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1

Competitive Inhibitors of Helicobacter pylori Type II Dehydroquinase: Synthesis, Biological Evaluation, and NMR Studies

Cristina Sánchez-Sixto, Verónica F. V. Prazeres, Luis Castedo, Se Won Suh, Heather Lamb, Alastair R. Hawkins, Francisco Javier Cañada, Jesús Jiménez-Barbero, Concepción González-Bello

Journal:

Year:

2008

Language:

english

File:

PDF, 746 KB

english, 2008

2

β-Lactamase Inhibitors to Restore the Efficacy of Antibiotics against Superbugs

González-Bello, Concepción, Rodríguez, Diana, Pernas, Marina, Rodríguez, Ángela, Colchón, Esther

Journal:

Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 21.39 MB

english, 2019

3

ChemInform Abstract: Synthesis of (2R)-2-Bromodehydroquinic Acid and (2R)-2- Fluorodehydroquinic Acid.

M. K. MANTHEY, C. GONZALEZ-BELLO, C. ABELL

Journal:

Year:

1997

File:

PDF, 32 KB

1997

4

ChemInform Abstract: Synthesis of Tetrahydroquinolines, Hexahydrobenzoindolizines and an Aryl Phosphonate Linker for the Generation of Catalytic Antibodies.

C. GONZALEZ-BELLO, C. ABELL, F. J. LEEPER

Journal:

Year:

1997

File:

PDF, 34 KB

1997

5

ChemInform Abstract: Syntheses of 2-Bromo- and 2-Fluoro-3-dehydroshikimic Acids and 2-Bromo- and 2-Fluoroshikimic Acids Using Synthetic and Enzymatic Approaches.

C. GONZALEZ-BELLO, M. K. MANTHEY, J. H. HARRIS, A. R. HAWKINS, J. R. COGGINS, C. ABELL

Journal:

Year:

1998

File:

PDF, 35 KB

1998

6

ChemInform Abstract: Synthesis of 4-Deoxyquinic, 4-Deoxyshikimic and 4-Deoxy-3-dehydroshikimic Acid.

Concepcion Gonzalez-Bello, John R. Coggins, Alastair R. Hawkins, Chris Abell

Journal:

Year:

1999

File:

PDF, 25 KB

1999

7

ChemInform Abstract: Six-Membered Heterocycles: Pyridines

Concepcion Gonzalez-Bello, Luis Castedo

Journal:

Year:

2012

File:

PDF, 18 KB

2012

8

Determination of the Bound Conformation of a Competitive Nanomolar Inhibitor of Mycobacterium tuberculosis Type II Dehydroquinase by NMR Spectroscopy

Verónica F. V. Prazeres, Cristina Sánchez-Sixto, Luis Castedo, Ángeles Canales, Francisco Javier Cañada, Jesús Jiménez-Barbero, Heather Lamb, Alastair R. Hawkins, Concepción González-Bello

Journal:

Year:

2006

Language:

english

File:

PDF, 492 KB

english, 2006

9

Nanomolar Competitive Inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor Type II Dehydroquinase

Verónica F. V. Prazeres, Cristina Sánchez-Sixto, Luis Castedo, Heather Lamb, Alastair R. Hawkins, Alan Riboldi-Tunnicliffe, John R. Coggins, Adrian J. Lapthorn, Concepción González-Bello

Journal:

Year:

2007

Language:

english

File:

PDF, 646 KB

english, 2007

10

Cover Picture: Nanomolar Competitive Inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor Type II Dehydroquinase (ChemMedChem 2/2007)

Verónica F. V. Prazeres, Cristina Sánchez-Sixto, Luis Castedo, Heather Lamb, Alastair R. Hawkins, Alan Riboldi-Tunnicliffe, John R. Coggins, Adrian J. Lapthorn, Concepción González-Bello

Journal:

Year:

2007

File:

PDF, 43 KB

2007

11

2-Substituted-3-Dehydroquinic Acids as Potent Competitive Inhibitors of Type II Dehydroquinase

Verónica F. V. Prazeres, Luis Castedo, Heather Lamb, Alastair R. Hawkins, Concepción González-Bello

Journal:

Year:

2009

Language:

english

File:

PDF, 538 KB

english, 2009

12

Synthesis of Amino Carba Sugars and Conformationally Restricted Polyhydroxy γ-Amino Acids from (−)-Quinic Acid

Montserrat Carballido, Luis Castedo, Concepción González-Bello

Journal:

European Journal of Organic Chemistry

Year:

2004

Language:

english

File:

PDF, 151 KB

english, 2004

13

Stereoselective Synthesis of Novel Cyclic γ-Amino Acids and Triazole Derivatives

Verónica F. V. Prazeres, Luis Castedo, Concepción González-Bello

Journal:

European Journal of Organic Chemistry

Year:

2008

Language:

english

File:

PDF, 487 KB

english, 2008

14

Progress in type II dehydroquinase inhibitors: From concept to practice

Concepción González-Bello, Luis Castedo

Journal:

Medicinal Research Reviews

Year:

2007

Language:

english

File:

PDF, 1.09 MB

english, 2007

15

A selective resin for trans-diequatorial-1,2-diols

Emilio Lence, Luis Castedo, Concepción González-Bello

Journal:

Tetrahedron Letters

Year:

2009

Language:

english

File:

PDF, 560 KB

english, 2009

16

Functional desymmetrization of 1,3-dioximes for the obtention of 1,2,3-hetero trisubstituted carbocycles

Valdemar B.C. Figueira, Arantxa G. Esqué, Ravi Varala, Concepción González-Bello, Sundaresan Prabhakar, Ana M. Lobo

Journal:

Tetrahedron Letters

Year:

2010

Language:

english

File:

PDF, 233 KB

english, 2010

17

Synthesis of Spiro Carba-Sugars by Ring-Closing Metathesis

Concepción González-Bello, Luis Castedo, Francisco Javier Cañada

Journal:

European Journal of Organic Chemistry

Year:

2006

Language:

english

File:

PDF, 234 KB

english, 2006

18

Synthesis of 3-alkyl enol mimics inhibitors of type II dehydroquinase: factors influencing their inhibition potency

Blanco, Beatriz, Sedes, Antía, Peón, Antonio, Lamb, Heather, Hawkins, Alastair R., Castedo, Luis, González-Bello, Concepción

Journal:

Organic & Biomolecular Chemistry

Year:

2012

Language:

english

File:

PDF, 2.80 MB

english, 2012

19

Structural variety of zinc and copper complexes based on a 2,3-disubstituted 1,2,3,4-tetrahydroquinazoline ligand

Sanmartín-Matalobos, Jesús, Portela-García, Cristina, Martínez-Rodríguez, Luis, González-Bello, Concepción, Lence, Emilio, García-Deibe, Ana M., Fondo, Matilde

Journal:

Dalton Transactions

Year:

2012

Language:

english

File:

PDF, 1.16 MB

english, 2012

20

Mechanistic Basis of the Inhibition of Type II Dehydroquinase by (2 S )- and (2 R )-2-Benzyl-3-dehydroquinic Acids

Lence, Emilio, Tizón, Lorena, Otero, José M., Peón, Antonio, Prazeres, Verónica F. V., Llamas-Saiz, Antonio L., Fox, Gavin C., van Raaij, Mark J., Lamb, Heather, Hawkins, Alastair R., González-Bello,

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 3.61 MB

english, 2013

21

Comparative Binding Energy (COMBINE) Analysis for Understanding the Binding Determinants of Type II Dehydroquinase Inhibitors

Peón, Antonio, Coderch, Claire, Gago, Federico, González-Bello, Concepción

Journal:

Year:

2013

Language:

english

File:

PDF, 940 KB

english, 2013

22

Mycobacterium tuberculosis Shikimate Kinase Inhibitors: Design and Simulation Studies of the Catalytic Turnover

Blanco, Beatriz, Prado, Verónica, Lence, Emilio, Otero, José M., Garcia-Doval, Carmela, van Raaij, Mark J., Llamas-Saiz, Antonio L., Lamb, Heather, Hawkins, Alastair R., González-Bello, Concepción

Journal:

Journal of the American Chemical Society

Year:

2013

Language:

english

File:

PDF, 1.49 MB

english, 2013

23

Synthesis of 2-Bromo- and 2-Fluoro-3-dehydroshikimic Acids and 2-Bromo- and 2-Fluoroshikimic Acids Using Synthetic and Enzymatic Approaches

González-Bello, C., Manthey, M. K., Harris, J. H., Hawkins, A. R., Coggins, J. R., Abell, C.

