George W. J. Fleet: search on Z-Library

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51

Design, Synthesis, and Biological Evaluation of Enantiomeric β-N-Acetylhexosaminidase Inhibitors LABNAc and DABNAc as Potential Agents against Tay-Sachs and Sandhoff Disease

J. S. Shane Rountree, Terry D. Butters, Mark R. Wormald, Stephanie D. Boomkamp, Raymond A. Dwek, Naoki Asano, Kyoko Ikeda, Emma L. Evinson, Robert J. Nash, George W. J. Fleet

Journal:

Year:

2009

Language:

english

File:

PDF, 529 KB

english, 2009

52

Synthesis of the enantiomers of 6-epicastanospermine and 1,6-diepicastanospermine from d- and l-gulonolactone

George W.J. Fleet, Nigel G. Ramsden, Robert J. Nash, Linda E. Fellows, Gary S. Jacob, Russell J. Molyneux, Isabelle Cenci di Bello, Bryan Winchester

Journal:

Carbohydrate Research

Year:

1990

Language:

english

File:

PDF, 1.05 MB

english, 1990

53

X-ray crystal structure of the hydrochloride of 6-epicastanospermine [(1S,6R,7R,8R,8aR)-1,6,7,8-tetrahydroxy-octahydroindolizine]

Robert J. Nash, Linda E. Fellows, Aarti Girdhar, George W.J. Fleet, Josephine M. Peach, David J. Watkin, Mervyn P. Hegarty

Journal:

Year:

1990

Language:

english

File:

PDF, 233 KB

english, 1990

54

Two alexines [3-hydroxymethyl-1,2,7-trihydroxypyrrolizidines] from Castanospermum australe

Robert J. Nash, Linda E. Fellows, Janet V. Dring, George W.J. Fleet, Aarti Girdhar, Nigel G. Ramsden, Josephine M. Peach, Mervyn P. Hegarty, Anthony M. Scofield

Journal:

Year:

1990

Language:

english

File:

PDF, 388 KB

english, 1990

55

A practical synthesis of deoxymannojirimycin and of (2s,3R,4R,5R)-3,4,5-trihydroxypipecolic acid from D-glucose

George W.J. Fleet, Nigel G. Ramsden, David R Witty

Journal:

Year:

1989

Language:

english

File:

PDF, 683 KB

english, 1989

56

Synthesis of, and lack of inhibition of a rhamnosidase by, both enantiomers of deoxyrhamnojirimycin and rhamnolactam: β-mannosidase inhibition by δ-lactams

Anthony J. Fairbanks, Neil C. Carpenter, George W.J. Fleet, Nigel G. Ramsden, I. Cenci de Bello, Bryan G. Winchester, Samer S. Al-Daher, Gerry Nagahashi

Journal:

Year:

1992

Language:

english

File:

PDF, 865 KB

english, 1992

57

Synthesis of (3S,5S)-quinuclidine-3,5-diol and of [3S-(3α,3aα,7aα)]-octahydro-2-furo[2,3-c]pyridinol from D-arabinose

M. Pilar Vázquez-Tato, Julio A. Seijas, George W.J. Fleet, Christopher J. Mathews, Philippa R. Hemmings, David Brown

Journal:

Year:

1995

Language:

english

File:

PDF, 1.03 MB

english, 1995

58

Synthesis of 5-epihydantocidin from D-Ribose

Antony J. Fairbanks, George W.J. Fleet

Journal:

Year:

1995

Language:

english

File:

PDF, 1.22 MB

english, 1995

59

α-Azidoesters as divergent intermediates for combinatorial generation of glucofuranose libraries of novel N-linked glycopeptides

Tilmann W. Brandstetter, Carmen de la Fuente, Yong-ha Kim, Richard I. Cooper, David J. Watkin, Nikos G. Oikonomakos, Louise N. Johnson, George W.J. Fleet

Journal:

Year:

1996

Language:

english

File:

PDF, 606 KB

english, 1996

60

Short syntheses of D-deoxymannojirimycin and D-mannonolactam from L-gulonolactone and of L-deoxymannojirimycin and L-mannonolactam from D-gulonolactone

George W.J. Fleet, Nigel G. Ramsden, David R. Witty

Journal:

Tetrahedron Letters

Year:

1988

Language:

english

File:

PDF, 223 KB

english, 1988

61

Synthesis of 6-epicastanospermine and 1,6-diepicastanospermine from L-gulonolactone and synthesis of L-6-epicastanospermine and L-1,6-diepicastanospermine from D-gulonolactone

George W.J. Fleet, Nigel G. Ramsden, Russell J. Molyneux, Gary S. Jacob

Journal:

Tetrahedron Letters

Year:

1988

Language:

english

File:

PDF, 317 KB

english, 1988

62

A reductive aldol strategy for the synthesis of very highly substituted cyclopentanes from sugar lactones

Russell P. Elliott, George W.J. Fleet, Lisa Pearce, Colin Smith, David J. Watkin

Journal:

Tetrahedron Letters

Year:

1991

Language:

english

File:

PDF, 334 KB

english, 1991

63

Casuarine: A very highly oxygenated pyrrolizidine alkaloid

Robert J. Nash, Paul I. Thomas, Roger D. Waigh, George W.J. Fleet, Mark R. Wormald, Paul M. de Q. Lilley, David J. Watkin

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 229 KB

english, 1994

64

Potent inhibition of glycogen phosphorylase by a spirohydantoin of glucopyranose: First pyranose analogues of hydantocidin

Claire J.F. Bichard, Edward P. Mitchell, Mark R. Wormald, Kimberley A. Watson, Louise N. Johnson, Spyros E. Zographos, Demetra D. Koutra, Nikos G. Oikonomakos, George W.J. Fleet

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 287 KB

english, 1995

65

Spirohydantoins of glucofuranose: Analogues of hydantocidin

Tilmann W. Brandstetter, Yong-ha Kim, Jong Chan Son, Helen M. Taylor, Paul M. de Q. Lilley, David J. Watkin, Louise N. Johnson, Nikos G. Oikonomakos, George W.J. Fleet

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 257 KB

english, 1995

66

Tetrazoles of manno- and rhamno-pyranoses: inhibition of glycosidases by tetrazoles and other mannose mimics

Tilmann W. Brandstetter, Benjamin Davis, David Hyett, Colin Smith, Lucy Hackett, Bryan G. Winchester, George W.J. Fleet

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 348 KB

english, 1995

67

Tetrazoles of manno- and rhamno-furanoses

Benjamin Davis, Tilmann W. Brandstetter, Colin Smith, Lucy Hackett, Bryan G. Winchester, George W.J. Fleet

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 308 KB

english, 1995

68

Spirodiketopiperazines at the anomeric position of mannopyranose: Novel N- linked glycopeptides incorporating an α- amino acid at the anomeric position of mannopyranose

Juan C. Estevez, Daniel D. Long, Mark R. Wormald, Raymond A. Dwek, George W.J. Fleet

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 298 KB

english, 1995

69

The isolation from Nicandra physalodes and identification of the 3-O-β-D-glucopyranoside of 1α,2β,3α,6α-tetrahydroxy-nor-tropane (Calystegine B1)

Rhodri C Griffiths, Alison A Watson, Haruhisa Kizu, Naoki Asano, Hazel J Sharp, M.George Jones, Mark R. Wormald, George W.J. Fleet, Robert J Nash

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 117 KB

english, 1996

70

L-(+)-swainsonine and other pyrrolidine inhibitors of naringinase: Through an enzymic looking glass from D-mannosidase to L-rhamnosidase?

Benjamin Davis, Andrew A. Bell, Robert J. Nash, Alison A. Watson, Rhodri C. Griffiths, M.George Jones, Colin Smith, George W.J. Fleet

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 298 KB

english, 1996

71

2-Hydroxycastanospermines (dihydroxy-L-swainsonines) from octonolactones: Inhibition of naringinase (L-rhamnosidase)

Andrew A. Bell, Lea Pickering, Alison A. Watson, Robert J. Nash, Rhodri C. Griffiths, M.George Jones, George W.J. Fleet

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 299 KB

english, 1996

72

A galactopyranose analogue of hydantocidin

Tilmann W. Brandstetter, Mark R. Wormald, Raymond A. Dwek, Terry D. Butters, Frances M. Platt, Katerina E. Tsitsanou, Spyros E. Zographos, Nikos G. Oikonomakos, George W.J. Fleet

Journal:

Tetrahedron: Asymmetry

Year:

1996

Language:

english

File:

PDF, 742 KB

english, 1996

73

Mimics ofl-rhamnose: Synthesis of C-glycosides of L-rhamnofuranose and an α-azidoester as divergent intermediates for combinatorial generation of rhamnofuranose libraries

Juan C. Estevez, John Saunders, Gurdyal S. Besra, Patrick J. Brennan, Robert J. Nash, George W.J. Fleet

Journal:

Tetrahedron: Asymmetry

Year:

1996

Language:

english

File:

PDF, 221 KB

english, 1996

74

Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases

Yasuhiro Minami, Chinami Kuriyama, Kyoko Ikeda, Atsushi Kato, Kenji Takebayashi, Isao Adachi, George W.J. Fleet, Aikkarach Kettawan, Tadashi Okamoto, Naoki Asano

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 221 KB

english, 2008

75

Looking glass inhibitors: efficient synthesis and biological evaluation of d-deoxyfuconojirimycin

Yves Blériot, Dirk Gretzke, Thomas M. Krülle, Terry D. Butters, Raymond A. Dwek, Robert J. Nash, Naoki Asano, George W.J. Fleet

Journal:

Carbohydrate Research

Year:

2005

Language:

english

File:

PDF, 145 KB

english, 2005

76

Enantiomeric 2-acetamido-1,4-dideoxy-1,4-iminoribitols as potential pyrrolidine hexosaminidase inhibitors

J.S. Shane Rountree, Terry D. Butters, Raymond A. Dwek, George W.J. Fleet

Journal:

Comptes Rendus Chimie

Year:

2011

Language:

english

File:

PDF, 260 KB

english, 2011

77

Chemical instability promotes apparent electrochemical irreversibility: Studies on the electrode kinetics of the one electron reduction of the 2,6-diphenylpyrylium cation in acetonitrile solution

Ian Streeter, Sarah F. Jenkinson, George W.J. Fleet, Richard G. Compton

Journal:

Journal of Electroanalytical Chemistry

Year:

2007

Language:

english

File:

PDF, 588 KB

english, 2007

78

Isolation of the pyrrolizidine alkaloid 1-epialexine from Castanospermum australe

Laurence Jones, Jacqueline Hollinshead, George W.J. Fleet, Amber L. Thompson, David J. Watkin, Zoltan A. Gal, Sarah F. Jenkinson, Atsushi Kato, Robert J. Nash

Journal:

Phytochemistry Letters

Year:

2010

Language:

english

File:

PDF, 96 KB

english, 2010

79

Steviamine, a new indolizidine alkaloid from Stevia rebaudiana

Agnieszka Michalik, Jacqueline Hollinshead, Laurence Jones, George W.J. Fleet, Chu-Yi Yu, Xiang-Guo Hu, Renate van Well, Graeme Horne, Francis X. Wilson, Atsushi Kato, Sarah F. Jenkinson, Robert J. Na

Journal:

Phytochemistry Letters

Year:

2010

Language:

english

File:

PDF, 98 KB

english, 2010

80

An α-glucoside of 1,4-dideoxy-1,4-imino-d-lyxitol with an eleven carbon side chain

Atsushi Kato, Jackie Hollinshead, Yukiko Yamashita, Shinpei Nakagawa, Yuriko Koike, Isao Adachi, Chu-Yi Yu, George W.J. Fleet, Robert J. Nash

Journal:

Phytochemistry Letters

Year:

2010

Language:

english

File:

PDF, 186 KB

english, 2010

81

Synthesis of 4-aminomethyl-tetrahydrofuran-2-carboxylates with 2,4-cis and 2,4-trans relationships

Alison A. Edwards, Gangadharar J. Sanjayan, Shuji Hachisu, Raquel Soengas, Alistair Stewart, George E. Tranter, George W.J. Fleet

Journal:

Year:

2006

Language:

english

File:

PDF, 300 KB

english, 2006

82

A novel series of oligomers from 4-aminomethyl-tetrahydrofuran-2-carboxylates with 2,4-cis and 2,4-trans stereochemistry

Alison A. Edwards, Gangadharar J. Sanjayan, Shuji Hachisu, George E. Tranter, George W.J. Fleet

Journal:

Year:

2006

Language:

english

File:

PDF, 311 KB

english, 2006

83

Towards hydroxylated nylon 6: oligomers from a protected 6-amino-6-deoxy-d-allonate

Darren F.A. Hunter, George W.J. Fleet

Journal:

Tetrahedron: Asymmetry

Year:

2003

Language:

english

File:

PDF, 347 KB

english, 2003

84

Towards hydroxylated nylon 6: linear and cyclic oligomers from a protected 6-amino-6-deoxy-d-galactonate––a novel class of carbopeptoid-cyclodextrin (CPCD)

Benjamin A. Mayes, Rebecca J.E. Stetz, Mark P. Watterson, Alison A. Edwards, Christopher W.G. Ansell, George E. Tranter, George W.J. Fleet

Journal:

Tetrahedron: Asymmetry

Year:

2004

Language:

english

File:

PDF, 463 KB

english, 2004

85

Pseudoenantiomeric oxetane δ-amino acid scaffolds derived from L-rhamnose and D-xylose: D/L-alanine-D-serine and glycine-L-serine dipeptide isosteres

Stephen W. Johnson, Sarah. F. Jenkinson (née Barker), Donald Angus, John H. Jones, David J. Watkin, George W.J. Fleet

Journal:

Tetrahedron: Asymmetry

Year:

2004

Language:

english

File:

PDF, 389 KB

english, 2004

86

Carbohydrate Science

George W.J. Fleet

Journal:

Tetrahedron: Asymmetry

Year:

2005

Language:

english

File:

PDF, 76 KB

english, 2005

87

Sugar amino acids at the anomeric position of carbohydrates: synthesis of spirocyclic amino acids of 6-deoxy-l-lyxofuranose

Yves Blériot, Michela I. Simone, Mark R. Wormald, Raymond A. Dwek, David J. Watkin, George W.J. Fleet

Journal:

Tetrahedron: Asymmetry

Year:

2006

Language:

english

File:

PDF, 249 KB

english, 2006

88

Homochiral carbon branched piperidines from carbon branched sugar lactones: 4-C-methyl-deoxyfuconojirimycin (DFJ) and its enantiomer—removal of glycosidase inhibition

David J. Hotchkiss, Atsushi Kato, Barbara Odell, Timothy D.W. Claridge, George W.J. Fleet

Journal:

Tetrahedron: Asymmetry

Year:

2007

Language:

english

File:

PDF, 297 KB

english, 2007

89

Synthesis of and NMR studies on the four diastereomeric 1-deoxy-d-ketohexoses

Nigel A. Jones, Sarah F. Jenkinson, Raquel Soengas, Mette Fanefjord, Mark R. Wormald, Raymond A. Dwek, Gullapalli P. Kiran, Rao Devendar, Goro Takata, Kenji Morimoto, Ken Izumori, George W.J. Fleet

Journal:

Tetrahedron: Asymmetry

Year:

2007

Language:

english

File:

PDF, 496 KB

english, 2007

90

Synthesis of 2-C-branched derivatives of d-mannose: 2-C-aminomethyl-d-mannose binds to the human C-type lectin DC-SIGN with affinity greater than an order of magnitude compared to that of d-mannose

Daniel A. Mitchell, Nigel A. Jones, Stuart J. Hunter, Joseph M.D. Cook, Sarah F. Jenkinson, Mark R. Wormald, Raymond A. Dwek, George W.J. Fleet

Journal:

Tetrahedron: Asymmetry

Year:

2007

Language:

english

File:

PDF, 268 KB

english, 2007

91

A compendium of sugar amino acids (SAA): scaffolds, peptide- and glyco-mimetics

Martijn D.P. Risseeuw, Mark Overhand, George W.J. Fleet, Michela I. Simone

Journal:

Tetrahedron: Asymmetry

Year:

2007

Language:

english

File:

PDF, 349 KB

english, 2007

92

Bioproduction of a novel sugar 1-deoxy-l-fructose by Enterobacter aerogenes IK7; isomerization of a 6-deoxyhexose to a 1-deoxyhexose

Pushpakiran Gullapalli, Takayuki Shiji, Devendar Rao, Akihide Yoshihara, Kenji Morimoto, Goro Takata, George W.J. Fleet, Ken Izumori

Journal:

Tetrahedron: Asymmetry

Year:

2007

Language:

english

File:

PDF, 319 KB

english, 2007

93

Isomerization of deoxyhexoses: green bioproduction of 1-deoxy-d-tagatose from l-fucose and of 6-deoxy-d-tagatose from d-fucose using Enterobacter agglomerans strain 221e

Akihide Yoshihara, Satoshi Haraguchi, Pushpakiran Gullapalli, Davendar Rao, Kenji Morimoto, Goro Takata, Nigel Jones, Sarah F. Jenkinson, Mark R. Wormald, Raymond A. Dwek, George W.J. Fleet, Ken Izumo

Journal:

Tetrahedron: Asymmetry

Year:

2008

Language:

english

File:

PDF, 261 KB

english, 2008

94

Oxetane amino acids: synthesis of tetrameric and hexameric carbopeptoids derived from l-ribo 4-(aminomethyl)-oxetan-2-carboxylic acid

Beatrice Lopez-Ortega, Sarah F. Jenkinson, Timothy D.W. Claridge, George W.J. Fleet

Journal:

Tetrahedron: Asymmetry

Year:

2008

Language:

english

File:

PDF, 177 KB

english, 2008

95

Green syntheses of new 2-C-methyl aldohexoses and 5-C-methyl ketohexoses: d-tagatose-3-epimerase (DTE)—a promiscuous enzyme

Nigel A. Jones, Devendar Rao, Akihide Yoshihara, Pushpakiran Gullapalli, Kenji Morimoto, Goro Takata, Stuart J. Hunter, Mark R. Wormald, Raymond A. Dwek, Ken Izumori, George W.J. Fleet

Journal:

Tetrahedron: Asymmetry

Year:

2008

Language:

english

File:

PDF, 526 KB

english, 2008

96

Carbon-branched carbohydrate chirons: practical access to both enantiomers of 2-C-methyl-ribono-1,4-lactone and 2-C-methyl-arabinonolactone

Kathrine V. Booth, Filipa P. da Cruz, David J. Hotchkiss, Sarah F. Jenkinson, Nigel A. Jones, Alexander C. Weymouth-Wilson, Robert Clarkson, Thomas Heinz, George W.J. Fleet

Journal:

Tetrahedron: Asymmetry

Year:

2008

Language:

english

File:

PDF, 273 KB

english, 2008

97

Studies on the transformation of nitrosugars into branched chain iminosugars. Part II: Synthesis of (3R,4R,5R,6S)-2,2-bis(hydroxymethyl)azepane-3,4,5,6-tetraol

José M. Otero, Amalia M. Estévez, Raquel G. Soengas, Juan C. Estévez, Robert J. Nash, George W.J. Fleet, Ramón J. Estévez

Journal:

Tetrahedron: Asymmetry

Year:

2008

Language:

english

File:

PDF, 245 KB

english, 2008

98

Carbon-branched δ-tetrahydrofuran sugar amino acids (SAAs) as dipeptide isostere scaffolds

Michela I. Simone, Alison A. Edwards, George E. Tranter, George W.J. Fleet

Journal:

Tetrahedron: Asymmetry

Year:

2008

Language:

english

File:

PDF, 515 KB

english, 2008

99

Carbon-branched carbohydrate chirons: synthesis of C-3 and C-4-branched sugar lactones derived from d-erythronolactone

Sarah F. Jenkinson, K. Victoria Booth, Amalia M. Estévez Reino, Graeme Horne, Ramón J. Estévez, George W.J. Fleet

Journal:

Tetrahedron: Asymmetry

Year:

2009

Language:

english

File:

PDF, 617 KB

english, 2009

100

Looking glass inhibitors: scalable syntheses of DNJ, DMDP, and (3R)-3-hydroxy-l-bulgecinine from d-glucuronolactone and of l-DNJ, l-DMDP, and (3S)-3-hydroxy-d-bulgecinine from l-glucuronolactone. DMDP inhibits β-glucosidases and β-galactosidases whereas l-DMDP is a potent and specific inhibitor of α-glucosidases

Daniel Best, Chen Wang, Alexander C. Weymouth-Wilson, Robert A. Clarkson, Francis X. Wilson, Robert J. Nash, Saori Miyauchi, Atsushi Kato, George W.J. Fleet

Journal:

Tetrahedron: Asymmetry

Year:

2010

Language:

english

File:

PDF, 592 KB

english, 2010

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