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1

Characterization of bromosulphophthalein binding to human glutathione S-transferase A1-1: thermodynamics and inhibition kinetics

KOLOBE, Doris, SAYED, Yasien, DIRR, Heini W.

Journal:

Biochemical Journal

Year:

2004

Language:

english

File:

PDF, 363 KB

english, 2004

2

Energetics of Glutathione Binding to Human Eukaryotic Elongation Factor 1 Gamma: Isothermal Titration Calorimetry and Molecular Dynamics Studies

Tshabalala, Thabiso N., Tomescu, Mihai-Silviu, Prior, Allan, Balakrishnan, Vijayakumar, Sayed, Yasien, Dirr, Heini W., Achilonu, Ikechukwu

Journal:

The Protein Journal

Year:

2016

Language:

english

File:

PDF, 1.30 MB

english, 2016

3

Solvent effects on the spectroscopic properties of aflatoxin B1

Journal:

International Journal of Biochemistry

Year:

1987

Language:

english

File:

PDF, 291 KB

english, 1987

4

Accessibility of the tryptophan residues and flavin prosthetic group of β-cyclopiazonate oxidocyclase to solvent studied by fluorescence quenching

Heini W. Dirr, Gerdinand L. Erasmus, Johan C. Schabort

Journal:

International Journal of Biochemistry

Year:

1988

Language:

english

File:

PDF, 261 KB

english, 1988

5

Purification and properties of an esterase from Cucurbita maxima fruit tissue

Amanda Nourse, Johan C. Schabort, Heini W. Dirr, Ian A. Dubery

Journal:

Year:

1989

Language:

english

File:

PDF, 721 KB

english, 1989

6

Stability of the domain interface contributes towards the catalytic function at the H-site of class alpha glutathione transferase A1-1

David Balchin, Sylvia Fanucchi, Ikechukwu Achilonu, Roslin J. Adamson, Jonathan Burke, Manuel Fernandes, Samantha Gildenhuys, Heini W. Dirr

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2010

Language:

english

File:

PDF, 696 KB

english, 2010

7

Characterization of the binding of 8-anilinonaphthalene sulfonate to rat class Mu GST M1-1

Nichole Kinsley, Yasien Sayed, Salerwe Mosebi, Richard N. Armstrong, Heini W. Dirr

Journal:

Biophysical Chemistry

Year:

2008

Language:

english

File:

PDF, 478 KB

english, 2008

8

Arginine 15 stabilizes an SNAr reaction transition state and the binding of anionic ligands at the active site of human glutathione transferase A1-1

Samantha Gildenhuys, Marina Dobreva, Nichole Kinsley, Yasien Sayed, Jonathan Burke, Stephen Pelly, Graeme P. Gordon, Muhammed Sayed, Trevor Sewell, Heini W. Dirr

Journal:

Biophysical Chemistry

Year:

2010

Language:

english

File:

PDF, 725 KB

english, 2010

9

Energetics of ligand binding to human glutathione transferase A1-1: Tyr-9 associated localisation of the C-terminal helix is ligand-dependent

David Balchin, Heini W. Dirr, Yasien Sayed

Journal:

Biophysical Chemistry

Year:

2011

Language:

english

File:

PDF, 646 KB

english, 2011

10

Conformational stability of pGEX-expressed Schistosoma japonicum glutathione S-transferase: A detoxification enzyme and fusion-protein affinity tag

Warren Kaplan, Julija Erhardt, Nicolas Sluis-Cremer, Heini Dirr, Paul Hüsler, Horst Klump

Journal:

Protein Science

Year:

1997

Language:

english

File:

PDF, 2.17 MB

english, 1997

11

Characterization of the aflatoxin B1-binding site of rat albumin

Heini W. Dirr, Johannes C. Schabort

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1987

Language:

english

File:

PDF, 625 KB

english, 1987

12

Purification and partial characterization of the glutathione S-transferase of rat erythrocytes

Heini W. Dirr, Johan C. Schabort

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1988

Language:

english

File:

PDF, 721 KB

english, 1988

13

Porcine class π glutathione S-transferase: anionic ligand binding and conformational analysis

Paula Bico, Julija Erhardt, Warren Kaplan, Heini Dirr

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1995

Language:

english

File:

