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1

Natural Product Triptolide Mediates Cancer Cell Death by Triggering CDK7-Dependent Degradation of RNA Polymerase II

Manzo, S. G., Zhou, Z.-L., Wang, Y.-Q., Marinello, J., He, J.-X., Li, Y.-C., Ding, J., Capranico, G., Miao, Z.-H.

Journal:

Cancer Research

Year:

2012

Language:

english

File:

PDF, 1.42 MB

english, 2012

2

Interaction of ionizing radiation with topotecan in two human tumor cell lines

Renato Marchesini, Ambrogio Colombo, Claudia Caserini, Paola Perego, Rosanna Supino, Giovanni Capranico, Marco Tronconi, Franco Zunino

Journal:

International Journal of Cancer

Year:

1996

Language:

english

File:

PDF, 531 KB

english, 1996

3

Gene expression of DNA topoisomerases I, IIα and IIβ and response to cisplatin-based chemotherapy in advanced ovarian carcinoma

Mariagrazia Cornarotti, Giovanni Capranico, Silvia Bohm, Saro Oriana, Gian Battista Spatti, Luigi Mariani, Giuseppina Ballabio, Franco Zunino

Journal:

International Journal of Cancer

Year:

1996

Language:

english

File:

PDF, 765 KB

english, 1996

4

ChemInform Abstract: Synthesis, DNA-Damaging and Cytotoxic Properties of Novel Topoisomerase II-Directed Bisantrene Analogues.

G. ZAGOTTO, A. OLIVA, F. GUANO, E. MENTA, G. CAPRANICO, M. PALUMBO

Journal:

Year:

1998

File:

PDF, 32 KB

1998

5

ChemInform Abstract: Drugs Acting on DNA Topoisomerases: Recent Advances and Future Perspectives

B. Gatto, G. Capranico, M. Palumbo

Journal:

Year:

1999

File:

PDF, 24 KB

1999

6

ChemInform Abstract: Anthracyclines: Selected New Developments.

M. Binaschi, M. Bigioni, A. Cipollone, C. Rossi, C. Goso, C. A. Maggi, G. Capranico, F. Animati

Journal:

Year:

2002

File:

PDF, 22 KB

2002

7

Comparison of doxorubicin-induced DNA damage in doxorubicin-sensitive and -resistant P388 murine leukemia cells

Giovanni Capranico, Teresa Dasdia, Franco Zunino

Journal:

International Journal of Cancer

Year:

1986

Language:

english

File:

PDF, 465 KB

english, 1986

8

Comparison of dna cleavage induced by etoposide and doxorubicin in two human small-cell lung cancer lines with different sensitivities to topoisomerase ii inhibitors

Monica Binaschi, Giovanni Capranico, Paola De Isabella, Mariangela Mariani, Rosanna Supino, Stella Tinelli, Franco Zunino

Journal:

International Journal of Cancer

Year:

1990

Language:

english

File:

PDF, 653 KB

english, 1990

9

Relationships among tumor responsiveness, cell sensitivity, doxorubicin cellular pharmacokinetics and drug-induced DNA alterations in two human small-cell lung cancer xenografts

G. Pratesi, G. Capranico, M. Binaschi, P. De Isabella, S. Pilotti, R. Supino, F. Zunino

Journal:

International Journal of Cancer

Year:

1990

Language:

english

File:

PDF, 771 KB

english, 1990

10

A study of cross-resistance pattern and expression of molecular markers of multidrug resistance in a human small-cell lung-cancer cell line selected with doxorubicin

Rosanna Supino, Monica Binaschi, Giovanni Capranico, Romolo A. Gambetta, Elena Sala, Franco Zunino, Ennio Prosperi

Journal:

International Journal of Cancer

Year:

1993

Language:

english

File:

PDF, 920 KB

english, 1993

11

MRP gene overexpression in a human doxorubicin-resistant SCLC cell line: Alterations in cellular pharmacokinetics and in pattern of cross-resistance

Monica Binaschi, Rosanna Supino, Romolo A. Gambetta, Giuseppe Giaccone, Ennio Prosperi, Giovanni Capranico, Ignazio Catalog, Franco Zunino

Journal:

International Journal of Cancer

Year:

1995

Language:

english

File:

PDF, 697 KB

english, 1995

12

Conformational properties of topoisomerase II inhibitors and sequence specificity of DNA cleavage

M. Palumbo, M. Mabilia, A. Pozzan, G. Capranico, S. Tinelli, F. Zunino

Journal:

Journal of Molecular Recognition

Year:

1994

Language:

english

File:

PDF, 527 KB

english, 1994

13

Molecular modelling studies, synthesis and biological activity of a series of novel bisnaphthalimides and their development as new DNA topoisomerase II inhibitors

Rosanna Filosa, Antonella Peduto, Simone Di Micco, Paolo de Caprariis, Michela Festa, Antonello Petrella, Giovanni Capranico, Giuseppe Bifulco

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.01 MB

english, 2009

14

Synthesis, DNA-damaging and cytotoxic properties of novel topoisomerase II-directed bisantrene analogues

Giuseppe Zagotto, Ambrogio Oliva, Fulvio Guano, Ernesto Menta, Giovanni Capranico, Manlio Palumbo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 402 KB

english, 1998

15

Directed evolution to increase camptothecin sensitivity of human DNA topoisomerase I

Serena Scaldaferro, Stella Tinelli, Maria E Borgnetto, Alessandro Azzini, Giovanni Capranico

Journal:

Chemistry & Biology

Year:

2001

Language:

english

File:

PDF, 645 KB

english, 2001

16

Doxorubicin cellular pharmacokinetics and DNA breakage in a multi-drug resistant B16 melanoma cell line

Supino, R, Mariani, M, Capranico, G, Colombo, A, Parmiani, G

Journal:

British Journal of Cancer

Year:

1988

Language:

english

File:

PDF, 909 KB

english, 1988

17

P-glycoprotein gene amplification and expression in multidrug-resistant murine P388 and B16 cell lines

Capranico, G, De Isabella, P, Castelli, C, Supino, R, Parmiani, G, Zunino, F

Journal:

British Journal of Cancer

Year:

1989

Language:

english

File:

PDF, 1.28 MB

english, 1989

18

Characterization of novel antisense HIF-1α transcripts in human cancers

Bertozzi, Davide, Iurlaro, Raffaella, Sordet, Olivier, Marinello, Jessica, Zaffaroni, Nadia, Capranico, Giovanni

Journal:

Year:

2011

Language:

english

File:

PDF, 3.40 MB

english, 2011

19

In hepatocellular carcinoma miR-519d is up-regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2

Francesca Fornari, Maddalena Milazzo, Pasquale Chieco, Massimo Negrini, Elena Marasco, Giovanni Capranico, Vilma Mantovani, Jessica Marinello, Silvia Sabbioni, Elisa Callegari, Matteo Cescon, Matteo R

Journal:

The Journal of Pathology

Year:

2012

Language:

english

File:

PDF, 3.18 MB

english, 2012

20

Mechanism of action of DNA topoisomerase inhibitors

Monica Binaschi, Franco Zunino, Giovanni Capranico

Journal:

Year:

1995

Language:

english

File:

PDF, 981 KB

english, 1995

21

Lack of effect of glutathione depletion on cytotoxicity, mutagenicity and DNA damage produced by doxorubicin in cultured cells

Giovanni Capranico, Nora Babudri, Gino Casciarri, Lucilla Dolzani, Romolo A. Gambetta, Ester Longoni, Bianca Pani, Carla Soranzo, Franco Zunino

Journal:

Chemico-Biological Interactions

Year:

1986

Language:

english

File:

PDF, 694 KB

english, 1986

22

Formation, resealing and persistence of DNA breaks produced by 4-demethoxydaunorubicin in P388 leukemia cells

Giovanni Capranico, Stella Tinelli, Franco Zunino

Journal:

Chemico-Biological Interactions

Year:

1989

Language:

english

File:

PDF, 567 KB

english, 1989

23

Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development

Giovanni Capranico, Stella Tinelli, Caroline A. Austin, Mark L. Fisher, Franco Zunino

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1992

Language:

english

File:

PDF, 575 KB

english, 1992

24

Differential expression of DNA topoisomerases in non-small cell lung cancer and normal lung

Giuseppe Giaccone, Jannette van Ark-Otte, Giorgio Scagliotti, Giovanni Capranico, Paul van der Valk, Gonzalo Rubio, Otilia Dalesio, Rafael Lopez, Franco Zunino, Jan Walboomers, Herbert M. Pinedo

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1995

Language:

english

File:

PDF, 1.42 MB

english, 1995

25

Dissecting the transcriptional functions of human DNA topoisomerase I by selective inhibitors: Implications for physiological and therapeutic modulation of enzyme activity

Giovanni Capranico, Jessica Marinello, Laura Baranello

Journal:

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Year:

2010

Language:

english

File:

PDF, 949 KB

english, 2010

26

Antitumor AZA-anthrapyrazoles: biophysical and biochemical studies on 8- and 9-aza regioisomers

Claudia Sissi, Elisabetta Leo, Stefano Moro, Giovanni Capranico, Annalaura Mancia, Ernesto Menta, A.Paul Krapcho, Manlio Palumbo

Journal:

Biochemical Pharmacology

Year:

2004

Language:

english

File:

PDF, 488 KB

english, 2004

27

A specific transcriptional response of yeast cells to camptothecin dependent on the Swi4 and Mbp1 factors

Luca Lotito, Alessandra Russo, Susana Bueno, Giovanni Chillemi, Maria Vittoria Fogli, Giovanni Capranico

Journal:

European Journal of Pharmacology

Year:

2009

Language:

english

File:

PDF, 512 KB

english, 2009

28

A comparative study of cellular and molecular pharmacology of doxorubicin and MEN 10755, a disaccharide analogue

Mario Bigioni, Carmela Salvatore, Angela Bullo, Daniela Bellarosa, Elisabetta Iafrate, Fabio Animati, Giovanni Capranico, Cristina Goso, Carlo Alberto Maggi, Graziella Pratesi, Franco Zunino, Stefano

Journal:

Biochemical Pharmacology

Year:

2001

Language:

english

File:

PDF, 328 KB

english, 2001

29

Configurational requirements of the sugar moiety for the pharmacological activity of anthracycline disaccharides

Federico Arcamone, Fabio Animati, Mario Bigioni, Giovanni Capranico, Claudia Caserini, Amalia Cipollone, Michelandrea De Cesare, Alessandro Ettorre, Fulvio Guano, Stefano Manzini, Edith Monteagudo, Gr

Journal:

Biochemical Pharmacology

Year:

1999

Language:

english

File:

PDF, 263 KB

english, 1999

30

Further insight into the Zn2+-mediated binding of streptonigrin to DNA

Michele Marcazzan, Barbara Gatto, Claudia Sissi, Giuseppe Zagotto, Giovanni Capranico, Manlio Palumbo

Journal:

Year:

1998

Language:

english

File:

PDF, 133 KB

english, 1998

31

New developments in antitumor anthracyclines

Federico Arcamone, Fabio Animati, Giovanni Capranico, Paolo Lombardi, Graziella Pratesi, Stefano Manzini, Rosanna Supino, Franco Zunino

Journal:

Pharmacology & Therapeutics

Year:

1997

Language:

english

File:

PDF, 825 KB

english, 1997

32

DNA sequence selectivity of topoisomerases and topoisomerase poisons

Giovanni Capranico, Monica Binaschi

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1998

Language:

english

File:

PDF, 176 KB

english, 1998

33

Conformational Drug Determinants of the Sequence Specificity of Drug-stimulated Topoisomerase II DNA Cleavage

Giovanni Capranico, Manlio Palumbo, Stella Tinelli, Massimo Mabilia, Alfonso Pozzan, Franco Zunino

Journal:

Journal of Molecular Biology

Year:

1994

File:

PDF, 1.48 MB

1994

34

Genomic sites of topoisomerase II activity determined by comparing DNA breakage enhanced by three distinct poisons

M.Evelina Borgnetto, Stella Tinelli, Laura Carminati, Giovanni Capranico

Journal:

Journal of Molecular Biology

Year:

1999

Language:

english

File:

PDF, 258 KB

english, 1999

35

Distribution of topoisomerase II cleavage sites in simian virus 40 DNA and the effects of drugs

Yves Pommier, Giovanni Capranico, Ann Orr, Kurt W. Kohn

Journal:

Journal of Molecular Biology

Year:

1991

Language:

english

File:

PDF, 8.47 MB

english, 1991

36

The effects of camptothecin on RNA polymerase II transcription: Roles of DNA topoisomerase I

Giovanni Capranico, Francesca Ferri, Maria Vittoria Fogli, Alessandra Russo, Luca Lotito, Laura Baranello

Journal:

Year:

2007

Language:

english

File:

PDF, 236 KB

english, 2007

37

Metallothionein cDNA cloning, metallothionein expression and heavy metals in Scapharca inaequivalvis along the Northern Adriatic coast of Italy

Giulia Andreani, Emilio Carpenè, Giovanni Capranico, Gloria Isani

Journal:

Ecotoxicology and Environmental Safety

Year:

2011

Language:

english

File:

PDF, 543 KB

english, 2011

38

Enhanced CPT Sensitivity of Yeast Cells and Selective Relaxation of Gal4 Motif-containing DNA by Novel Gal4–Topoisomerase I Fusion Proteins

