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1

The PI3K Pathway in Human Disease

Fruman, David A., Chiu, Honyin, Hopkins, Benjamin D., Bagrodia, Shubha, Cantley, Lewis C., Abraham, Robert T.

Journal:

Year:

2017

Language:

english

File:

PDF, 2.41 MB

english, 2017

2

Cyclosporin A and FK506: molecular mechanisms of immunosuppression and probes for transplantation biology

Barbara E. Bierer, Georg Holländer, David Fruman, Steven J. Burakoff

Journal:

Current Opinion in Immunology

Year:

1993

Language:

english

File:

PDF, 2.52 MB

english, 1993

3

Regulation of quiescence in lymphocytes

Isharat Yusuf, David A. Fruman

Journal:

Trends in Immunology

Year:

2003

Language:

english

File:

PDF, 355 KB

english, 2003

4

PHOSPHOINOSITIDE KINASES

Fruman, David A., Meyers, Rachel E., Cantley, Lewis C.

Journal:

Annual Review of Biochemistry

Year:

1998

Language:

english

File:

PDF, 244 KB

english, 1998

5

Viral/Nonviral Chimeric Nanoparticles To Synergistically Suppress Leukemia Proliferation via Simultaneous Gene Transduction and Silencing

Hong, Cheol Am, Cho, Soo Kyung, Edson, Julius A., Kim, Jane, Ingato, Dominique, Pham, Bryan, Chuang, Anthony, Fruman, David A., Kwon, Young Jik

Journal:

Year:

2016

Language:

english

File:

PDF, 1.53 MB

english, 2016

6

Correlation of calcineurin phosphatase activity and programmed cell death in murine T cell hybridomas

David A. Fruman, Pamela E. Mather, Steven J. Burakoff, Barbara E. Bierer

Journal:

European Journal of Immunology

Year:

1992

Language:

english

File:

PDF, 646 KB

english, 1992

7

FK506 binding protein 12 mediates sensitivity to both FK506 and rapamycin in murine mast cells

David A. Fruman, Michael A. Wood, Carl K. Gjertson, Howard R. Katz, Steven J. Burakoff, Barbara E. Bierer

Journal:

European Journal of Immunology

Year:

1995

Language:

english

File:

PDF, 1.14 MB

english, 1995

8

Frontline: The p85α isoform of phosphoinositide 3-kinase is essential for a subset of B cell receptor-initiated signaling responses

Kristen L. Hess, Amber C. Donahue, Kwan L. Ng, Travis I. Moore, Jean Oak, David A. Fruman

Journal:

European Journal of Immunology

Year:

2004

Language:

english

File:

PDF, 191 KB

english, 2004

9

Distinct signaling mechanisms activate the target of rapamycin in response to different B-cell stimuli

Amber C. Donahue, David A. Fruman

Journal:

European Journal of Immunology

Year:

2007

Language:

english

File:

PDF, 526 KB

english, 2007

10

Foxo1 regulates marginal zone B-cell development

Jing Chen, Jose J. Limon, Caroline Blanc, Stanford L. Peng, David A. Fruman

Journal:

European Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 345 KB

english, 2010

11

Phosphoinositide 3-kinase and its targets in B-cell and T-cell signaling

Journal:

Current Opinion in Immunology

Year:

2004

Language:

english

File:

PDF, 153 KB

english, 2004

12

Fine tuning the immune response with PI3K

David A. Fruman, Georges Bismuth

Journal:

Immunological Reviews

Year:

2009

Language:

english

File:

PDF, 712 KB

english, 2009

13

10.1038/81735

Cantley, Lewis C., Fruman, David A., Mauvais-Jarvis, Franck, Pollard, Daniel A., Yballe, Claudine M., Brazil, Derek, Bronson, Roderick T., Kahn, C. Ronald

Journal:

Nature Neuroscience

Year:

2000

Language:

english

File:

PDF, 67 KB

english, 2000

14

10.1038/81722

Cantley, Lewis C., Fruman, David A., Mauvais-Jarvis, Franck, Pollard, Daniel A., Yballe, Claudine M., Brazil, Derek, Bronson, Roderick T., Kahn, C. Ronald