PDF, 543 KB

english, 1995

14

Domain–domain interface packing at conserved Trp-20 in class α glutathione transferase impacts on protein stability

Louise A. Wallace, Jonathan Burke, Heini W. Dirr

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

2000

Language:

english

File:

PDF, 356 KB

english, 2000

15

Aflatoxin B1 and sulphobromophthalein binding to the dimeric human glutathione S-transferase A1-1 : a fluorescence spectroscopic analysis

Nicolas Sluis-Cremer, Louise Wallace, Jonathan Burke, Julie Stevens, Heini Dirr

Journal:

Year:

1998

Language:

english

File:

PDF, 265 KB

english, 1998

16

Class π glutathione S-transferase from pig lung : Purification, biochemical characterization, primary structure and crystallization

Heini W. DIRR, Karlheinz MANN, Robert HUBER, Rudi LADENSTEIN, Peter REINEMER

Journal:

Year:

1991

Language:

english

File:

PDF, 661 KB

english, 1991

17

X-ray crystal structures of cytosolic glutathione S-transferases : Implications for protein architecture, substrate recognition and catalytic function

Heini DIRR, Peter REINEMER, Robert HUBER

Journal:

Year:

1994

Language:

english

File:

PDF, 1.94 MB

english, 1994

18

Native Dimer Stabilizes the Subunit Tertiary Structure of Porcine Class pi Glutathione S-transferase

Julija Erhardt, Heini Dirr

Journal:

Year:

1995

Language:

english

File:

PDF, 787 KB

english, 1995

19

Determination of a Binding Site for a Non-Substrate Ligand in Mammalian Cytosolic Glutathione S-Transferases by means of Fluorescence-Resonance Energy Transfer

Nicolas Sluis-Cremer, Nirinjini N. Naidoo, Warren H. Kaplan, T. Herbert Manoharan, William E. Fahl, Heini W. Dirr

Journal:

Year:

1996

Language:

english

File:

PDF, 584 KB

english, 1996

20

Class-pi Glutathione S-Transferase is Unable to Regain Its Native Conformation After Oxidative Inactivation by Hydrogen Peroxide

Nicolas Sluis-Cremer, Nirinjini Naidoo, Heini Dirr

Journal:

Year:

1996

Language:

english

File:

PDF, 803 KB

english, 1996

21

Structure Determination and Refinement of Human Alpha Class Glutathione Transferase A1-1, and a Comparison with the Mu and Pi Class Enzymes

Irmgard Sinning, Gerard J. Kleywegt, Sandra W. Cowan, Peter Reinemer, Heini W. Dirr, Robert Huber, Gary L. Gilliland, Richard N. Armstrong, Xinhua Ji, Philip G. Board, Birgit Olin, Bengt Mannervik, T.

Journal:

Journal of Molecular Biology

Year:

1993

File:

PDF, 1.22 MB

1993

22

Refined Crystal Structure of Porcine Class Pi Glutathione S-Transferase (pGST P1-1) at 2·1 Å Resolution

Heini Dirr, Peter Reinemer, Robert Huber

Journal:

Journal of Molecular Biology

Year:

1994

File:

PDF, 1.53 MB

1994

23

The Cochaperone Murine Stress-Inducible Protein 1: Overexpression, Purification, and Characterization

Jacqueline van der Spuy, Michael E. Cheetham, Heini W. Dirr, Gregory L. Blatch

Journal:

Protein Expression and Purification

Year:

2001

Language:

english

File:

PDF, 224 KB

english, 2001

24

Conformational stability of Cys45-alkylated and hydrogen peroxide-oxidised glutathione S-transferase

Nicolas Sluis-Cremer, Heini Dirr

Journal:

Year:

1995

Language:

english

File:

PDF, 513 KB

english, 1995

25

Effect of glutathione, glutathione sulphonate and S-hexylglutathione on the conformational stability of class pi glutathione S-transferase

Julija Erhardt, Heini Dirr

Journal:

Year:

1996

Language:

english

File:

PDF, 428 KB

english, 1996

26

Three-dimensional structure of class π glutathione S-transferase from human placenta in complex with S-hexylglutathione at 2.8 Å resolution