Journal:

Journal of Organic Chemistry

Year:

1998

Language:

english

File:

PDF, 106 KB

english, 1998

24

Parallel Solid-Phase Synthesis and Evaluation of Inhibitors of Streptomyces c oelicolor Type II Dehydroquinase

González-Bello, Concepción, Lence, Emilio, Toscano, Miguel D., Castedo, Luis, Coggins, John R., Abell, Chris

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 331 KB

english, 2003

25

Metal-Assisted Ring-Closing/Opening Process of a Chiral Tetrahydroquinazoline

García-Deibe, Ana M., Sanmartín-Matalobos, Jesús, González-Bello, Concepción, Lence, Emilio, Portela-García, Cristina, Martínez-Rodríguez, Luis, Fondo, Matilde

Journal:

Inorganic Chemistry

Year:

2012

Language:

english

File:

PDF, 4.94 MB

english, 2012

26

Exploring the Water-Binding Pocket of the Type II Dehydroquinase Enzyme in the Structure-Based Design of Inhibitors

Blanco, Beatriz, Sedes, Antía, Peón, Antonio, Otero, José M., van Raaij, Mark J., Thompson, Paul, Hawkins, Alastair R., González-Bello, Concepción

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 6.15 MB

english, 2014

27

Structure-Based Design, Synthesis, and Biological Evaluation of Inhibitors of Mycobacterium t uberculosis Type II Dehydroquinase

Sánchez-Sixto, Cristina, Prazeres, Verónica F. V., Castedo, Luis, Lamb, Heather, Hawkins, Alastair R., González-Bello, Concepción

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 372 KB

english, 2005

28

Synthesis of (2R)-2-bromodehydroquinic acid and (2R)-2-fluorodehydroquinic acid

Manthey, Michael K., González-Bello, Concepción, Abell , Chris

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1997

Language:

english

File:

PDF, 349 KB

english, 1997

29

Serendipitous formation of 3-tosyl-1,2,3,4-tetrahydroquinazoline

Sanmartín-Matalobos, Jesus, García-Deibe, Ana M., Briones-Miguéns, Lucía, Lence, Emilio, González-Bello, Concepcion, Portela-García, Cristina, Fondo, Matilde

Journal:

New Journal of Chemistry

Year:

2013

Language:

english

File:

PDF, 2.50 MB

english, 2013

30

Synthesis of 4-deoxyquinic, 4-deoxyshikimic and 4-deoxy-3-dehydroshikimic acids

González-Bello, Concepción, Coggins, John R., Hawkins, Alastair R., Abell, Chris

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1999

Language:

english

File:

PDF, 176 KB

english, 1999

31

The conformational rigidity of butane-1,2-diacetals as a powerful synthetic tool

Lence, Emilio, Castedo, Luis, González-Bello, Concepción

Journal:

Chemical Society Reviews

Year:

2008

Language:

english

File:

PDF, 1.08 MB

english, 2008

32

Synthesis of tetrahydroquinolines, hexahydrobenzoindolizines and an aryl phosphonate linker for the generation of catalytic antibodies

González-Bello, Concepción, Abell, Chris, Leeper, Finian J.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1997

Language:

english

File:

PDF, 450 KB

english, 1997

33

Irreversible covalent modification of type I dehydroquinase with a stable Schiff base

Tizón, Lorena, Maneiro, María, Peón, Antonio, Otero, José M., Lence, Emilio, Poza, Sergio, van Raaij, Mark J., Thompson, Paul, Hawkins, Alastair R., González-Bello, Concepción

Journal:

Organic & Biomolecular Chemistry

Year:

2015

Language:

english

File:

PDF, 1.97 MB

english, 2015

34

Using Surface Enhanced Raman Scattering to Analyze the Interactions of Protein Receptors with Bacterial Quorum Sensing Modulators

Costas, Celina, López-Puente, Vanesa, Bodelón, Gustavo, González-Bello, Concepción, Pérez-Juste, Jorge, Pastoriza-Santos, Isabel, Liz-Marzán, Luis M.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.72 MB

english, 2015

35

Chiral Aziridination of Olefins Using a Chiral Sulfinamide as the Nitrogen Source

Bonifácio, Vasco, González-Bello, Concepción, Rzepa, Henry, Prabhakar, Sundaresan, Lobo, Ana

Journal:

Year:

2010

Language:

english

File:

PDF, 162 KB

english, 2010

36

Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct

González-Bello, Concepción, Tizón, Lorena, Lence, Emilio, Otero, José M., van Raaij, Mark J., Martinez-Guitian, Marta, Beceiro, Alejandro, Thompson, Paul, Hawkins, Alastair R.

