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1

Structure-based design of parasitic protease inhibitors

Rongshi Li, Xiaowu Chen, Baoqing Gong, Paul M. Selzer, Zhe Li, Eugene Davidson, Gary Kurzban, Robert E. Miller, Edwin O. Nuzum, James H. McKerrow, Robert J. Fletterick, Sarah A. Gillmor, Charles S. Cr

Journal:

Bioorganic & Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 553 KB

english, 1996

2

Hydrogen bonds involving sulfur atoms in proteins

Lydia M. Gregoret, Stephen D. Rader, Robert J. Fletterick, Fred E. Cohen

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1991

Language:

english

File:

PDF, 694 KB

english, 1991

3

10.1038/20708

Ybe, Joel A., Brodsky, Frances M., Hofmann, Kay, Lin, Kai, Liu, Shu-Hui, Chen, Lin, Earnest, Thomas N., Fletterick, Robert J., Hwang, Peter K.

Journal:

Year:

1999

Language:

english

File:

PDF, 645 KB

english, 1999

4

A structural role for hormone in the thyroid hormone receptor

Wagner, Richard L., Apriletti, James W., McGrath, Mary E., West, Brian L., Baxter, John D., Fletterick, Robert J.

Journal:

Year:

1995

File:

PDF, 2.45 MB

1995

5

Structural origins of substrate discrimination in trypsin and chymotrypsin

Perona, John J., Hedstrom, Lizbeth, Rutter, William J., Fletterick, Robert J.

Journal:

Year:

1995

Language:

english

File:

PDF, 5.16 MB

english, 1995

6

Proteases

Phillips, Margaret A., Fletterick, Robert J.

Journal:

Current Opinion in Structural Biology

Year:

1992

Language:

english

File:

PDF, 785 KB

english, 1992

7

Delocalizing Trypsin Specificity with Metal Activation †

Willett, W. Scott, Brinen, Linda S., Fletterick, Robert J., Craik, Charles S.

Journal:

Year:

1996

Language:

english

File:

PDF, 467 KB

english, 1996

8

NUCLEAR-RECEPTOR LIGANDS AND LIGAND-BINDING DOMAINS

Weatherman, Ross V., Fletterick, Robert J., Scanlan, Thomas S.

Journal:

Annual Review of Biochemistry

Year:

1999

Language:

english

File:

PDF, 1.28 MB

english, 1999

9

Two Resistance to Thyroid Hormone Mutants with Impaired Hormone Binding

Huber, B. Russell, Sandler, Ben, West, Brian L., Cunha Lima, Suzana T., Nguyen, Hoa T., Apriletti, James W., Baxter, John D., Fletterick, Robert J.

Journal:

Molecular Endocrinology

Year:

2003

Language:

english

File:

PDF, 393 KB

english, 2003

10

Thyroid Hormone Receptor-β Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit Decreased Stability in the N-Terminal Ligand-Binding Domain

Huber, B. Russell, Desclozeaux, Marion, West, Brian L., Cunha-Lima, Suzana T., Nguyen, Hoa T., Baxter, John D., Ingraham, Holly A., Fletterick, Robert J.

Journal:

Molecular Endocrinology

Year:

2003

Language:

english

File:

PDF, 506 KB

english, 2003

11

Hormone Selectivity in Thyroid Hormone Receptors

Wagner, Richard L., Huber, B. Russell, Shiau, Andrew K., Kelly, Alex, Cunha Lima, Suzana T., Scanlan, Thomas S., Apriletti, James W., Baxter, John D., West, Brian L., Fletterick, Robert J.

Journal:

Molecular Endocrinology

Year:

2001

Language:

english

File:

PDF, 2.13 MB

english, 2001

12

Three-dimensional model of the ligand binding domain of the nuclear receptor for 1α,25-dihydroxy-vitamin D3

Anthony W. Norman, Derk Adams, Elaine D. Collins, William H. Okamura, Robert J. Fletterick

Journal:

Journal of Cellular Biochemistry

Year:

1999

Language:

english

File:

PDF, 449 KB

english, 1999

13

Reversing a ‘backwards’ motor

Sharyn A. Endow, Robert J. Fletterick

Journal:

Year:

1998

Language:

english

File:

PDF, 78 KB

english, 1998

14

McArdle's disease: Biochemical and molecular genetic studies

Serenella Servidei, Sara Shanske, Massimo Zeviani, Roger Lebo, Robert Fletterick, Dr. Salvatore DiMauro

Journal:

Annals of Neurology

Year:

1988

Language:

english

File:

PDF, 810 KB

english, 1988

15

Color-coded α-carbon models of proteins

Robert J. Fletterick, Raymond Matela

Journal:

Year:

1982

Language:

english

File:

PDF, 279 KB

english, 1982

16

Three-dimensional structural analysis of fibronectin heparin-binding domain mutations

Yvonne Kapila, Denise Doan, Elizabeth Tafolla, Robert Fletterick

Journal:

Journal of Cellular Biochemistry

Year:

2001

Language:

english

File:

PDF, 454 KB

english, 2001

17

Redesigning trypsin via genetic engineering

Charles S. Craik, Steven Roczniak, Stephen Sprang, Robert Fletterick, William Rutter

Journal:

Journal of Cellular Biochemistry

Year:

1987

Language:

english

File:

PDF, 835 KB

english, 1987

18

Purification of glycogen phosphorylase isozymes by metal-affinity chromatography

Christine B.H. Luong, Michelle F. Browner, Robert J. Fletterick, Barry L. Haymore

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1992

Language:

english

File:

PDF, 2.04 MB

english, 1992

19

Computer simulation of cellular self-sorting: A topological exchange model

Raymond J. Matela, Robert J. Fletterick

Journal:

Journal of Theoretical Biology

Year:

1980

Language:

english

File:

PDF, 737 KB

english, 1980

20

Structure-Activity Analysis of the Purine Binding Site of Human Liver Glycogen Phosphorylase

Jennifer L Ekstrom, Thomas A Pauly, Maynard D Carty, Walter C Soeller, Jeff Culp, Dennis E Danley, Dennis J Hoover, Judith L Treadway, E.Michael Gibbs, Robert J Fletterick, Yasmina S.N Day, David G My

Journal:

Chemistry & Biology

Year:

2002

Language:

english

File:

PDF, 320 KB

english, 2002

21

A negative electrostatic determinant mediates the association between the Escherichia coli trp repressor and its operator DNA

Jeanmarie Guenot, Robert J. Fletterick, Peter A. Kollman

Journal:

Protein Science

Year:

1994

Language:

english

File:

PDF, 9.52 MB

english, 1994

22

Ecotin: Lessons on survival in a protease-filled world

Mary E. Mcgrath, Sarah A. Gillmor, Robert J. Fletterick

Journal:

Protein Science

Year:

1995

Language:

english

File:

PDF, 8.78 MB

english, 1995

23

Structural determinants of specificity in the cysteine protease cruzain

Sarah A. Gillmor, Charles S. Craik, Robert J Fletterick

Journal:

Protein Science

Year:

1997

Language:

english

File:

PDF, 7.02 MB

english, 1997

24

Molecular basis for dimer formation of TRβ variant D355R

Natalia Jouravel, Elena Sablin, Marie Togashi, John D. Baxter, Paul Webb, Robert J. Fletterick

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2009

Language:

english

File:

PDF, 524 KB

english, 2009

25

Modeling the biochemical differences between rabbit muscle and human liver phosphorylase

Virginia L. Rath, Christopher B. Newgard, Stephen R. Sprang, Elizabeth J. Goldsmith, Robert J. Fletterick

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1987

Language:

english

File:

PDF, 1.10 MB

english, 1987

26

Erratum

Ludia M. Gregoret, Stephen D. Rader, Robert J. Fletterick, Fred E. Cohen

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1991

Language:

english

File:

PDF, 48 KB

english, 1991

27

Introduction to protein structure, by Carl Branden and John Tooze. New York: Garland Publishing Company, 302 pages, $27.95 (paper), 1991

Robert J. Fletterick

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1992

Language:

english

File:

PDF, 101 KB

english, 1992

28

Crystallization and preliminary structural studies of the ncd motor domain

Elena P. Sablin, Robert J. Fletterick

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1995

Language:

english

File:

PDF, 218 KB

english, 1995

29

Crystallization and preliminary diffraction studies of thioesterase II from rat mammary gland

Jenny L. Buchbinder, Andrzej Witkowski, Stuart Smith, Robert J. Fletterick

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1995

Language:

english

File:

PDF, 294 KB

english, 1995

30

Rare McArdle disease locus polymorphic site on 11q13 contains CpG sequence

Roger V. Lebo, Lee A. Anderson, Salvatore DiMauro, Eric Lynch, Peter Hwang, Robert Fletterick

Journal:

Year:

1990

Language:

english

File:

PDF, 1.26 MB

english, 1990

31

Ecotin: A most adaptable protease inhibitor

Sarah A. Gillmor, Mary E. McGrath, Robert J. Fletterick

Journal:

Perspectives in Drug Discovery and Design

Year:

1995

Language:

english

File:

PDF, 832 KB

english, 1995

32

A topological exchange model for cell self-sorting

Raymond J. Matela, Robert J. Fletterick

Journal:

Journal of Theoretical Biology

Year:

1979

Language:

english

File:

PDF, 1.32 MB

english, 1979

33

MOLECULAR AND STRUCTURAL BIOLOGY OF THYROID HORMONE RECEPTORS

James W. Apriletti, Ralff CJ Ribeiro, Richard L. Wagner, Weijun Feng, Paul Webb, Peter J. Kushner, Brian L. West, Stefan Nilsson, Thomas S. Scanlan, Robert J. Fletterick, John D. Baxter

Journal:

Clinical and Experimental Pharmacology and Physiology

Year:

1998

Language:

english

File:

PDF, 1.04 MB

english, 1998

34

Molecular modelling of the androgen receptor axis: rational basis for androgen receptor intervention in androgen-independent prostate cancer

ROBERT J. FLETTERICK

Journal:

BJU International

Year:

2005

Language:

english

File:

PDF, 992 KB

english, 2005

35

10.1038/27463

Vale, Ronald D., Sablin, Elena P., Case, Ryan B., Dai, Shirleko C., Hart, Cynthia L., Ruby, Aaron, Fletterick, Robert J.

Journal:

Year:

1998

Language:

english

File:

PDF, 359 KB

english, 1998

36

Intron–exon splice junctions map at protein surfaces

Craik, Charles S., Sprang, Stephen, Fletterick, Robert, Rutter, William J.

Journal:

Year:

1982

File:

PDF, 310 KB

1982

37

Convergent and divergent evolution of regulatory sites in eukaryotic phosphorylases

Hwang, Peter K., Fletterick, Robert J.

Journal:

Year:

1986

File:

PDF, 752 KB

1986

38

AIDS virus and scrapie protein genes

BAZAN, J. FERNANDO, FLETTERICK, ROBERT J., PRUSINER, STANLEY B.

Journal:

Year:

1987

File:

PDF, 135 KB

1987

39

The burden of proof in linking AIDS to scrapie

BRAUN, MICHAEL J., GONDA, MATTHEW A., GEORGE, DAVID G., BAZAN, J. FERNANDO, FLETTERICK, ROBERT J., PRUSINER, STANLEY B.

Journal:

Year:

1987

File:

PDF, 285 KB

1987

40

10.1038/35078000

Kikkawa, Masahide, Sablin, Elena P., Okada, Yasushi, Yajima, Hiroaki, Fletterick, Robert J., Hirokawa, Nobutaka

Journal:

Year:

2001

Language:

english

File:

PDF, 496 KB

english, 2001

41

Three-dimensional structure of a tubulin-motor-protein complex

Vale, Ronald D., Fletterick, Robert J., Milligan, Ronald A., Hoenger, Andreas, Sablin, Elena P.

Journal:

Year:

1995

File:

PDF, 1.20 MB

1995

42

Crystal structure of the kinesin motor domain reveals a structural similarity to myosin

Jon Kull, F., Sablin, Elena P., Lau, Rebecca, Fletterick, Robert J., Vale, Ronald D.

Journal:

Year:

1996

File:

PDF, 1.95 MB

1996

43

Crystal structure of the motor domain of the kinesin-related motor ncd

Sablin, Elena P., Jon Kull, F., Cooke, Roger, Vale, Ronald D., Fletterick, Robert J.

Journal:

Year:

1996

File:

PDF, 1.54 MB

1996

44

10.1038/78992

Waugh, Sandra M., Craik, Charles S., Harris, Jennifer L., Fletterick, Robert

Journal:

Natural Structural Biology

Year:

2000

Language:

english

File:

PDF, 394 KB

english, 2000

45

Burying a charge

Browner, Michelle F., Gillmor, Sarah A., Fletterick, Robert

Journal:

Natural Structural Biology

Year:

1998

File:

PDF, 90 KB

1998

46

Deconvoluting serpins

Fletterick, Robert J., McGrath, Mary E.

Journal:

Natural Structural Biology

Year:

1994

File:

PDF, 477 KB

1994

47

Identification of the molecular trigger for allosteric activation in glycogen phosphorylase

Browner, Michelle F., Hackos, David, Fletterick, Robert

Journal:

Natural Structural Biology

Year:

1994

File:

PDF, 779 KB

1994

48

When one and one are not two

Fletterick, Robert J., Bazan, J. Fernando

Journal:

Natural Structural Biology

Year:

1995

File:

PDF, 306 KB

1995

49

Parallel evolution in two homologues of phosphorylase

Rath, Virginia L., Fletterick, Robert J.

Journal:

Natural Structural Biology

Year:

1994

File:

PDF, 1.20 MB

1994

50

The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity

Gillmor, Sarah A., Villaseñor, Armando, Fletterick, Robert, Sigal, Elliott, Browner, Michelle F.

Journal:

Natural Structural Biology

Year:

1997

File:

PDF, 1.09 MB

1997