Marco Alessandri, Giovanni L. Beretta, Edmondo Ferretti, Annalaura Mancia, Andriy Khobta, Giovanni Capranico

Journal:

Journal of Molecular Biology

Year:

2004

Language:

english

File:

PDF, 1.21 MB

english, 2004

39

Early Effects of Topoisomerase I Inhibition on RNA Polymerase II Along Transcribed Genes in Human Cells

Andriy Khobta, Francesca Ferri, Luca Lotito, Alessandra Montecucco, Rossella Rossi, Giovanni Capranico

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 544 KB

english, 2006

40

Global Transcription Regulation by DNA Topoisomerase I in Exponentially Growing Saccharomyces cerevisiae Cells: Activation of Telomere-Proximal Genes by TOP1 Deletion

Luca Lotito, Alessandra Russo, Giovanni Chillemi, Susana Bueno, Duccio Cavalieri, Giovanni Capranico

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 1.06 MB

english, 2008

41

Amsacrine-promoted DNA cleavage site determinants for the two human DNA topoisomerase II isoforms α and β

Katherine L. Marsh, Elaine Willmore, Stella Tinelli, Mariagrazia Cornarotti, Emma L. Meczes, Giovanni Capranico, L.Mark Fisher, Caroline A. Austin

Journal:

Biochemical Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.54 MB

english, 1996

42

A protein-mediated mechanism for the DNA sequence-specific action of topoisomerase II poisons

Giovanni Capranico, Monica Binaschi, M.Evelina Borgnetto, Franco Zunino, Manlio Palumbo

Journal:

Trends in Pharmacological Sciences

Year:

1997

Language:

english

File:

PDF, 184 KB

english, 1997

43

A protein-mediated mechanism for the DNA sequence-specific action of topoisomerase II poisons

Giovanni Capranico, Monica Binaschi, M.Evelina Borgnetto, Franco Zunino, Manlio Palumbo

Journal:

Trends in Pharmacological Sciences

Year:

1997

Language:

english

File:

PDF, 999 KB

english, 1997

44

The camptothecins: from discovery to the patient: edited by P. Pantazis, B. C. Giovanella and M. L. Rothenberg, New York Academy of Sciences, 1996. $100.00 (335 pages) ISBN 1 57331 0573

Giovanni Capranico

Journal:

Trends in Pharmacological Sciences

Year:

1997

Language:

english

File:

PDF, 260 KB

english, 1997

45

Eighth conference on DNA topoisomerases and therapy Amsterdam, The Netherlands 15–17 October 1997

Giuseppe Giaccone, Giovanni Capranico

Journal:

Drug Resistance Updates

Year:

1998

Language:

english

File:

PDF, 501 KB

english, 1998

46

10th Conference on DNA Topoisomerases in therapy

Giuseppe Giaccone, Giovanni Capranico

Journal:

Drug Resistance Updates

Year:

1999

Language:

english

File:

PDF, 122 KB

english, 1999

47

The role of topoisomerase II in drug resistance

Paola De Isabella, Giovanni Capranico, Franco Zunino

Journal:

Year:

1991

Language:

english

File:

PDF, 831 KB

english, 1991

48

G1 cell-cycle arrest and apoptosis by histone deacetylase inhibition in MLL-AF9 acute myeloid leukemia cells is p21 dependent and MLL-AF9 independent

Tonelli, R, Sartini, R, Fronza, R, Freccero, F, Franzoni, M, Dongiovanni, D, Ballarini, M, Ferrari, S, D'apolito, M, Di Cola, G, Capranico, G, Khobta, A, Campanini, R, Paolucci, P, Minucci, S, Pession

Journal:

Year:

2006

Language:

english

File:

PDF, 293 KB

english, 2006

49

Inhibitors of mammalian DNA topoisomerases

Giovanni Capranico, Franco Zunino

Journal:

Pharmacological Research

Year:

1995

Language:

english

File:

PDF, 163 KB

english, 1995

50

Physicochemical properties, cytotoxic activity and topoisomerase ii inhibition of 2,3-diaza-anthracenediones

Paola De Isabella, Manlio Palumbo, Claudia Sissi, Nives Carenini, Giovanni Capranico, Emesto Menta, Ambrogio Oliva, Silvano Spinelli, A.Paul Krapcho, Fernando C. Giuliani, Franco Zunino

Journal:

Biochemical Pharmacology

Year:

1997

Language:

english

File:

PDF, 1.06 MB

english, 1997

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