heme biosynthesis

Timothy C Cox, Timothy J Sadlon, Quenten P Schwarz, Christopher S Matthews, Phillip D Wise, Liza L Cox, Sylvia S Bottomley, Brian K May

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2004

Language:

english

File:

PDF, 360 KB

english, 2004

25

Escalated-dose versus standard-dose conformal radiotherapy in prostate cancer: first results from the MRC RT01 randomised controlled trial

David P Dearnaley, Matthew R Sydes, John D Graham, Edwin G Aird, David Bottomley, Richard A Cowan, Robert A Huddart, Chakiath C Jose, John HL Matthews, Jeremy Millar, A Rollo Moore, Rachel C Morgan, J

Journal:

The Lancet Oncology

Year:

2007

Language:

english

File:

PDF, 420 KB

english, 2007

26

Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH

Surdo, Paola Lo, Bottomley, Matthew J, Calzetta, Alessandra, Settembre, Ethan C, Cirillo, Agostino, Pandit, Shilpa, Ni, Yan G, Hubbard, Brian, Sitlani, Ayesha, Carfí, Andrea

Journal:

Year:

2011

Language:

english

File:

PDF, 715 KB

english, 2011

27

Escalated-dose versus control-dose conformal radiotherapy for prostate cancer: long-term results from the MRC RT01 randomised controlled trial

Dearnaley, David P, Jovic, Gordana, Syndikus, Isabel, Khoo, Vincent, Cowan, Richard A, Graham, John D, Aird, Edwin G, Bottomley, David, Huddart, Robert A, Jose, Chakiath C, Matthews, John H L, Millar,

Journal:

The Lancet Oncology

Year:

2014

Language:

english

File:

PDF, 385 KB

english, 2014

28

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of SpyCEP, a candidate antigen for a vaccine against Streptococcus pyogenes

Abate, Francesca, Malito, Enrico, Falugi, Fabiana, Margarit Y Ros, Immaculada, Bottomley, Matthew James

Journal:

Acta Crystallographica Section F Structural Biology and Crystallization Communications

Year:

2013

Language:

english

File:

PDF, 315 KB

english, 2013

29

Can we deliver randomized trials of focal therapy in prostate cancer?

Ahmed, Hashim U., Berge, Viktor, Bottomley, David, Cross, William, Heer, Rakesh, Kaplan, Richard, Leslie, Tom, Parker, Chris, Relton, Clare, Stephens, Richard, Sydes, Matthew R., Turnbull, Lindsay, va

Journal:

Nature Reviews Clinical Oncology (formerly Nature Clinical Practice Oncology)

Year:

2014

Language:

english

File:

PDF, 785 KB

english, 2014

30

Covalent Inhibition of Bacterial Quorum Sensing

Amara, Neri, Mashiach, Roi, Amar, Dotan, Krief, Pnina, Spieser, Stéphane A. H., Bottomley, Matthew J., Aharoni, Amir, Meijler, Michael M.

Journal:

Journal of the American Chemical Society

Year:

2009

Language:

english

File:

PDF, 3.52 MB

english, 2009

31

Technical Reproducibility of Single-Nucleotide and Size-Based DNA Biomarker Assessment Using DNA Extracted from Formalin-Fixed, Paraffin-Embedded Tissues

Zhang, Shenli, Tan, Iain B., Sapari, Nur S., Grabsch, Heike I., Okines, Alicia, Smyth, Elizabeth C., Aoyama, Toru, Hewitt, Lindsay C., Inam, Imran, Bottomley, Dan, Nankivell, Matthew, Stenning, Sally

Journal:

The Journal of Molecular Diagnostics

Year:

2015

Language:

english

File:

PDF, 1.06 MB

english, 2015

32

CD57 expression in CD8 T cells and development of cutaneous squamous cell carcinoma in renal transplant recipients: a prospective cohort study

Bottomley, Matthew, Harden, Paul, Wood, Kathryn

Journal:

Year:

2015

Language:

english

File:

PDF, 51 KB

english, 2015

33

Takayasu arteritis

Kurien, Matthew, Bottomley, John R., McGrath, Emmet E.

Journal:

European Journal of Cardio-Thoracic Surgery

Year:

2011

Language:

english

File:

PDF, 136 KB

english, 2011

34

Apo, Zn 2+ -bound and Mn 2+ -bound structures reveal ligand-binding properties of SitA from the pathogen Staphylococcus pseudintermedius

Abate, Francesca, Malito, Enrico, Cozzi, Roberta, Lo Surdo, Paola, Maione, Domenico, Bottomley, Matthew J.

Journal:

Bioscience Reports

Year:

2014

Language:

english

File:

PDF, 1.96 MB

english, 2014

35

X-linked Pyridoxine-Responsive Sideroblastic Anemia Due to a Thr 388 -to-Ser Substitution in Erythroid 5-Aminolevulinate Synthase

Cox, Timothy C., Bottomley, Sylvia S., Wiley, James S., Bawden, Michael J., Matthews, Chris S., May, Brian K.

Journal:

Boston Medical and Surgical Journal

Year:

1994

Language:

english

File:

PDF, 612 KB

english, 1994

36

Crystal Structure and Nuclear Magnetic Resonance Analyses of the SAND Domain from Glucocorticoid Modulatory Element Binding Protein-1 Reveals Deoxyribonucleic Acid and Zinc Binding Regions

Surdo, Paola Lo, Bottomley, Matthew J., Sattler, Michael, Scheffzek, Klaus

Journal:

Molecular Endocrinology

Year:

2003

Language:

english

File:

PDF, 693 KB

english, 2003

37

Genetic evaluation of traits in a standardized behavioral test for potential guide dog puppies using crossbreed models

Evans, Katy M., Lewis, Thomas W., Asher, Lucy, Blythe, Simon, Bottomley, Matthew, Tootill, Lisa, Roberts, Rena, Whiteside, Helen, England, Gary C.W., Blott, Sarah C.