Journal:

Nature Genetics

Year:

2000

Language:

english

File:

PDF, 53 KB

english, 2000

15

10.1038/81715

Cantley, Lewis C., Fruman, David A., Mauvais-Jarvis, Franck, Pollard, Daniel A., Yballe, Claudine M., Brazil, Derek, Bronson, Roderick T., Kahn, C. Ronald

Journal:

Nature Genetics

Year:

2000

Language:

english

File:

PDF, 610 KB

english, 2000

16

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

Scharenberg, Andrew M., El-Hillal, Ousama, Fruman, David A., Beitz, Laurie O., Li, Zuomei, Lin, Siqi, Gout, Ivan, Cantley, Lewis C., Rawlings, David J., Kinet, Jean-Pierre

Journal:

The EMBO Journal

Year:

1998

Language:

english

File:

PDF, 572 KB

english, 1998

17

A Lipid Kinase Cousin Cooperates to Promote Cancer

Brandon Beagle, David A. Fruman

Journal:

Year:

2011

Language:

english

File:

PDF, 384 KB

english, 2011

18

Role of phosphoinositide 3-kinase signaling in autoimmunity

Oak, Jean S., Fruman, David A.

Journal:

Year:

2007

Language:

english

File:

PDF, 213 KB

english, 2007

19

Mouse Phosphoinositide 3-Kinase p110α Gene: Cloning, Structural Organization, and Localization to Chromosome 3 Band B

Ibrahim A. Aksoy, Marilyn J. Ramsey, David A. Fruman, Saime Aksoy, Lewis C. Cantley, James D. Tucker, Thomas M. Roberts

Journal:

Biochemical and Biophysical Research Communications

Year:

1999

Language:

english

File:

PDF, 105 KB

english, 1999

20

Structural Organization and Alternative Splicing of the Murine Phosphoinositide 3-Kinase p85α Gene

David A. Fruman, Lewis C. Cantley, Christopher L. Carpenter

Journal:

Year:

1996

Language:

english

File:

PDF, 272 KB

english, 1996

21

Measurement of Calcineurin Phosphatase Activity in Cell Extracts

David A. Fruman, Sung-Yun Pai, Claude B. Klee, Steven J. Burakoff, Barbara E. Bierer

Journal:

Year:

1996

Language:

english

File:

PDF, 174 KB

english, 1996

22

Phosphoinositide 3-kinase in immunological systems

David A Fruman, Lewis C Cantley

Journal:

Seminars in Immunology

Year:

2002

Language:

english

File:

PDF, 262 KB

english, 2002

23

PI3K signaling controls cell fate at many points in B lymphocyte development and activation

Amber C. Donahue, David A. Fruman

Journal:

Seminars in Cell & Developmental Biology

Year:

2004

Language:

english

File:

PDF, 500 KB

english, 2004

24

Phosphoinositide Binding Domains: Embracing 3-Phosphate

David A Fruman, Lucia E Rameh, Lewis C Cantley

Journal:

Year:

1999

Language:

english

File:

PDF, 162 KB

english, 1999

25

Xid-like Phenotypes: A B Cell Signalosome Takes Shape

David A Fruman, Anne B Satterthwaite, Owen N Witte

Journal:

Year:

2000

Language:

english

File:

PDF, 74 KB

english, 2000

26

A Peptide Library Approach Identifies a Specific Inhibitor for the ZAP-70 Protein Tyrosine Kinase

Kiyotaka Nishikawa, Sansana Sawasdikosol, David A. Fruman, Jack Lai, Zhou Songyang, Steven J. Burakoff, Michael B. Yaffe, Lewis C. Cantley

Journal:

Year:

2000

Language:

english

File:

PDF, 316 KB

english, 2000

27

Reply to Coffer: FOXO proteins in lymphocyte quiescence

Isharat Yusuf, David A. Fruman

Journal:

Trends in Immunology

Year:

2003

Language:

english

File:

PDF, 40 KB

english, 2003

28

PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances

So, Lomon, Fruman, David A.

