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1

New Mechanistic and Functional Insights into DNA Topoisomerases

Chen, Stefanie Hartman, Chan, Nei-Li, Hsieh, Tao-shih

Journal:

Annual Review of Biochemistry

Year:

2013

Language:

english

File:

PDF, 610 KB

english, 2013

2

Structural basis of the mercury(II)-mediated conformational switching of the dual-function transcriptional regulator MerR

Chang, Chih-Chiang, Lin, Li-Ying, Zou, Xiao-Wei, Huang, Chieh-Chen, Chan, Nei-Li

Journal:

Nucleic Acids Research

Year:

2015

Language:

english

File:

PDF, 8.43 MB

english, 2015

3

Insights into desaturation of cyclopeptin and its C3-epimer catalyzed by a non-heme iron enzyme: structural characterization and mechanism elucidation

CHANG, WEI-CHEN, Liao, Hsuan-Jen, Li, Jikun, Huang, Jhih-Liang, Davidson, Madison, Kurnikov, Igor, Lin, Te-Sheng, Lee, Justin L., Kurnikova, Maria, Guo, Yisong, Chan, Nei-Li

Journal:

Angewandte Chemie International Edition

Year:

2018

Language:

english

File:

PDF, 1.09 MB

english, 2018

4

Crystal structure of the conserved hypothetical cytosolic protein Xcc0516 from Xanthomonas campestris reveals a novel quaternary structure assembled by five four-helix bundles

Li-Ying Lin, Chung-Lun Ching, Ko-Hsin Chin, Shan-Ho Chou, Nei-Li Chan

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2006

Language:

english

File:

PDF, 277 KB

english, 2006

5

The crystal structure of XC1258 from Xanthomonas campestris: A putative procaryotic Nit protein with an arsenic adduct in the active site

Ko-Hsin Chin, Ying-Der Tsai, Nei-Li Chan, Kai-Fa Huang, Andrew H.-J. Wang, Shan-Ho Chou

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2007

Language:

english

File:

PDF, 669 KB

english, 2007

6

Mutation of a key residue in the type II secretion system ATPase uncouples ATP hydrolysis from protein translocation

Sheng-Jie Shiue, I-Ling Chien, Nei-Li Chan, Wei-Ming Leu, Nien-Tai Hu

Journal:

Molecular Microbiology

Year:

2007

Language:

english

File:

PDF, 442 KB

english, 2007

7

Asymmetrical Synthesis of l-Homophenylalanine Using Engineered Escherichia coli Aspartate Aminotransferase

Hsueh-Hsia Lo, Shih-Kuang Hsu, Wei-De Lin, Nei-Li Chan, Wen-Hwei Hsu

Journal:

Biotechnology Progress

Year:

2005

Language:

english

File:

PDF, 117 KB

english, 2005

8

10.1038/90337

Chan, Nei-Li, Hill, Christopher P.

Journal:

Natural Structural Biology

Year:

2001

Language:

english

File:

PDF, 1.40 MB

english, 2001

9

XpsE oligomerization triggered by ATP binding, not hydrolysis, leads to its association with XpsL

Shiue, Sheng-Jie, Kao, Ko-Min, Leu, Wei-Ming, Chen, Ling-Yun, Chan, Nei-Li, Hu, Nien-Tai

Journal:

The EMBO Journal

Year:

2006

Language:

english

File:

PDF, 350 KB

english, 2006

10

Anthracenedione–methionine conjugates are novel topoisomerase II-targeting anticancer agents with favorable drug resistance profiles

Chieh-Hua Lee, Mei-Yi Hsieh, Ling-Wei Hsin, Hsiang-Chin Chen, Su-Chi Lo, Jia-Rong Fan, Wan-Ru Chen, Hung-Wei Chen, Nei-Li Chan, Tsai-Kun Li

Journal:

Biochemical Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.23 MB

english, 2012

11

In trans interaction of hepatitis C virus helicase domains mediates protease activity critical for internal NS3 cleavage and cell transformation

Ren-You Pan, Tzu-Min Hung, Yi-Hen Kou, Nei-Li Chan, Ming-Fu Chang, Shin C. Chang

Journal:

Year:

2010

Language:

english

File:

PDF, 480 KB

english, 2010

12

The many blades of the β-propeller proteins: conserved but versatile

Cammy K.-M. Chen, Nei-Li Chan, Andrew H.-J. Wang

Journal:

Trends in Biochemical Sciences

Year:

2011

Language:

english

File:

PDF, 1.38 MB

english, 2011

13

Crystal Structure of the Human Prostacyclin Synthase

Chia-Wang Chiang, Hui-Chun Yeh, Lee-Ho Wang, Nei-Li Chan

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 1.35 MB

english, 2006

14

New insights into DNA-binding by type IIA topoisomerases

Chang, Chih-Chiang, Wang, Ying-Ren, Chen, Shin-Fu, Wu, Chyuan-Chuan, Chan, Nei-Li

Journal:

Current Opinion in Structural Biology

Year:

2013

Language:

english

File:

PDF, 2.06 MB

english, 2013

15

Structural characteristics of the nonallosteric human cytosolic malic enzyme

Hsieh, Ju-Yi, Li, Shao-Yu, Chen, Meng-Chun, Yang, Pai-Chun, Chen, Hui-Yi, Chan, Nei-Li, Liu, Jyung-Hurng, Hung, Hui-Chih

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2014

Language:

english

File:

PDF, 3.22 MB

english, 2014

16

Crystal Structure of the S-Nitroso Form of Liganded Human Hemoglobin †,‡

Chan, Nei-Li, Rogers, Paul H., Arnone, Arthur

Journal:

Year:

1998

Language:

english

File:

PDF, 133 KB

english, 1998

17

Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Hemoglobin †,‡

Chan, Nei-Li, Kavanaugh, Jeffrey S., Rogers, Paul H., Arnone, Arthur

Journal:

Year:

2004

Language:

english

File:

PDF, 1.47 MB

english, 2004

18

DNA Topoisomerase II Is Involved in Regulation of Cyst Wall Protein Genes and Differentiation in Giardia lamblia

Lin, Bo-Chi, Su, Li-Hsin, Weng, Shih-Che, Pan, Yu-Jiao, Chan, Nei-Li, Li, Tsai-Kun, Wang, Hsin-Chih, Sun, Chin-Hung, Singer, Steven M.