Journal:

Journal of Veterinary Behavior: Clinical Applications and Research

Year:

2015

Language:

english

File:

PDF, 255 KB

english, 2015

38

Self-assembling protein nanoparticles in the design of vaccines

Sagaseta, Jacinto López, Malito, Enrico, Rappuoli, Rino, Bottomley, Matthew J.

Journal:

Computational and Structural Biotechnology Journal

Year:

2015

Language:

english

File:

PDF, 1.40 MB

english, 2015

39

An observational study of patient characteristics and mortality following hypoglycemia in the community

Elwen, Francesca R, Huskinson, Alice, Clapham, Linda, Bottomley, Matthew J, Heller, Simon R, James, Cathryn, Abbas, Afroze, Baxter, Paul, Ajjan, Ramzi A

Journal:

BMJ Open Diabetes Research & Care

Year:

2015

Language:

english

File:

PDF, 497 KB

english, 2015

40

Don't Distract Me When I'm Media Multitasking: Toward a Theory for Raising Advertising Recall and Recognition

Angell, Robert, Gorton, Matthew, Sauer, Johannes, Bottomley, Paul, White, John

Journal:

Journal of Advertising

Year:

2016

Language:

english

File:

PDF, 400 KB

english, 2016

41

Interruptions during drug rounds: an observational study

Kreckler, Simon, Catchpole, Ken, Bottomley, Matthew, Handa, Ashok, McCulloch, Peter

Journal:

British Journal of Nursing

Year:

2008

Language:

english

File:

PDF, 120 KB

english, 2008

42

Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design

Rappuoli, Rino, Bottomley, Matthew J., D’Oro, Ugo, Finco, Oretta, De Gregorio, Ennio

Journal:

Journal of Experimental Medicine

Year:

2016

Language:

english

File:

PDF, 1.27 MB

english, 2016

43

Crystal structure of FhuD at 1.6 Å resolution: a ferrichrome-binding protein from the animal and human pathogen Staphylococcus pseudintermedius

Abate, Francesca, Cozzi, Roberta, Maritan, Martina, Lo Surdo, Paola, Maione, Domenico, Malito, Enrico, Bottomley, Matthew James

Journal:

Acta Crystallographica Section F Structural Biology Communications

Year:

2016

Language:

english

File:

PDF, 622 KB

english, 2016

44

Understanding fans’ responses to the sponsor of a rival team

Angell, Robert J., Gorton, Matthew, Bottomley, Paul, White, John

Journal:

European Sport Management Quarterly

Year:

2016

Language:

english

File:

PDF, 1.96 MB

english, 2016

45

Can the buck always be passed to the highest level of clustering?

Bottomley, Christian, Kirby, Matthew J., Lindsay, Steve W., Alexander, Neal

Journal:

BMC Medical Research Methodology

Year:

2016

Language:

english

File:

PDF, 551 KB

english, 2016

46

Modelling the elimination of river blindness using long-term epidemiological and programmatic data from Mali and Senegal

Walker, Martin, Stolk, Wilma A., Dixon, Matthew A., Bottomley, Christian, Diawara, Lamine, Traoré, Mamadou O., de Vlas, Sake J., Basáñez, María-Gloria

Journal:

Year:

2017

Language:

english

File:

PDF, 2.41 MB

english, 2017

47

Application of Operational Tolerance Signatures Are Limited by Variability and Type of Immunosuppression in Renal Transplant Recipients

Bottomley, Matthew J., Chen, Mian, Fuggle, Sue, Harden, Paul N., Wood, Kathryn J.

Journal:

Transplantation Direct

Year:

2017

Language:

english

File:

PDF, 514 KB

english, 2017

48

Impact of intrapatient variability (IPV) in tacrolimus trough levels on long-term renal transplant function: multicentre collaborative retrospective cohort study protocol

Goldsmith, Petra M, Bottomley, Matthew J, Okechukwu, Okidi, Ross, Victoria C, Ghita, Ryan, Wandless, David, Falconer, Stuart J, Papachristos, Stavros, Nash, Philip, Androshchuk, Vitaliy, Clancy, Marc

Journal:

Year:

2017

Language:

english

File:

PDF, 300 KB

english, 2017

49

Corrigendum: Can we deliver randomized trials of focal therapy in prostate cancer?

Ahmed, Hashim U., Berge, Viktor, Bottomley, David, Cross, William, Heer, Rakesh, Kaplan, Richard, Leslie, Tom, Parker, Chris, Relton, Clare, Stephens, Richard, Sydes, Matthew R., Turnbull, Lindsay, va

Journal:

Nature Reviews Clinical Oncology (formerly Nature Clinical Practice Oncology)

Year:

2017

Language:

english

File:

PDF, 52 KB

english, 2017

50

Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp

López-Sagaseta, Jacinto, Beernink, Peter T., Bianchi, Federica, Santini, Laura, Frigimelica, Elisabetta, Lucas, Alexander H., Pizza, Mariagrazia, Bottomley, Matthew J.

Journal:

Nature Communications

Year:

2018

Language:

english

File:

PDF, 1.82 MB

english, 2018