Journal:

Biochemical Journal

Year:

2012

Language:

english

File:

PDF, 833 KB

english, 2012

29

P hosphoinositide 3-K inase : Diverse Roles in Immune Cell Activation

Deane, Jonathan A., Fruman, David A.

Journal:

Annual Review of Immunology

Year:

2004

Language:

english

File:

PDF, 648 KB

english, 2004

30

A polyvalent aptamer system for targeted drug delivery

Zhang, Zhiqing, Ali, M. Monsur, Eckert, Mark A., Kang, Dong-Ku, Chen, Yih Yang, Sender, Leonard S., Fruman, David A., Zhao, Weian

Journal:

Year:

2013

Language:

english

File:

PDF, 2.14 MB

english, 2013

31

PI3K and cancer: lessons, challenges and opportunities

Fruman, David A., Rommel, Christian

Journal:

Nature Reviews Drug Discovery

Year:

2014

Language:

english

File:

PDF, 1.15 MB

english, 2014

32

Perfluoroctyl bromide as a blood pool contrast agent for computed tomographic angiography

Fruman, Stuart A., Harned, Roger K., Marcus, David, Kaufman, Stephen, Swenson, Richard B., Bernardino, Michael E.

Journal:

Academic Radiology

Year:

1994

Language:

english

File:

PDF, 1.26 MB

english, 1994

33

T cell receptor (β chain) transgenic mice have selective deficits in γδ T cell subpopulations

Rimm, Ilonna J., Fruman, David A., Abhyankar, Sunil, Sakamoto, Hirohiko, Orme, Ian M., Milstone, David, Seidman, J.G., Ferrara, James L.M.

Journal:

Transplant Immunology

Year:

1994

Language:

english

File:

PDF, 795 KB

english, 1994

34

Cover Picture: DNA-Scaffolded Multivalent Ligands to Modulate Cell Function (ChemBioChem 9/2014)

Zhang, Zhiqing, Eckert, Mark A., Ali, M. Monsur, Liu, Linan, Kang, Dong-Ku, Chang, Elizabeth, Pone, Egest J., Sender, Leonard S., Fruman, David A., Zhao, Weian

Journal:

Year:

2014

Language:

english

File:

PDF, 721 KB

english, 2014

35

DNA-Scaffolded Multivalent Ligands to Modulate Cell Function

Zhang, Zhiqing, Eckert, Mark A., Ali, M. Monsur, Liu, Linan, Kang, Dong-Ku, Chang, Elizabeth, Pone, Egest J., Sender, Leonard S., Fruman, David A., Zhao, Weian

Journal:

Year:

2014

Language:

english

File:

PDF, 1.30 MB

english, 2014

36

Signal transduction and autoimmunity: Introduction

Fruman, David A., Walsh, Craig M.

Journal:

Year:

2007

Language:

english

File:

PDF, 42 KB

english, 2007

37

Achieving cancer cell death with PI3K/mTOR-targeted therapies

Yea, Sung Su, Fruman, David A.

Journal:

Annals of the New York Academy of Sciences

Year:

2013

Language:

english

File:

PDF, 548 KB

english, 2013

38

The p85β regulatory subunit of phosphoinositide 3-kinase has unique and redundant functions in B cells

Oak, Jean S., Chen, Jing, Peralta, Raechel Q., Deane, Jonathan A., Fruman, David A.

Journal:

Year:

2009

Language:

english

File:

PDF, 785 KB

english, 2009

39

mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition

Limon, Jose J., So, Lomon, Jellbauer, Stefan, Chiu, Honyin, Corado, Juana, Sykes, Stephen M., Raffatellu, Manuela, Fruman, David A.