Peter Reinemer, Heini W. Dirr, Rudolf Ladenstein, Robert Huber, Mario Lo Bello, Giorgio Federici, Michael W. Parker

Journal:

Journal of Molecular Biology

Year:

1992

Language:

english

File:

PDF, 2.45 MB

english, 1992

27

Mutational substitution of residues implicated by crystal structure in binding the substrate glutathione to human glutathione S-transferase π

T.Herbert Manoharan, Andrew M. Gulick, Peter Reinemer, Heini W. Dirr, Robert Huber, William E. Fahl

Journal:

Journal of Molecular Biology

Year:

1992

Language:

english

File:

PDF, 408 KB

english, 1992

28

Tertiary Interactions Stabilise the C-terminal Region of Human Glutathione Transferase A1-1: a Crystallographic and Calorimetric Study

Diane C. Kuhnert, Yasien Sayed, Salerwe Mosebi, Muhammed Sayed, Trevor Sewell, Heini W. Dirr

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 516 KB

english, 2005

29

Equilibrium unfolding of class π glutathione S-transferase

Heini W. Dirr, Peter Reinemer

Journal:

Biochemical and Biophysical Research Communications

Year:

1991

Language:

english

File:

PDF, 379 KB

english, 1991

30

The hydrophobic lock-and-key intersubunit motif of glutathione transferase A1-1: implications for catalysis, ligandin function and stability

Yasien Sayed, Louise A. Wallace, Heini W. Dirr

Journal:

Year:

2000

Language:

english

File:

PDF, 219 KB

english, 2000

31

Impact of domain interchange on conformational stability and equilibrium folding of chimeric class μ glutathione transferases

Jiann-Kae Luo, Judith A.T. Hornby, Louise A. Wallace, Jihong Chen, Richard N. Armstrong, Heini W. Dirr

Journal:

Protein Science

Year:

2002

Language:

english

File:

PDF, 296 KB

english, 2002

32

Role of Individual Histidines in the pH-Dependent Global Stability of Human Chloride Intracellular Channel 1

Achilonu, Ikechukwu, Fanucchi, Sylvia, Cross, Megan, Fernandes, Manuel, Dirr, Heini W.

Journal:

Year:

2012

Language:

english

File:

PDF, 2.30 MB

english, 2012

33

Role of Arginine 29 and Glutamic Acid 81 Interactions in the Conformational Stability of Human Chloride Intracellular Channel 1

Legg-E’Silva, Derryn, Achilonu, Ikechukwu, Fanucchi, Sylvia, Stoychev, Stoyan, Fernandes, Manuel, Dirr, Heini W.

Journal:

Year:

2012

Language:

english

File:

PDF, 2.03 MB

english, 2012

34

Polymorphic Diversity: N -Phenylbenzamide as a Possible Polymorphophore

Zipp, Caitlin F., Dirr, Heini W., Fernandes, Manuel A., Marques, Helder M., Michael, Joseph P.

Journal:

Crystal Growth & Design

Year:

2013

Language:

english

File:

PDF, 1.84 MB

english, 2013

35

Residue 219 Impacts on the Dynamics of the C-Terminal Region in Glutathione Transferase A1-1: Implications for Stability and Catalytic and Ligandin Functions †

Mosebi, Salerwe, Sayed, Yasien, Burke, Jonathan, Dirr, Heini W.

Journal:

Year:

2003

Language:

english

File:

PDF, 98 KB

english, 2003

36

F99 is Critical for Dimerization and Activation of South African HIV-1 Subtype C Protease

Naicker, Previn, Seele, Palesa, Dirr, Heini W., Sayed, Yasien

Journal:

The Protein Journal

Year:

2013

Language:

english

File:

PDF, 502 KB

english, 2013

37

Purification and characterisation of recombinant human eukaryotic elongation factor 1 gamma

Achilonu, Ikechukwu, Siganunu, Thendo P., Dirr, Heini W.

Journal:

Protein Expression and Purification

Year:

2014

Language:

english

File:

PDF, 1.11 MB

english, 2014

38

Afaltoxin B1 transport in rat blood plasma. Binding to albumin in vivo and in vitro and spectrofluorimetric studies into the nature of the interaction

Dirr, Heini W., Schabort, Johan C.