Journal:

PLoS Neglected Tropical Diseases

Year:

2013

Language:

english

File:

PDF, 5.01 MB

english, 2013

19

Chemical Inhibition of Human Thymidylate Kinase and Structural Insights into the Phosphate Binding Loop and Ligand-induced Degradation

Chen, Yi-Hsuan, Hsu, Hua-Yi, Yeh, Ming-Tyng, Chen, Chen-Cheng, Huang, Chang-Yu, Chung, Ying-Hsuan, Chang, Zee-Fen, Kuo, Wei-Chen, Chan, Nei-li, Weng, Jui-Hsia, Chung, Bon-chu, Chen, Yu-Ju, Jian, Cheng

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.30 MB

english, 2016

20

Functional characterization of the meiosis-specific DNA double-strand break inducing factor SPO-11 from C. elegans

Yeh, Hsin-Yi, Lin, Sheng-Wei, Wu, Yi-Chun, Chan, Nei-Li, Chi, Peter

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 2.76 MB

english, 2017

21

Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity

Lee, Yi-Ru, Lin, Te-Sheng, Lai, Shu-Jung, Liu, Mu-Sen, Lai, Mei-Chin, Chan, Nei-Li

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 2.05 MB

english, 2016

22

Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry

Wang, Ying-Ren, Chen, Shin-Fu, Wu, Chyuan-Chuan, Liao, Yi-Wen, Lin, Te-Sheng, Liu, Ko-Ting, Chen, Yi-Song, Li, Tsai-Kun, Chien, Tun-Cheng, Chan, Nei-Li

Journal:

Nucleic Acids Research

Year:

2017

Language:

english

File:

PDF, 415 KB

english, 2017

23

Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry

Wang, Ying-Ren, Chen, Shin-Fu, Wu, Chyuan-Chuan, Liao, Yi-Wen, Lin, Te-Sheng, Liu, Ko-Ting, Chen, Yi-Song, Li, Tsai-Kun, Chien, Tun-Cheng, Chan, Nei-Li

Journal:

Nucleic Acids Research

Year:

2017

Language:

english

File:

PDF, 5.09 MB

english, 2017

24

Topoisomerases as anticancer targets

Delgado, Justine L., Hsieh, Chao-Ming, Chan, Nei-Li, Hiasa, Hiroshi

Journal:

Biochemical Journal

Year:

2018

Language:

english

File:

PDF, 3.23 MB

english, 2018

25

Insights into the Desaturation of Cyclopeptin and its C3 Epimer Catalyzed by a non-Heme Iron Enzyme: Structural Characterization and Mechanism Elucidation

Liao, Hsuan-Jen, Li, Jikun, Huang, Jhih-Liang, Davidson, Madison, Kurnikov, Igor, Lin, Te-Sheng, Lee, Justin L., Kurnikova, Maria, Guo, Yisong, Chan, Nei-Li, Chang, Wei-chen

Journal:

Angewandte Chemie

Year:

2018

Language:

english

File:

PDF, 2.86 MB

english, 2018

26

Correction: DNA Topoisomerase II Is Involved in Regulation of Cyst Wall Protein Genes and Differentiation in Giardia lamblia

Lin, Bo-Chi, Su, Li-Hsin, Weng, Shih-Che, Pan, Yu-Jiao, Chan, Nei-Li, Li, Tsai-Kun, Wang, Hsin-Chih, Sun, Chin-Hung

Journal:

PLoS Neglected Tropical Diseases

Year:

2017

Language:

english

File:

PDF, 935 KB

english, 2017

27

Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate

Chen, Shin-Fu, Huang, Nan-Lan, Lin, Jung-Hsin, Wu, Chyuan-Chuan, Wang, Ying-Ren, Yu, Yu-Jen, Gilson, Michael K., Chan, Nei-Li

Journal:

Nature Communications

Year:

2018

Language:

english

File:

PDF, 4.50 MB

english, 2018

28

Epoxidation Catalyzed by the Non-heme Iron- and 2-Oxoglutarate-Dependent Oxygenase, AsqJ: Mechanistic Elucidation of Oxygen Atom Transfer by a Ferryl Intermediate

Li, Jikun, Liao, Hsuan-Jen, Tang, Yijie, Huang, Jhih-Liang, Cha, Lide, Lin, Te-Sheng, Lee, Justin L., Kurnikov, Igor V, Kurnikova, Maria G, Chang, Wei-chen, Chan, Nei-Li, Guo, Yisong

Journal:

Journal of the American Chemical Society

Year:

2020

File:

PDF, 1.65 MB

2020

29

Structure of Human Phosphodiesterase 5A1 Complexed with Avanafil Reveals Molecular Basis of Isoform Selectivity and Guide-lines for Targeting Î±-Helix Backbone Oxygen by Halogen Bonding

Hsieh, Chao-Ming, Chen, Chun-Yi, Chern, Ji-Wang, Chan, Nei-Li

Journal:

Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.11 MB

2020

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