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51

Neuropeptide-hydrolysing activities in synaptosomal fractions from dog ileum myenteric, deep muscular and submucous plexi. Their participation in neurotensin inactivation

Barelli, Hélène, Ahmad, Sultan, Kostka, Peter, Fox, Jo-Ann E.T., Daniel, Edwin E., Vincent, Jean-Pierre, Checler, Frédéric

Journal:

Year:

1989

Language:

english

File:

PDF, 686 KB

english, 1989

52

P3-213

Dunys, Julie, Kawarai, Toshitaka, St. George-Hyslop, Peter, Alves da Costa, Cristine, Checler, Frédéric

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 59 KB

english, 2006

53

P3-238

Sévalle, Jean, Eyral, Erwan, Hernandez, Jean-François, Martinez, Jean, Checler, Frédéric

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 57 KB

english, 2006

54

The transcription factor X-box binding protein-1 in neurodegenerative diseases

Dunys, Julie, Duplan, Eric, Checler, Frédéric

Journal:

Molecular Neurodegeneration

Year:

2014

Language:

english

File:

PDF, 381 KB

english, 2014

55

p53 Is Regulated by and Regulates Members of the γ-Secretase Complex

Checler, Frédéric, Dunys, Julie, Pardossi-Piquard, Raphaelle, Alves da Costa, Cristine

Journal:

Neurodegenerative Diseases

Year:

2010

Language:

english

File:

PDF, 235 KB

english, 2010

56

Catabolism of endogenous and overexpressed APH1a and PEN2: evidence for artifactual involvement of the proteasome in the degradation of overexpressed proteins

Dunys, Julie, Kawarai, Toshitaka, Wilk, Sherwin, St. George-Hyslop, Peter, Alves Da Costa, Cristine, Checler, Frédéric

Journal:

Biochemical Journal

Year:

2006

Language:

english

File:

PDF, 511 KB

english, 2006

57

Nuclear TP53: An unraveled function as transcriptional repressor of PINK1

Checler, Frédéric, Goiran, Thomas, Alves da Costa, Cristine

Journal:

Year:

2018

Language:

english

File:

PDF, 883 KB

english, 2018

58

α-Secretase-Derived Product of β-Amyloid Precursor Protein Is Decreased by Presenilin 1 Mutations Linked to Familial Alzheimer's Disease

Karine Ancolio, Philippe Marambaud, Pascale Dauch, Frédéric Checler

Journal:

Journal of Neurochemistry

Year:

1997

Language:

english

File:

PDF, 751 KB

english, 1997

59

10.1038/ncb1101-1030

Armogida, Marianna, Petit, Agnès, Vincent, Bruno, Scarzello, Sabine, da Costa, Cristine Alves, Checler, Frédéric

Journal:

Nature Cell Biology

Year:

2001

Language:

english

File:

PDF, 170 KB

english, 2001

60

Wild-Type and Mutated Nicastrins Do Not Display Aminopeptidase M- and B-like Activities

Anissa Fergani, G. Yu, Peter St. George-Hyslop, Frédéric Checler

Journal:

Biochemical and Biophysical Research Communications

Year:

2001

Language:

english

File:

PDF, 56 KB

english, 2001

61

The beta-secretase-derived C-terminal fragment of APP (C99): a key determinant for intraneuronal pathology in the 3xTgAD mouse

Lauritzen, Inger, Pardossi-Piquard, Raphaelle, Druon, Charlotte, Brigham, Elizabeth, Abraham, Daniel, Ranaldi, Sébatien, Chami, Linda, Dunys, Julie, Checler, Fréderic

Journal:

Molecular Neurodegeneration

Year:

2013

Language:

english

File:

PDF, 66 KB

english, 2013

62

Parkin acts as a transcription factor modulating presenilin-1 and presenilin-2 promoter transactivations

Duplan, Eric, Sévalle, Jean, Viotti, Julien, Goiran, Thomas, Bauer, Charlotte, Renbaum, Paul, Levy-Lahad, Ephrat, Gautier, Clément A, Corti, Olga, Leroudier, Nathalie, Checler, Frédéric, da Costa, Cri

Journal:

Molecular Neurodegeneration

Year:

2013

Language:

english

File:

PDF, 87 KB

english, 2013

63

Aβ42 oligomers modulate β-secretase through an XBP-1s-dependent pathway involving HRD1

Gerakis, Yannis, Dunys, Julie, Bauer, Charlotte, Checler, Fréderic

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 1.64 MB

english, 2016

64

Constitutive and Protein Kinase C-Regulated Secretory Cleavage of Alzheimer's β-Amyloid Precursor Protein: Different Control of Early and Late Events by the Proteasome

Philippe Marambaud, Elvira Lopez-Perez, Sherwin Wilk, Frédéric Checler

Journal:

Journal of Neurochemistry

Year:

1997

Language:

english

File:

PDF, 958 KB

english, 1997

65

Inactivation of Neurotensin by Rat Brain Synaptic Membranes. Cleavage at the Pro10-Tyr11 Bond by Endopeptidase 24.11 (Enkephalinase) and a Peptidase Different from Proline-Endopeptidase

Frédéric Checler, P. C. Emson, J. P. Vincent, P. Kitabgi

Journal:

Journal of Neurochemistry

Year:

1984

Language:

english

File:

PDF, 752 KB

english, 1984

66

10.1038/ncb1101-1033a

Armogida, Marianna, Petit, Agnès, Vincent, Bruno, Scarzello, Sabine, da Costa, Cristine Alves, Checler, Frédéric

Journal:

Nature Cell Biology

Year:

2001

Language:

english

File:

PDF, 54 KB

english, 2001

67

Novel proline endopeptidase inhibitors do not modify Aβ40/42 formation and degradation by human cells expressing wild-type and Swedish mutated β-amyloid precursor protein

Agnès Petit, Hélène Barelli, Philippe Morain, Frédéric Checler

Journal:

British Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 157 KB

english, 2000

68

Presenilins: Multifunctional Proteins Involved in Alzheimer's Disease Pathology

Frederic Checler

Journal:

Year:

1999

Language:

english

File:

PDF, 180 KB

english, 1999

69

Comparison of some biological properties of neurotensin and its natural analogue LANT-6

Patrick Kitabgi, Frédéric Checler, Jean-Pierre Vincent

Journal:

European Journal of Pharmacology

Year:

1984

Language:

english

File:

PDF, 236 KB

english, 1984

70

Neuromedin N: High affinity interaction with brain neurotensin receptors and rapid inactivation by brain synaptic peptidases

Frederic Checler, Jean-Pierre Vincent, Patrick Kitabgi

Journal:

European Journal of Pharmacology

Year:

1986

Language:

english

File:

PDF, 442 KB

english, 1986

71

Aging Increased Amyloid Peptide and Caused Amyloid Plaques in Brain of Old APP/V717I Transgenic Mice by a Different Mechanism than Mutant Presenilin1

Dewachter, Ilse, Van Dorpe, Jo, Smeijers, Liesbet, Gilis, Martine, Kuipéri, Cuno, Laenen, Isabelle, Caluwaerts, Nathalie, Moechars, Dieder, Checler, Frédéric, Vanderstichele, Hugo, Van Leuven, Fred

Journal:

Journal of Neuroscience

Year:

2000

Language:

english

File:

PDF, 550 KB

english, 2000

72

Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-β oligomers

Sam Gandy, Adam J. Simon, John W. Steele, Alex L. Lublin, James J. Lah, Lary C. Walker, Allan I. Levey, Grant A. Krafft, Efrat Levy, Frédéric Checler, Charles Glabe, Warren B. Bilker, Ted Abel, James

Journal:

Annals of Neurology

Year:

2010

Language:

english

File:

PDF, 1.19 MB

english, 2010

73

Presenilins

Frédéric Checler

Journal:

Molecular Neurobiology

Year:

1999

Language:

english

File:

PDF, 975 KB

english, 1999

74

Increased expression of neuronal cyclooxygenase-2 in the hippocampus in amyotrophic lateral sclerosis both with and without dementia

Osamu Yokota, Seishi Terada, Hideki Ishizu, Takeshi Ishihara, Hanae Nakashima, Aki Kugo, Kuniaki Tsuchiya, Kenji Ikeda, Toshiyuki Hayabara, Yuko Saito, Shigeo Murayama, Kenji Uéda, Frédéric Checler, S

Journal:

Acta Neuropathologica

Year:

2004

Language:

english

File:

PDF, 302 KB

english, 2004

75

ERK1-independent α-secretase cut of β-amyloid precursor protein via M1 muscarinic receptors and PKCα/ε

Moustapha Cisse, Ursula Braun, Michael Leitges, Abraham Fisher, Gilles Pages, Frédéric Checler, Bruno Vincent

Journal:

Molecular and Cellular Neuroscience

Year:

2011

Language:

english

File:

PDF, 1.30 MB

english, 2011

76

Leaky Ryanodine receptors increases Amyloid-beta load and induces memory impairments in Tg2576 mouse model of Alzheimer disease

Oulès, Bénédicte, Del Prete, Dolores, Greco, Barbara, Zhang, Xuexin, Lauritzen, Inger, Trebak, Mohamed, Benfenati, Fabio, Checler, Frédéric, Chami, Mounia

Journal:

Molecular Neurodegeneration

Year:

2013

Language:

english

File:

PDF, 84 KB

english, 2013

77

p53 in neurodegenerative diseases and brain cancers

Checler, Frédéric, Alves da Costa, Cristine

Journal:

Pharmacology & Therapeutics

Year:

2014

Language:

english

File:

PDF, 689 KB

english, 2014

78

Two-steps control of cellular prion physiology by the Extracellular Regulated Kinase-1 (ERK1)

Checler, Frédéric

Journal:

Year:

2012

Language:

english

File:

PDF, 377 KB

english, 2012

79

The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from γ-secretase

Janelle Nunan, Mark S. Shearman, Frédéric Checler, Roberto Cappai, Geneviève Evin, Konrad Beyreuther, Colin L. Masters, David H. Small

Journal:

Year:

2001

Language:

english

File:

PDF, 602 KB

english, 2001

80

Design and characterization of a novel cellular prion-derived quenched fluorimetric substrate of α-secretase

Moustapha Alfa Cissé, Céline Gandreuil, Jean-François Hernandez, Jean Martinez, Frédéric Checler, Bruno Vincent

Journal:

Biochemical and Biophysical Research Communications

Year:

2006

Language:

english

File:

PDF, 365 KB

english, 2006

81

α-Secretase in Alzheimers Disease and Beyond: Mechanistic, Regulation and Function in the Shedding of Membrane Proteins

Vincent, Bruno, Checler, Frederic

Journal:

Current Alzheimer Research

Year:

2012

Language:

english

File:

PDF, 1.49 MB

english, 2012

82

Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments

Meckler, Xavier, Checler, Frédéric

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 10.31 MB

english, 2016

83

Nuclear factor-κB regulates βAPP and β- and γ-secretases differently at physiological and supraphysiological Aβ concentrations.

Chami, Linda, Buggia-Prévot, Virginie, Duplan, Eric, Del Prete, Dolores, Chami, Mounia, Peyron, Jean-François, Checler, Frédéric

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 40 KB

english, 2015

84

Stably Transfected Human Cells Overexpressing Rat Brain Endopeptidase 3.4.24.16: Biochemical Characterization of the Activity and Expression of Soluble and Membrane-Associated Counterparts

Bruno Vincent, Pascale Dauch, Jean Pierre Vincent, Frédéric Checler

Journal:

Journal of Neurochemistry

Year:

1997

Language:

english

File:

PDF, 1.04 MB

english, 1997

85

Cathepsin D displays in vitro β-secretase-like specificity

Nathalie Chevallier, Jean Vizzavona, Philippe Marambaud, Claus Peter Baur, Maria Spillantini, Pierre Fulcrand, Jean Martinez, Michel Goedert, Jean-Pierre Vincent, Frédéric Checler

Journal:

Year:

1997

Language:

english

File:

PDF, 404 KB

english, 1997

86

Phenotypic alterations triggerred by a novel mutation responsible for early onset Alzheimer's disease: A study on βAPP maturation and apoptotic response

Frederic Checler, Karine Ancolio, Cecile Dumanchin, Olivier Fouques, Dominique Campion, Thierry Frebourg

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 154 KB

english, 2000

87

Ryanodine receptors

Chami, Mounia, Checler, Frédéric

Journal:

Year:

2014

Language:

english

File:

PDF, 421 KB

english, 2014

88

AICD is preferentially produced from C99 in a gamma-secretase in vitro assay

Flammang, Brice, Pardossi-Piquard, Raphaelle, Checler, Frederic

Journal:

Alzheimer's & Dementia

Year:

2011

Language:

english

File:

PDF, 77 KB

english, 2011

89

Neurolysin: From Initial Detection to Latest Advances

Checler, Frédéric, Ferro, Emer S.