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

1986

Language:

english

File:

PDF, 580 KB

english, 1986

39

JNK1β1 is phosphorylated during expression in E. coli and in vitro by MKK4 at three identical novel sites

Owen, Gavin R., Stoychev, Stoyan, Achilonu, Ikechukwu, Dirr, Heini W.

Journal:

Biochemical and Biophysical Research Communications

Year:

2013

Language:

english

File:

PDF, 805 KB

english, 2013

40

High yield purification of JNK1β1 and activation by in vitro reconstitution of the MEKK1→MKK4→JNK MAPK phosphorylation cascade

Owen, Gavin R., Achilonu, Ikechukwu, Dirr, Heini W.

Journal:

Protein Expression and Purification

Year:

2013

Language:

english

File:

PDF, 1.46 MB

english, 2013

41

A conserved cationic motif enhances membrane binding and insertion of the chloride intracellular channel protein 1 transmembrane domain

Peter, Bradley, Fanucchi, Sylvia, Dirr, Heini W.

Journal:

European Biophysics Journal

Year:

2014

Language:

english

File:

PDF, 992 KB

english, 2014

42

Influence of the Dimer Interface on Glutathione Transferase Structure and Dynamics Revealed by Amide H/D Exchange Mass Spectrometry †

Codreanu, Simona G., Thompson, Lawrence C., Hachey, David L., Dirr, Heini W., Armstrong, Richard N.

Journal:

Year:

2005

Language:

english

File:

PDF, 507 KB

english, 2005

43

Equilibrium and Kinetic Unfolding Properties of Dimeric Human Glutathione Transferase A1-1 †

Wallace, Louise A., Sluis-Cremer, Nicolas, Dirr, Heini W.

Journal:

Year:

1998

Language:

english

File:

PDF, 118 KB

english, 1998

44

Stability and Unfolding of Reduced Escherichia coli Glutaredoxin 2: A Monomeric Structural Homologue of the Glutathione Transferase Family †

Gildenhuys, Samantha, Wallace, Louise A., Dirr, Heini W.

Journal:

Year:

2008

Language:

english

File:

PDF, 1.58 MB

english, 2008

45

A Lys–Trp Cation−π Interaction Mediates the Dimerization and Function of the Chloride Intracellular Channel Protein 1 Transmembrane Domain

Peter, Bradley, Polyansky, Anton A., Fanucchi, Sylvia, Dirr, Heini W.

Journal:

Year:

2014

Language:

english

File:

PDF, 3.32 MB

english, 2014

46

Molecular Recognition at the Dimer Interface of a Class Mu Glutathione Transferase: Role of a Hydrophobic Interaction Motif in Dimer Stability and Protein Function †

Hornby, Judith A. T., Codreanu, Simona G., Armstrong, Richard N., Dirr, Heini W.

Journal:

Year:

2002

Language:

english

File:

PDF, 327 KB

english, 2002

47

Formation of an Unfolding Intermediate State of Soluble Chloride Intracellular Channel Protein CLIC1 at Acidic pH †

Fanucchi, Sylvia, Adamson, Roslin J., Dirr, Heini W.

Journal:

Year:

2008

Language:

english

File:

PDF, 960 KB

english, 2008

48

S- Nitrosation Destabilizes Glutathione Transferase P1-1

Balchin, David, Stoychev, Stoyan H., Dirr, Heini W.

Journal:

Year:

2013

Language:

english

File:

PDF, 506 KB

english, 2013

49

Phosphorylation- and Nucleotide-Binding-Induced Changes to the Stability and Hydrogen Exchange Patterns of JNK1β1 Provide Insight into Its Mechanisms of Activation

Owen, Gavin R., Stoychev, Stoyan, Achilonu, Ikechukwu, Dirr, Heini W.

Journal:

Journal of Molecular Biology

Year:

2014

Language:

english

File:

PDF, 3.86 MB

english, 2014

50

Membrane Mimetics Induce Helix Formation and Oligomerization of the Chloride Intracellular Channel Protein 1 Transmembrane Domain

Peter, Bradley, Ngubane, Nomxolisi Chloë Mina-Liz, Fanucchi, Sylvia, Dirr, Heini W.

Journal:

Year:

2013

Language:

english

File:

PDF, 3.67 MB

english, 2013