Journal:

Proceedings of the National Academy of Sciences

Year:

2014

Language:

english

File:

PDF, 2.03 MB

english, 2014

40

Positive and Negative Roles of p85α and p85β Regulatory Subunits of Phosphoinositide 3-Kinase in Insulin Signaling

Ueki, Kohjiro, Fruman, David A., Yballe, Claudine M., Fasshauer, Mathias, Klein, Johannes, Asano, Tomoichiro, Cantley, Lewis C., Kahn, C. Ronald

Journal:

Journal of Biological Chemistry

Year:

2003

Language:

english

File:

PDF, 1.19 MB

english, 2003

41

Akt and mTOR in B Cell Activation and Differentiation

Limon, Jose J., Fruman, David A.

Journal:

Frontiers in Immunology

Year:

2012

Language:

english

File:

PDF, 21.47 MB

english, 2012

42

Idelalisib — A PI3Kδ Inhibitor for B-Cell Cancers

Fruman, David A., Cantley, Lewis C.

Journal:

New England Journal of Medicine

Year:

2014

Language:

english

File:

PDF, 374 KB

english, 2014

43

B-1 Cell Lymphoma in Mice Lacking the Steroid and Xenobiotic Receptor, SXR

Casey, Stephanie C., Nelson, Edward L., Turco, Gina M., Janes, Matthew R., Fruman, David A., Blumberg, Bruce

Journal:

Molecular Endocrinology

Year:

2011

Language:

english

File:

PDF, 2.64 MB

english, 2011

44

Effects of Cyclosporin A and FK506 on FcεReceptor Type I- Initiated Increases in Cytokine mRNA in Mouse Bone Marrow-Derived Progenitor Mast Cells: Resistance to FK506 is Associated with a Deficiency in FK506-Binding Protein FKBP12

Randall E. Kaye, David A. Fruman, Barbara E. Bierer, Mark W. Albers, Lynne D. Zydowsky, Susanna I. Ho, Young-Jiu Jin, Maria C. Castells, Stuart L. Schreiber, Christopher T. Walsh, Steven J. Burakoff,

Journal:

Proceedings of the National Academy of Sciences

Year:

1992

Language:

english

File:

PDF, 1.09 MB

english, 1992

45

Cancer therapy: staying current with AMPK: Figure 1

Fruman, David A., Edinger, Aimee L.

Journal:

Biochemical Journal

Year:

2008

Language:

english

File:

PDF, 117 KB

english, 2008

46

Calcineurin Phosphatase Activity in T Lymphocytes is Inhibited by FK 506 and Cyclosporin A

David A. Fruman, Claude B. Klee, Barbara E. Bierer and Steven J. Burakoff

Journal:

Proceedings of the National Academy of Sciences

Year:

1992

Language:

english

File:

PDF, 903 KB

english, 1992

47

Targeting mTOR for the treatment of B cell malignancies

Lee, J. Scott, Vo, Thanh-Trang, Fruman, David A.

Journal:

British Journal of Clinical Pharmacology

Year:

2016

Language:

english

File:

PDF, 524 KB

english, 2016

48

DISRUPTION OF T CELL DEVELOPMENT AND REPERTOIRE SELECTION BY CALCINEURIN INHIBITION IN VIVO

Holländer, Georg A., Fruman, David A., Bierer, Barbara E., Burakoff, Steven J.

Journal:

Transplantation Journal

Year:

1994

File:

PDF, 689 KB

1994

49

Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins

Romero Rosales, Kimberly, Singh, Gurpreet, Wu, Kevin, Chen, Jie, Janes, Matthew R., Lilly, Michael B., Peralta, Eigen R., Siskind, Leah J., Bennett, Michael J., Fruman, David A., Edinger, Aimee L.

Journal:

Biochemical Journal

Year:

2011

Language:

english

File:

PDF, 1.54 MB

english, 2011

50

Competitive inhibition of calcineurin phosphatase activity by its autoinhibitory domain

SAGOO, Jasbir K., FRUMAN, David A., WESSELBORG, Sebastian, WALSH, Christopher T., BIERER, Barbara E.

Journal:

Biochemical Journal

Year:

1996

Language:

english

File:

PDF, 446 KB

english, 1996