Journal:

Journal of the American Chemical Society

Year:

2015

Language:

english

File:

PDF, 1.24 MB

english, 2015

37

Hydrolysis of imidazolidine ligands mediated by CuII: Mononuclear, tetranuclear and 1D CuII-amine complexes

Fondo, Matilde, Doejo, Jesús, García-Deibe, Ana M., Sanmartín, Jesús, González-Bello, Concepción, Vicente, Ramón

Journal:

Year:

2015

Language:

english

File:

PDF, 1.39 MB

english, 2015

38

Editorial [ The Medicinal Chemistry of Anti-Infectious Agents Guest Editor: Concepcion Gonzalez-Bello ]

Gonzalez-Bello, Concepcion

Journal:

Current Topics in Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 12 KB

english, 2008

39

Specific chemical modification of bacterial type I dehydroquinase – opportunities for drug discovery

González-Bello, Concepción

Journal:

Future Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 2.96 MB

english, 2015

40

LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48

Vallejo, Juan A., Martínez-Guitián, Marta, Vázquez-Ucha, Juan C., González-Bello, Concepción, Poza, Margarita, Buynak, John D., Bethel, Christopher R., Bonomo, Robert A., Bou, German, Beceiro, Alejand

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2016

Language:

english

File:

PDF, 624 KB

english, 2016

41

Targeting the Motion of Shikimate Kinase: Development of Competitive Inhibitors that Stabilize an Inactive Open Conformation of the Enzyme

Prado, Verónica, Lence, Emilio, Maneiro, María, Vázquez-Ucha, Juan C., Beceiro, Alejandro, Thompson, Paul, Hawkins, Alastair R., González-Bello, Concepción

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 2.03 MB

english, 2016

42

[Society of Petroleum Engineers SPE Trinidad and Tobago Section Energy Resources Conference - Port of Spain, Trinidad and Tobago (2016-06-13)] SPE Trinidad and Tobago Section Energy Resources Conference - Casabe: Water Injection Optimization and Surveillance in a Mature Field

Agudelo, O. C., Acosta, T. J., Tellez-Mejia, C. E., Gonzalez-Bello, P., Navas, E. E., Duran, J. P., Porlles, J.

Language:

english

File:

PDF, 3.14 MB

english

43

Study of the Phosphoryl-Transfer Mechanism of Shikimate Kinase by NMR Spectroscopy

Prado, Verónica, Lence, Emilio, Vallejo, Juan A., Beceiro, Alejandro, Thompson, Paul, Hawkins, Alastair R., González-Bello, Concepción

Journal:

Chemistry - A European Journal

Year:

2016

Language:

english

File:

PDF, 5.71 MB

english, 2016

44

ChemInform Abstract: Designing Irreversible Inhibitors - Worth the Effort?

Gonzalez-Bello, Concepcion

Journal:

Year:

2016

File:

PDF, 16 KB

2016

45

Designing Irreversible Inhibitors-Worth the Effort?

González-Bello, Concepción

Journal:

Year:

2016

Language:

english

File:

PDF, 3.85 MB

english, 2016

46

Evidence from kinetic isotope studies for an enolate intermediate in the mechanism of type II dehydroquinases

HARRIS, Joanna M, GONZALEZ-BELLO, Concepcion, KLEANTHOUS, Colin, HAWKINS, Alastair R., COGGINS, John R., ABELL, Chris

Journal:

Biochemical Journal

Year:

1996

Language:

english

File:

PDF, 360 KB

english, 1996

47

Freezing the Dynamic Gap for Selectivity: Motion-Based Design of Inhibitors of the Shikimate Kinase Enzyme

Prado, Verónica, Lence, Emilio, Thompson, Paul, Hawkins, Alastair R., González-Bello, Concepción

Journal:

Chemistry - A European Journal

Year:

2016

Language:

english

File:

PDF, 11.19 MB

english, 2016

48

Frontispiece: Freezing the Dynamic Gap for Selectivity: Motion-Based Design of Inhibitors of the Shikimate Kinase Enzyme

Prado, Verónica, Lence, Emilio, Thompson, Paul, Hawkins, Alastair R., González-Bello, Concepción

Journal:

Chemistry - A European Journal

Year:

2016

File:

PDF, 2.46 MB

2016

49

Mapping a protein recognition centre with chiral photoactive ligands. An integrated approach combining photophysics, reactivity, proteomics and molecular dynamics simulation studies

Limones-Herrero, Daniel, Pérez-Ruiz, Raúl, Lence, Emilio, González-Bello, Concepción, Miranda, Miguel A., Jiménez, M. Consuelo

Journal:

Chemical Science

Year:

2017

Language:

english

File:

PDF, 1.77 MB

english, 2017

50

Reducing the Flexibility of Type II Dehydroquinase Enzyme for Inhibition - A Fragment-Based Approach and Molecular Dynamics Simulation Study

Peón, Antonio, Robles, Adrián, Blanco, Beatriz, Convertino, Marino, Thompson, Paul, Hawkins, Alastair R., Caflisch, Amedeo, Gonzalez-Bello, Concepcion

Journal:

Year:

2017

Language:

english

File:

PDF, 2.24 MB

english, 2017