Journal:

Neurochemical Research

Year:

2018

Language:

english

File:

PDF, 719 KB

english, 2018

90

Mutant Presenilin 1 Increases the Levels of Alzheimer Amyloid β-Peptide Aβ42 in Late Compartments of the Constitutive Secretory Pathway

Suzana S. Petanceska, Mary Seeger, Frederic Checler, Sam Gandy

Journal:

Journal of Neurochemistry

Year:

2000

Language:

english

File:

PDF, 229 KB

english, 2000

91

Neurotensin and Neuromedin N Are Differently Metabolized in Ventral Tegmental Area and Nucleus Accumbens

Frédéric Checler, Pascale Dauch, Yoshinori Masuo, Jean-Pierre Vincent

Journal:

Journal of Neurochemistry

Year:

1991

Language:

english

File:

PDF, 941 KB

english, 1991

92

O4-06-01: APP and PRPC physiological metabolisms are both controlled by muscarinic receptors via ADAM17 phosphorylation

Bruno Vincent, Moustapha Alfa Cissé, Claire Sunyach, Barbara E. Slack, Abraham Fisher, Frédéric Checler

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 54 KB

english, 2008

93

Apathy-like syndrome associated with early lesion in the triple-transgenic 3xTgAD mouse

Lauritzen, Inger, Pardossi-Piquard, Raphaelle, Checler, Frederic

Journal:

Alzheimer's & Dementia

Year:

2011

Language:

english

File:

PDF, 50 KB

english, 2011

94

P3-225

Alves da Costa, Cristine, Sunyach, Claire, Pardossi-Piquard, Raphaelle, Vincent, Bruno, Sevalle, Jean, Kawarai, Toshitaka, St. George-Hyslop, Peter, Shen, Jie, Checler, Frédéric

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 70 KB

english, 2006

95

P4-219: TMP21 association with the γ-secretase complex and its regulation of protease activity

Pardossi-Piquard, Raphaelle, Chen, Fusheng, Bohm, Christopher, Checler, Frédéric, St George-Hyslop, Peter, Fraser, Paul

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 58 KB

english, 2008

96

Combined pharmacological, mutational and cell biology approaches indicate that p53-dependent caspase 3 activation triggered by cellular prion is dependent on its endocytosis

Claire Sunyach, Frédéric Checler

Journal:

Journal of Neurochemistry

Year:

2005

Language:

english

File:

PDF, 511 KB

english, 2005

97

10.1038/35074581

Petit, Agnès, Bihel, Frédéric, da Costa, Cristine Alvès, Pourquié, Olivier, Checler, Frédéric, Kraus, Jean-Louis

Journal:

Nature Cell Biology

Year:

2001

Language:

english

File:

PDF, 265 KB

english, 2001

98

Murine T cells expressing high activity of prolyl endopeptidase are susceptible to activation-induced cell death

Chikako Odaka, Toshiaki Mizuochi, Takuo Shirasawa, Philippe Morain, Fredéric Checler

Journal:

Year:

2002

Language:

english

File:

PDF, 136 KB

english, 2002

99

MONOIODO-Trp11-NEUROTENSIN, A NEW LIGAND TO STUDY THE INTERACTION OF NEUROTENSIN WITH ITS RECEPTOR

Jean-Pierre Vincent, Jean Mazella, Claudine Poustis, Frédéric Checler, Patrick Kitabgi, Catherin Labbé, Claude Granier, Jurphaas van Rietschoten

Journal:

Annals of the New York Academy of Sciences

Year:

1982

Language:

english

File:

PDF, 99 KB

english, 1982

100

Contribution of endopeptidase 3.4.24.15 to central neurotensin inactivation

Bruno Vincent, Jirı̀ Jiracek, Florence Noble, Mart Loog, Bernard Roques, Vincent Dive, Jean-Pierre Vincent, Frédéric Checler

Journal:

European Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 61 KB

english, 1997

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